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Comparison of health literacy profile of patients with end stage kidney disease on dialysis versus non-dialysis chronic kidney disease and the influencing factors: a cross-sectional study
<p><strong>Objectives</strong>: Lower health literacy (HL) is associated with poor outcomes in patients with kidney disease. Since HL matches the patient's competencies with the complexities of the care package, the level of HL sufficient in earlier stages of chronic kidney disease (CKD) may be inadequate for end-stage kidney disease (ESKD) patients on dialysis. We aimed to analyse the HL profile of ESKD and non-dialysis CKD patients and examine if there were significant associations with covariates which could be targeted to address HL deficits, thereby improving patient outcomes.</p> <p><strong>Design and setting</strong>: Cross-sectional study of CKD and ESKD patients from a single Australian health district.</p> <p><strong>Methods</strong>: We assessed the HL profile of 114 CKD and 109 ESKD patients using a 44-item multi-domain HL Questionnaire (HLQ) and examined its association with demographic factors (age, gender, race), smoking, income, education, comorbidities, carer status, cognitive function and depression. Using multi-variable logistic regression models, HL profiles of CKD and ESKD patients were evaluated after adjusting for covariates.</p> <p><strong>Results</strong>: Patients with ESKD had similar demographics and educational levels compared to CKD patients. ESKD had significantly higher frequency of vascular disease, cognitive impairment and depression. ESKD patients had better HL scores for the social support domain (37.1% vs 19.5% in higher HLQ4 tertile, p=0.004), whereas all other HL domains including engagement with healthcare providers were comparable to CKD. Depression was independently associated with nearly all of the HL domains (HLQ1: OR 2.6, p=0.030, HLQ2: OR 7.9, p=<0.001, HLQ3: OR 7.6, p<0.001, HLQ4: OR 3.5, p=0.010, HLQ5: OR 8.9, p=0.001, HLQ6: OR 3.9, p=0.002, HLQ7: OR 4.8, p=0.001, HLQ8: OR 5.3, p=0.001) and education with HL domains relevant to processing health related information (HLQ8: OR 2.6, p=0.008, HLQ9: OR 2.5, p=0.006).</p> <p><strong>Conclusions</strong>: Despite very frequent interactions with health systems, ESKD patients on dialysis did not have higher HL in engagement with health providers and most other HL domains, compared to CKD patients. Strategies promoting patient-provider engagement and managing depression which strongly associates with lower HL may address the impact of HL deficits and favourably modify clinical outcomes in renal patients. </p>
Attitudes, Stressors and Work Outcomes related to the COVID-19 Pandemic among Dental Assistants in Germany: A cross-sectional Study
<p>This dataset stems from across-sectional study conducted early April 2020 among n=1481 dental assistants from entire Germany during the peak of the SARS-CoV-2 pandemic. The study questionnaire was distributed online with help of the Association of Medical Professionals on their social media channels. The collected data provides insights into major stressors among dental assistants at the peak of the pandemic in Germany and allows for analysis of possible determinants of major stressors via logistic regression analysis. No funding was obtained for this study. </p> <p> </p> <p><strong>Dataset information: </strong></p> <p>File type: SPSS file (.sav)</p> <p>Study type: Cross-sectional study</p> <p>Population: Dental assistants in Germany</p> <p>Study period: April 7th-April 14th, 2020</p> <p>Number of participants: 1481</p> <p>Research question: Investigation of attitudes, stressors and work outcomes related to the COVID-19 pandemic among dental assistants in Germany</p> <p>Missing values: None </p> <p>Original variables: v_982, v_1, v_2, v_3, v_5, v_6, v_7, v_10, v_11, v_13, v_14, v_21, v_22, v_23, v_24, v_26, v_27, v_28, v_29, v_31, v_32, v_33, v_40, v_41, v_42, v_43, v_46, v_47, v_48, v_49, v_52, v_57, Beruf_ZFA</p> <p>Modification of variables: All other variables were calculated from the original variables bei either rescaling or dichotomization. </p> <p>Dichotomization of attitudes, stressors and work outcomes: <br> Answer options "Strongly disagree" and "Disagree" were labelled as "no"<br> Answer options "Agree" and "Strongly Agree" were labelled as "yes"</p> <p>Dichotomization of self-rated health:<br> Answer options "Very bad", "Bad" and "Moderate" were labelled as "Bad".<br> Answer options "Good" and "Very good" were labelled as "Good". </p> <p>Rescaling of the variable "Where do you currently work?":<br> Participants who stated "dental practice" as their place of work were labelled as working in a "dental practice". Additionally, all free text answers (v_10 and v_11) were screened and answers "Zahnarztpraxis für Kinder", "Große Zahnarztpraxis" and "Zahnarztpraxis ausschließlich Kinder" were also added to the answer option "dental practice". </p> <p> </p> <p> </p>
