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7,582 results for “clinical study”
Clinical questions in primary care: where to find the answers - a cross-sectional study
<p>Dataset for the study "Clinical questions in primary care: where to find the answers - a cross-sectional study". </p>
Clinical Study Reports published by the European Medicines Agency 2016-2018
<p>Clinical Study Reports published by the European Medicines Agency 2016-2018</p>
Clinical characteristics, risk factors and complications of COVID-19 among critically ill older adults – A case control study
<p><strong>Background</strong>: The older population is often disproportionately and adversely affected during humanitarian emergencies, as has also been seen during the COVID-19 pandemic. Data regarding COVID-19 in older adults is usually over-generalised and does not delve into details of the clinical characteristics in them. This study was conducted to analyse clinical and laboratory characteristics, risk factors, and complications of COVID-19 between older adults who survived and those who did not.</p> <p><strong>Methods</strong>: We conducted a case-control study among older adults(age > 60 years) admitted to the Intensive Care Unit(ICU) during the COVID-19 pandemic. The non-survivors (cases) were matched with age and sex-matched survivors (control) in a ratio of 1: 3. The data regarding socio-demographics, clinical characteristics, complications, treatment, laboratory data, and outcomes were analysed.</p> <p><strong>Results</strong>: The most common signs and symptoms observed were fever (cases vs controls) (68.92 vs. 68.8%), followed by shortness of breath (62.2% Vs. 52.2%), and cough (47.3% Vs. 60.2%). Our analysis found no association between the presence of any of the comorbidities and mortality. At admission, laboratory markers such as LDH(Lactate Dehydrogenase), WBC(White Blood Count), creatinine, CRP(C-Reactive Protein), D-dimer, ferritin, and IL-6(Interleukin-6) were found to be significantly higher among the cases than among the controls. Complications such as development of seizure, bacteremia, acute renal injury, respiratory failure, and septic shock were seen to have a significant association with non-survivors.</p> <p><strong>Conclusions</strong>: Hypoxia, tachycardia, and tachypnoea at presentation were associated with higher mortality. The older adults in this study mostly presented with the typical clinical features of COVID-19 pneumonia. The presence of comorbid illnesses among them did not affect mortality. Higher death was seen among those with higher levels of CRP, LDH, D-dimer, and ferritin; and with lower lymphocyte counts.</p>
Comparison of Tele Dentistry with Clinical Diagnosis (on-site) by Employing ICDAS in the Population of Rawalpindi & Islamabad: A Validation Study
<p>The study was cross sectional validation study was done from Jan 2022 to Jan 2023 in private<br> clinics of Rawalpindi and Islamabad in which tele dental diagnosis was compared with onsite<br> clinical diagnosis by using the instrument of ICDAS. A dentist primarily examined the patient<br> caries than that same patient was diagnosed by another dentist through photographs, which<br> were taken by patients’ attendant on verbal guidelines by a dentist. later, this whole data was<br> assessed by a third dentist.</p>
Clinical Features, Socio-Cultural Characteristics, Sleep Patterns, and Depression in Fibromyalgia Patients from India: A Cross-Sectional Study
<p><strong>Introduction</strong>: Fibromyalgia is a complex and chronic disease with significant regional variation and lack of studies from Indian population.</p> <p><strong>Objective</strong>: Aim to investigate the clinical features of fibromyalgia patients in India, including the prevalence and distribution of comorbidities, sleep patterns, and depression.</p> <p><strong>Method</strong>: Cross-sectional analysis of consecutive patients attending outpatient Rheumatology clinic from 2019-2020 satisfying ACR2016 criteria for fibromyalgia.</p> <p><strong>Results:</strong></p> <p>Of the 121 patients enrolled in the study, the majority (93.4%) were female, with a female-to-male ratio of 14:1. The mean age of the patients was 45 ±11 years. The socio-cultural profile of the patients revealed that the majority were married (88%) and homemakers (68.8%), lived in nuclear families (56%) and were middle to upper middle class (68.6%). Contrary to the existing literature, a higher prevalence of fibromyalgia has been observed in people with a higher educational status. Common clinical symptoms were extensive body aches (100%), fatigue (88%), difficulty concentrating (69.4%), irritability and gastrointestinal complaints (58.5%). We observed a high prevalence of primary headache (76%), mainly migraine (42%) and compulsive behaviour (OCB) (71%). Sleep disturbances and depression were found to be significant factors associated with fibromyalgia. The patients reported various sleep problems, such as snoring, waking up at night, daytime sleepiness, and taking daytime naps. Most of the patients had mild (50.8%) to moderate (29%) depression, while a smaller proportion experienced severe (6.6%) symptoms. Most of the patients had low vitamin D(91%).</p> <p><strong>Conclusion</strong>: The demographic profile of Indian patients was similar to that reported in the literature but had varied socio-cultural profiles needing further community-based studies. The high prevalence of psychological comorbidities and sleep disturbances highlights their importance in managing FM patients.</p>
Clinical Study to Evaluate the Safety and Effectiveness of MER® Stents in Carotid Revascularisation.
