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opencc-zeroAug 2020View details →

Educational Material For: Development of video-based educational materials for kidney-transplant patients

Introduction Treatment adherence has been evaluated as a major predictor of long-term outcome, and education has been suggested to improve adherence. Considering the characteristics of adult learners, it is necessary to implement educational programs that meet the needs of transplant patients. Multimedia education may be well-suited for this. This study aims to develop video education materials in accordance with transplant patients' self-care needs. Methods This study includes a literature review and patient interviews aimed at developing video education materials for the self-care needs of patients who underwent renal transplant surgery at a university hospital in Seoul. Ten patients were interviewed about the desired educational content, accessibility, and other preferences. After verifying the validity of the data, the video scenarios were produced and satisfaction surveys were conducted. Results Eleven self-care education items were identified through interviews with 10 kidney transplant patients. The expert validation of video-based educational content result was high (mean CVI = 0.94). The mean score of the patients' satisfaction evaluation of the completed 7-minute video instructional materials was also high (4.55 on a 5-point Likert scale). Conclusion Findings indicate that the video education materials will meet the needs of adult learners and mitigate the limitations of the existing education programs by increasing interest and motivation and may contribute to increased treatment adherence and ultimately, positively effect self-care for new transplant patients.

opencc-zeroSep 2020View details →

The benefit of kidney transplantation versus remaining on the waitlist depends on patients' baseline comorbidities: a retrospective study

Background: Patients with end-stage renal disease present comorbidities that increase mortality risk on the waitlist and after kidney transplantation. This study aimed to determine the impact of baseline comorbidities on the risk of death after kidney transplantation compared to remaining on the waitlist. Methods: Records of waitlisted patients were retrospectively analyzed. Multivariable time-dependent Cox-regression model was used to determine the initial and the lowest relative hazard-risk of death (HRD) after exposure to kidney transplantation. Results: 1692 patients were included in the study. Patients without comorbidities had the relative HRD 3-fold higher, immediately after kidney transplantation, but it reduced progressively, reaching equality to waitlist at 75 days and a HRD of 0.28 thereafter (p<0.001). Patients with Diabetes and coronary artery disease had an initial relative HRD of 2.41 (p=0.009) and 2.68 (p=0.009) and matched to the waitlist at 175 and 200 days, respectively. Patients with peripheral vascular disease, had an initial relative HRD 3.6-fold in the first 240 days (p=0.008) and patients with congestive heart failure a relative HRD of 7.47 (p=0.07). Both declined rapidly, reaching equality at 110 days. Finally, all comorbidities, except cerebrovascular disease, presented lower HRD on long-term follow-up. Conclusions: This study shows that the time and the range of relative HRD between kidney transplantation and waitlist varies depending upon the patients´ baseline comorbidities.

opencc-zeroDec 2014View details →

Data from: Diabetes mellitus and prediabetes on kidney transplant waiting list- prevalence, metabolic phenotyping and risk stratification approach

Background: Despite a significant prognostic impact, little is known about disturbances in glucose metabolism among kidney transplant candidates. We assess the prevalence of diabetes mellitus (DM) and prediabetes on kidney transplant waiting list, its underlying pathophysiology and propose an approach for individual risk stratification. Methods: All patients on active kidney transplant waiting list of a large European university hospital transplant center were metabolically phenotyped. Results: Of 138 patients, 76 (55%) had disturbances in glucose metabolism. 22% of patients had known DM, 3% were newly diagnosed. 30% were detected to have prediabetes. Insulin sensitivity and -secretion indices allowed for identification of underlying pathophysiology and risk factors. Age independently affected insulin secretion, resulting in a relative risk for prediabetes of 2.95 (95%CI 1.38-4.83) with a cut-off at 48 years. Body mass index independently affected insulin sensitivity as a continuous variable. Conclusions: The prevalence of DM or prediabetes on kidney transplant waiting list is as high as 55%, with more than one third of patients previously undiagnosed. Oral glucose tolerance test is mandatory to detect all patients at risk. Metabolic phenotyping allows for differentiation of underlying pathophysiology and provides a basis for early individual risk stratification and specific intervention to improve patient and allograft outcome.

opencc-zeroJul 2022View details →

Long-term outcomes and prognostic factors in kidney transplant recipients in Jakarta, Indonesia: a cohort study