Factors associated with COVID-19 infections and mortality in Africa: A cross-sectional study using publicly available data
<p><span><b>Introduction</b></span></p> <p><span>The current COVID-19 pandemic is a global threat. This elicits questions on the level of preparedness and capacity of health systems to respond to emergencies. Relative to other parts of the world, Africa has poorly developed health systems with limited capacity to respond to health crises. Africa is particularly disadvantaged.</span></p> <p><span><b>Methods</b></span></p> <p><span>This cross-sectional study uses publicly available core health data for 53 African countries, to determine risk factors for cumulative COVID-19 deaths and cases per million in all countries in the continent. Descriptive statistics were determined for the indicators and a negative binomial regression was used for modelling the risk factors.</span></p> <p><span><b>Results</b></span></p> <p><span>In Sub-Saharan Africa, an increase in the number of nursing and midwifery personnel decreased the risk of COVID-19 deaths (p=0.0178) while a unit increase in UHC index of service coverage and prevalence of insufficient physical activity among adults increased the risk of COVID-19 deaths (p=0.0432 and p=0.0127). An increase in the proportion of infants initiating breastfeeding reduced the number of cases per million (p<0.0001) while an increase in higher healthy life expectancy at birth increased the number of cases per million (p=0.0340).</span></p> <p><span><b>Conclusion</b></span></p> <p><span>Despite its limited resources, Africa's preparedness and response to the COVID-19 pandemic can be improved by identifying and addressing <i>specific</i> gaps in the funding of health services delivery. These gaps impact negatively on service delivery but appear to have received limited funding and policy priority. </span></p>
Data from: Anxiety and depressive symptoms are associated with poor sleep health during a period of COVID-19 induced nation-wide lockdown: a cross-sectional analysis of adults in the Middle East
<p><strong>Background</strong>: Jordan, a Middle Eastern country, declared a state of national emergency due to the novel coronavirus (COVID-19) and a strict nation-wide lockdown on March 17, 2020, banning all travel and movement around the country, potentially impacting mental health. This study sought to investigate the association between mental health (e.g., anxiety and depressive symptoms) and sleep health among a sample of Jordanians living through a state of COVID-19 induced nation-wide lockdown.</p> <p><strong>Methods</strong>: Using Facebook, participants (N=1,240) in Jordan in March 2020 were recruited and direct to a web-based survey measuring anxiety (items from GAD-7 instrument), depressive symptoms (items from DES-10), sleep health (items from the PSQI), and sociodemographic. A modified Poisson regression model with robust error variance. Adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were estimated to examine how anxiety and depressive symptoms may affect different dimensions of sleep health: 1) poor sleep quality, 2) short sleep duration, 3) encountering sleep problems.</p> <p><strong>Results</strong>: The majority of participants reported having experienced mild (33.8%), moderate (12.9%), or severe (6.3%) levels of anxiety during lockdown, and nearly half of respondents reported depressive symptoms during lockdown. Similarly, over 60 percent of participants reported having experienced at least one sleep problem in the last week, and nearly half reported having had short sleep duration. Importantly, Anxiety was associated with poor sleep health outcomes. For example, corresponding to the dose-response relationship between anxiety and sleep health outcomes, those reporting severe anxiety were the most likely to experience poor sleep quality (aPR =8.95; 95% CI =6.12–13.08), short sleep duration (aPR =2.23; 95% CI = 1.91–2.61), and at least one problem sleep problem (aPR = 1.73; 95% CI = 1.54–1.95). Moreover, depressive symptoms were also associated with poor sleep health outcomes. As compared to scoring in the first quartile, scoring fourth quartile was associated with poor sleep quality (aPR = 11.82; 95% CI = 6.64 – 21.04), short sleep duration (aPR = 1.87; 95% CI = 1.58–2.22), and experiencing at least one sleep problem (aPR = 1.90; 95% CI = 1.66 – 2.18).</p> <p><strong>Conclusions</strong>: Increased levels of anxiety and depressive symptoms can negatively influence sleep health among a sample of Jordanian adults living in a state of COVID-19<br> induced nation-wide lockdown.</p>
Are lifestyle pattern changes associated to poor subjective sleep quality?: a cross-sectional study by gender among the general Japanese population underwent specified medical checkups in 2014 and 2015.
