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13,064 results for “predictions”

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zenodo40/100

Mining folded proteomes in the era of accurate structure prediction

<p>Supplementary data to accompany the manuscript &ldquo;Mining folded proteomes in the era of accurate structure prediction&rdquo;. Contains three zip files with fold matching search results to support results in the main text.</p>

opencc-by-4.0Jan 2022View details →
dryad40/100

Incorporating effects of age on energy dynamics predicts non-linear maternal allocation patterns in iteroparous animals

<p>Iteroparous parents face a trade-off between allocating current resources to reproduction versus maximizing survival to produce further offspring. Optimal allocation varies across age, and follows a hump-shaped pattern across diverse taxa, including mammals, birds and invertebrates. This non-linear allocation pattern lacks a general theoretical explanation, potentially because most studies focus on offspring number rather than quality and do not incorporate uncertainty or age-dependence in energy intake or costs. Here, we develop a life history model of maternal allocation in iteroparous animals. We identify the optimal allocation strategy in response to stochasticity when energetic costs, feeding success, energy intake, and environmentally-driven mortality risk are age-dependent. As a case study, we use tsetse, a viviparous insect that produces one offspring per reproductive attempt and relies on an uncertain food supply of vertebrate blood. Diverse scenarios generate a hump-shaped allocation: when energetic costs and energy intake increase with age; and also when energy intake decreases, and energetic costs increase or decrease. Feeding success and mortality risk have little influence on age-dependence in allocation. We conclude that ubiquitous evidence for age-dependence in these influential traits can explain the prevalence of non-linear maternal allocation across diverse taxonomic groups.</p>

opencc-zeroJan 2022View details →
dryad40/100

Simple attributes predict the value of plants as hosts to fungal and arthropod communities

Fungal and arthropod consumers constitute the vast majority of global terrestrial biodiversity. Yet, the link from richness and composition of producer (plant) communities to the richness of consumer communities is poorly understood. Fungal and arthropod species richness could be a simple function of producer species richness at a site. Alternatively, it could be a complex function of chemical and structural properties of the producer species making up communities. We used databases on plant-fungus and plant-arthropod trophic links to derive the richness of consumer biota per associated plant species (coined link score). We assessed how well link scores could be predicted by simple attributes of plant species. Next, we used a multi-taxon inventory of 130 sites, representing all major habitat types in a country (Denmark), to investigate whether link scores summed over plant species in communities (coined link sum) could outperform simple plant species richness as predictor of fungal and arthropod richness at the sites. We found plant species' link scores for both fungi and arthropods to be positively related to plant size, regional occupancy, nativeness and ectomycorrhizal status. Link-based indices generally improved the prediction of richness of fungal and arthropod communities. For fungal communities, both observed link sum (from databases) and predicted link sum (from plant attributes) had high predictive power, while plant richness alone had none. For arthropod communities, predictive performance varied between functional groups. For both fungi and arthropods, richness predictions were further improved by considering abiotic habitat conditions. Our results underline the importance of plants as niche space for the megadiverse groups of arthropods and fungi. The plant-attribute approach holds promise for predicting local and regional consumer richness in areas of the world lacking detailed plant-consumer databases.

opencc-zeroFeb 2022View details →
zenodo40/100

Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits

<p>Full summary statistics for the publication &quot;Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits&quot;.&nbsp;</p> <p>The files, bmi.UKBBsummary.txt and height.UKBBsummary.txt, contain tissue specific associations with body mass index (BMI) and height respectively. The suffix UKBB450k indicates results from all ~450,000 European ancestry individuals in UK Biobank. The suffix&nbsp;UKBB50k corresponds to results from a subset of 50,000 Europeans in the UK Biobank. The suffix PAGE corresponds to results from ~50,000 individuals in the&nbsp;Population Architecture using Genomics and Epidemiology (PAGE) study.&nbsp;</p> <p>The file&nbsp;PAGE_PrediXcan_associations.txt includes trait~tissue specific GReX associations for 25 traits. The first field specifies the tissue.trait.gene of the association results.</p>

opencc-by-4.0Jan 2022View details →
zenodo40/100

Fig. 2. – Species prediction for a grid cell. A in Geographical patterns of woody plants' functional traits in Burkina Faso

