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4,871 results for “Symptom”
Frontal Atrophy and CSF Tau Levels With Neuropsychiatric Symptoms in Patients With Cognitive Impairment
<p>This database includes the raw data linked with the paper “ Frontal Atrophy and CSF Tau Levels With Neuropsychiatric Symptoms in Patients With Cognitive Impairment: A Memory Clinic Experience. ” published on “ Frontiers in Aging Neuroscience 5, March, 2021”.</p> <p>Behavioral and psychological symptoms of dementia (BPSD) are a distressful condition. We aimed to investigate the BPSD distribution in subjects with cognitive impairment, and the potential correlations between BPSD and neurodegeneration in terms of cerebrospinal fluid (CSF) tau and brain atrophy.</p> <p>One-hundred patients with mild cognitive impairment (MCI) or dementia (Alzheimer’s disease; Lewy-body disease, LBD; frontotemporal dementia; vascular dementia) underwent a complete diagnostic workup, including 3T-MRI and/or CT and CSF.</p> <p>Cortical atrophy was assessed with MTA, PA and GCA-F scales. BPSD were rated using Neuropsychiatric Inventory (NPI), and BPSD clusters were defined according to the European Alzheimer Disease Consortium.</p> <p>Delusions, hallucinations and psychosis cluster were differently distributed among the diagnostic groups (p<0.05, p<0.001, and p<0.05), with LBD patients showing higher scores for hallucinations (vs MCI, p<0.001, and AD, p<0.05) and psychosis cluster (vs MCI, p<0.05). In primary dementias, we found a negative trend between NPI total score and tau levels (p=0.08), while a positive relationship was observed in MCI (p=0.60). Higher GCA-F scores were associated to delusions and apathy (p<0.05, on both hemispheres) and to hallucinations (left: p<0.01, right: p<0.05). GCA-F scores were positively correlated with delusions and psychosis cluster (right: p<0.05), and agitation/aggression (left: p<0.05). Conversely, nighttime disturbances were positively correlated with both GCA-F and MTA scores (left: p<0.01; right: p<0.05).</p> <table align="left"> <tbody> <tr> <td> <p> </p> </td> </tr> </tbody> </table>
Data used for the scientific work "Effectiveness of Cognitive Behavioral Therapy in naturalistic settings for patients with and without personality disorders: a comparative study of the English IAPT and the Italian inTHERAPY programs on anxiety and depression symptoms"
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Dataset related to the article "Associations of Preoperative Self-rated Symptoms of Anxiety and Depression on Length of Hospital Stay and Long-term Quality of Life in Patients Undergoing Cardiac Surgery"
<p>This record contains raw data related to the article "Associations of Preoperative Self-rated Symptoms of Anxiety and Depression on Length of Hospital Stay and Long-term Quality of Life in Patients Undergoing Cardiac Surgery"</p> <p><strong>ABSTRACT</strong></p> <p><strong>Background: </strong>Anxiety and depression are often associated with cardiovascular diseases. Nevertheless, few study authors have investigated psychological effects on immediate and long-term cardiac surgery-related outcomes, such as surgical complications, length of hospital stay (LOS), and long-term health-related quality of life (HRQoL).</p> <p><strong>Objectives: </strong>The aims of this study were to (a) investigate the role of preoperative symptoms of anxiety and depression in predicting LOS in a sample of surgical patients and (b) evaluate the impact of preoperative symptoms of anxiety and depression on the patients' HRQoL 3 months after surgery.</p> <p><strong>Methods: </strong>One hundred fifty-one patients waiting for surgery were included. To evaluate symptoms of anxiety and depression, the Hospital Anxiety and Depression Scale was used. Multiple regression analyses were conducted to evaluate the impact of both clinical and psychological factors on LOS, whereas quantile regression was performed to assess their effect on the patients' HRQoL 3 months after surgery.</p> <p><strong>Results: </strong>The multiple regression shows that EuroSCORE, length of endotracheal intubation, and anxiety symptoms predict LOS. The multiple quantile regression analyses also show that both symptoms of anxiety and depression predict a negative HRQoL up to 3 months after surgery.</p> <p><strong>Conclusion: </strong>Preoperative symptoms of anxiety predict the patients' LOS, and both symptoms of anxiety and depression predict a scarce HRQoL 3 months after cardiac surgery. These results suggest the need for implementing presurgical in-hospital screening procedures for both symptoms of anxiety and depression. Finally, focused psychological interventions should be implemented for reducing inpatients' hospital LOS and improving their future quality of life.</p>
