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Fig. 1. A in Structure and activity of a novel robust peroxidase from Alkanna frigida cell culture
Fig. 1. A) A. frigida callus at the end of a 31- day subculture and B) its corresponding growth profile. C) POX production in the calluses of A. frigida [A.f], Arnebia euchroma [A.e], Lithospermum officinale [L.o], Onosma dasytrichum [O.d], and Nonea caspica [N.c]. D) POX (filled columns) and CAT (dashed columns) activities in the extract of A. frigida callus during a 31-day subculture. The subcultures were carried out on solid MS medium containing kinetin (10 μM), 2,4-D (1 μM), and sucrose (5% w/v) in darkness at 25 ◦ C. See the experimental section for the enzymatic assays conditions.
Fig. 5 in Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085
Fig. 5. Experimental ECD spectra of compounds 1 and 2 in CHCl3 compared with calculated spectra of (2R,3R,4R,6S,7S)-1 and (2S,3S,4S,6R,7R)-1.
Fig. 3. Key 1H in Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085
Fig. 3. Key 1H NMR region of the bergamotene's bicyclic ring analogues (1 and 3) demonstrating the multiplicity and coupling constants (J) of the bridgering protons.
Fig. 1 in Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085
Fig. 1. Chemical structures of compounds 1–35; the undescribed bergamotenes, α-pyrone, and guaiane in blue, red and green, respectively. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 7 in Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085
Fig. 7. Experimental ECD spectrum of compound 6 in CHCl3 compared with calculated spectra of (1R,2S,6R, 7R)-6, (1S,2R,6S, 7S)-6, (1R,2S,6R, 7S)-6 and (1S,2R,6S, 7R)-6.
Fig. 3. X in Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity
Fig. 3. X-ray crystallographic structure of 1 (displacement ellipsoids are drawn at the 30% probability level).
ADAR1 Links R-Loop Homeostasis to ATR Activation in Replication Stress Response
<p>Unscheduled R-loops are a major source of replication stress and DNA damage. R-loop-induced replication defects are sensed and suppressed by ATR kinase, whereas it is not known whether R-loop itself is actively involved in ATR activation and, if so, how this is achieved. Here, we report that the nuclear form of RNA-editing enzyme ADAR1 promotes ATR activation and resolves genome-wide R-loops, a process that requires its double-stranded RNA-binding domains. Mechanistically, ADAR1 interacts with TOPBP1 and facilitates its loading on perturbed replication forks by enhancing the association of TOPBP1 with RAD9 of the 9-1-1 complex. When replication is inhibited, DNA-RNA hybrid competes with TOPBP1 for ADAR1 binding to promote the translocation of ADAR1 from damaged fork to R-loop region. There, ADAR1 recruits RNA helicases DHX9 and DDX21 to unwind R-loops, simultaneously allowing TOPBP1 to stimulate ATR more efficiently. Collectively, we propose that the tempo-spatially regulated assembly of ADAR1-nucleated protein complexes link R-loop clearance and ATR activation, while R-loops crosstalk with blocked replication forks by transposing ADAR1 to finetune ATR activity and safeguard the genome.</p>
Fig. 6 in Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085
Fig. 6. Experimental ECD spectra of compound 3 and the mixture of 4 and 5 in MeOH compared with calculated spectra of (2S,6S,7S)-3 and (2R,6R,7R)-3.
