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6,171 results for “mutant”
Data from: Abnormal brain development in child and adolescent carriers of mutant huntingtin
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Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss
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Data from: Calcium imaging with genetically encoded sensor Case12: facile analysis of α7/α9 nAChR mutants
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Data from: High-throughput genotyping of green algal mutants reveals random distribution of mutagenic insertion sites and endonucleolytic cleavage of transforming DNA
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Data from: The fitness effects of a pale mutant in the aposematic seed bug Lygaeus simulans indicate pleiotropy between warning coloration and life history
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Data from: Mutant invasions and adaptive dynamics in variable environments
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Data from: No evidence for induction or selection of mutant sodium channel expression in the copepod Acartia husdsonica challenged with the toxic dinoflagellate Alexandrium fundyense
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Phosphatidylserine exposure promotes increased adhesion in Dictyostelium Copine A mutants
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Data from: Drosophila FoxP mutants are deficient in operant self-learning
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nkx3.2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish
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Data from: Systems analysis of adaptive responses to MAP Kinase pathway blockade in BRAF mutant melanoma
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Data from: Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme
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Data from: Within-host stochastic emergence dynamics of immune-escape mutants
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Supplementary mass spectonomy data to analyse generation of spliced mutant Kras/RAC2 epitopes
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Data from: Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1
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Data from: Simulation of the nodal flow of mutant embryos with small number of cilia: comparison of mechanosensing and vesicle transport hypotheses
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Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer (Ruan et al.)
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During development the Sku6 mutant roots engage different genes than wild type Col-0 roots either on the ground or in spaceflight.
The wild type Col-0 plants and the Sku-6 mutant plants of the Col-0 background were germinated on ISS or on the ground and the gene expression profiles in roots at 4 days or 8 days were established. The Sku6 gene (At2g03680) codes for a protein that localizes to microtubule within the cortical array and putatively acting as an intramolecular linker. The development of Col-0 and Sku-6 plants on orbit differs from that on the ground as demonstrated by the comparison of the gene expression profiles between 4 days old to 8 days old plant in the two environments. However the development of Sku-6 mutant plants also differs from Col-0 at either age and in either environment suggesting the role of the genetic background in these developmental decisions. The 4 days old Sku-6 roots in orbit engaged more genes than the 4 days old Col-0 roots in orbit but also more than the 4 days old Sku-6 roots on the ground. Overall the 4 days old roots differentially expressed more genes in spaceflight relative to ground than the 8 days old roots of either genotype.
Synergistic effects of space radiation and microgravity (miRNA WT and dys-mutant)
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still controversial. A mRNA microarray and microRNA microarray in dauer larvae of Caenorhabditis elegans (C. elegans) that endured spaceflight environment and space radiations environment during 16.5-day Shenzhou-8 space mission were performed. In our study wild type and dys-1 mutant strains of C.elegans endured four conditions during shenzhou-8 spaceflight mission including spaceflight static condition(ss) spaceflight 1-g centrifugal condition(sc) ground control condition(gc) and no-transport control. Limited to the quantity of worm samples we performed technical-repeat test but not sample-repeat test. Accordingly eight miRNA microarrays were performed.
Dissecting transcriptional responses of nucleolin mutants to red light stimulation and darkness in ground reference conditions
Understanding plant adaptive responses to the space environment is a requisite for enabling space farming. Spaceflight produce deleterious effects on plant cells particularly affecting ribosome biogenesis a complex stress-sensitive process coordinated with cell division and differentiation known to be activated by red light. Here we have used mutants from the two nucleolin genes in Arabidopsis (NUC1 and NUC2) encoding the main regulator of the ribosome biogenesis in the nucleolus in order to better understand their role in adaptive response mechanisms to stress. Thus we show that nucleolin stress-related gene NUC2 can compensate the environmental stress provided by darkness in nuc1 plants while nuc2 plants are not able to provide a complete response to red light. These ground control findings as part of the ESA/NASA Seedling Growth spaceflight experiments will determine the basis for the identification of a genetic background enabling an adaptive advantage for plants in future space experiments.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.