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Fig. 7 in Piperazine-2,5-dione derivatives and an α-pyrone polyketide from Penicillium griseofulvum and their immunosuppression activity
Fig. 7. DP4 probabilities of 13C NMR data for both diastereoisomers of 4; comparing of experimental and calculated ECD spectra of 4-A and 4-B.
Fig. 4. Linear correlation between the experimental and calculated 13C in Piperazine-2,5-dione derivatives and an α-pyrone polyketide from Penicillium griseofulvum and their immunosuppression activity
Fig. 4. Linear correlation between the experimental and calculated 13C NMR chemical shift of 1-A and 1-B and their compared 13C NMR data (Δδ δ – δ).
Fig. 5. Linear correlation between the experimental and calculated 13C NMR chemical shifts for 1A and 1B in (±)-hyperzewalsins A D, four pairs of nor-monocyclic polyprenylated acylphloroglucinols with immunosuppressive activity from hypericum przewalskii maxim
Fig. 5. Linear correlation between the experimental and calculated 13C NMR chemical shifts for 1A and 1B.
Fig. 4 in Screening of in vitro and in silico α-amylase, α-glucosidase, and lipase inhibitory activity of oxyprenylated natural compounds and semisynthetic derivatives
Fig. 4. Docking of compounds 3, 9, 11, and 15 in human lipase enzyme. The original structure of the lipase enzyme (1LPB) contains the inhibitor methoxyundecylphosphinic acid (MUP, carbons coloured purple (A)). The docking results in lipase enzyme (B-E, green surface) with compounds 3 (pink, B), 9 (cyan, C), 11 (magenta, D), and 15 (green, E) are shown with their respective binding energies. The carbons of the residues lining the binding pocket are coloured in white, with the active site residues in yellow (S169, D193, and H280). Residues making hydrogen bonds with the ligands are indicated (B–E). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 3 in Screening of in vitro and in silico α-amylase, α-glucosidase, and lipase inhibitory activity of oxyprenylated natural compounds and semisynthetic derivatives
Fig. 3. Docking of compounds 3, 9, 11, and 15 in human α-amylase and α-glucosidase enzymes. The original structures of α-amylase (1XD0) and α-glucosidase (3TOP) enzymes contain the inhibitor acarbose (carbons coloured in orange and hexoses numbered in A and F, respectively). The docking results in α-amylase (B-E, light grey surface) and α-glucosidase (G-J, beige) enzymes with compounds 3 (pink, B and G), 9 (cyan, C and H), 11 (magenta, D and I), and 15 (green, E and J) are shown with their respective binding energies. The carbons of the residues lining the binding pocket are coloured in white, with the active site residues in yellow (R210, D212, E248, and R352 in α-amylase; D1420, E1423, and D1526 in α-glucosidase enzyme). Residues making hydrogen bonds with the ligands are indicated (B- E and G-J). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 7 in Xylarinaps A-E, five pairs of naphthalenone derivatives with neuroprotective activities from Xylaria nigripes
Fig. 7. Effects of compounds 1–5 on SOD in OGD-induced PC12 cells. The values represent mean ± SD (n = 6). *P <0.05, **P <0.01 vs. the control group; #P <0.05, ##P <0.01 vs. the model group.
Fig. 8 in Xylarinaps A-E, five pairs of naphthalenone derivatives with neuroprotective activities from Xylaria nigripes
Fig. 8. Effects of compounds 1–5 on MDA in OGD-induced PC12 cells. The values represent mean ± SD (n = 6). *P <0.05, **P <0.01 vs. the control group; #P <0.05, ##P <0.01 vs. the model group.
Fig. 10 in Xylarinaps A-E, five pairs of naphthalenone derivatives with neuroprotective activities from Xylaria nigripes
Fig. 10. Effects of compounds 1–5 on OGD-induced apoptosis of PC12 cells. (A) Apoptosis of PC12 cells detected by Hochest staining. (B) Apoptosis rate of PC12 cells for compounds 1–5. The values represent mean ± SD (n = 6). *P <0.05, **P <0.01 vs. the control group; #P <0.05, ##P <0.01 vs. the model group.
