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29,897 results for “activism”
Fig. 7 in Four undescribed ergostane-type steroids from Lasiodiplodia pseudotheobromae and their neuroprotective activity
Fig. 7. Effects of compounds 1–4 on the viability of Glu-treated SH-SY5Y cell lines. Compound 4 exerted a concentration dependent protective effect on SHSY5Y cell lines. Control represents the no glutamate or compounds-treated group. Data are presented as the means ± S.D. (n = 3). Data are presented as the means ± S.D. (n = 3). *p <0.05, **p <0.01 and ***p <0.001 vs. the glutamate-treated group.
Fig. 1. Figure showing the 2D in Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Fig. 1. Figure showing the 2D structural representation of lemongrass oil components (A–H). Component structures taken from Pubchem database.
Fig. 3 in Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Fig. 3. Pharmacophores of ligands H-bond interactions with receptor binding amino acid residues of human HSP90-ATPase binding with (A) ADP; (B) Geldanamycin; (C) Geraniol; (D) Citral; (E) Geranyl Acetate; (F) Methyl Eugenol; (G) Myrcene; (H) Elemicin.
Fig. 8. Compound 4 in Four undescribed ergostane-type steroids from Lasiodiplodia pseudotheobromae and their neuroprotective activity
Fig. 8. Compound 4 decreased glutamate-induced cellular apoptosis in SH-SY5Y cell lines. (A) Cellular morphological changes were observed by phase contrast microscopy. (B) Flow cytometry was applied to determine the apoptotic ratio after Annexin V-FITC/PI staining. The percentage of apoptotic cells was calculated in the bar chart. Data are presented as the means S.D. (n 3). ###p <0.001 vs. the control group (the no glutamate or compound 4-treated group); *p <0.05 and ± = ***p <0.001 vs. the glutamate-treated group.
Fig. 2 in Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Fig. 2. Docking scores of all screened ligands with HSP90 protein of humans (A), P. falciparum (B) and S. cerevisiae (C) which are showing the minimum free binding affinity (ΔG = kcal/mol).
Fig. 8 in Highly oxygenated isoryanodane diterpenoids from the leaves of Cinnamomum cassia and their immunomodulatory activities
Fig. 8. Effects of 1, 2, 6, and 10 on ConA-induced T-cells proliferation (A) and effects of 1, 2, 6, and 10–12 on LPS-induced B-cells proliferation (B), mean ± SD of three replicates are shown.
Fig. 5 in Highly oxygenated isoryanodane diterpenoids from the leaves of Cinnamomum cassia and their immunomodulatory activities
Fig. 5. Linear correlation plots (A) and the relative errors (B) between the experimental and calculated 13C NMR chemical shifts of 4a 4d.
Fig. 6 in Hyjapones A D, trimethylated acyphloroglucinol meroterpenoids from Hypericum japonicum thunb. With anti-inflammatory activity
Fig. 6. Effects of compound 6 on the NF-κB signaling pathway in LPS-induced RAW264.7 cells. Cells were pretreated with various concentrations of compound 6 (5, 10, 20, 40 μM) for 1 h and then stimulated with LPS (1 μg/mL) for 24 h. Data are expressed as the mean ± SD (n = 3). ns: no significance, *p<0.05, **p<0.01, and ***p<0.001 vs LPS group.
Fig. 7. The relative errors between the experimental and calculated 13C in Highly oxygenated isoryanodane diterpenoids from the leaves of Cinnamomum cassia and their immunomodulatory activities
Fig. 7. The relative errors between the experimental and calculated 13C NMR chemical shifts of 5 and 6.
Fig. 5. A in Hyjapones A D, trimethylated acyphloroglucinol meroterpenoids from Hypericum japonicum thunb. With anti-inflammatory activity
Fig. 5. A. Effect of compound 6 on the secretion of TNF-α, IL-1β, IL-6. B. Effect of compound 6 on the expression level of iNOS, TNF-α, IL-1β and IL-6 mRNA. RAW264.7 cells were pretreated with various concentrations of compound 6 (5, 10, 20, 40 μM) for 1 h and then stimulated with LPS (1 μg/mL) for 24 h. Data are expressed as the mean ± SD (n = 3). *p<0.05, **p<0.01, and ***p<0.001 vs LPS group.
