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12,871 results for “aging;”
Figure 6 in Mating behaviour in ageing Teratorhabditis palmarum (Nematoda: Rhabditida)
Figure 6. Number of contacts before mating in different age groups.
Figure 7 in Mating behaviour in ageing Teratorhabditis palmarum (Nematoda: Rhabditida)
Figure 7. Mating after first contact in different age groups.
Raw data of Archaeomagnetic Dating of an Early Iron Age archaeological settlement: El Castillar site (Navarra, Northern Spain)
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Effect of lutein on blood lipids and AGEs
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Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus
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Ialongo_2024_book_supplement_Bronze_Age_Weights_Database
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Table ¹: Summary statistics for mandible measurements (in mm) of each age group of Choloepus (mean ± standard deviation [range] sample size). in Harpy eagle kill sample provides insights into the mandibular ontogenetic patterns of two-toed sloths (Xenarthra: Choloepus)
<p><b>Table ¹:</b> Summary statistics for mandible measurements (in mm) of each age group of <i>Choloepus</i> (mean ± standard deviation [range] sample size).</p><table><tbody><tr><th><b>Measurement</b></th><th><b>Age classes</b></th></tr></tbody><tbody><tr><th></th><td><b>Infant</b></td><td><b>Įuvenile</b></td><td><b>Subadult</b></td><td><b>Adult</b></td></tr><tr><th>BAC</th><td>44.08 ± 3.04 [40.7–47.92] 4</td><td>48.54 ± 2.65 [42.39–52.29] 15</td><td>54.46 ± 3.79 [50.78–59.2] 4</td><td>65.12 ± 3.28 [61.05–71.01] 9</td></tr><tr><th>BCC</th><td>20.57 ± 1.47 [18.76–22.35] 4</td><td>23.08 ± 1.33 [20.83–25.78] 16</td><td>26.51 ± 0.73 [25.53–27.25] 4</td><td>31.81 ± 1.59 [28.84–33.69] 9</td></tr><tr><th>HCA</th><td>12.84 ± 1.41 [9.66–15.12] 13</td><td>15.66 ± 1.74 [11.95–20.11] 18</td><td>17.48 ± 1.13 [16.32–18.88] 4</td><td>21 ± 1.25 [18.49–23.08] 9</td></tr><tr><th>HCC</th><td>8.16 ± 1.4 [6.01–10.29] 13</td><td>9.65 ± 1.23 [7.52–11.68] 15</td><td>13.08 ± 0.72 [12.11–13.83] 4</td><td>23.68 ± 0.98 [22.16–25.02] 9</td></tr><tr><th>LAM</th><td>17.74 ± 1.57 [14.58–20.44] 13</td><td>20.6 ± 1.15 [19.15–22.72] 18</td><td>24.11 ± 2.11 [21.29–26.3] 4</td><td>26.28 ± 1.67 [23.31–28.9] 9</td></tr><tr><th>LCD</th><td>8.69 ± 1.11 [7.48–11.43] 13</td><td>9.88 ± 0.75 [8.89–11.73] 18</td><td>11.43 ± 0.8 [10.7–12.54] 4</td><td>12 ± 1.07 [10.18–13.89] 9</td></tr><tr><th>LMS</th><td>14.78 ± 0.84 [13.52–16.22] 13</td><td>16.98 ± 0.54 [16–18.11] 18</td><td>18.74 ± 0.69 [17.72–19.15] 4</td><td>20.06 ± 0.71 [19.15–21.38] 9</td></tr><tr><th>TML</th><td>56.3 ± 3.76 [50.53–61.07] 13</td><td>64.9 ± 1.99 [62.81–68.57] 18</td><td>72.42 ± 2.12 [69.41–74.39] 4</td><td>86.67 ± 3.52 [81.7–91.93] 9</td></tr></tbody></table><p>See main text for measurement abbreviations.</p>
SCHOOL UP TO AGE HAS BEEN CHILDREN WITH WORK
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Data of The Effect of Game-Based Intervention on Locomotor Skills of Female Students Aged 9 To 11 Years with Flat Foot Research
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Supplementary tables of the research article "Comparative Analysis of Yukmijihwang-tang and Palmijihwang-tang: Lifespan Extension and Kidney Function Improvement in Aging Models"
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Data for The Absolute Age of Milky Way Globular Clusters
<p>MC isochrones used to estimate the absolute age of 8 Milky Way GCs.</p> <p>Isochrone data for each GC is stored in HDF5 format and compressed. Each file comprises 10000 sets of isochrones with information such as age, mass, magnitude, etc. The stellar evolution parameters used to construct each isochrone can also be found in the file. The HDF5 file can be accessed using tools like python.</p> <p>Detailed instruction to read MC parameters and MC isochrones can be found in the notebook: Instruction on reading isochrones.ipynb</p>
Exploring the mechanisms of cow placental peptides in delaying liver aging based on mitochondrial energy metabolism
<p>By analyzing and integrating changes in liver transcriptomics and targeted mitochondrial energy metabolomics, the mechanisms by which CPP delays liver aging are revealed.</p>
BIOCHEMICAL CHANGES IN THE AGING PROCESS
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Data from: Trophic level, successional age and trait matching determine specialization of deadwood-based interaction networks of saproxylic beetles