<p>Objectives: Subjective sleep quality (SSQ) is defined by the satisfaction of one's overall sleep experience, and is composed of sleep depth and restfulness. It has not been clarified how poor SSQ is associated to changes in lifestyles. The purpose is to reveal the association of lifestyle pattern changes and poor SSQ.</p> <p>Design: A cross-sectional study.</p> <p>Setting: The data on basic attributes, SSQ, and lifestyle such as presence/absence of smoking, exercise, physical activity, supper time close to bedtime, drinking habits, and alcohol intake amount per day were obtained from database and questionnaire of specified medical checkups in FY 2014 and 2015 in Japan. The analysis was conducted in 2019.</p> <p>Participants: The subjects comprised 49,483 residents (26,087 males and 23,396 females), aged 40 to 74 years who had undergone an annual specified medical checkup from 2014 to 2015 in Fukushima Prefecture, Japan.</p> <p>Outcome measure: Status of SSQ in 2015 was assessed using a question asking whether or not the subjects usually got enough sleep. Poor SSQ in 2015 and lifestyle pattern changes in 2014-2015 were compared between those who were in healthy status both in 2014 and 2015 (referent) and non-referent, using binary logistic regression analysis.</p> <p>Results: Unhealthy lifestyle pattern for 2014-2015 was significantly associated to poor SSQ in 2015: "absent to absent" in exercise for males (Odds ratio [OR] = 1.472; 95% confidence interval [CI] = 1.316, 1.647) and females (OR = 1.428; 95%CI = 1.285, 1.587), physical activity for males (OR = 1.420; 95%CI = 1.270, 1.588) and females (OR = 1.471; 95%CI = 1.322, 1.638), and "present to present" in supper time for males (OR = 1.149; 95%CI = 1.020, 1.294) and females (OR = 1.288; 95%CI = 1.102, 1.505).</p> <p>Conclusions: Health care workers may be able to contribute to the improvement of SSQ, focusing on changeable lifestyles.</p>
Data from: Epidemiology of injuries in elite taekwondo athletes: two Olympic periods cross-sectional retrospective study
Objective: Taekwondo injuries differ according to the characteristics of the athletes and the competition. This analytical cross-sectional retrospective cohort study aimed to describe reported taekwondo injuries and to determine the prevalence, characteristics and possible risk factors for injuries sustained by athletes of the Spanish national team. In addition, we compared each identified risk factor—age, weight category, annual quarter, injury timing and competition difficulty level—with its relation to injury location and type. Settings: Injury occurrences in taekwondo athletes of the Spanish national team during two Olympic periods at the High Performance Centre in Barcelona were analysed. Participants: 48 taekwondo athletes (22 male, 26 female; age range 15–31 years) were studied; 1678 injury episodes occurred. Inclusion criteria were: (1) having trained with the national taekwondo group for a minimum of one sports season; (2) being a member of the Spanish national team. Results: Independently of sex or Olympic period, the anatomical sites with most injury episodes were knee (21.3%), foot (17.0%), ankle (12.2%), thigh (11.4%) and lower leg (8.8%). Contusions (29.3%) and cartilage (17.6%) and joint (15.7%) injuries were the prevalent types of injury. Chronological age, weight category and annual quarter can be considered risk factors for sustaining injuries in male and female elite taekwondists according to their location and type (p≤0.001). Conclusions: This study provides epidemiological information that will help to inform future injury surveillance studies and the development of prevention strategies and recommendations to reduce the number of injuries in taekwondo competition.
