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12,346 results for “derivatives”
Analysis of hMSC-derived chondrocytes in response to stimulation with SARS-CoV-2 spike proteins
<p>Previous studies have detected the presence of SARS-CoV-2 viral proteins in bronchial cartilage chondrocytes. We hypothesised that the leakage of viral proteins to local joint tissue was due to virus-induced endothelial dysfunction. Studies have also shown upregulation of endothelin-1 (ET-1), the most potent vasoconstrictor, in COVID patients. We are investigating the direct effect of SARS-CoV-2 spike protein (SP) and the host response to chondrocytes.</p> <p>Human mesenchymal stem cells (hMSCs)-differentiated chondrocytes were treated with either full-length SARS-CoV-2 spike protein (SP) only or a combination of spike protein, neutralising antibody to S1 and endothelin-1 (SAE) to mimic viral insult and host response respectively. RNA sequencing was performed to compared the change in transcriptome in control, SP, and SAE. All samples were processed in the same batch. Default quality control parameters were used.</p>
Fig. 3 in External Sex Specific Signs In The Structure Of Derivatives Of Sterlet (Acipenser Ruthenus, Linnaeus, 1758) Corium
Fig. 3. Typical dorsal scutes of males (upper) and females (lower) sterlet larvae. Age - 3 months. The average length is 70.3 ± 3.6 mm.
Fig. 1 in External Sex Specific Signs In The Structure Of Derivatives Of Sterlet (Acipenser Ruthenus, Linnaeus, 1758) Corium
Fig. 1. Typical contours of dorsal scutes of males (upper) and females (lower) of adult sterlet. Age - 3 years. The second stage of gonad maturity. The average length is 61.2 ± 1.3 cm.
FIB-SEM tomography datasets of entire single-cell human monocyte derived macrophages
<p>FIB-SEM tomography was used to determine the absolute number of internalized gold nanoparticles in GM-CSF and M-CSF human monocyte-derived macrophages at the single-cell level. All experiments were performed using a Thermo Scientific Scios 2 Dual Beam microscope (Thermo Fisher Scientific, Waltham, MA, USA). A selected cell was protected with a platinum (Pt) layer of 1 µm thickness (30 kV and current of 1 nA). Then, a trench of 5 µm in depth was milled on the front face and each side of the cell of interest using the ion beam at 7 nA current. Finally, the front face of the volume of interest was polished with an ion beam current of 1 nA until the beginning of the cell was visible to optimize the focus and contrast. FIB-SEM tomography of the whole cell was performed using the FEI Slice and View software (Thermo Fisher Scientific, Waltham, MA, USA, version 4.1). The electron beam acceleration voltage was set to 5 kV, the current to 0.4 nA, the resolution to 1536 × 1024 pixels, and the dwell time to 30 µs. Images were acquired in immersion mode with the backscattered electron detector, yielding clear signals from AuNPs due to the detector's sensitivity to backscattered electrons, which correlates with the atomic number of Au (Z = 79). The ion beam operating with a current of 1 nA current at 30 kV was used to slice through the cell of interest at an interval of 18 nm and a depth of 5 µm. The datasets available on the repository have been aligned and cropped.</p>
FIGURE 12. Ultrastenos huberi, shared derived character states. A-D in A reinterpretation and taxonomic revision of Ultrastenos willisi Stein, Hand and Archer, 2016, a short-snouted mekosuchine crocodylian from the Oligocene of northern Australia
FIGURE 12. Ultrastenos huberi, shared derived character states. A-D: QM F42665, holotype of Ultrastenos willisi. A, B, Right temporal fragment in dorsal view (A) and lateral view (B). C, D, ventral portion of braincase (with attached, displaced fragment of right pterygoid) in right lateral view (C) and occipital view (D). E-H: QM F31075, 'WH Cranial Form 1'. E, F, right temporal region in dorsal view (E) and lateral view (F). G, H, ventral portion of braincase in right lateral view (G) and occipital view (H). Numbered character states: 1, distance from the ventrolateral tip of the paroccipital process to the dorsal margin of the quadrate condyle is less than the transverse width of the quadrate condyle (shown by rectangular bracket); 2, short posterolateral process of the squamosal descends at an angle steeper than 65⁰; 3, parabasisphenoid-pterygoid suture recessed within a sulcus; 4, enlarged sagittal, ventral keel of the basioccipital prominent in lateral view; 5, otoccipital-basioccipital suture (marked with red line) fails to cross the synovial surface of the occipital condyle. Scale bars equal 20 mm.
FIGURE 8 in Body length estimation of Neogene macrophagous lamniform sharks (Carcharodon and Otodus) derived from associated fossil dentitions
FIGURE 8. Correlation between summed crown width and total body length in 17 modern Carcharodon carcharias individuals, comparing the upper versus lower dentition. (A) linear function (upper dentition: R2 = 0.93); (B) power function (upper dentition: R2 = 0.97); (C) linear function (lower dentition: R2 = 0.90); and (D) power function (lower dentition: R2 = 0.95).