Psychiatric symptoms and emotional impact of the COVID-19 pandemic on Italian adolescents during the third lockdown: a cross-sectional cohort study
<p>This database includes the raw data linked with the paper “Psychiatric Symptoms and Emotional Repercussions of the COVID-19 Pandemic on Italian Adolescents: Third Lockdown Survey” .</p> <p>In this paper, we proposed a questionnaire to investigate the presence of symptoms related to anxiety, panic, depression, eating disorders, sleep disorders, tendency to social withdrawal, stress disorders, psychotic symptoms, anti-conservative thoughts, and self-harming acts aggravated by COVID-19 restrictions. Our aim was to investigate: (1) The prevalence rate and sociodemographic correlates of COVID-19 related stress disorders, depressive, anxious, panic, and psychotic symptoms, according to DSM-5 criteria, during the third lockdown in Italy. (2) Perception of personal stress level, dysfunctional eating behaviours, sleep problems, substances abuse, perceived social withdrawal, and suicidal ideation and self-harm during the third lockdown in Italy. (3) Differences between male adolescents and female adolescents.</p> <p>We administered an online anonymous questionnaire, built ad hoc using validated scales, to a cohort of 500 Italian adolescents (12-18 y.o.).</p> <p>Our study highlighted that the respondents felt more stress than during the first lockdown. Participants showed suprathreshold symptoms for post-traumatic stress disorder and isolated symptoms of acute or post-traumatic stress due to the pandemic. In addition, we found psychotic symptoms, panic, anxiety, depression, eating-related symptoms, sleep difficulties, tendency to social withdrawal after the pandemic, suicidal ideation, and self-harming behaviour. Furthermore, girls showed a more severe level of distress than boys did. The results show a high prevalence of symptoms developed as a result of the COVID-19 pandemic and which are undermining the psychological health of Italian adolescents.</p>
Detecting Symptoms of Depression on Reddit
<p>Depression is known to have heterogeneous symptom manifestations. Investigating various symptoms of depression is essential to understanding underlying mechanisms and personalizing treatments. </p> <p>We use Reddit posts from depression and mental health-related subreddits to detect symptoms of depression in a distantly supervised manner. Specifically:</p> <p>- We identified the online language markers of 13 symptoms of depression using 1,318,749 posts from 43 subreddit communities.<br> - We built 13 prediction models (based on RoBERTa embeddings) that can detect specific symptom discourse vs. posts from control subreddits contributed by the same Reddit users.<br> - We validated the prediction models on a sample who shared their Facebook posts and also took self-report depression (PHQ-9), anxiety (GAD-7), and loneliness (UCLA-3) surveys.</p> <p>The description of the data and models is part of our paper published at the 15th ACM Web Science Conference 2023 as a full paper.</p> <p><br> <strong>Brief Description of the Lexica </strong></p> <p>We employed happierfuntokenizer from the DLATK Python library to tokenize all posts. Using Latent Dirichlet Allocation (LDA) with MALLET implementation, we generated 200 topics at an alpha level of 5. We then analyzed the topic distribution of all posts in the Reddit dataset for each depression symptom. </p> <p>The current data includes: </p> <ul> <li>symptom vs. control</li> <li>symptom vs. control + all other symptoms</li> </ul> <p>To learn more about how to utilize the lexica, please refer to this link: <a href="https://github.com/sjgiorgi/dlatk-lexica">https://github.com/sjgiorgi/dlatk-lexica</a></p>
Morphological changes in the fronto-limbic circuit are associated with the occurrence of neuropsychiatric symptoms in neurocognitive disorders