The specialization of ecological networks provides important insights into possible consequences of biodiversity loss for ecosystem functioning. However, mostly mutualistic and antagonistic interactions of living organisms have been studied, whereas detritivore networks and their successional changes are largely unexplored. We studied the interactions of saproxylic (deadwood-dependent) beetles with their dead host trees. In a large-scale experiment, 764 logs of 13 tree species were exposed to analyse network structure of three trophic groups of saproxylic beetles over 3 successional years. We found remarkably high specialization of deadwood-feeding xylophages and lower specialization of fungivorous and predatory species. During deadwood succession, community composition, network specialization and network robustness changed differently for the functional groups. To reveal potential drivers of network specialization, we linked species' functional traits to their network roles, and tested for trait matching between plant (i.e. chemical compounds) and beetle (i.e. body size) traits. We found that both plant and animal traits are major drivers of species specialization, and that trait matching can be more important in explaining interactions than neutral processes reflecting species abundance distributions. High network specialization in the early successional stage and decreasing network robustness during succession indicate vulnerability of detritivore networks to reduced tree species diversity and beetle extinctions, with unknown consequences for wood decomposition and nutrient cycling.
Data from: Age of heart disease presentation and dysmorphic nuclei in patients with LMNA mutations
Nuclear shape defects are a distinguishing characteristic in laminopathies, cancers, and other pathologies. Correlating these defects to the symptoms, mechanisms, and progression of disease requires unbiased, quantitative, and high-throughput means of quantifying nuclear morphology. To accomplish this, we developed a method of automatically segmenting fluorescently stained nuclei in 2D microscopy images and then classifying them as normal or dysmorphic based on three geometric features of the nucleus using a package of Matlab codes. As a test case, cultured skin-fibroblast nuclei of individuals possessing LMNA splice-site mutation (c.357-2A>G), LMNA nonsense mutation (c.736 C>T, pQ246X) in exon 4, LMNA missense mutation (c.1003C>T, pR335W) in exon 6, Hutchinson-Gilford Progeria Syndrome, and no LMNA mutations were analyzed. For each cell type, the percentage of dysmorphic nuclei, and other morphological features such as average nuclear area and average eccentricity were obtained. Compared to blind observers, our procedure implemented in Matlab codes possessed similar accuracy to manual counting of dysmorphic nuclei while being significantly more consistent. The automatic quantification of nuclear defects revealed a correlation between in vitro results and age of patients for initial symptom onset. Our results demonstrate the method's utility in experimental studies of diseases affecting nuclear shape through automated, unbiased, and accurate identification of dysmorphic nuclei.
Data from: Ageing via perception costs of reproduction magnifies sexual selection
Understanding what factors modulate sexual selection intensity is crucial to a wide variety of evolutionary processes. Recent studies show that perception of sex pheromones can severely impact male mortality when it is not followed by mating (perception costs of reproduction). Here, we examine the idea that this may magnify sexual selection by further decreasing the fitness of males with inherently low mating success, hence increasing the opportunity for sexual selection. We use mathematical modelling to show that even modest mortality perception costs can significantly increase variability in male reproductive success under a wide range of demographic conditions. We then conduct a series of assays suggesting that, in D. melanogaster, failure to reproduce early in life may, via perception costs of reproduction, significantly reduce the subsequent fitness of males (ca. 25%), due mostly to increased reproductive ageing. Altogether, our results strongly suggest that perception costs of reproduction can magnify sexual selection in a biologically significant way. Finally, we estimate that around 29% of available studies quantify sexual selection based on short-term fitness estimates that may fail to capture these effects (if they were present in their subject species), and suggest addressing the existence and impact of perception costs of reproduction across taxa should thus be a priority.