FIGURE 3 in Body length estimation of Neogene macrophagous lamniform sharks (Carcharodon and Otodus) derived from associated fossil dentitions
FIGURE 3. Associated dentitions of Otodus megalodon in lingual view. (A) UF-VP-311000; (B) GHC 1; (C) CH-31- 46P; and (D) UF-VP-460000. Scale bars equal 5 cm.
FIGURE 4 in Body length estimation of Neogene macrophagous lamniform sharks (Carcharodon and Otodus) derived from associated fossil dentitions
FIGURE 4. Associated dentitions of Otodus chubutensis in lingual view. (A) USNM 411881 (adapted from Perez et al., 2019; fig. 5); (B) USNM 299832; (C) GHC 3; and (D) UF-VP-312864. Scale bars equal 5 cm.
FIGURE 1 in Body length estimation of Neogene macrophagous lamniform sharks (Carcharodon and Otodus) derived from associated fossil dentitions
FIGURE 1. Premise of summed crown width method. (A) Carcharodon carcharias dentition in lingual view, with applicable terminology. The right half is an illustration of the typical dental formula for C. carcharias. The left half is from a 5.18 m female with one less posterior tooth in the lower tooth series (originally figured in Hubbell, 1996; figure 5). Scale bar equals 5 cm. (B) The most complete known associated dentition of Otodus megalodon (CH-31-46P) in lingual view. Scale bar equals 5 cm. (C) Body length of fossil taxa is calculated under the assumption that the ratio of summed crown width to total body length (TL) is proportional in ecologically and taxonomically related species. Silhouette proportions for O. megalodon are based on Cooper et al. (2020). A/a = anterior, I = intermediate, and L/l = lateral. Uppercase letters denote upper teeth and lowercase letters denote lower teeth.
FIGURE 4. Covariation patterns derived from the standard model studied using a in Geometric morphometrics in ammonoids based on virtual modelling
FIGURE 4. Covariation patterns derived from the standard model studied using a theoretical subrectangular whorl cross-section with the following parameters: aperture height (ah) = ¾, whorl width (ww) = 1, whorl height (wh) = 1. A) Semilandmark configuration showing the expected transformations from an arbitrary variation (± 0.1 units) in the whorl width, causing an expansion (red) or compression (blue). B) Graph bars showing the change in locations for each semilandmark in the horizontal x-axis from A. C) Semilandmark configuration showing the expected transformations from an arbitrary variation (± 0.1 units) in the aperture height and whorl height, causing an elongation (orange) or contraction (purple), and an increase (yellow) or decrease (green) in involution. D) Graph bars showing the change in locations for each semilandmark in the vertical y-axis from C. Note that a covariation pattern will be a combination of the x and y vectorial components (e.g., an expansion, elongation, and a decrease in involution).
A new global marine gravity model NSOAS24 derived from multi-satellite sea surface slopes
<p><span><span><span>NSOAS24 is the global marine gravity anomaly model on a grid of 1′×1′, which is derived based on sea surface slopes from multi-satellite altimetry missions. </span></span></span><span><span><span>Its spatial coverage is 80°S-80°N.</span></span></span></p>
Occurrence data on TBBPA and its derivatives provided to EFSA
<p>The file contains the raw occurrence dataset on TBBPA and its derivatives in food as extracted from EFSA DWH on 1 of December 2022 and presented in the EFSA opinion on the update of the risk assessment of TBBPA and its derivatives in food available. This dataset is compliant with EFSA SSD2 data model and contains two additional columns documenting issues identified in the cleaning process (column: issue) and the outcome of the action taken (column: outcome) to address the issue (e.g. delete record or update values in specific fields). The link to the catalogues of controlled terminologies for the updated textual description of fields values can be found under "Related works, supplemented by”.</p>
X-ray diffraction data set for PDB 9G3L: LecB from PA01 in complex with beta-fucosylamide-indole derivative
<p>X-ray diffraction images collected on proxima 1 Soleil the 7th of march 2024 at SOLEIL synchrotron, Saint Aubin, France for PDB ID 9G3L using a DECTRIS EIGER X 16M detector. X-ray dataset and xdsme processing for the structure of LecB from <em>Pseudomonas aeruginosa</em> PA01 strain in complex with synthetic beta-fucosylamide-indole derivative. Images 1-900 were removed during processing and resolution was cut to 1.74 angstrom.</p>
Fig. 2. Post mortem examination. Post mortem examination for typical calves showing signs associated with Theileria infection. A in Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva
Fig. 2. Post mortem examination. Post mortem examination for typical calves showing signs associated with Theileria infection. A: Copious frothy exudate from nasal cavities of BJ031 and BJ037. B: Pleural exudate in thoracic cavities of BJ033 and BJ041. C: Frothing in trachea of BJ026 and BJ033.
