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12,871 results for “aging;”
Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice
<p>The loss of skeletal muscle function with age, known as sarcopenia, significantly reduces independence and quality of life and can have significant metabolic consequences. Although exercise is effective in treating sarcopenia it is not always a viable option clinically, and currently there are no pharmacological therapeutic interventions for sarcopenia. Here we show that chronic treatment with pan-adiponectin receptor agonist AdipoRon improved muscle function in male mice by a mechanism linked to skeletal muscle metabolism and tissue remodeling. In aged mice, 6 weeks of AdipoRon treatment improved skeletal muscle functional measures in vivo and ex vivo. Improvements were linked to changes in fiber type, including an enrichment of oxidative fibers, and an increase in mitochondrial activity. In young mice, 6 weeks of AdipoRon treatment improved contractile force and activated the energy sensing kinase AMPK and the mitochondrial regulator PGC-1a (peroxisome proliferator activated receptor gamma coactivator 1 alpha). In cultured cells, the AdipoRon induced stimulation of AMPK and PGC-1a was associated with increased mitochondrial membrane potential, reorganization of mitochondrial architecture, increased respiration, and increased ATP production. Furthermore, the ability of AdipoRon to stimulate AMPK and PGC1a was conserved in nonhuman primate cultured cells. These data show that AdipoRon is an effective agent for the prevention of sarcopenia in mice and indicate that its effects translate to primates, suggesting it may also be a suitable therapeutic for sarcopenia in clinical application.</p>
Age-specific habitat preference, carrying capacity, and landscape structure determine the response of population spatial variability to fishing-driven age truncation
<p>1. Understanding the mechanisms underlying spatial variability of exploited fish is critical for the sustainable management of fish stocks. Empirical studies suggest that size-selective fishing can elevate fish population spatial variability (i.e., more heterogeneous distribution) through age truncation, making the population less resilient to changing environment. However, species differ in how their spatial variability respond to age truncation and the underlying mechanisms remain unclear.</p> <p>2. We hypothesize that age-specific habitat preference, together with environmental carrying capacity and landscape structure, determines the response of population spatial variability to fishing-induced age truncation. To test these hypotheses, we design an individual-based model of an age-structured fish population on a two-dimensional landscape under size-selective fishing. Individual fish reproduces and survives, and moves between habitats according to age-specific habitat preference and density-dependent habitat selection.</p> <p>3. Population spatial variability elevates with increasing age truncation and the response is stronger for populations with stronger age-specific habitat preference. On a gradient landscape, reducing carrying capacity elevates the relative importance of density-dependence in habitat selection, which weakens the response of spatial variability to age truncation for populations with strong age-specific habitat preference. On a fragmented landscape, both populations with strong and weak age-specific habitat preferences are restricted at local optimal habitats, and reducing carrying capacity weakens the responses of spatial variability to age truncation for both populations.</p> <p>4. Synthesis and applications. We demonstrate that to track and predict the changes in population spatial variability under exploitation, it is essential to consider the interactive effects of age-specific habitat preference, carrying capacity, and landscape structure. To improve spatial management in fisheries, it is crucial to enhance empirical and theoretical developments in the methodology to quantify age-specific habitat preference of marine fish, and to understand how climatic change influences carrying capacity and landscape continuity.</p>
Fig. 1 in Patterns of tooth crown wear in Dryomys nitedula (Mammalia, Rodentia): age-related variation in the light of annual cycle specifics based on museum collections
Fig. 1. Geographic details of the studied sample: record localities and the southern boundary of the forest dormouse's distribution.
Data from: Effects of age and disease duration on excess mortality in patients with multiple sclerosis from a French nationwide cohort
<p><strong>Objective: </strong>To determine the effects of current age and disease duration on excess mortality in multiple sclerosis, we described the dynamics of excess deaths rates over these two time scales and studied the impact of age at multiple sclerosis clinical onset on these dynamics, separately in each initial phenotype.</p> <p><strong>Methods: </strong>We used data from 18 French multiple sclerosis expert centers participating in the Observatoire Français de la Sclérose en Plaques. Patients with multiple sclerosis living in metropolitan France and having a clinical onset between 1960 and 2014 were included. Vital status was updated on January 1st, 2016. For each multiple sclerosis phenotype separately (relapsing onset (R-MS) or primary progressive (PPMS)), we used an innovative statistical method to model the logarithm of excess death rates by a multidimensional penalized spline of age and disease duration.</p> <p><strong>Results: </strong>Among 37524 patients (71% women, mean age at multiple sclerosis onset ± standard deviation 33.0 ± 10.6 years), 2883 (7.7%) deaths were observed and 7.8% of patients were lost-to-follow-up. For R-MS patients, there was no excess mortality during the first 10 years after disease onset; afterwards, whatever age at onset, excess death rates increased with current age. From current age 70, the excess death rates values converged and became identical whatever the age at disease onset, which means that disease duration had no more impact. Excess death rates were higher in men with an excess hazard ratio of 1.46 (95% confidence interval 1.25-1.70). In contrast, in PPMS patients, excess death rates rapidly increased from disease onset, and were associated with age at onset, but not with sex.</p> <p><strong>Conclusions:</strong> In R-MS, current age has a stronger impact on multiple sclerosis mortality than disease duration while their respective effects are not so clear in PPMS. </p>
Mechanical and electrochemical characterization of 3D printed orthodontic metallic appliances after in vivo ageing
<p>Dataset for all analyses</p>
Duration of swimming participation and age of subjects
<p>Duration of swimming participation and age of subjects</p>
Chinchilla lanigera (captive) Germany. Photo: Jurgen & Christine Sohns/ age fotostock in Chinchillidae
Chinchilla lanigera (captive) Germany. Photo: Jurgen & Christine Sohns/ age fotostock
Exogenous oxidative stressors elicit differing age and sex effects
<p>Data and scripts for the manuscript entitled "Exogenous oxidative stressors elicit differing age and sex effects" submitted to <em>Experimental Gerontology. </em></p>
Regeneration biomass (AGB & BGB), age, NSCs and light: F. sylvatica and Acer spp.