Data from: Association of perceived tinnitus with duration of hormone replacement therapy in Korean postmenopausal women: a cross-sectional study
Objective: The purpose of this study was to determine the relationship between hormone replacement therapy and tinnitus in South Korea using data from the Korea National Health and Nutrition Examination Surveys (KNHANES) (2010 ~ 2012). Study Design : Cross-sectional analysis of a nationwide health survey. Methods: KNHANES is a nationally representative cross-sectional survey of South Korea population. Only postmenopausal women aged 19-65 years were included in the study (n = 2736). Auditory function was evaluated using pure-tone audiometric testing according to established KNHANES protocols. Subjects were questioned about their experience with tinnitus. Exogenous hormone-related factors included the starting age and duration of hormone replacement therapy Results: The overall prevalence of tinnitus was 22.2% among postmenopausal women. 1) Tinnitus severity was significantly higher in women using hormone replacement therapy (p = 0.0024) and 2) significantly lower in women who breast-fed their children (p = 0.0386). 3) According to logistic regression models, the longer duration of hormone replacement therapy was significantly associated with increasing tinnitus (OR = 1.323, 95% CI = 1.007-1.737, p = 0.0441). Conclusion: A longer duration of hormone replacement therapy was associated with developing tinnitus in Korean postmenopausal women. Further experimental and epidemiological researches are needed to elucidate the causal relationship between hormone replacement therapy and tinnitus.
Data from: Poor housing conditions in association with child health in a disadvantaged immigrant population: a cross-sectional study in Rosengård, Malmö, Sweden
Objectives: To describe the home environment in terms of housing conditions and their association with child health in a disadvantaged immigrant population. Design: A cross-sectional observational study. Setting: Enrolment took place during 2010–2011 in Rosengård, Malmö, Sweden. Participants: Children aged 0–13 years in 2 study neighbourhoods were recruited from local health records and from schools. 359 children participated, with a participation rate of 40%. Data on health, lifestyle and apartment characteristics from questionnaire-led interviews with the mothers of the children were obtained together with data from home inspections carried out by trained health communicators. Outcome measures: Logistic regression analysis was used to estimate ORs for various health outcomes, adjusted for demographic information and lifestyle factors. Results: The housing conditions were very poor, especially in one of the study neighbourhoods where 67% of the apartments had been sanitised of cockroaches, 27% were infested with cockroaches and 40% had a visible mould. The association between housing conditions and health was mostly inconclusive, but there were statistically significant associations between current asthma and dampness (OR=4.1, 95% CI 1.7 to 9.9), between asthma medication and dampness (OR=2.8, 95% CI 1.2 to 6.4), and between mould and headache (OR=4.2, 95% CI 1.2 to 14.8). The presence of cockroaches was associated with emergency care visits, with colds, with headache and with difficulty falling asleep, and worse general health was associated with mould and presence of cockroaches. Conclusions: The associations between dampness and asthma, and the association between mould and headache, are in line with current knowledge. The presence of cockroaches seemed to be associated with various outcomes, including those related to mental well-being, which is less described in the literature. The results of the present study are hypothesis generating and provide strong incentives for future studies in this study population.
