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517
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Dataset results
517 results for “Checkpoint inhibitors”
Tumor-intrinsic ETV5 Expression Promotes MDSCs-mediated Immune Evasion and Immune Checkpoint Inhibitor Resistance
GEO Series GSE286508. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and metabolic effect of immune checkpoint inhibitors on cellular components in renal cell tumor microenvironment and in Sunitinib resistant renal cell carcinoma [III]
GEO Series GSE226968. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis
GEO Series GSE205501. Homo sapiens. 86 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of the IL-17A axis Protects against Immune-related Adverse Events while Supporting Checkpoint Inhibitor Anti-tumor Efficacy [RNA-seq (human)]
GEO Series GSE192580. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Engineered Nanobodies Targeting Endogenous Digoxin-like Substances Function as Novel Immune Checkpoints Inhibitors and Enhance Immunotherapy against Cancer Metastasis
GEO Series GSE308031. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
First-in-class microbial ecosystem therapeutics 4 (MET4) in combination with immune checkpoint inhibitors in patients with advanced solid tumours (MET4-IO Trial)
GEO Series GSE199245. human feces metagenome. 170 samples. Type: Other.
Analytical performance of OncoPrism-HNSCC, an RNA-based assay to inform immune checkpoint inhibitor treatment decisions for recurrent/metastatic head and neck squamous cell carcinoma
GEO Series GSE270047. Homo sapiens. 434 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and metabolic effect of immune checkpoint inhibitors on cellular components in renal cell tumor microenvironment and in Sunitinib resistant renal cell carcinoma
GEO Series GSE226969. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles of melanoma tumor samples from patients treated with checkpoint inhibitors (human)
GEO Series GSE122220. Homo sapiens. 10 samples. Type: Expression profiling by array.
Epigenetic repression of STING by MYC promotes immune evasion and resistance to immune checkpoint inhibitors in triple negative breast cancer [RNA-seq]
GEO Series GSE196323. Homo sapiens; Mus musculus. 55 samples. Type: Expression profiling by high throughput sequencing.
Molecular mechanisms of PD-1 immune checkpoint inhibitors in mouse mammary tumours
GEO Series GSE268752. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptome profiles of tumor tissues from lung cancer patients receiving immune checkpoint inhibitors.
GEO Series GSE205335. Homo sapiens. 33 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and metabolic effect of immune checkpoint inhibitors on cellular components in renal cell tumor microenvironment and in Sunitinib resistant renal cell carcinoma [1]
GEO Series GSE226965. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Engineered Nanobodies Targeting Endogenous Digoxin-like Substances Function as Novel Immune Checkpoints Inhibitors and Enhance Immunotherapy against Cancer Metastasis
GEO Series GSE308027. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury [bulk RNA-seq]
GEO Series GSE287540. Homo sapiens. 128 samples. Type: Expression profiling by high throughput sequencing.
Tumor regression of recurrent chemo-resistant placental site trophoblastic tumor after anti-PD-1 immune checkpoint inhibitor therapy
GEO Series GSE128222. Homo sapiens. 2 samples. Type: Expression profiling by array.
Targeting NTRK1 Enhances Immune Checkpoint Inhibitor Efficacy in NTRK1 Wild-type Non-Small Cell Lung Cancer
GEO Series GSE274960. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Clonal CD8 T cells orchestrate arrhythmogenic inflammation in immune checkpoint inhibitor-associated myocarditis
GEO Series GSE299032. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing; Other.
IFN-γ signature as a peripheral blood biomarker for immune checkpoint inhibitors outcomes
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Dataset related to article "Impact of Antibiotic Therapy and Metabolic Parameters in Non-Small Cell Lung Cancer Patients Receiving Checkpoint Inhibitors"
<p>This record contains raw data related to article “Impact of Antibiotic Therapy and Metabolic Parameters in Non-Small Cell Lung Cancer Patients Receiving Checkpoint Inhibitors"</p> <p><strong>Introduction: </strong> In the current study, we aimed to assess the impact of antibiotics (ATB) and metabolic parameters on clinical outcome of non-small cell lung carcinoma (NSCLC) patients treated with immune checkpoint inhibitors (ICI).</p> <p><strong>Methods: </strong> Data from fifty NSCLC patients referred for ICI between December 2015 and May 2019 were analyzed. All patients underwent 18F-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG PET/CT) and contrast-enhanced CT at baseline and for response assessment after 6-8 weeks. Patients who received ATB within 1 month before or after the first dose of ICI were compared with those who did not. Response assessment according to iRECIST and EORTC was evaluated, as well as progression-free survival (PFS) and overall survival (OS). For semi-quantitative parameters, we computed metabolic tumor volume (MTV), total lesion glycolysis (TLG) and their variations (∆).</p> <p><strong>Results: </strong> Twenty NSCLC cases of 50 (40%) had received ATB. Patients receiving ATB had a higher number of metastases (<em>p</em> = 0.046), and were associated with an elevated tumor burden, expressed by TLG (687 vs. 235.3, <em>p</em> = 0.007) and MTV (125.6 vs. 40.6, <em>p</em> = 0.002), compared to no-ATB patients. According to iRECIST, progressive disease rate was significantly higher for ATB group (64.7% vs. 27.6%, <em>p</em> = 0.029). Likewise, PFS was shorter for ATB compared to no-ATB (median 4.1 vs. 12.4 months, <em>p</em> = 0.004), while no difference for OS was detected. On multivariate analysis, the effect of ATB remained significant for poor PFS along with performance status (ECOG ≥ 1), and ∆SUVmax.</p> <p><strong>Conclusions: </strong> ATB therapy seems to be associated with a worse treatment response, PFS, and higher metabolic tumor burden in NSCLC patients treated with ICI.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.