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15,277 results for “GENETICS”
FIGURE 3 in Phylogeography, genetic structure and wing pattern variation of Erebia pronoe (Esper, 1780) (Lepidoptera: Nymphalidae) in Europe
FIGURE 3. Statistical parsimony network of Erebia pronoe based on the COI mitochondrial dataset and statistical parsimony as implemented in TCS v1.21. Each haplotype is labelled by a number. Unsampled and extinct haplotypes are indicated by small circles. Division of the E. pronoe populations into seven haplogroups was detected, described in the Results section. These groups are illustrated with different symbols. Collection sites are indicated in the legend.
FIGURE 1 in Phylogeography, genetic structure and wing pattern variation of Erebia pronoe (Esper, 1780) (Lepidoptera: Nymphalidae) in Europe
FIGURE 1. Map of collection sites of Erebia pronoe in European mountain ranges and possible re-colonization paths of E. pronoe after the retreat of glacial stages during the Pleistocene. Grey shading and symbols represent different collection sites (by states); dashed arrows illustrate hypothesized paths of re-colonization from the refugia in the Pyrenees and Alps/Central Europe; triangles illustrate specimens collected from the European mountain ranges; circles illustrate specimens mined from the GenBank and BOLD databases. The number of analysed specimens is given in Table 1.
FIGURE 2 in Multi-locus phylogeny of southern African Acontias aurantiacus (Peters) subspecies (Scincidae: Acontinae) confirms the presence of three genetically, geographically and morphologically discrete taxa
FIGURE 2. Haplotype phylogeny of the South African and nominate subspecies of Acontias aurantiacus inferred from a concatenated cyt b, 16S and RAG1 dataset comprising of 3,159 nucleotides (cyt b = 1,045, 16S = 526 and RAG1 = 1,588 nt) using a Maximum Likelihood algorithm. Maximum Likelihood (ML) bootstrap values ḵ70% (upper) and Bayesian posterior probability (BPP, lower) support values ḵ0.95 are indicated, while nodes with statistical support below these thresholds have no associated support values. Melanistic specimens are indicated with an asterisk and the mottled specimen with a cross.
FIGURE 1 in Multi-locus phylogeny of southern African Acontias aurantiacus (Peters) subspecies (Scincidae: Acontinae) confirms the presence of three genetically, geographically and morphologically discrete taxa
FIGURE 1. Molecular phylogeny of the genus Acontias inferred using a Maximum Likelihood algorithm and a concatenated cyt b, 16S and RAG1 dataset comprising of 2,244 nt. Maximum Likelihood (ML) bootstrap values ḵ70% and Bayesian posterior probability (BPP) support values ḵ0.95 are shown above and below each of the supported nodes, respectively, while unsupported nodes have no associated values. Taxa marked with an asterisk were sourced from GenBank.
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia: A report from the TARGET initiative
<p>Acute myeloid leukemias (AML) are characterized by distinct mutations of tumor suppressor and oncogenes, involving distinct genes in adults and children. While certain mutations have been associated with the increased risk of AML relapse the genomic landscape of primary chemotherapy resistant AML is not well defined. As part of the TARGET initiative, we performed whole-genome DNA sequencing, transcriptome RNA, and miRNA sequencing analysis of pediatric AML with failure of induction chemotherapy. We identified three distinct genetic groups of patients with induction failure, including those with <em>NUP98</em> rearrangements, somatic mutations of <em>WT1</em>, <em>ELF1</em>, <em>KMT2C</em>, <em>MLLT10,</em> and additional recurrent gene mutations, fusions, and structural rearrangements, some of which have been observed in other malignancies. Comparison of specimens before and after chemotherapy revealed distinct and invariant gene expression programs. While exhibiting gross therapy resistance, these leukemias had diverse forms of clonal evolution upon chemotherapy exposure. This included selection for mutant alleles of <em>FRMD8</em>, <em>DHX32</em>, <em>PIK3R1</em>, <em>SHANK3</em>, <em>MKLN1</em>, as well as persistence of <em>WT1</em> and <em>TP53</em> mutant clones, and elimination or contraction of <em>FLT3</em>, <em>PTPN11</em>, and <em>NRAS</em> mutant clones. These findings delineate genetic mechanisms of primary chemotherapy resistance in pediatric AML, which should inform improved approaches for its diagnosis and therapy.</p>