Data from: Effectiveness of diagnostic screening tests in mass screening for COPD using a cooperative regional system in a region with heavy air pollution: a cross-sectional study
Objective: This research aimed to evaluate the effectiveness of a cooperative health care model for early detection and diagnosis of chronic obstructive pulmonary disease (COPD), in Omuta Japan. Methods: This was a cross-sectional observational study. We performed diagnosis of COPD at four public health centres in Omuta, Japan from March 2015 to March 2016, by adding screening for COPD at the time of routine medical evaluations. All patients over 50 years were eligible to participate. Of a total of 397 eligible patients, 293 agreed to take part in the study. Results: The estimated prevalence of COPD in Omuta was 10% among subjects over 40 years and was 17% among smokers. Out of those who were screened, over half had questionnaire scores over the cut-off of 17 points and decreased FEV1/FVC%, indicating COPD (p>0.05). Thirty subjects with suspected COPD were given a referral for further investigation at a local central hospital, but only six underwent further medical examinations. Conclusion: The combination of COPD questionnaire and medical exam was effective as a COPD screening tool. Future research should investigate behavioural interventions for smoking cessation that can be offered in a cooperative model, as well as for improving participation in COPD screening and for encouraging early presentation for treatment in those suspected of having COPD.
Data from: Difficult patient-doctor encounters in a Swiss university outpatient clinic: a cross-sectional study.
Introduction: Previous research has shown that multiple factors contribute to healthcare providers perceiving encounters as difficult, and are related to both medical and non-medical demands. Aim: To measure the prevalence and to identify predictors of encounters perceived as difficult by medical residents. Design and Setting: Cross-sectional study at the Department of Ambulatory Care and Community Medicine (DACCM), a university outpatient clinic with a long tradition of caring for vulnerable patients. Method: We identified difficult doctor-patient encounters using the validated Difficult Doctor-Patient Relationship Questionnaire (DDPRQ-10), and characterized patients using the Patient's Vulnerability Grid, a validated questionnaire measuring 5 domains of vulnerability, both completed by medical residents after each encounter. We used a multiple linear regression model with the outcome variable as the DDPRQ-10 score, controlling for resident characteristics. Participants: We analyzed 527 patient encounters performed by all 27 DACCM residents (17 women and 10 men). We asked each medical resident to evaluate 20 consecutive consultations starting on the same date. Outcome: One hundred and fifty-seven encounters (29,8%) were perceived as difficult. Results: After adjusting for differences among residents, all five domains of the Patient Vulnerability Grid were independently associated with a difficult encounter: frequent health care user; psychological comorbidity; health comorbidity; risky behaviors and a precarious social situation. Conclusion: Nearly a third of encounters were perceived as difficult by medical residents in our university outpatient clinic that cares for a high proportion of vulnerable patients. This represents twice the average ratio of difficult encounters in general practice. All five domains of patient vulnerability appear to have partial explanatory power on medical residents' perception of difficult patient encounters.
Data from: Evaluation of exposure to effervescent drugs in a large health check-up population in France: a cross-sectional study
OBJECTIVES: The relationship between high dietary sodium intake and hypertension is well established. Some drugs are associated with high-sodium content, particularly effervescent tablets (ETs). Despite a possible cardiovascular risk associated with the use of such drugs, observational data describing exposure to ETs in ambulatory subjects are lacking. The aim of this study was to estimate the prevalence of exposure to ETs, and to highlight factors associated with this exposure, in a large French health check-up population. DESIGN: This was cross-sectional study. SETTING AND PARTICIPANTS: Participants were French individuals who underwent medical check-ups at the Investigations Préventives et Cliniques center between April and June 2017. RESULTS: In total, 1,043 subjects were included in the study. The prevalence of exposure to ETs in the last 30 days was 26.9% (95% CI: 24.2 – 29.6). Exposure was frequent (i.e. two ETs per week or more in the last 30 days) for 7.3% of subjects. Self-medication was the major source of exposure (93.8%). Paracetamol, aspirin, vitamins, and betaine accounted for 95.3% of the ETs used. The factors associated with this exposure by multivariate analysis were: male gender, Overseas French origin, depression and body mass index ≥ 25 kg.m-2. A diagnosis of hypertension or treatment with diuretics were not protective factors against exposure to ETs. CONCLUSION: Exposure to ETs is frequent in the general population, particularly through self-medication. Clinical conditions associated with low-salt requirements were not associated with lower exposure to ETs, suggesting a lack of awareness by practitioners and patients about this iatrogenic issue.