Fig. 2. – Species prediction for a grid cell. A. Average of maximal plant size; B. Percentage of spinescent species; C. Percentage of species containing latex; D. Percentage of species with compound leaves.

opencc-by-4.0Nov 2013View details →
zenodo40/100

Predicting global patterns in the biomolecular composition of marine phytoplankton and their stoichiometry

<p>Data to predict the biomolecular composition of marine phytoplankton and their stoichiometry using key environmental properties (temp, nutrients, light, etc.)</p>

opencc-by-4.0Feb 2022View details →
zenodo40/100

Dataset: A multi-label classifier for predicting the most appropriate instrumental method for the analysis of contaminants of emerging concern

<p>NORMAN Suspect List Exchange was used for the generation of the dataset. Datasets with clear label (LC or GC) were used. More specifically, we used S3 NORMANCT15, which contains a list of compounds that were detected in surface water from the Danube River in a pan-European collaborative trial employing both GC-HRMS and LC-HRMS. Moreover, the GC and LC target list were used by the following two institutes: National and Kapodistrian University of Athens (NKUA) and Helmholtz Centre for Environmental Research (UFZ). S21 UATHTARGETS is the LC target list of NKUA, S65 UATHTARGETSGC is the GC target list of NKUA and S53 UFZWANATARG contains the LC and GC target list of UFZ. Finally, two GC target lists (S51 WRIGCHRMS and S70 EISUSGCEIMS) were used. These lists contain GC substance lists and were provided by two Slovak institutes, the Water Research Institute (WRI) and Environmental Institute. The aforementioned compound lists were merged together to form a labelled dataset. The SMILES were used to calculate 1446 molecular descriptors. 1446 descriptors were produced by PaDEL-descriptor, logP was produced by JRgui and boiling point by USEPA ECOSAR.</p> <p>The dataset is used in the publication:</p> <p>&quot;A multi-label classifier for predicting the most appropriate instrumental method for the analysis of contaminants of emerging concern&quot; authored by</p> <p>Nikiforos Alygizakis, Vasileios Konstantakos, Grigoris Bouziotopoulos , Evangelos Kormentzas, Jaroslav Slobodnik and Nikolaos S. Thomaidis</p> <p>Github repository:&nbsp;https://github.com/nalygizakis/LCvsGC</p>

opencc-by-4.0Feb 2022View details →
zenodo40/100

Data: Spatio-temporal prediction of soil moisture using soil maps, topographic indices and SMAP retrievals

<p><strong>Data used in:</strong></p> <p>Sch&ouml;nauer, M., Prinz, R., V&auml;&auml;t&auml;inen, K., Astrup, R., Pszenny, D., Lindeman, H., et al. (2022). Spatiotemporal prediction of soil moisture using soil maps, topographic indices and SMAP retrievals. <em>International Journal of Applied Earth Observation and Geoinformation</em>, 102730. doi: 10.1016/j.jag.2022.102730</p>

opencc-by-4.0Feb 2021View details →
zenodo40/100

Galaxy Training Data for "Designing plasmids encoding predicted pathways by using the BASIC assembly method"

<p>This dataset provides the data needed for the Galaxy BASIC assembly workflow training tutorial (<a href="https://galaxy-synbiocad.org">https://galaxy-synbiocad.org</a>). This workflow provides a pathway to design plasmids encoding predicted metabolic pathways using the BASIC assembly method (<a href="https://doi.org/10.1021/sb500356d">https://doi.org/10.1021/sb500356d</a>). It generates scripts allowing the automatic construction of these plasmids using an Opentrons liquid handling robot. After downloading these scripts on a computer connected to an Opentrons (<a href="https://opentrons.com">https://opentrons.com</a>), the user can perform the automatic construction of the plasmids on the bench.</p> <p>The content of the dataset is as follows:</p> <ul> <li> <p>an SBML file modeling a heterologous pathway producing lycopene such as those produced by the Pathway Analysis Workflow (<a href="https://galaxy-synbiocad.org">https://galaxy-synbiocad.org</a>).</p> </li> <li> <p>a CSV file listing the parts to be used (linkers, backbone and promoters) in the constructions.</p> </li> <li> <p>two YAML files providing two examples of settings, i.e. providing the identifiers of the laboratory equipment and the parameters of the DNA robot.</p> </li> </ul>

opencc-by-4.0Feb 2022View details →
dryad40/100

Data from: Seeing the Forest for the trees: Assessing genetic offset predictions from Gradient Forest