<p>Introduction</p> <p>This database includes the raw data linked with the paper “ Morphological changes in the fronto-limbic circuit are associated with the occurrence of neuropsychiatric symptoms in neurocognitive disorders . ” still pending .</p> <p>Background:</p> <p>Neuropsychiatric symptoms (NPSs) are a common and distressful aspect of dementia. Knowledge of structural correlates of NPSs is limited, but the fronto-limbic circuit appears to play a crucial role. We aimed to identify associations of fronto-limbic circuit morphometry with specific NPSs in patients with various types of cognitive impairment.</p> <p>Methods:</p> <p>Of 84 participants, 27 were diagnosed with mild cognitive impairment (MCI), 41 with Alzheimer’s disease (AD) dementia and 16 with non-AD dementia. In all patients we assessed regional brain morphometry using a region of interest (ROI)-based analysis. The mean cortical thickness (CT) of 20 cortical areas and the volume (V) of 4 subcortical areas of the fronto-limbic system were extracted. NPSs were rated by means of the Neuropsychiatric Inventory (NPI). We used multiple linear regression models adjusted for age and disease duration to identify significant associations between scores of NPI sub-domains and MRI measures of brain morphometry.</p> <p>Results:</p> <p>All significant associations found were negative (inverse), except those between irritability and the rostral middle frontal gyrus, the right pars opercularis and the left pars triangularis regions in MCI patients. Apathy showed more evident morphological associations in demented patients, with the involvement of the inferior frontal gyrus and the cingulate cortex. Depression and anxiety correlated in MCI patients with the left paracentral lobule and left rostral anterior cingulate, respectively. Hallucinations were not associated with any of the ROIs. Agitation and delusions showed associations exclusively in the AD group, with the frontal regions (superior, middle and inferior frontal gyri), the entorhinal cortex and the temporal pole. By contrast, euphoria, disinhibition and eating abnormalities were found to be significantly related, predominantly in the MCI group, to the entorhinal, para-hippocampal and fusiform cortices, the temporal pole, the caudal middle frontal gyrus and the amygdala, especially on the right-side.</p>
Drawing lines and circles in Parkinson's Disease: The lateralized symptoms interfere with the movements of the unaffected hand
<p>Dataset associated with the article:</p> <p>Scarpina F, Bruno V, Rabuffetti M, Priano L, Tagini S, Gindri P, Mauro A, Garbarini F. Drawing lines and circles in Parkinson's Disease: The lateralized symptoms interfere with the movements of the unaffected hand. <em>Neuropsychologia.</em> 2020 Dec 10;151:107718. doi: 10.1016/j.neuropsychologia.2020.107718.</p> <p> </p>
DIAPASON Project - TIME WILL TELL: ASSOCIATIONS BETWEEN UNBALANCED TIME PERSPECTIVES AND SYMPTOM SEVERITY IN INDIVIDUALS WITH SCHIZOPHRENIA SPECTRUM DISORDERS
<p>Dataset of the paper entitled "<strong>TIME WILL TELL: ASSOCIATIONS BETWEEN UNBALANCED TIME PERSPECTIVES AND SYMPTOM SEVERITY IN INDIVIDUALS WITH SCHIZOPHRENIA SPECTRUM DISORDERS" </strong>of the project "DAILY TIME USE, PHYSICAL ACTIVITY, QUALITY OF CARE AND INTERPERSONAL RELATIONSHIPS IN PSYCHIATRIC RESIDENTIAL FACILITIES: AN ITALIAN MULTICENTRE STUDY" Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-<a>2018-12365514</a>) (https://www.diapason-study.eu/)</p>
DIAPASON Project - Interplay between negative symptoms, time spent doing nothing, and negative emotions in patients with schizophrenia spectrum disorders: results from a 37-site study.
<p>Datasets of the paper <em>Interplay between negative symptoms, time spent doing nothing, and negative emotions in patients with schizophrenia spectrum disorders: results from a 37-site study. NPJ Schizophrenia</em>, 2023 of the project "DAILY TIME USE, PHYSICAL ACTIVITY, QUALITY OF CARE AND INTERPERSONAL RELATIONSHIPS IN PSYCHIATRIC RESIDENTIAL FACILITIES: AN ITALIAN MULTICENTRE STUDY" Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-<a>2018-12365514</a>) (https://www.diapason-study.eu/)</p>
Internet-delivered cognitive behavioural therapy programme to reduce depressive symptoms in patients with multiple sclerosis: a multicentre, randomised, controlled, phase 3 trial in Germany and the USA
<p>Patient-level data on primary and secondary endpoints of an international multicenter randomized controlled trial of internet-delivered cognitive behavioral therapy (iCBT) to reduce depressive symptoms in multiple sclerosis (MS).</p> <p>ClinicalTrials.gov Identifier: NCT02740361</p>
How To Treat Endometriosis Patients With Ongoing Symptoms (Charite Style)
<p>How To Treat Endometriosis Patients With Ongoing Symptoms (Charite Style)</p>
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