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Figure source data for 'Ultrafast activation of the double-exchange interaction in antiferromagnetic manganites'
<p>This repository contains figure source data for 'Ultrafast activation of the double-exchange interaction in antiferromagnetic manganites'</p>
Dataset for study of inhibition or activation of yeast and human IRE1 dimers, by Quercetin and Quercitrine.
<p>Docked structures, MD trajectories, BPMD simulation files and video of RNase motion cycles in apo scIre1p dimer. </p>
Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription
<p>This dataset includes the raw imaging data and custom codes related to the publication: Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription, Nat. Commun., 2023.</p>
Fig. 6 in Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity
Fig. 6. The neuroprotective effects of compounds 1a/1b-7 against H2O2-induced injury in SH-SY5Y cells. After H2O2 (200 μM) treatment, cell viabilities were determined by MTT assay in the presence or absence of the tested compounds at different concentrations (12.5, 25, 50 μM).
Fig. 6 in Undescribed phloroglucinol derivatives with antiviral activities from Dryopteris atrata (Wall. Ex Kunze) Ching
Fig. 6. Antivirus activity of compound 7 against HSV-1 by using a fluorescence assay. Compound 7 was added at 20 μM at different times post-infection (1, 2, 4, 6, 8, 12, and 20 h), and acyclovir was used as the positive control. Data were expressed as mean ± SD from three independent experiments (***p <0.001 compared with the viral control group).
Fig. 1 in Scabiosa atropurpurea: A rich source of iridoids with α-glucosidase inhibitory activity evaluated by in vitro and in silico studies
Fig. 1. LC-MS profile (Base Peak chromatogram) in negative ion mode of Scabiosa atropurpurea methanol extract.
Fig. 8 in 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity
Fig. 8. The inhibition of p-IκK, p-IκBα and p-p65 NF-κB protein expression by compound 4 in LPS induced RAW264.7 cells.
Fig. 3 in Scabiosa atropurpurea: A rich source of iridoids with α-glucosidase inhibitory activity evaluated by in vitro and in silico studies
Fig. 3. Docking poses of A) 5 (colored by atom type: C green, O red, polar H light grey); B) 15 (colored by atom type: C light blue, O red, polar H light grey); C) 16 (colored by atom type: C orange, O red, polar H light grey), showing the most promising inhibitory activity against α-glucosidase from Saccharomyces cerevisiae (represented with light grey ribbons; key residues are reported as sticks and colored by atom type: C grey, O red, N blue, polar H light grey). H-bonds are represented with dotted green lines in the 3D representation (for interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article).
Fig. 6 in 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity
Fig. 6. (A)The inhibition of iNOS protein expression by compound 4 in LPS induced RAW264.7 cells; (B) Compound 4 was positioned in the interacting pocket of iNOS (PDB: 3E7G); (C) 2D interaction diagram of compound 4 at the active site of iNOS.
Fig. 4. Main 1H–1H in 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity
Fig. 4. Main 1H–1H gCOSY (blue thick lines) and HMBC correlations (red arrows, from 1H to 13C) of 2–5. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2. Main 1H–1H in 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity
Fig. 2. Main 1H–1H gCOSY (blue thick lines), HMBC (red arrows, from 1H to 13C) and Key NOESY (blue double arrows) correlations of 1 and 2. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 7 in 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity
Fig. 7. Effects of compound 4 on the production of inflammatory cytokines (A: TNF-α, B: IL-1β, and C: IL-6) in LPS-activated RAW264.7 cells using enzyme-linked immunoassay (ELISA). Data were expressed as mean values ± SD, n = 3. #p <0.05, ####p <0.0001, compared with the control group (without compound 4 and LPS), ****p <0.001, compared with the LPS-induced group (only treated with LPS).
Fig. 7. Superimposed 3D in Structure and activity of a novel robust peroxidase from Alkanna frigida cell culture
Fig. 7. Superimposed 3D structure of HRP-C (in brown) on A) 1AP2 and B) POXalf. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 6. A in Structure and activity of a novel robust peroxidase from Alkanna frigida cell culture
Fig. 6. A) RMSD and B) RMSF plots obtained from the analysis of MD simulations (120 ns) of POXalf model.
Fig. 5. A in Structure and activity of a novel robust peroxidase from Alkanna frigida cell culture
Fig. 5. A) Approved 3D model of POXalf (residues 61–75 are 80% transparent). B) Topology of helices in 3D structures of POXalf and HRP (PDB:1HCH). C) Stereo environments of distal and proximal Ca ions in POXalf structure.
Fig. 5 in Unique guanidine-conjugated catechins from the leaves of Alchornea rugosa and their autophagy modulating activity
Fig. 5. (A) The level of autophagy marker protein expression in cells treated with compounds 4–7. LC3B was determined using the LC3B II/I ratio, which was then standardized against the control group (nontreated group). The p62 protein level was detected, and the expression level was normalized by dividing by the protein level in the control group. (CQ: chloroquine treatment group at 25 μM, Rapa: rapamycin treatment group at 0.25 μM). (B) GFP-mRFP-tagged LC3 puncta after treatment with the test compounds. HEK293 cells were treated with autophagy-regulating compounds 4–7, and LC3 puncta were detected by using confocal microscopy.
Fig. 4 in Unique guanidine-conjugated catechins from the leaves of Alchornea rugosa and their autophagy modulating activity
Fig. 4. Screening for autophagy regulation by compounds (1–9) isolated from A. rugosa in HEK293 cells. HEK293 cells stably expressing GFP-LC3 were treated with 20 μM compounds for 24 h, and confocal imaging was used to examine the production of LC3-GFP puncta.
Fig. 5 in Phytotoxic meroterpenoids with herbicidal activities from the phytopathogenic fungus Pseudopestalotiopsis theae
Fig. 5. Phytotoxic effects of different metabolites on seed germination and seedling growth of S. viridis in Petri dishes of experiment: (a) control; (b) 1; (c) 2; (d) 3; (e) 4; (f) 8.
Fig. 3. A in Structure and activity of a novel robust peroxidase from Alkanna frigida cell culture
Fig. 3. A) The 2-D gel IEF of POXalf. B) Optimal pH of activity, C) optimal temperature of activity, and D) the thermal stability of POXalf in the presence of phenol (●) and guaiacol (▴). The average of triple assays of POXsolution (stored at 4 ◦ C) activity in the presence of phenol on E) day 1 and F) day 720. All the phenol (8.6 mM) alf and guaiacol (5 mM) reactions were carried out in PBS (10 mM) in the presence of constant amounts of POXalf (65.35 nM) and H2O2 (6.76 mM). Constant pH of 7 and 6 (for phenol and guaiacol, respectively) and constant temperature (20 ± 1 ◦ C) were applied when needed. POXwas maintained 10 min at the desired pH and alf temperature prior to the assays for the stability examinations.
Fig. 2. A in Structure and activity of a novel robust peroxidase from Alkanna frigida cell culture
Fig. 2. A) SDS-PAGE of purified POXalf [lane1: Ladder, lane2:HRP, lanes3,4&5: POXalf] stained by Coomassie blue (left) and silver nitrate (right). Chromatograms of POXalf purification on B) size exclusion column [Sephadex G50, pH 6] and C) ion-exchange column [S-Sepharose, pH 6, NaCl 0.2 M]. D) UV–Visible spectrum of purified POXalf. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.