Fig. 4 in Highly oxygenated isoryanodane diterpenoids from the leaves of Cinnamomum cassia and their immunomodulatory activities
Fig. 4. Linear correlation plots (A) and the relative errors (B) between the experimental and calculated 13C NMR chemical shifts of (8R*)-3a and (8S*)-3b.
Fig. 4 in Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity
Fig. 4. Cucurbitacins induced caspase apoptosis pathway activation in HepG2 cells. (A) Apoptosis induction effects of four cucurbitacins on HepG2 cells. The cells were treated with each cucurbitacin for 24 h, and stained with Hoechst 33258 for cell apoptosis assay. Arrows, chromatin condensed HepG2 cells. (B) Quantitative data of panel A, percentage of apoptosis cells is shown. **P <0.01, ***P <0.001, student t-test. (C) Inhibition effects of four cucurbitacins in caspase apoptosis pathway on HepG2 cells. The cells were treated with each cucurtibitcin for 24 h, respectively, and the major apoptosis-related proteins (PARP, cleaved PARP, Caspase-9, Caspase-8 and Caspase-3) were detected by Western blot. β-actin was used as internal reference. (D) Quantitative data of panel C, expression levels of apoptosis-related proteins are shown. **P <0.01, ***P <0.001, student t-test.
Fig. 5 in Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC
Fig. 5. Dose-dependent curve of compound 1 inhibiting the RFU signals of dopamine on HEK293-D1 cells.
Fig. 10 in Kiiacylphnols A H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim
Fig. 10. Effects of compounds 1 and 10 to cancer cell lines. HL60 and SU-DHL-4 cells were exposed to vehicle control (DMSO, <0.1%), compounds 1 or 10 for 48 h, respectively. (A) Dose-dependent viability curves for two cancer cell lines after treatment with 1 and 10 (mean ± SD for three independent experiments). (B) The IC50 of 1 and 10 were calculated using the SPSS software. (C–D) Cells were harvested after 1 or 10 treatment and apoptosis was determined by Annexin V-FITC and PI staining using flow cytometry analysis. Data are expressed as the mean SD of three independent experiments. #p <0.05, **p <0.01, ****p <0.001, unpaired two± tailed Student's t-test.
Fig. 3 in Isosteroidal alkaloids of Fritillaria taipaiensis and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity
Fig. 3. Key NOESY () correlations for compounds 1–4 [some hydrogens were removed for a clearer exhibition of their 3D structures].
Fig. 8 in Lignans from the seeds of Herpetospermum pedunculosum and their farnesoid X receptor-activating effect
Fig. 8. Effects of compounds (20 μM) on the FXR expression in induced L02 cells. (A) High-content screening of FXR protein expressions. (B) Analysis of fluorescence intensity. (C) Ratio of cell number in visual field. ##p <0.01, vs. control group; *p <0.05, **p <0.01, vs. model group.
Fig. 9 in Lignans from the seeds of Herpetospermum pedunculosum and their farnesoid X receptor-activating effect
Fig. 9. Molecular docking of compound 11 with FXR (3DCT). (A) The 3D bonding modes between FXR and 11. (B) Compound 11 bound with FXR at the active site. (C) The 2D interaction of compound 11 with FXR at the active site.
Fig. 5 in Lanostane-type triterpenoids from the mycelial mat of Ganoderma lucidum and their hepatoprotective activities
Fig. 5. Effects of compounds 1, 6, and 8–10 (15 μM) on ALT activity (A), AST activity (B), LDH activity (C) and GSH level (D) in HepG2 cells. Results are expressed as the mean SEM (n 3). NAC was used as positive control (15 μM). (#) P <0.05 and (##) P <0.01 with respect to the normal group; (*) P <0.05 and (**) P <0.01 ± = with respect to the model group.
Fig. 4 in Lanostane-type triterpenoids from the mycelial mat of Ganoderma lucidum and their hepatoprotective activities
Fig. 4. Hepatoprotective effects of the indicated compounds against H2O2-induced injury in HepG2 cells. Compounds were used at 15 μM. Results are expressed as the mean SEM (n 4). NAC was used as positive control (15 μM). (##) P <0.01 with respect to the normal (untreated) group; (*) P <0.05 and (**) P <0.01 with ± = respect to the model (H2O2-treated) group.
Fig. 4 in Lanostane triterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activities
Fig. 4. (a) Key 1H–1H COSY () and selected HMBC correlations (H→C) of 7; (b) Key NOESY correlations of 7.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.