<p><span>Being able to persist in deep shade is an important characteristic of juvenile trees often leading to a strong dominance of shade-tolerant species in forests with low canopy turnover and disturbance rate. While leaf, growth and storage traits are known to be key components of shade tolerance, their interplay during regeneration development and influence on juveniles' survival time remains unclear. We assessed the ontogenetic effects of these three traits on survival time of beech (Fagus sylvatica), Norway and sycamore maples (Acer pseudoplatanus, Acer platanoides) in a primeval beech forest. Biomass allocation, age and content of non-structural carbohydrates (NSC) were measured in stems and roots of 289 seedlings and saplings in high and low vitality classes. Saplings experience a trade-off between absolute growth rate (AGR), and storage (NSC) at decreasing leaf area ratio (LAR) with biomass development. High LAR but slow AGR and low NSC confer beech with a marked ability to persist in deep shade awaiting canopy release. In turn, a comparably small LAR in combination with fast AGR and higher storage (NSC), as observed in Norway maple and sycamore maple, reduces their survival time, thus offering an explanation for beech dominance and maples disappearance in the undergrowth of old-growth beech forests.</span></p>
Myrmecobius fasciatus Western Australia, Australia. Photo: Mint Frans Lanting/ age fotostock in Myrmecobiidae
Myrmecobius fasciatus Western Australia, Australia. Photo: Mint Frans Lanting/ age fotostock
Zaglossus bartoni Papua New Guinea. Photo: Jean-Paul Ferrero/ age fotostock in Tachyglossidae
Zaglossus bartoni Papua New Guinea. Photo: Jean-Paul Ferrero/ age fotostock
Processd TESS light curves of stars with known ages
<p>We present light curves of ~100,000 stars (most within 500 pc) with ages inferred from membership of the nearby moving groups from Untangling The Galaxy series of papers. The light curves are generated from TESS full frame images using Eleanor (Feinstein+19). The nine zip files are split based on the first digit of TIC id, with the nested folders inside corresponding to the first three digits.</p>
Data from: Age, state, environment and season dependence of senescence in body mass
[No abstract entered]
Data from: Mutation accumulation is still potentially problematic, despite declining paternal age: a comment on Arslan et al. (2017).
[No abstract entered]
Supplementary material 5 from: Sturm U, Heyne E, Herrmann E, Arends B, Dieter A-L, Dorfman E, Drauschke F, Heller N, Kahn R, Kaiser K, Koch G, Kramar N, Mansilla Sánchez A, Mauelshagen F, Nadim T, Pell R, Petersen M, Schmidt-Loske K, Scholz H, Sterling C, Trischler H, Wagner S (2022) Anthropocenic Objects. Collecting Practices for the Age of Humans. Research Ideas and Outcomes 8: e89446. https://doi.org/10.3897/rio.8.e89446
Keynote Nature after Europe
Supplementary material 3 from: Sturm U, Heyne E, Herrmann E, Arends B, Dieter A-L, Dorfman E, Drauschke F, Heller N, Kahn R, Kaiser K, Koch G, Kramar N, Mansilla Sánchez A, Mauelshagen F, Nadim T, Pell R, Petersen M, Schmidt-Loske K, Scholz H, Sterling C, Trischler H, Wagner S (2022) Anthropocenic Objects. Collecting Practices for the Age of Humans. Research Ideas and Outcomes 8: e89446. https://doi.org/10.3897/rio.8.e89446
Flyer: Perspectives for the future of conservational institutions and collection practices
Mouse at different ages
SciDraw upload
Zinc kinetics correlate with length-for-age z scores in Bangladeshi infants
<p>A comparison of zinc kinetics in infants </p>
Text-fig. 17. Biostratigraphic correlations of Moghara, Egypt, and Gebel Zelten, Libya, with inferred age ranges in millions of years. ELMA – European Land Mammal Age (MN – Mammal Neogene Zone) (Mein 1989), FS – East African Faunal Set (Pickford 1981). The double-headed arrow is the range of ages obtained by Strontium isotope dating analyses (Hassan et al. 2013). in New Suoid Fossils (Mammalia, Artiodactyla) From The Miocene Of Moghara, Egypt, And Gebel Zelten, Libya: Biochronological Implications
Text-fig. 17. Biostratigraphic correlations of Moghara, Egypt, and Gebel Zelten, Libya, with inferred age ranges in millions of years. ELMA – European Land Mammal Age (MN – Mammal Neogene Zone) (Mein 1989), FS – East African Faunal Set (Pickford 1981). The double-headed arrow is the range of ages obtained by Strontium isotope dating analyses (Hassan et al. 2013).
Data and code for: Evidence of maternal and paternal age effects on speed in thoroughbred racehorses
<p>Anonymised data set on thoroughbred racehorse performance in UK and Ireland that was used for analysis of parental age effects. File also contains code used for statistical analyses presented in Sharman et al 2022 manuscript entitled 'Evidence of maternal and paternal age effects on speed in thoroughbred racehorses'. Code is for analyses using ASReml (stand-alone not R version).</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.