FIGURE 2 in Needle in a haystack-genetic evidence confirms the expansion of the alien echinoid Diadema setosum (Echinoidea: Diadematidae) to the Mediterranean coast of Israel
FIGURE 2 Phylogenetic relationships of the genus Diadema. Superimposed Maximum Likelihood and Bayesian Inference phylogenetic trees based on COI sequences representing all extant species of Diadema, rooted by Astropyga radiata. Major clades were collapsed. The clades including Mediterranean Diadema sequences are highlighted in yellow (D. setosum clade b). Supporting values (> 0.9 posterior probabilities and> 70% ML bootstrap values) are shown above the nodes (before and after the slash, respectively). ML bootstrap support was calculated from 1000 replications and BI posterior probabilities from 7.5 million generations (after burn-in). GenBank accession numbers of the corresponding sequences used in the analysis are given in Supplementary materials Tab. S2.
FIGURE 1 in Needle in a haystack-genetic evidence confirms the expansion of the alien echinoid Diadema setosum (Echinoidea: Diadematidae) to the Mediterranean coast of Israel
FIGURE 1 Images of live Diadema setosum in the field: A) from Tel Aviv, Israel (32.086358°N, 34.763918°E), on 10.11.2016, at a depth of 6-8 m (Photograph: Adi Gvir; specimen not collected). B) from Tel Aviv, Israel (32.083633°N, 34.762836°E), on 17.06.2017, at depth of 3.5 m (a single spine was retrieved from specimen, deposited at the Steinhardt Museum of Natural History, Tel Aviv University under voucher number SMNH_Ec_25635). Scanning electron microscope images of D. setosum spines from specimen shown in B. C) longitudinal view showing the characteristic diadematoid verticillation; D) transverse section showing the axial cavity and solid wedges of the spine. See also Supplementary materials Fig. S3.
FIGURE 2 in No more machismo in Callyntra (Coleoptera: Tenebrionidae): Callyntra femina, a new species discovered based on female genitalia and genetic evidence
FIGURE 2. Comparative scheme of the ventral and lateral view respectively of the ovipositors from different species of Callyntra. a–d) Callyntra femina sp. nov., b–e) Callyntra carbonaria and c–f) Callyntra riverai. g: gonostyle, cl 2+3+4: lobes of the coxite 2, 3 and 4 fused, cl 1: first lobe of the coxite and p: paraproct. Scale bar: 1 mm.
FIGURE 3. Phylogenetic tree for the four species under study. A in No more machismo in Callyntra (Coleoptera: Tenebrionidae): Callyntra femina, a new species discovered based on female genitalia and genetic evidence
FIGURE 3. Phylogenetic tree for the four species under study. A) Tree obtained using Bayesian Inference with mitochondrial COI and 16S genes combined. Number above the nodes correspond to the posterior probabilities. B) Clade G from the COI + 16S combined tree obtained by Zúñiga-Reinoso & Méndez (2018), highlighting the species under study with colorful branches. The colors are matching the species in both trees.
FIGURE 1 in No more machismo in Callyntra (Coleoptera: Tenebrionidae): Callyntra femina, a new species discovered based on female genitalia and genetic evidence
FIGURE 1. Dorsal view of Callyntra femina sp. nov. a) Head: la, labrum; cl, clipeus; fr, front; amp, anterior margin of pronotum. b) Pronotum: amp, anterior margin of pronotum; prd, pronotal disc; prc, pronotal carena; lmp, lateral margin of the pronotum. c) Elytra: mc, main carenae; es, elytral suture. Scale bar: 1 mm.