<p><span>Gradient Forest (GF) is a machine learning algorithm designed to analyze spatial patterns of biodiversity as a function of environmental gradients. An offset measure between the GF predicted environmental association of adapted alleles and a new environment (GF Offset), is increasingly being used to predict the loss of environmentally adapted alleles under rapid environmental change, but remains mostly untested for this purpose. Here we explore the robustness of GF Offset to assumption violations, and its relationship to measures of fitness, using SLiM simulations with explicit genome architecture and a spatial metapopulation. We evaluate measures of GF Offset in: (1) a neutral model with no environmental adaptation; (2) a monogenic "population genetic" model with a single environmentally adapted locus; and (3) a polygenic "quantitative genetic" model with two adaptive traits, each adapting to a different environment. We found GF Offset to be broadly correlated with fitness offsets under both single locus and polygenic architectures. However, neutral demography, genomic architecture, and the nature of the adaptive environment can all confound relationships between GF Offset and fitness. GF Offset is a promising tool, but it is important to understand its limitations and underlying assumptions, especially when used in the context of predicting maladaptation.</span></p>

opencc-zeroFeb 2022View details →
zenodo40/100

Raw data of: "Controlling Hand Movements Relying on Tactile Illusions: A Model Predictive Control Framework"

<p>in Fig4_a.txt: raw the data for the plot of Fig4_a&nbsp; (x and y of the first simulated trajectory from trajectory 1 to 50)</p> <p>in Fig4_b.txt:&nbsp;raw the data for the plot of Fig4_b&nbsp;</p> <p>in Fig4_c.txt&nbsp;raw the data for the plot of Fig4_b. Each column corresponds to the optimal angle of the plate for each of the 50 trajectories simulated in Fig4_a</p>

opencc-by-4.0Feb 2022View details →
zenodo40/100

Cellpose models for Label Prediction from Brightfield and Digital Phase Contrast images