Data from: Clinical spectrum and risk factors associated with asymptomatic erosive esophagitis as determined by Los Angeles classification: a cross-sectional study
Background: Gastro esophageal reflux disease (GERD) is a chronic and recurrent disease, and it varies in regions. However, to date, there are no reports available on clinical features and the risk factors for the asymptomatic reflux esophagitis in Nepalese adults. Methods: Data were gathered from 142 erosive patients who had undergone endoscopy at Bir Hospital, Kathmandu. Los Angeles classification was used to grade the severity of the disease. Patients were interviewed to find out the presence of various reflux symptoms. Results: Based on the Los Angeles classification, the severity of the disease assessed was; grade A 31.8% (31/142), grade B 39.4 % (56/142), grade C 33.8% (48/142), and grade D 4.9% (7/142). One hundred and twenty six (88.7%) subjects had reflux symptoms. Prevalence of asymptomatic esophagits was 16(11.3%). Age was independently linked to asymptomatic esophagitis (P<0.05), and the odd of being asymptomatic appeared lower in younger adults (P<0.05; OR: 0.118; CI: 0.014-.994). Conclusion: A low prevalence of asymptomatic reflux esophagits (RE) was seen. Most subjects experienced mild to moderate RE. Age remained an independent factors associated with reflux esophagitis, and the odd of being asymptomatic was lower in younger age.
Data from: Joint effect of education and main lifetime occupation on late life health: a cross-sectional study of older adults in Xiamen, China
Background: The effects of education and occupation on health have been well documented individually, but little is known about their joint effect, especially their cumulative joint effect on late life health. Methods: We enrolled 14,292 participants aged 60+ years by multistage sampling across 173 communities in Xiamen, China, in 2013. Heath status was assessed by the ability to perform six basic activities of daily life. Education was classified in four categories: 'Illiterate', 'Primary', 'Junior high school' and 'Senior high school and beyond'. Main lifetime occupation was also four categorized: 'Employed', 'Farmer', 'Jobless' and 'Others'. Odds ratios (ORs) were estimated by random-intercept multilevel models regressing health status on education and main lifetime occupation with or without their interactions, adjusting by some covariates. Results: Totally, 13,880 participants had complete data, of whom 12.5% suffered from disability, and 'Illiterate' and 'Farmer' took up the greatest proportion (33.01% and 42.72%, respectively). Participants who were higher educated had better health status (ORs = 0.62, 0.46, and 0.44 for the 'Primary', 'Junior high school', and 'Senior high school and beyond', respectively, in comparison with 'Illiterate'). Those who were long term jobless in early life had poorest heath (ORs = 1.88, 95% CI 1.47 to 2.40). Unexpectedly, for the farmers, the risk of poor health gradually increased in relation to higher education level (ORs = 1.26, 1.28, 1.40 and 2.24, respectively). For the 'Employed', similar ORs were obtained for the 'Junior high school' and 'Senior high school and beyond' educated (both ORs = 1.01). For the 'Farmer' and 'Jobless', participants who were 'Illiterate' and 'Primary' educated also showed similar ORs. Conclusions: Both education and main lifetime occupation were associated with late life health. Higher education was observed to be associated with better health, but such educational advantage was mediated by main lifetime occupation.