Fig. 1 in Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva
Fig. 1. Kaplan–Meier survival analysis. Kaplan–Meier survival analysis of vaccinated (dashed line) and control (solid line) calves following field exposure. The black circle and red cross at day 30 represent the animals remaining alive at the end of the experiment (censored). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
Fig. 2 in Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
Fig. 2 Effect of probenecid (PBN) on the activity of PM, MTX, and TMX. Y axis represents the percentage decrease in IC50 in the presence of PBN. One hundred percent (100%) represents the IC50 in the absence of PBN. In the absence of PBN, the MTX, TMX, and PM IC50 values were 30, 7, and 1,200 nM, respectively
Electrophysiological recordings from human-derived cardiomyocytes in the form of MEA (microelectrode array) recordings
<p><span>The electrophysiological data were acquired using standard software for MEA acquisition, such as the programs provided with the used MEA acquisition system coupled with the SiMulTox prototype.</span></p>
Fig. 4. Tree derived from a in Geometric morphometric on a new species of Trichodinidae. A tool to discriminate trichodinid species combined with traditional morphology and molecular analysis
Fig. 4. Tree derived from a Maximum Likelihood (ML) analysis. The bootstrap consensus tree bases on ML inferred from 500 replicates. Bootstrap values for ML are given above nodes.
Lab_28_SOP - Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards
<h1>Lab_28_SOP - Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards - mzML files</h1><p>This dataset is part of the <a href="https://doi.org/10.5281/zenodo.12632989" target="_blank">ILS Ceramide Ring Trial</a>. The suffix 'SOP' indicates that the results were obtained using the recommended and standard operating procedure protocol to prepare and measure all samples, while the suffix 'OTHER' indicates that the corresponding lab prepared and measured the samples according to their own internal protocol. Please check the corresponding mapping file 'ILS-Ceramide-Ring-Trial-Datasets.csv' in the ILS Ceramide Ring Trial record for a mapping of the originally submitted lab reports and the final lab number as reported in the manuscript.</p><p>All reports together with the code for analysis and visualization, reproducing the figures in the manuscript, are available under the following doi: <a href="https://zenodo.org/doi/10.5281/zenodo.10081970" target="_blank">https://zenodo.org/doi/10.5281/zenodo.10081970</a>. This links to releases of the following GitHub repository: <a href="https://github.com/lifs-tools/ils-ceramide-ring-trial" target="_blank">https://github.com/lifs-tools/ils-ceramide-ring-trial</a>. The archived version of the lab reports, workflow source code and manuscript visualizations are also available <a href="https://zenodo.org/doi/10.5281/zenodo.10081970" target="_blank">here</a>.</p><p>Please note that most datasets have been acquired in MRM mode, such that the msconvert conversion to mzML has stored the MRM data in the chromatogram part of the mzML files.</p> <p>The msconvert Docker container (Proteowizard release: 3.0.24172 (63d00b1), build date Jun 202 2024 20:01:14) was used with the native vendor libraries / peak picking for conversion, using default arguments. m/z values were encoded with 64 bit (default), while intensity values were encoded with 32 bit (default). All binary data was zlib-compressed.</p>
Lab_27_SOP - Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards
<h1>Lab_27_SOP - Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards - mzML files</h1><p>This dataset is part of the <a href="https://doi.org/10.5281/zenodo.12632989" target="_blank">ILS Ceramide Ring Trial</a>. The suffix 'SOP' indicates that the results were obtained using the recommended and standard operating procedure protocol to prepare and measure all samples, while the suffix 'OTHER' indicates that the corresponding lab prepared and measured the samples according to their own internal protocol. Please check the corresponding mapping file 'ILS-Ceramide-Ring-Trial-Datasets.csv' in the ILS Ceramide Ring Trial record for a mapping of the originally submitted lab reports and the final lab number as reported in the manuscript.</p><p>All reports together with the code for analysis and visualization, reproducing the figures in the manuscript, are available under the following doi: <a href="https://zenodo.org/doi/10.5281/zenodo.10081970" target="_blank">https://zenodo.org/doi/10.5281/zenodo.10081970</a>. This links to releases of the following GitHub repository: <a href="https://github.com/lifs-tools/ils-ceramide-ring-trial" target="_blank">https://github.com/lifs-tools/ils-ceramide-ring-trial</a>. The archived version of the lab reports, workflow source code and manuscript visualizations are also available <a href="https://zenodo.org/doi/10.5281/zenodo.10081970" target="_blank">here</a>.</p><p>Please note that most datasets have been acquired in MRM mode, such that the msconvert conversion to mzML has stored the MRM data in the chromatogram part of the mzML files.</p> <p>The msconvert Docker container (Proteowizard release: 3.0.24172 (63d00b1), build date Jun 202 2024 20:01:14) was used with the native vendor libraries / peak picking for conversion, using default arguments. m/z values were encoded with 64 bit (default), while intensity values were encoded with 32 bit (default). All binary data was zlib-compressed.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.