<p><strong>Name:&nbsp;</strong>Cellpose models for Brightfield and Digital Phase Contrast images</p> <p><strong>Data type:&nbsp;</strong>Cellpose models trained via transfer learning from the &lsquo;nuclei&rsquo; and &lsquo;cyto2&rsquo; pretrained model with additional <strong>Training Dataset . Includes</strong>&nbsp;corresponding&nbsp;csv files with &#39;Quality Control&#39; metrics(&sect;) (model.zip).</p> <p><strong>Training Dataset:&nbsp;</strong>Light microscopy (Digital Phase Contrast or Brightfield) and automatic annotations (nuclei or cyto) (<a href="https://doi.org/10.5281/zenodo.6140064">https://doi.org/10.5281/zenodo.6140064</a>)</p> <p><strong>Training Procedure: </strong>The cellpose models were trained using cellpose version 1.0.0 with GPU support (NVIDIA GeForce K40) using default settings as per the&nbsp;<a href="https://cellpose.readthedocs.io/en/latest/train.html">Cellpose documentation</a>&nbsp;. Training was done using a <a href="https://datascience.ch/renku/">Renku </a>environment (<a href="https://github.com/BIOP/renku-templates/tree/main/VNC-Napari-Fiji-Omero-CUDA11.4-cellpose-omnipose">renku template</a>).</p> <p>&nbsp;</p> <p><strong>Command Line Execution for the different trained models</strong></p> <p><strong>nuclei_from_bf: </strong></p> <pre><code class="language-python">cellpose --train --dir 'data/train/' --test_dir 'data/test/' --pretrained_model nuclei  --img_filter _bf --mask_filter _nuclei --chan 0 --chan2 0 --use_gpu --verbose</code></pre> <p><strong>cyto_from_bf</strong>:</p> <pre><code class="language-python">cellpose --train --dir 'data/train/' --test_dir 'data/test/' --pretrained_model cyto2 --img_filter _bf --mask_filter _cyto --chan 0 --chan2 0 --use_gpu --verbose</code></pre> <p>&nbsp;</p> <p><strong>nuclei_from_dpc:</strong></p> <pre><code class="language-python">cellpose --train --dir 'data/train/' --test_dir 'data/test/' --pretrained_model nuclei  --img_filter _dpc --mask_filter _nuclei --chan 0 --chan2 0 --use_gpu --verbose</code></pre> <p><strong>cyto_from_dpc</strong>:</p> <pre><code>cellpose --train --dir 'data/train/' --test_dir 'data/test/' --pretrained_model cyto2 --img_filter _dpc --mask_filter _cyto --chan 0 --chan2 0 --use_gpu --verbose</code></pre> <p>&nbsp;</p> <p><strong>nuclei_from_sqrdpc</strong>:</p> <pre><code class="language-python">cellpose --train --dir 'data/train/' --test_dir 'data/test/' --pretrained_model nuclei --img_filter _sqrdpc --mask_filter _nuclei --chan 0 --chan2 0 --use_gpu --verbose</code></pre> <p><strong>cyto_from_sqrdpc</strong>:</p> <pre><code class="language-python">cellpose --train --dir 'data/train/' --test_dir 'data/test/' --pretrained_model cyto2 --img_filter _sqrdpc --mask_filter _cyto --chan 0 --chan2 0 --use_gpu --verbose</code></pre> <p>&nbsp;</p> <p><em><strong>NOTE&nbsp;</strong></em>(&sect;):&nbsp;We provide&nbsp;a notebook for Quality Control, which is an adaptation of the&nbsp;<a href="https://colab.research.google.com/github/HenriquesLab/ZeroCostDL4Mic/blob/master/Colab_notebooks/Beta%20notebooks/Cellpose_2D_ZeroCostDL4Mic.ipynb">&quot;Cellpose (2D and 3D)&quot; notebook from ZeroCostDL4Mic</a>&nbsp;.</p> <p><em><strong>NOTE</strong></em>: This dataset used a training dataset from the Zenodo entry(<a href="https://doi.org/10.5281/zenodo.6140064">https://doi.org/10.5281/zenodo.6140064</a>) generated from the &ldquo;HeLa &ldquo;Kyoto&rdquo; cells&nbsp;under the scope&rdquo; &nbsp;dataset Zenodo entry(<a href="https://doi.org/10.5281/zenodo.6139958">https://doi.org/10.5281/zenodo.6139958</a>) in order to automatically generate the label images.</p> <p><strong><em>NOTE</em></strong>:<strong> </strong>Make sure that you delete the &ldquo;_flow&rdquo; images that are auto-computed when running the training. If you do not, then the flows from previous runs will be used for the new training, which might yield confusing results.</p> <p>&nbsp;</p>

opencc-by-4.0Feb 2022View details →
dryad40/100

Shifting balances in the weighting of sensory modalities are predicted by divergence in brain morphology in incipient species of Heliconius butterflies

<p>Integrating and weighting sensory perception across modalities is crucial to how animals adapt to their environment. Divergence in brain structure is often in sensory processing regions, suggesting that investment reflects ecological needs. Here, we use two parapatric closely related species, <em>Heliconius erato cyrbia</em> and <em>Heliconius himera</em>, to test the hypothesis that divergence in sensory brain regions affects foraging decisions. These butterflies are isolated across an ecological gradient, which is linked to differences in brain morphology, with <em>H. e. cyrbia </em>investing more in visual centres and <em>H. himera</em> investing in olfactory centres. Here, we demonstrate that these two species vary in how they associate visual and olfactory cues with positive food rewards. We found that when individuals were trained on paired olfactory and visual stimuli, then presented with these stimuli in conflict, they showed distinct behavioural responses. <em>Heliconius himera</em> was more likely to favour positive olfactory cues than <em>H. e. cyrbia</em>, which favoured visual cues regardless of the paired stimulus. This suggests that these species have diverged in the emphasis placed on these different sensory domains during foraging, consistent with observed differences in brain morphology. This result strengthens evidence that speciation initiated by local adaptation is partly facilitated by changes in the neural basis of key behavioural functions.</p>

opencc-zeroMar 2022View details →
zenodo40/100

Datasets for chromatin hub prediction in six cell lines based on multiple genomic features

