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459
datasets available to search
ShareScore release 0.9.0
Dataset results
459 results for “mesenchymal stromal cells”
miRNOME of healthy donor and myelodysplastic bone marrow mesenchymal stromal cells (MSC)
GEO Series GSE139471. synthetic construct; Homo sapiens. 7 samples. Type: Non-coding RNA profiling by array.
Bone marrow-derived multipotent mesenchymal stromal cells promote tongue cancer invasion by inducing collagen production
GEO Series GSE44458. Homo sapiens. 4 samples. Type: Expression profiling by array.
DNA methylation characterization in mesenchymal stromal cells (MSCs) of MDS (myelodysplastic syndromes), AML (acute myeloid leukemia) and healthy donors (HD)
GEO Series GSE124390. Homo sapiens. 32 samples. Type: Methylation profiling by array.
Mesenchymal stromal cells-derived small extracellular vesicles affect T-lymphocytes mRNA expression
GEO Series GSE198738. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional gene profile of peripheral blood derived mesenchymal stromal cells from GFP transgenic rat
GEO Series GSE11283. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Transcriptomic landscape of human primary stromal cells (fibroblasts, endothelial cells and mesenchymal stem cells) upon therapy-induced senescence (genotoxic chemotherapy）
GEO Series GSE216842. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in Inflammatory Bowel Disease-Induced Bone Loss
GEO Series GSE298548. Mus musculus. 6 samples. Type: Methylation profiling by high throughput sequencing.
Mesenchymal Stromal Cells Derived from Human Embryonic Stem Cells, Fetal Limb and Bone Marrow Share a Common Phenotype but are Transcriptionally and Biologically Different
GEO Series GSE100752. Homo sapiens. 136 samples. Type: Expression profiling by array.
Mesenchymal stromal cell reprogramming and aberrant inflammatory signalling in myelofibrosis: insights from single-cell RNA sequencing
GEO Series GSE241825. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Expression data in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients
GEO Series GSE122917. Homo sapiens. 9 samples. Type: Expression profiling by array.
RNA-seq of healthy CD34+ HSPCs after co-culture with myelodyplastic syndrome patient-derived mesenchymal stromal cells
GEO Series GSE119916. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article "Neuropeptide Y promotes adipogenesis of human cardiac mesenchymal stromal cells in arrhythmogenic cardiomyopathy"
<p>This record contains raw data related to the article “Neuropeptide Y promotes adipogenesis of human cardiac mesenchymal stromal cells in arrhythmogenic cardiomyopathy"</p> <p><strong>Background: </strong>Arrhythmogenic Cardiomyopathy (AC) is a familial cardiac disease, mainly caused by mutations in desmosomal genes. AC hearts show fibro-fatty myocardial replacement, which favors stress-related life-threatening arrhythmias, predominantly in the young and athletes. AC lacks effective therapies, as its pathogenesis is poorly understood. Recently, we showed that cardiac Mesenchymal Stromal Cells (cMSCs) contribute to adipose tissue in human AC hearts, although the underlying mechanisms are still unclear.</p> <p><strong>Purpose: </strong>We hypothesize that the sympathetic neurotransmitter, Neuropeptide Y (NPY), participates to cMSC adipogenesis in human AC.</p> <p><strong>Methods: </strong>For translation of our findings, we combined in vitro cytochemical, molecular and pharmacologic assays on human cMSCs, from myocardial biopsies of healthy controls and AC patients, with the use of existing drugs to interfere with the predicted AC mechanisms. Sympathetic innervation was inspected in human autoptic heart samples, and NPY plasma levels measured in healthy and AC subjects.</p> <p><strong>Results: </strong>AC cMSCs expressed higher levels of pro-adipogenic isotypes of NPY-receptors (i.e. Y1-R, Y5-R). Consistently, NPY enhanced adipogenesis in AC cMSCs, which was blocked by FDA-approved Y1-R and Y5-R antagonists. AC-associated PKP2 reduction directly caused NPY-dependent adipogenesis in cMSCs. In support of the involvement of sympathetic neurons (SNs) and NPY in AC myocardial remodeling, patients had elevated NPY plasma levels and, in human AC hearts, SNs accumulated in fatty areas and were close to cMSCs.</p> <p><strong>Conclusions: </strong>Independently from the disease origin, AC causes in cMSCs a targetable gain of responsiveness to NPY, which leads to increased adipogenesis, thus playing a role in AC myocardial remodeling.</p>