Data from: An expansion of age constraints for microbial clades that lack a conventional fossil record using phylogenomic dating
Most microbial taxa lack a conventional microfossil or biomarker record, and so we currently have little information regarding how old most microbial clades and their associated traits are. Building on the previously published oxygen age constraint, two new age constraints are proposed based on the ability of microbial clades to metabolize chitin and aromatic compounds derived from lignin. Using the archaeal domain of life as a test case, phylogenetic analyses, along with published metabolic and genetic data, showed that members of the Halobacteriales and Thermococcales are able to metabolize chitin. Ancestral state reconstruction combined with phylogenetic analysis of the genes underlying chitin degradation predicted that the ancestors of these two groups were also likely able to metabolize chitin or chitin-related compounds. These two clades were therefore assigned a maximum age of 1.0 Ga (when chitin likely first appeared). Similar analyses also predicted that the ancestor to the Sulfolobus solfataricus-Sulfolobus islandicus clade was able to metabolize phenol using catechol dioxygenase, so this clade was assigned a maximum age of 475 Ma. Inferred ages of archaeal clades using relaxed molecular clocks with the new age constraints were consistent with those inferred with the oxygen age constraints. This work expands our current toolkit to include Paleoproterozoic, Neoproterozoic, and Paleozoic age constraints, and should aid in our ability to phylogenetically reconstruct the antiquity of a wide array of microbial clades and their associated morphological and biogeochemical traits, spanning deep geologic time. Such hypotheses-although built upon evolutionary inferences-are fundamentally testable.
Data from: Ontogenetic timing as a condition-dependent life history trait: high-condition males develop quickly, peak early and age fast
Within-population variation in ageing remains poorly understood. In males, condition-dependent investment in secondary sexual traits may incur costs which limit ability to invest in somatic maintenance. Moreover, males often express morphological and behavioural secondary sexual traits simultaneously, but the relative effects on ageing of investment in these traits remain unclear. We investigated the condition-dependence of male life history in the neriid fly Telostylinus angusticollis. Using a fully factorial design, we manipulated male early-life condition by varying nutrient content of the larval diet and, subsequently, manipulated opportunity for adult males to interact with rival males. We found that high-condition males developed more quickly and reached their reproductive peak earlier in life, but also experienced faster reproductive ageing and died sooner than low-condition males. By contrast, interactions with rival males reduced male lifespan but did not affect male reproductive ageing. High condition in early life is therefore associated with rapid ageing in T. angusticollis males, even in the absence of damaging male-male interactions. Our results show that abundant resources during the juvenile phase are used to expedite growth and development and enhance early-life reproductive performance at the expense of late-life performance and survival, demonstrating a clear link between male condition and ageing.
Data from: Body acceleration as indicator for walking economy in an ageing population
Background: In adults, walking economy declines with increasing age and negatively influences walking speed. This study aims at detecting determinants of walking economy from body acceleration during walking in an ageing population. Methods: 35 healthy elderly (18 males, age 51 to 83 y, BMI 25.5±2.4 kg/m2) walked on a treadmill. Energy expenditure was measured with indirect calorimetry while body acceleration was sampled at 60Hz with a tri-axial accelerometer (GT3X+, ActiGraph), positioned on the lower back. Walking economy was measured as lowest energy needed to displace one kilogram of body mass for one meter while walking (WCostmin, J/m/kg). Gait features were extracted from the acceleration signal and included in a model to predict WCostmin. Results: On average WCostmin was 2.43±0.42 J/m/kg and correlated significantly with gait rate (r2 = 0.21, p<0.01) and regularity along the frontal (anteroposterior) and lateral (mediolateral) axes (r2 = 0.16, p<0.05 and r2 = 0.12, p<0.05 respectively). Together, the three variables explained 46% of the inter-subject variance (p<0.001) with a standard error of estimate of 0.30 J/m/kg. WCostmin and regularity along the frontal and lateral axes were related to age (WCostmin: r2 = 0.44, p<0.001; regularity: r2 = 0.16, p<0.05 and r2 = 0.12, p<0.05 respectively frontal and lateral). Conclusions: The age associated decline in walking economy is induced by the adoption of an increased gait rate and by irregular body acceleration in the horizontal plane.
Data from: Exposure to males, but not receipt of sex peptide, accelerates functional aging in female fruit flies
Increased exposure to males can affect females negatively, reducing female lifespan and fitness. These costs could derive from increased mating rate and also harassment by males. Additionally, early investment in reproduction can increase the onset or rate of senescence in reproductive traits. Hence, there is a tight link between reproduction and aging. Here, we assess how mating and encounter rate with males impacts declines in female functional traits that are not directly involved in reproduction. In Drosophila melanogaster fruit flies, exposure to males and mating reduces female lifespan through harassment and receipt of seminal proteins, including sex peptide. We manipulated the intensity of female exposure to males and regularly assessed female stress responses and recorded physiological traits over her lifetime. Both mating itself and increased exposure to males accelerates declines in female climbing ability and starvation resistance. However, this is not related to changes in female body mass or fat storage. Moreover, these declines are not driven by the receipt of sex peptide. Our results suggest some synchrony in senescence across traits in response to female exposure to males, however this is not universal, as we did not find this for physiological traits. Synchrony in senescence has been theorised but little supported in the literature. It is clear that aging is a multifaceted trait; to understand environmental impacts on aging rates we must measure more than lifespan, and indeed measure senescence in multiple traits. Specifically, our work shows that we must identify which female traits are sensitive to elevated mating activity to understand the impact of antagonistic interactions between the sexes on female aging patterns.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.