<p>Tables with features and classes for machine learning prediction of chromatin hubs. Genomic features include CTCF, EP300, H3K27me3, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K9ac, H3K9me3, RAD21, RNAPol2, and RNA.Seq, while the classes are Hubs and Non-Hubs.</p> <p>The cell lines featured here are A549, H1ESC, HeLa, IMR90, K562, and MCF7. They happen to be the 6 cell lines out of 8 existing in our integrative database, GREG (https://doi.org/10.1093/database/baz162). The normalized read-coverages from features (variables) are mapped through genomic intervals of 2 Kbs, genome-wide. Such genomic intervals (bins), are classified as Hubs or Non-Hubs. Hubs are those bins with multiple chromatin interactions, including at least one long-range interaction (larger than 1Mb) or an inter-chromosomal interaction (tagged as Inf).</p> <p>Columns per table:<br> chr&nbsp;&nbsp; &nbsp;start&nbsp;&nbsp; &nbsp;end&nbsp;&nbsp; &nbsp;CTCF&nbsp;&nbsp; &nbsp;EP300&nbsp;&nbsp; &nbsp;H3K27me3&nbsp;&nbsp; &nbsp;H3K36me3&nbsp;&nbsp; &nbsp;H3K4me1&nbsp;&nbsp; &nbsp;H3K4me2&nbsp;&nbsp; &nbsp;H3K4me3&nbsp;&nbsp; &nbsp;H3K9ac&nbsp;&nbsp; &nbsp;H3K9me3&nbsp;&nbsp; &nbsp;RAD21&nbsp;&nbsp; &nbsp;RNA.Seq&nbsp;&nbsp; &nbsp;RNAPol2&nbsp;&nbsp; &nbsp;Class</p> <p>Note that features may be inconsistent across different cell types, due to the availability of data. The BAM files have been sourced from ENCODE and NCBI repositories.</p> <p>The analysis following this data can be found at https://github.com/mora-lab/GREG-Hubs.</p>

opencc-by-4.0Nov 2020View details →
zenodo40/100

Protein language model embeddings and predictions for the fly proteome (FlyBase)