Objectives To determine the long-term survival rates and prognostic factors in kidney transplant (KT) recipients in Jakarta, Indonesia. Design Retrospective cohort study. Setting A KT centre in Jakarta. Participants We enrolled 754 consecutive adult recipients who underwent KT between 2010 and 2020. Main outcome measures Rates of 10-year patient, all-cause and death-censored graft survival and their prognostic factors in KT recipients. Results The 10-year patient survival, all-cause survival and death-censored graft survival rates of KT recipients were 74%, 68% and 81%, respectively. The prognostic factors for poor patient survival were a pretransplant dialysis duration>24 months (HR 1.64, 95% CI, 1.08 to 2.49; p=0.02), cardiovascular disease (HR 1.59, 95% CI, 1.11 to 2.31; p=0.01), delayed graft function (DGF) (HR 4.94, 95% CI, 2.76 to 8.82; p<0.001), post-transplant infection (HR 2.63, 95% CI, 1.56 to 4.43; p<0.001) and acute rejection (HR 2.49, 95% CI, 1.20 to 5.15; p=0.01). All-cause graft survival was prognosticated by a pretransplant dialysis duration>24 months (HR 1.74, 95% CI, 1.15 to 2.47; p=0.007), cardiovascular disease (HR 1.65, 95% CI, 1.18 to 2.33; p=0.004), DGF (HR 5.39, 95% CI, 3.13 to 9.28; p<0.001), post-transplant infection (HR 2.46, 95% CI, 1.05 to 4.02; p<0.001) and acute rejection (HR 4.18, 95% CI, 2.23 to 7.84; p<0.001). Factors associated with poor death-censored graft survival were a pretransplant dialysis duration >24 months (HR 2.19, 95% CI, 1.32 to 3.63; p=0.002), cardiovascular disease (HR 1.65, 95% CI, 1.02 to 2.68; p=0.04) and acute rejection (HR 5.52, 95% CI, 2.80 to 10.83; p<0.001). Conclusions The survival rates of KT recipients are prognosticated by pretransplant dialysis duration, cardiovascular disease, DGF, post-transplant infection and acute rejection. Stricter eligibility criteria for recipients, more sensitive cross-match testing methods and better infection management strategies may be beneficial for improving the survival rates.

opencc-zeroAug 2021View details →

Dynamics of glucose metabolism after liver transplantation: Prediabetes as a window of opportunity for patient survival and long‐term kidney function

Posttransplantation diabetes mellitus (PTDM) is a relevant complication following liver transplantation with profound impact on morbidity and mortality. To date, little is known about the evolution and dynamics of glucose metabolism and the impact of prediabetes in long-term follow-up. To address this issue, all consecutive adult liver transplant recipients (n=429) from a European university hospital transplant center between 2007 and 2017 were analyzed retrospectively. In patients without pre-existing diabetes (n=327), we conducted a longitudinal characterization of glucose metabolism. Median follow-up was 37 [9-64, IQR] months. Median prevalence of prediabetes was 39 [37-39]% and of PTDM 21 [17-22]%. Throughout follow-up, intra-individual glucose regulation of patients was highly variable, continuously fluctuating between different states of glucose metabolism (normal glucose tolerance, prediabetes, PTDM). Whereas overall survival and long-term kidney function of patients with PTDM were significantly lower than that of patients with normal glucose metabolism, prediabetes was not associated with adverse outcome. This study provides new insight into the dynamics and impact of glucose metabolism after liver transplantation. Unlike PTDM, prediabetes is not associated with adverse outcome, providing a window of opportunity for targeted intervention. The results underline the need for constant screening and intervention in post-transplant care of liver allograft recipients.

A Pharmacokinetic Study of CellCept (Mycophenolate Mofetil) Versus Mycophenolate Sodium in Kidney Transplant Patients

ClinicalTrials.gov study NCT01033864. IPD Sharing: Not stated. Countries: 1. Publications: 0.

closedIPD-NOFeb 2026View details →

Home-based Therapeutic Drug Monitoring in Kidney Transplantation

ClinicalTrials.gov study NCT05005221. IPD Sharing: NO. Countries: 1. Publications: 0.

Extension Study Of Subjects From Study A3921030 For The Prevention Of Acute Rejection In Kidney Transplant Patients

ClinicalTrials.gov study NCT00658359. IPD Sharing: Not stated. Countries: 15. Publications: 0.

Pharmacokinetics, Safety and Tolerability of Single-dose Belatacept in Adolescent Kidney Transplant Recipients

ClinicalTrials.gov study NCT01791491. IPD Sharing: Not stated. Countries: 1. Publications: 0.

Eculizumab Therapy for Subclinical Antibody-mediated Rejection in Kidney Transplantation

ClinicalTrials.gov study NCT02113891. IPD Sharing: Not stated. Countries: 0. Publications: 4.

Pharmacokinetics of LCP-Tacro in Stable Kidney Transplant Patients

ClinicalTrials.gov study NCT00496483. IPD Sharing: Not stated. Countries: 1. Publications: 0.

Randomized Trial of Induction Therapies in High Immunological Risk Kidney Transplant Recipients

ClinicalTrials.gov study NCT00782821. IPD Sharing: Not stated. Countries: 1. Publications: 0.

closedIPD-NOFeb 2026View details →

Examination of Immunosuppression Adjustment Impact on Kidney Function in Liver Transplant

ClinicalTrials.gov study NCT04104438. IPD Sharing: NO. Countries: 1. Publications: 0.

controlledIPD-YESFeb 2026View details →

Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy

ClinicalTrials.gov study NCT04741074. IPD Sharing: YES. Countries: 1. Publications: 0.

Early Conversion From Tacrolimus to Efalizumab Maintenance Therapy in Kidney Transplant Recipients

ClinicalTrials.gov study NCT00472082. IPD Sharing: Not stated. Countries: 1. Publications: 0.

Multicenter, Prospective, Rand, PK Study of LCP-Tacro™ Compared to Prograf® Capsules in De Novo Adult Kidney Transplant

ClinicalTrials.gov study NCT01666951. IPD Sharing: Not stated. Countries: 1. Publications: 0.