ClinicalTrials.gov study NCT03133429. IPD Sharing: NO. Countries: 1. Publications: 6.
CRP on Radiobiological and Clinical Studies on Viral-Induced Cancer's Response to Radiotherapy
ClinicalTrials.gov study NCT00122772. IPD Sharing: Not stated. Countries: 11. Publications: 7.
Phase III Controlled Clinical Study of NPO-11 in Patients Undergoing Gastric Endoscopy
ClinicalTrials.gov study NCT00742599. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Albuterol DPI (A006) Clinical Study-B3:Efficacy, Dose-ranging and Safety Evaluation
ClinicalTrials.gov study NCT02210806. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Clinical Study to Assess the Mode of Action of QBW251 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov study NCT04268823. IPD Sharing: YES. Countries: 4. Publications: 0.
Platform Clinical Study for Conquering Scleroderma
ClinicalTrials.gov study NCT06195072. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Study of Desmoteplase in Japanese Patients With Acute Ischemic Stroke
ClinicalTrials.gov study NCT01104467. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Graphene-Reinforced CAD/CAM Restorations for MIH-Affected Molars in Adolescents: A Prospective Clinical Study
ClinicalTrials.gov study NCT07329244. IPD Sharing: NO. Countries: 1. Publications: 2.
Analysis of Volatile Organic Compounds in Expired Air in Healthy Volunteers: Comparison of Three Mass Spectrometry Techniques for the Characterization of Volatolome in Clinical Studies
ClinicalTrials.gov study NCT06020521. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Post Market Clinical Follow Up Study for Evaluation of Agluna® METS
ClinicalTrials.gov study NCT02779504. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Study of HiR+X Therapy for Newly Diagnosed Elderly Patients with DLBCL Intolerant to Chemotherapy
ClinicalTrials.gov study NCT06758037. IPD Sharing: NO. Countries: 1. Publications: 2.
Phase I Clinical Study of CWP232291 in Acute Myeloid Leukemia Patients
ClinicalTrials.gov study NCT01398462. IPD Sharing: Not stated. Countries: 2. Publications: 1.
iCLAS™ Cryoablation System Post-Market Clinical Follow-up (PMCF) Study
ClinicalTrials.gov study NCT05416086. IPD Sharing: NO. Countries: 3. Publications: 0.
Phase Ib/II Study Assessing the Clinical Activity and Safety of Brexucabtagene Autoleucel as a Consolidation in Patients With Relapsed/Refractory (R/R) and Newly Diagnosed B-cell Acute Lymphocytic Leu
ClinicalTrials.gov study NCT06287229. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Phase II Clinical Study to Assess the Efficacy and Safety of IBI310 or Placebo Combined With Sintilimab for Advanced Cervical Cancer Subjects Who Have Failed or Cannot Tolerate First-line or Above P
ClinicalTrials.gov study NCT04590599. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.