Inducibility of plant secondary metabolites predicts genetic variation in resistance against a key insect herbivore in maritime pine
<p>SNP dataset in maritime pine (<em>Pinus pinaster</em>) together with the population structure (<em>Q</em>) and kinship (<em>K</em>) matrices.</p>
Population genetics of Paramecium mitochondrial genomes; genome assemblies and annotation files
<p>Because of issues arising during submission to GenBank of Paramecium mitochondrial genomes due to the highly unconventional nature of the genetic code used in these genomes, we are initially making the genomes publicly available here (while we are still working on a submission to official databases).</p>
Alignment, ML and MCC trees of dataset A from "Reconstruction of the genetic history and the current spread of HIV-1 subtype A in Germany"
<p>-Alignment and phylogeographic MCC tree of 708 HIV subtype A1 sequences called dataset A in the manuscript "Reconstruction of the genetic history and the current spread of HIV-1 subtype A in Germany"</p> <p>-marked up MCC tree showing SDRM in dataset A</p> <p>-marked up ML tree showing transmission cluster selection in dataset A</p>
FIGURE 3 in Geographically structured genetic variation in Ptychozoon lionotum (Squamata: Gekkonidae) and a new species from an isolated volcano in Myanmar
FIGURE 3. Deciduous dipterocap forest habitat of Ptychozoon popaense sp. nov. on Mt. Popa, Mandalay Region, Myanmar.
FIGURE 1 in Geographically structured genetic variation in Ptychozoon lionotum (Squamata: Gekkonidae) and a new species from an isolated volcano in Myanmar
FIGURE 1. Left: distribution of the samples of the Ptychozoon lionotum Group used in the molecular phylogenetic analysis. Right: Maximum likelihood consensus tree topology of Ptychozoon. Black dots denote nodes with BPP ¿ 0.95, UFB ¿ 95, and LRT ¿ 0.80. The grey dot denotes a node with BPP ¿ 0.95, UFB ± 95, and LRT ¿ 0.80. The open dot denotes a node with no significant support.
FIGURE 2 in Geographically structured genetic variation in Ptychozoon lionotum (Squamata: Gekkonidae) and a new species from an isolated volcano in Myanmar
FIGURE 2. Adult male holotype of Ptychozoon popaense sp. nov. (LSUHC 13508) from Yay Su camp, 16 km northeast of Kyauk-pa-taung Town, Kyauk-pa-taung Township, Mt. Popa, Mandalay Region, Myanmar.
FIGURE 3 in Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris
FIGURE 3. Details of Caparinia spp. A—Position of seta si, female of C. ictonyctis stat. res.; B—Same, female of C. tripilis; C—Coxal field III, male of C. ictonyctis stat. res.; D—Same, females of C. tripilis; E - Anal region, female of C. tripilis; F— Adanal shields, male of C. tripilis.
FIGURE 6. Caparinia ictonyctis Lawrence, 1955, protonymph. A in Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris
FIGURE 6. Caparinia ictonyctis Lawrence, 1955, protonymph. A—dorsal view; B—ventral view; C—tarsus I in dorsal view, D—same in ventral view; E—tarsus II in dorsal view; F—same in ventral view; G—leg III in ventral view; H—leg IV in ventral view. Scale bars: 100 µm = A, B; 50 µm = C–H.
FIGURE 5. Caparinia ictonyctis Lawrence, 1955, larva. A in Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris
FIGURE 5. Caparinia ictonyctis Lawrence, 1955, larva. A—dorsal view; B—ventral view; C—leg I in dorsal view, D—same in ventral view; E—leg II in dorsal view; F—same in ventral view; G—leg III in ventral view. Scale bars: 100 µm = A, B; 50 µm = C–G.
FIGURE 2 in Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris
FIGURE 2. SEM images of Caparinia ictonyctis stat. res. A—Tibia and tarsus IV of male, dorsal view; B—Tarsus IV of male, ventral view; C—Female, dorsal view; D—Posterior opisthosoma, dorsal view; E—Trochanter I, dorsal view; F—Tibia and tarsus III, dorsal view.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.