Data from: Drowning mortality by intent: a population-based cross-sectional study of 32 OECD countries, 2012–2014
Objective: To compare the drowning mortality rates and proportion of deaths of each intent among all drowning deaths in Organisation for Economic Co-operation and Development (OECD) countries in 2012–2014. Design: A population-based cross-sectional study. Setting: 32 OECD countries. Participants: Individuals in OECD countries who died from drowning. Main outcome measures: Drowning mortality rates (deaths per 100,000 population) and proportion (%) of deaths of each intent (i.e., unintentional intent, intentional self-harm, assault, undetermined intent, and all intents combined) among all drowning deaths. Results: Countries with the highest drowning mortality rates (deaths per 100,000 population) were Estonia (3.53), Japan (3.49), and Greece (2.40) for unintentional intent; Ireland (0.96), Belgium (0.96), and Korea (0.89) for intentional self-harm; Austria (0.57), Korea (0.56), and Hungary (0.44) for undetermined intent; and Japan (4.35), Estonia (3.70), and Korea (2.73) for all intents combined. Korea ranked 12th and third for unintentional intent and all intents combined, respectively. By contrast, Belgium ranked second and 15th for intentional self-harm and all intents combined, respectively. The proportion of deaths of each intent among all drowning deaths in each country varied greatly: from 26.2% in Belgium to 96.8% in Chile for unintentional intent; 0.7% in Mexico to 57.4% in Belgium for intentional self-harm; 0.0% in nine countries to 4.9% in Mexico for assault; and 0.0% in Israel and Turkey to 38.3% in Austria for undetermined intent. Conclusions: A large variation in the practice of classifying undetermined intent in drowning deaths across countries was noted and this variation hinders valid international comparisons of intent-specific (unintentional and intentional self-harm) drowning mortality rates.
Knee Proprioception, Muscle Strength, and Stability in Type 2 Diabetes Mellitus: Unveiling the Moderating Effects of Physical Activity – A cross-sectional study.
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DYNAMIC Tanzania Quality of Care Cluster RCT dataset from the 2nd cross-sectional survey
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data (Cognition and vascular endothelial function in hypertensive individuals with and without a history of Covid-19: A Cross-Sectional Study)
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Adherence to the Mediterranean diet and risk of anxiety and depression in people with obesity: a cross-sectional analysis
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The Impact of Sleep Position Preferences on the Sleep Quality, Comfort, and Catheter Care Quality in Patients After Endoscopic Nasobiliary Drainage: A Cross-Sectional Study
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CSF synaptic biomarkers in the preclinical stage of Alzheimer's disease and their association with MRI and PET markers of neurodegeneration: a cross-sectional study
<p>Objective: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer's <i>continuum</i> and associated with Alzheimer's disease (AD) risk factors, primary pathology, and neurodegeneration markers.</p> <p>Methods: Cross-sectional study in the ALFA+ cohort, comprising middle-aged cognitively unimpaired participants. CSF neurogranin and GAP-43 were measured using immunoassays and SNAP-25 and synaptotagmin-1 using immunoprecipitation mass spectrometry. AD CSF biomarkers Aβ42/40, p-tau and t-tau, and the neurodegeneration biomarker NfL were also measured. Participants underwent structural MRI, and <span>fluorodeoxyglucose and</span> Aβ<span> PET imaging. General linear modeling was used to test the associations between CSF synaptic biomarkers and risk factors, </span>Aβ<span> pathology, tau pathology, and neurodegeneration markers.</span></p> <p>Results: All CSF synaptic biomarkers increased with age. CSF neurogranin was higher in females, while CSF SNAP-25 was higher in <i>APOE-</i>ε4 carriers. All CSF synaptic biomarkers increased with higher Aβ load (as measured by CSF Aβ42/40 and Aβ PET Centiloid values) and, importantly, the synaptic biomarkers were increased even in individuals in the earliest stages of Aβ deposition. Higher CSF synaptic biomarkers were also associated with higher CSF p-tau and NfL. Higher CSF neurogranin and GAP-43 were significantly associated with higher brain metabolism, but lower cortical thickness in AD-related brain regions.</p> <p>Conclusion: CSF synaptic biomarkers increase in early preclinical stages of the Alzheimer's <i>continuum </i>even when a low burden of Aβ pathology is present, and they differ in their association with age, sex, <i>APOE-</i>ε4<i>,</i> and markers of neurodegeneration.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.