Fig. 9 in Xylarinaps A-E, five pairs of naphthalenone derivatives with neuroprotective activities from Xylaria nigripes
Fig. 9. Effects of compounds 1–5 on GSH-Px in OGD-induced PC12 cells. The values represent mean ± SD (n =6). *P <0.05, **P <0.01 vs. the control group; #P <0.05, ##P <0.01 vs. the model group.
Fig. 6 in Xylarinaps A-E, five pairs of naphthalenone derivatives with neuroprotective activities from Xylaria nigripes
Fig. 6. Effects of compounds 1–5 on cell viability in OGD-induced PC12 cells. The values represent mean ± SD (n = 6). *P <0.05, **P <0.01 vs. the control group; #P <0.05, ##P <0.01 vs. the model group.
Fig. 5 in Pyrrolyl 4-quinolone alkaloids from the mangrove endophytic fungus Penicillium steckii SCSIO 41025: Chiral resolution, configurational assignment, and enzyme inhibitory activities
Fig. 5. Molecular docking result of (+)-1 in α-glucosidase (PDB ID: 5NN8). (A) 3D structure of the enzyme docked with (+)-1. (B) Detail analysis of the 2D binding model of (+)-1 with the residues surrounding the binding pocket of α-glucosidase.
Fig. 3 in Chemical constituents of Psidium guajava leaves and their antibacterial activity
Fig. 3. Experimental CD spectra of (+)/()-1, (+)/()-2, and (+)/()-3, and calculated ECD spectra of R-3 and S-3.
Fig. 4 in Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line
Fig. 4. Interaction of compounds 1 (A), 2 (B) and 3 (C) with DNA sequence Seq-1. All three compounds are predicted to intercalate with the DNA base pairs.
Fig. 3 in Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line
Fig. 3. Morphological changes observed in HeLa (top row) and MIA PaCa-2 (bottom row) cells after incubation with gemcitabine (A and E), compound 1 (B and F), compound 2 (C and G) and compound 3 (D and H) at their respective IC50s for 8 h.
Fig. 4 in Alkaloids bearing rare skeletons from Forsythia suspensa with anti-inflammatory and anti-viral activities in vitro
Fig. 4. Experimental CD spectrum of 1 (in red) in MeOH and calculated ECD spectra of 1a (4bS,8S,8aR, in black) and 1b (4bR,8R,8aS, in blue) at the b3lyp/6–31 +g (d,p) level in MeOH. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 3 in Benzofuran ε-caprolactam glucosides, amides and phenylpropanoid derivatives with anti-inflammatory activity from Oxybaphus himalaicus
Fig. 3. Calculated and experimental ECD spectra (a) and chiral analysis chromatogram (b) of 1a and 1b.
Fig. 10 in Bisabolane-type sesquiterpenoids: Structural diversity and biological activity
Fig. 10. Substitution characteristics and structures of bisabolane-type sesquiterpenoids from species in the genus Bridelia.
Fig. 2. Key HMBC, 1 H– 1 H in Benzofuran ε-caprolactam glucosides, amides and phenylpropanoid derivatives with anti-inflammatory activity from Oxybaphus himalaicus
Fig. 2. Key HMBC, 1 H– 1 H COSY and NOESY correlations of compounds (1 3) and X-ray ORTEP drawing of 1.
Fig. 6 in Bisabolane-type sesquiterpenoids: Structural diversity and biological activity
Fig. 6. Structures of bisabolane-type sesquiterpenoids from species in the genera Coreopsis, Cremanthodium, Dendranthema, Eupatorium, Laggera, Leontopodium, Lychnophora, Scorzonera, and Senecio.
Fig. 4 in Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity
Fig. 4. Effect of compounds 1–15 on LPS-induced production of NO. Dexamethasone (Dex) was used as the positive control.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.