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499 results for “YAPS”
Dataset related to the article "Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation"
<p>This record contains raw data related to the article "Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation".</p> <p>Abstract</p> <p><strong>Background: </strong>Conversion of cardiac stromal cells into myofibroblasts is typically associated with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing factors to cardiac fibrosis and heart failure. We hypothesized that this conversion could be also mediated by response of these cells to mechanical cues through activation of the Hippo transcriptional pathway. The objective of the present study was to assess the role of cellular/nuclear straining forces acting in myofibroblast differentiation of cardiac stromal cells under the control of YAP (yes-associated protein) transcription factor and to validate this finding using a pharmacological agent that interferes with the interactions of the YAP/TAZ (transcriptional coactivator with PDZ-binding motif) complex with their cognate transcription factors TEADs (TEA domain transcription factors), under high-strain and profibrotic stimulation.</p> <p><strong>Methods: </strong>We employed high content imaging, 2-dimensional/3-dimensional culture, atomic force microscopy mapping, and molecular methods to prove the role of cell/nuclear straining in YAP-dependent fibrotic programming in a mouse model of ischemia-dependent cardiac fibrosis and in human-derived primitive cardiac stromal cells. We also tested treatment of cells with Verteporfin, a drug known to prevent the association of the YAP/TAZ complex with their cognate transcription factors TEADs.</p> <p><strong>Results: </strong>Our experiments suggested that pharmacologically targeting the YAP-dependent pathway overrides the profibrotic activation of cardiac stromal cells by mechanical cues in vitro, and that this occurs even in the presence of profibrotic signaling mediated by TGF-β1 (transforming growth factor beta-1). In vivo administration of Verteporfin in mice with permanent cardiac ischemia reduced significantly fibrosis and morphometric remodeling but did not improve cardiac performance.</p> <p><strong>Conclusions: </strong>Our study indicates that preventing molecular translation of mechanical cues in cardiac stromal cells reduces the impact of cardiac maladaptive remodeling with a positive effect on fibrosis.</p>
Chip-chip from mechanical stretched interfollicular epidermal stem cells (IFESCs) with YAP
GEO Series GSE71314. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Diwu Yanggan capcules alleviate hepatocellular carcinoma progression by regulating YAP signaling
GEO Series GSE297952. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Synergism of FAK and ROS1 inhibitors in the treatment of CDH1-deficient cancers mediated by FAK-YAP-TRX signaling
GEO Series GSE229195. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq of injured mouse hearts depleted for myofibroblast Yap [I]
GEO Series GSE163269. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The interplay between oxytocin receptor and YAP in regulating gastric cancer progression
GEO Series GSE283517. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of YAP and TFCP2 occupancy and regulated expression in liver cancer cells
GEO Series GSE99315. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
YAP and MRTF-A, transcriptional co-activators of RhoA- mediated gene expression, are critical for glioblastoma tumorigenicity
GEO Series GSE111571. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Function of YAP in glucose deprivation-induced gene expression
GEO Series GSE215815. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
TGF-β promotes colitis and cancer development in Smad4-deficient intestinal epithelium in a Yap-dependent manner (DSS)
GEO Series GSE205910. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
GEO Series GSE119024. Danio rerio. 12 samples. Type: Expression profiling by high throughput sequencing.
YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis
GEO Series GSE128042. Mus musculus. 6 samples. Type: Expression profiling by array.
Deregulation of the Hippo pathway promotestumor cell proliferation through YAP activity in human sporadic vestibular schwannoma
GEO Series GSE108237. Homo sapiens. 14 samples. Type: Expression profiling by array.
Wnt/β-catenin-YAP axis may be involved in primary intraosseous carcinoma, NOS, arising from odontogenic keratocyst
GEO Series GSE253232. Homo sapiens. 2 samples. Type: Expression profiling by array.
YAP-TEAD complex inhibits photoaging via transcriptional regulation of homologous recombination repair in mouse (smal) - lncRNA-seq
GEO Series GSE279221. Mus musculus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in Hippo-dependent cancer models
GEO Series GSE305254. Homo sapiens. 269 samples. Type: Expression profiling by high throughput sequencing.
TRAF4 promotes the malignancy of ovarian high-grade serous carcinoma by activating YAP pathway
GEO Series GSE202840. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis
GEO Series GSE128046. Mus musculus. 10 samples. Type: Expression profiling by array.
TGF-β promotes colitis and cancer development in Smad4-deficient intestinal epithelium in a Yap-dependent manner
GEO Series GSE205912. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis of YAP-overexpressing mouse embryonic fibroblasts in the context of reprogramming
GEO Series GSE131232. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
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