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Dataset results
984 results for “Cell stress”
Genomic profiles of oxidative stress-induced rat renal cell carcinomas
GEO Series GSE36101. Rattus norvegicus. 16 samples. Type: Expression profiling by array.
Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer
GEO Series GSE281129. Homo sapiens. 794 samples. Type: Other; Expression profiling by high throughput sequencing.
Data from: Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery
The human macula is more susceptible than the peripheral retina to developing blinding conditions such as age-related macular degeneration, diabetic retinopathy. A key difference between them may be the nature of their Müller cells. We found primary cultured Müller cells from macula and peripheral retina display significant morphological and transcriptomic differences. Macular Müller cells expressed more Phosphoglycerate Dehydrogenase (PHGDH, a rate-limiting enzyme in serine synthesis) than peripheral Müller cells. The serine synthesis, glycolytic and mitochondrial function were more activated in macular than peripheral Müller cells. Serine biosynthesis is critical in defending against oxidative stress. Intracellular reactive oxygen species and glutathione levels were increased in primary cultured macular Müller cells which were more susceptible to oxidative stress after inhibition of PHGDH. Our findings indicate serine biosynthesis is a critical part of the macular defence against oxidative stress and suggest dysregulation of this pathway as a potential cause of macular pathology.
Figure 1 from: Abbas AH, Mahmood AAR, Tahtamouni LH, Al-Mazaydeh ZA, Rammaha MS, Alsoubani F, Al-bayati RI (2021) A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity. Pharmacia 68(3): 679-692. https://doi.org/10.3897/pharmacia.68.e70654
Figure 1 Synthesis of the target compounds (4–7).
Figure 1 from: Kokanova-Nedialkova Z, Aluani D, Tzankova V, Nedialkov P (2021) Simultaneous quantification of the major flavonoids from wild spinach by UHPLC-HRMS and their neuroprotective effects in a model of H2O2-induced oxidative stress on SH-SY5Y cells. Pharmacia 68(3): 657-664. https://doi.org/10.3897/pharmacia.68.e71030
Figure 1 A chromatogram of the standard mixture of flavonoids.
Coumarin–Chalcone Hybrid LM-021 and Indole Derivative NC009-1 Targeting Inflammation and Oxidative Stress in Par-kinson's Disease Cell Models
<p>Figure S1: Wild type and A53T SNCA-GFP BE(2)-M17 cells; Figure S2: α-Synuclein aggregation and neurite outgrowth analyses on wild type and A53T SNCA-GFP BE(2)-M17 cells; Figure S3: Neuroprotective effects of LM-021 and NC009-1 on A53T-11 SNCA-GFP BE(2)-M17 cells; Figure S4: α-Synuclein aggregation reduction and neurite outgrowth promotion of LM-021 and NC009-1 on A53T-11 SNCA-GFP BE(2)-M17 cells.</p>
Stress Urinary Incontinence Study to Assess Safety and Efficacy of Muvon's Muscle Precursor Cell Therapy
ClinicalTrials.gov study NCT05534269. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Linagliptin in Comparison With Glimepiride as Add on to Metformin on Postprandial Beta Cell Function, Postprandial Metabolism and Oxidative Stress in Patients With Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT01547104. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Implication of the Oxydative Stress in the Pathophysiology of Sickle Cell Anemia:
ClinicalTrials.gov study NCT03368924. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Role of Unsteady Wall Shears Stress Stimuli on Human Umbilical Vein Endothelial Cells Harvested From Umbilical Cords
ClinicalTrials.gov study NCT04122794. IPD Sharing: NO. Countries: 1. Publications: 0.
Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease
ClinicalTrials.gov study NCT07316478. IPD Sharing: NO. Countries: 0. Publications: 0.
Effect of a Mediterranean Diet and Omega-3 Fatty Acids on Oxidative Stress and Endothelial Progenitor Cells (EPC's)
ClinicalTrials.gov study NCT00166088. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Stem Cell Therapy for Treatment of Female Stress Urinary Incontinence
ClinicalTrials.gov study NCT02334878. IPD Sharing: NO. Countries: 1. Publications: 0.
Replicative Stress in Hair Follicle Stem Cells and Pathogeny of Hidradenitis Suppurativa
ClinicalTrials.gov study NCT05531747. IPD Sharing: NO. Countries: 1. Publications: 0.
Effectiveness and Safety of Cell-Assisted Lipotransfer for the Treatment of Stress Urinary Incontinence
ClinicalTrials.gov study NCT01850342. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treatment of Stress Urinary Incontinence in Women With Autologous Adipose-derived Mesenchymal Stem Cells
ClinicalTrials.gov study NCT04446884. IPD Sharing: NO. Countries: 1. Publications: 0.
Exploring Blood Cell Function and Oxidative Stress to Improve Diagnosis and Treatment in Pre-Capillary Pulmonary Hypertension
ClinicalTrials.gov study NCT07176260. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
The Effects of Nanocurcumin on Serum Oxidative Stress,Inflammation,Adiponectin and NF-kB in Blood Mononuclear Cells in Metabolic Syndrome Patients (Nuclear Factor-κB)
ClinicalTrials.gov study NCT03514667. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Ashwagandha: Effects on Stress, Inflammation and Immune Cell Activation
ClinicalTrials.gov study NCT00817752. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autologous Muscle Derived Cells Compared to Placebo for Urinary Sphincter Repair in Post-surgical Female Stress Incontinence
ClinicalTrials.gov study NCT03104517. IPD Sharing: NO. Countries: 2. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.