Fig. 5 in Constituents promoting osteogenesis from the fruits of Psoralea corylifolia and their structure-activity relationship study
Fig. 5. Effects of psoralidin (0.1 μM) and neobavaisoflavone (0.1 μM) on osteogenic differentiation and mineralisation in MC3T3-E1 cell without or with ICI (0.1 μM) treatment. (A1) Calcium nodules after induction for 16 days stained by 1% Alizarin Red S. (A2) Quantification assay of the calcium nodules. (B) ALP activity after induction for 7 days; *P <0.05, **P <0.01, ***P <0.001, vs Control group; ###P <0.001, vs corresponding group without ICI. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Orientation-dependent propulsion of active Brownian spheres: from self-advection to programmable cluster shapes
<p>Supplemental data for the following manuscript: Stephan Bröker, Jens Bickmann, Michael te Vrugt, Michael E. Cates, Raphael Wittkowski, "Orientation-dependent propulsion of active Brownian spheres: from self-advection to programmable cluster shapes".</p>
Artifact for paper "An Experimental Evaluation of Conformance Testing Techniques in Active Automata Learning" at MODELS 2023
<p>This is the archival artifact intended for artefact evaluation of the paper "An Experimental Evaluation of Conformance Testing Techniques in Active Automata Learning" accepted at MODELS 2023. </p>
Assessing the size of non-Māori-speakers' active Māori lexicon
<p>Initial release of data and code</p>
Activity Skunk Dataset
<p>The activity skunk dataset is a minute-by-minute dataset containing activity data from a significant sample of individuals aged 12 to 63 years. </p> <p>This data is obtained through an activity wristband and collects intensity, number of steps, heart rate and raw type of activity. Within this fully anonymised sample (11625 records), that contains only standing, sitting, sleeping and walking activities data.</p>
Supraparticles on beads for supported catalytically active liquid metal solutions – the SCALMS suprabead concept
<p>Raw data for the article Supraparticles on beads for supported catalytically active liquid metal solutions – the SCALMS suprabead concept (DOI: 10.1039/D3MH01020A), including dynamic light scattering, ICP-AES, laser diffraction, nitrogen sorption, nano CT, propane dehydrogenation runs, photographs, SEM and EDX, TEM, and TPO measurements and analysis.</p>
Fig. 4. GLP-1 in Cucurbitane-type triterpenoids from the vines of Momordica charantia and their anti-inflammatory, cytotoxic, and antidiabetic activity
Fig. 4. GLP-1 secretory effects of compounds 1, 3, and 7 in STC-1 cells. GLP-1 secretory response under each condition was illustrated. Rutin (25 μg/mL) is positive control. Data represent Means ± SEM (n = 4). ***P <0.001, compared with None.
Fig. 2. 2D in Cucurbitane-type triterpenoids from the vines of Momordica charantia and their anti-inflammatory, cytotoxic, and antidiabetic activity
Fig. 2. 2D-NMR correlations of the isolated cucurbitanes. (A) 1H–1H COSY and key HMBC correlations of compounds 1, 4, 5, and 6. (B) Main NOESY correlations of compounds 1, 2, 6, and 7.
Fig. 5 in Alkaloids with cholinesterase inhibitory activities from the bulbs of Crinum × amabile Donn ex Ker Gawl
Fig. 5. Analysis of interactions between AChE and A) crystal (green) and re-docking (cyan) galanthamine structures, B) galanthamine, C) compound 29, as well as interactions between BuChE and D) crystal (violet red) and re-docking (pink) tacrine structures, E) galanthamine and F) compound 29. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 19 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 19. Synthesis of prenylated flavonoids 472–494 Reagents and conditions: (a): 3,3-dimethylallyl bromide, 10% KOH; (b): MOMCl, K CO, acetone, 0 ◦ C - RT; (c): 2 3 corresponding benzaldehyde, 10% KOH ethanol/H O, RT; (d): 5% HCl, MeOH/THF, reflux; (e) NaOAc, EtOH, reflux; (f) I, pyridine, 90 ◦ C.
Fig. 18 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 18. Synthesis of prenylated flavonoids (468–471). Reagents and conditions: (a) 1.3 N NaOH, acetone; 3,3-dimethylallyl bromide, benzene, reflux; (b) 3,3-dimethylallyl bromide, 10% KOH; (c) MOMCl, K CO, acetone, 0 ◦ C to RT; (d) p-methoxymethoxyl benzaldehyde, 10% KOH (H O/EtOH); (e) NaOAc, EtOH, reflux; (f) 3N 2 3 2 HCl, MeOH, reflux; (g) I, pyridine, 90 ◦ C.
Fig. 25 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 25. Synthetic route of C-6/C-8 prenylated flavonoids from natural precusor. Reagents and conditions: (a) CH3OCH2Cl, K2CO3, acetone, RT; (b) prenyl bromide, K CO, acetone, 45 ◦ C; (c) Florisil, toluene, reflux; (d) Montmorillonite K10, toluene, reflux; (e) dilute HCl (aq.), CH OH, RT.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.