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2,852 results for “Hepatocellular carcinoma”
Protein expression of hepatocellular carcinoma in a fibrotic liver in mice
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Data from: In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma
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Data from: Dynamically prognosticating patients with hepatocellular carcinoma through survival paths mapping based on time-series data
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New incidence or recurrence hepatocellular carcinoma (HCC) in genotype 4 hepatitis C virus treated with sofosbuvir/daclatasvir with or without ribavirin
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Esterase- responsive SLC7A11 shRNA Delivery System Induced Ferroptosis and Suppressed Hepatocellular Carcinoma Progression
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Characterization of the tumor-immune microenvironment in hepatocellular carcinoma patients undergoing immune checkpoint inhibitor therapy by highly multiplexed imaging mass cytometry
<p>Imaging mass cytometry data of 42 HCC patients that received immune checkpoint inhibtor therapy after tumor biopsy or resection. </p> <ul> <li>ICI_img_normalized: Preprocessed and normalized multistack .tiff images. Each stack represents one channel. Channel annotations are stored in the ICICohort_panel.csv file.</li> <li>ICI_cellmasks: Masks identifying individual cells on the images.</li> <li>ICI_stromamasks: Masks identifying stromal and parenchymal regions on the image.</li> <li>ICICohort_panel.csv: table containing channel information (metal tag and marker).</li> </ul> <p>Patient etadata may be found in the supplementary table 3 of DOI <a href="https://doi.org/10.1136/gutjnl-2024-332837" target="_blank" rel="noopener noreferrer">10.1136/gutjnl-2024-332837</a>.</p>
Quantitative assessment of the lipiodol staining after transarterial chemoembolization for hepatocellular carcinoma: can it predict tumor recurrence?
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Antioxidant and anti-inflammatory function of walnut green husk aqueous extract (WNGH-AE) on human hepatocellular carcinoma cells (HepG2) treated with t-BHP
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An AAV Gene Therapy Computes Over Multiple Cellular Inputs to Enable Precise Targeting of Multifocal Hepatocellular Carcinoma in Mice
<p>Data underlying the figures in the publication “An AAV gene therapy computes over multiple cellular inputs to enable precise targeting of multifocal hepatocellular carcinoma in mice”, published in <em>Sci. Transl. Med.</em>, <strong>2021</strong>, 13, eabh4456.</p> <p><a href="https://doi.org/10.1126/scitranslmed.abh4456">DOI: 10.1126/scitranslmed.abh4456</a></p> <p>Table of contents:</p> <p><strong>1. Supplementary Material</strong>: File containing Materials and Methods, <em>Fig S1-S8</em>, <em>Table S1</em>, Legend for <em>Table S2</em>, Legends for data files <em>S1</em> and <em>S2</em> and References (63-65).</p> <p><strong>2. Dataset 1.xlsx</strong>: Raw data points used to create the main figures of the paper (<em>1C, 1D, 2B, 2C, 2E, 2G, 2H, 2I, 2K, 3A, 3B, 3C, 4B, 4C, 51, 6A, 7A, 7B, 8B, 8C </em>and<em> 8F</em>) arranged in worksheets panel by panel. The processing steps are described in the methods section of the manuscript and in the supplementary material.</p> <p><strong>3. Dataset 2.xlsx:</strong> Raw data points used to create the supplementary figures of the paper (<em>S1A, S1B, S1C, S3D, S3E, S4A, S4B, S5B, S8A, S8B </em>and <em>S8C</em>) arranged in worksheets panel by panel. The processing steps are described in the methods section of the manuscript and in the supplementary material.</p> <p><strong>4. Table S2</strong>: Experimental data for <em>Table S2.</em></p>
Association of lymph node metastasis of hepatocellular carcinoma with the gut microbiota, bile acid metabolism, and MIP-1α
<p>Supplementary figures for the manuscript.</p>
Data from: Identification and validation of a novel immune-related signature associated with macrophages and CD8 T cell infiltration predicting overall survival for hepatocellular carcinoma
<p><b>Background:</b> Although the effects of macrophages and CD8 T cell infiltration on clinical outcomes have been widely reported, the association between immunity-associated gene with them for hepatocellular carcinoma (HCC) remains unclear.</p> <p><b>Materials and methods: </b>The ssGSEA served for quantifying the macrophages as well as CD8 T cell infiltration in the HCC samples obtained from TCGA database. Kaplan-Meier(KM) survival assay was used to determine the associations between macrophages and CD8 T cell infiltration with OS. LASSO Cox regressive method assisted in developing an immune gene signature as well as building a risk score. The performance was evaluated by the time-dependent ROC together with the KM survival analysis. The ICGC database were adopted for external verification. CIBERSORT was applied to the correlation analysis on the immune-related signature and the immunocyte infiltration. GSEA were employed exploring the underlying molecular mechanisms.</p> <p><b>Results:</b> Increased CD8+ T cell infiltration was associated with longer OS, whereas a greater infiltration of macrophages was related to shorter OS. There were 398 differential expression genes (DEGs) between the high- and low infiltration groups with the "edgeR" package. A prognostic signature consisted of 10 immune genes was built in TCGA and examined in ICGC. The uniform cutoff (0.927) was adopted for separating sufferers into the high-risk(HR) and low-risk(LR) groups. The ROC curves revealed that the AUC data for this signature predicting 1,2,3,4 and 5 year were all above 0.7 in both TCGA and ICGC cohort and patients in the HR<sub> </sub>group exhibited evidently weaker prognostic results compared with the LR group. The HR<sub> </sub>group presented evidently greater Tregs and Macrophage M0 relative to the LR group, whereas the LR group saw the enrichment of CD8 T cells.</p> <p><b>Conclusion:</b> The immune signature associated with macrophages as well as CD8 T cell infiltration has reliable prognostic and predictive value for HCC patients.</p>
Nomogram Built Based on Machine Learning to Predict Recurrence in Early-stage Hepatocellular Carcinoma Patients Treated with Ablation
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Doxorubicin-eluting LC Bead M1 for Patients With Hepatocellular Carcinoma
ClinicalTrials.gov study NCT02007954. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CTLA-4 /PD-L1 Blockade Following Transarterial Chemoembolization (DEB-TACE) in Patients With Intermediate Stage of HCC (Hepatocellular Carcinoma) Using Durvalumab and Tremelimumab
ClinicalTrials.gov study NCT03638141. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Safety and Efficacy Study of CC-122 in Combination With Nivolumab in Subjects With Unresectable Hepatocellular Carcinoma (HCC)
ClinicalTrials.gov study NCT02859324. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Hepatocellular Carcinoma Treated With Iodine-125 Implantation
ClinicalTrials.gov study NCT01717729. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Durvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver Transplant
ClinicalTrials.gov study NCT05027425. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Phase I / II Trial of Nintedanib in Asian Hepatocellular Carcinoma Patients
ClinicalTrials.gov study NCT00987935. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Hepatocellular Carcinoma Study Comparing Vaccinia Virus Based Immunotherapy Plus Sorafenib vs Sorafenib Alone
ClinicalTrials.gov study NCT02562755. IPD Sharing: NO. Countries: 16. Publications: 0.
Gemcitabine Plus Oxaliplatin Versus Oxaliplatin Plus Fluorouracil/Leucovorin for Hepatocellular Carcinoma
ClinicalTrials.gov study NCT02534337. IPD Sharing: Not stated. Countries: 0. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.