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1,036 results for “Cell mechanics”
Insights into the target-directed miRNA degradation mechanism in Drosophila ovarian cell culture
GEO Series GSE242116. Drosophila melanogaster. 5 samples. Type: Expression profiling by high throughput sequencing.
Studying human embryonic stem cell reveals molecular mechanisms of cold resistance
GEO Series GSE179344. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients
GEO Series GSE189735. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Microbiota-host crosstalk mechanism in the newborn and adult rumen at single-cell resolution
GEO Series GSE183285. Bos taurus. 3 samples. Type: Expression profiling by high throughput sequencing.
STAT1 employs myeloid cell-extrinsic mechanisms to regulate the neutrophil response and provide protection against invasive Klebsiella pneumoniae lung infection
GEO Series GSE251767. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Extensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells
GEO Series GSE63580. Homo sapiens. 246 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
NAC, Tiron and Trolox impair GBM tumorigenic cell survival by mechanisms independent from antioxidant activity
GEO Series GSE44099. Homo sapiens. 12 samples. Type: Expression profiling by array.
Comparative RNA sequencing identifies superior cytocidal mechanisms of imatinib over rapamycin in UMB1949 renal angiomyolipoma cells
GEO Series GSE193402. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
NETSseq Reveals Inflammatory and Aging Mechanisms in Distinct Cell Types Driving Cerebellar Decline in Ataxia Telangiectasia
GEO Series GSE282079. Homo sapiens. 318 samples. Type: Expression profiling by high throughput sequencing; Other.
APOE4 cell-specific mechanisms underlying cerebrovascular disorder precede neuronal and synaptic dysfunction and cognitive deficits in mice
GEO Series GSE185063. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Obesity accelerates hair thinning in stem cell-centric converging mechanism
GEO Series GSE131958. Mus musculus. 20 samples. Type: Expression profiling by array.
Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis
GEO Series GSE181027. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Effect of mechanically responsive miRNAs on biomechanical properties of airway smooth muscle cells and their related drug development studies [miRNA-Seq]
GEO Series GSE206433. Homo sapiens. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Limited Cell-Autonomous Anticancer Mechanisms in Long-Lived Bats
GEO Series GSE262772. Artibeus jamaicensis; Homo sapiens; Mus musculus; Mus spretus; Eonycteris spelaea; Myotis lucifugus; Eptesicus fuscus. 199 samples. Type: Expression profiling by high throughput sequencing.
Genome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in Uterine Fibroids and Breast Cancer (Expression BeadChip)
GEO Series GSE40725. Homo sapiens. 12 samples. Type: Expression profiling by array.
Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [inDrop]
GEO Series GSE147860. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Conservation of cell communication systems in invertebrate host–defence mechanisms: possible role in immunity and disease
<p>Video S1. TNT-like structures (white arrow) in live hemocytes from Mytilus galloprovincialis.</p>
Domain-invariant features for mechanism of action prediction in a multi-cell-line drug screen
<p><strong>Motivation: </strong>As a proxy for diseased cells, a cell line cannot be thought of as a perfect model. Many diseases feature an important molecular heterogeneity. Consequently, a drug may be effective against one molecular subtype of a disease, but less so against another. To characterise drugs with respect to their effect not only on one cell line but on a consensus of several is therefore a promising strategy to streamline the drug discovery process.</p> <p><strong>Results: </strong>The contribution of this paper is twofold. First, we investigate whether we can predict MOA at the molecular level without optimisation of the MOA classes to the screen specificities. To this end, we benchmark a set of algorithms within a conventional pipeline, and evaluate their MOA prediction performance according to a statistically rigorous framework. Second, we extend this conventional pipeline to the simultaneous analysis of multiple cell lines, each with potentially different morphological baselines. For this, we propose multitask autoencoders, including a domain-adaptive model used to construct domain-invariant feature representations across cell lines. We apply these methods to a pilot screen of two triple negative breast cancer cell lines as models for two different molecular subtypes of the disease.</p>
Conformational changes in the essential E. coli septal cell wall synthesis complex suggest an activation mechanism
<p>Molecular dynamics trajectories and data analysis notebooks to accompany the manuscript "Conformational changes in the essential E. coli septal cell wall synthesis complex suggest an activation mechanism"</p> <p>This dataset consists of a single zip archive. The archives contains two folders: one for molecular dynamics trajectories and one for data analysis notebooks. Each folder contains a README file describing files within.</p>
Mechanism of IL-10 Pathway-mediated Regulatory B Cell Dysfunction in Osteoarthritis
ClinicalTrials.gov study NCT06227195. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.