Dataset related to the article " Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells"
<p>This record contains raw data related to the article “Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca<sup>2+</sup> Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells"</p> <p>Abstract</p> <p>Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal (EL) Ca<sup>2+</sup> release. NAADP-induced lysosomal Ca<sup>2+</sup> release may be amplified by the endoplasmic reticulum (ER) through the Ca<sup>2+</sup>-induced Ca<sup>2+</sup> release (CICR) mechanism. NAADP-induced intracellular Ca<sup>2+</sup> signals were shown to modulate a growing number of functions in the cardiovascular system, but their occurrence and role in cardiac mesenchymal stromal cells (C-MSCs) is still unknown. Herein, we found that exogenous delivery of NAADP-AM induced a robust Ca<sup>2+</sup> signal that was abolished by disrupting the lysosomal Ca<sup>2+</sup> store with Gly-Phe β-naphthylamide, nigericin, and bafilomycin A1, and blocking TPC1 and TPC2, that are both expressed at protein level in C-MSCs. Furthermore, NAADP-induced EL Ca<sup>2+</sup> release resulted in the Ca<sup>2+</sup>-dependent recruitment of ER-embedded InsP<sub>3</sub>Rs and SOCE activation. Transmission electron microscopy revealed clearly visible membrane contact sites between lysosome and ER membranes, which are predicted to provide the sub-cellular framework for lysosomal Ca<sup>2+</sup> to recruit ER-embedded InsP<sub>3</sub>Rs through CICR. NAADP-induced EL Ca<sup>2+</sup> mobilization via EL TPC was found to trigger the intracellular Ca<sup>2+</sup> signals whereby Fetal Bovine Serum (FBS) induces C-MSC proliferation. Furthermore, NAADP-evoked Ca<sup>2+</sup> release was required to mediate FBS-induced extracellular signal-regulated kinase (ERK), but not Akt, phosphorylation in C-MSCs. These finding support the notion that NAADP-induced TPC activation could be targeted to boost proliferation in C-MSCs and pave the way for future studies assessing whether aberrant NAADP signaling in C-MSCs could be involved in cardiac disorders.</p>
Engineering a haematopoietic stem cell niche by reprogramming mesenchymal stromal cells (ATAC-Seq)
GEO Series GSE112231. Mus musculus. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Targeting microRNA-mediated gene repression limits the adipogenic conversion of skeletal muscle mesenchymal stromal cells
GEO Series GSE171505. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Other.
Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling
GEO Series GSE223283. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Expression data from bone marrow mesenchymal stromal cells obtained from healthy donors and myeloma patients
GEO Series GSE146649. Homo sapiens. 41 samples. Type: Expression profiling by array.
Comparison of gene expression profiles between a bone marrow-derived primary mesenchymal stromal cell clone (MSC2) without osteoblastic induction and with 14 days or 28 days of ostoblastic induction
GEO Series GSE83770. Mus musculus. 9 samples. Type: Expression profiling by array.
Dataset related to the article " Excess TGF-β1 Drives Cardiac Mesenchymal Stromal Cells to a Pro-Fibrotic Commitment in Arrhythmogenic Cardiomyopathy"
<p>This record contains raw data related to the article “Excess TGF-β1 Drives Cardiac Mesenchymal Stromal Cells to a Pro-Fibrotic Commitment in Arrhythmogenic Cardiomyopathy”</p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.