<p>Residue and sequence embeddings of the fly (drosophila melanogaster) proteome (FlyBase for organism drosophila melanogaster, downloaded on&nbsp;2022.03.01)&nbsp;computed using bio_embeddings (bioembeddings.com) using the ProtT5 embedder at full precision (https://www.biorxiv.org/content/10.1101/2020.07.12.199554v3). To open the embeddings file, please see&nbsp;<a href="https://github.com/sacdallago/bio_embeddings/blob/develop/notebooks/open_embedding_file.ipynb">this notebook</a>. The embeddings will be indexed by numbers according to the mapping file (mapping_file.csv)&nbsp;in this dataset. All following&nbsp;results will share the same mapping (for instance, to access the variation prediction results, by accessing index &quot;0&quot;, you will query results for the&nbsp;sequence &quot;FBpp0304622&quot;).</p> <p>Additionally:</p> <p>- Sequence-level&nbsp;predictions of subcellular localization in 10 classes using LA (https://www.biorxiv.org/content/10.1101/2021.04.25.441334v1)</p> <p>- Residue-level three state secondary structure prediction (alpha, sheet or other) using models reported&nbsp;in the ProtTrans paper (https://www.biorxiv.org/content/10.1101/2020.07.12.199554v3)</p> <p>- Residue-level prediction of conservation (in 9 states) and of variation effect (from 0 [no-effect] to 1 [effect]) using VESPAl&nbsp;(https://doi.org/10.1007/s00439-021-02411-y)</p> <p>&nbsp;</p> <p>Files included:</p> <p>- dmel-all-translation-r6.44.fasta --&gt; FASTA-formatted sequences of drosophila melanogaster from FlyBase</p> <p>- mapping_file.csv --&gt; A CSV file mapping the identifiers used in the following files (from 0 to&nbsp;30737) to the identifiers in the FlyBase fasta file (dmel-all-translation-r6.44.fasta).</p> <p>-&nbsp;DSSP3_fly_ProtT5Sec.fasta --&gt; Secondary structure predictions in three states for each residue of each protein&nbsp;in dmel-all-translation-r6.44.fasta. &quot;H&quot; stands for Helix; &quot;E&quot; stands for Sheet; &quot;C&quot; stands for Other.</p> <p>-&nbsp;subcell_fly_LA_ProtT5.csv --&gt; Subcellular location (10 states) and memrane-boundness (2 states)&nbsp;for each protein in dmel-all-translation-r6.44.fasta</p> <p>-&nbsp;embeddings_file.h5 --&gt; per-residue embeddings of sequences in dmel-all-translation-r6.44.fasta. Each dataset&nbsp;in the .h5 file represents a protein sequence and contains a matrix of length Lx1024, with L being the length of the protein sequence. Datasets are indexed using integers. The original sequence identifier (from the FASTA header) can be accessed through the &quot;original_id&quot; attribute. See&nbsp;https://docs.bioembeddings.com/v0.2.0/notebooks/open_embedding_file.html for information on how to open the file.</p> <p>-&nbsp;reduced_embeddings_file.h5 --&gt; per-sequence embeddings of sequences in dmel-all-translation-r6.44.fasta (obtained by mean-pooling the residue-embeddings along the length dimension of the protein sequence). Each dataset&nbsp;in the .h5 file represents a protein sequence and contains a vector of size 1024 (meaning, each sequence has the same dimension).</p> <p>-&nbsp;conspred_probs.h5 --&gt; per-sequence conservation probability (softmax) prediction of sequences in dmel-all-translation-r6.44.fasta in 9 classes. Each dataset&nbsp;in the .h5 file represents a protein sequence and contains a matrix of length 9xL, with L being the length of the protein sequence, and 9 being the predicted conservation class (index 0 = very variable; index 8 = very conserved)</p> <p>-&nbsp;vespal_SAVeffect_fly.zip --&gt; zipped .h5 file of per-sequence variation predictions&nbsp;of sequences in dmel-all-translation-r6.44.fasta on a scale from 0 (neutral) to 1 (effect). -1 indicates WT substitution.&nbsp;Each dataset&nbsp;in the .h5 file represents a protein sequence and contains a matrix of length 20xL, with L being the length of the protein sequence, and 20&nbsp;being the predicted variation score for each residue substitution&nbsp;(AAs in the following order: &quot;<strong>ALGVSREDTIPKFQNYMHWC</strong>&quot; . Meaning that index 0 = substitution of the residue to &quot;A&quot;, index = 1 substitution to residue &quot;L&quot;, aso.)</p>

openafl-3.0Mar 2022View details →
zenodo40/100

A Data Resource for Prediction of Thermodynamic Properties of Small Molecules

<p>We developed a database of 2869 experimental values of enthalpy of formation and 1403 values for entropy for substances composed of stable small molecules, derived from the literature. We developed a model for predicting enthalpy of formation and entropy from semiempirical quantum mechanical calculations of energy and atom counts, and applied the model to a comprehensive database of 16,417 small molecules. The database of small-molecule thermodynamic properties will be useful for predicting the outcome of any process that might involve the generation or destruction of volatile products, such as atmospheric chemistry, volcanism, or waste pyrolysis. Additionally, the collected experimental thermodynamic values will be of value to others developing models to predict enthalpy and entropy.</p>

opencc-by-saMar 2021View details →
zenodo40/100

Global predictions for the risk of establishment of Pierce's disease of grapevines

<p>Example to compute the risk of Pierce's Disease establishment from ERA5-Land temperature data. Related to the publication&nbsp;<em><a href="https://www.nature.com/articles/s42003-022-04358-w" target="_blank" rel="noopener">Global predictions for the risk of establishment of Pierce&rsquo;s disease of grapevines</a></em></p> <p>See <a href="https://github.com/agimenezromero/PierceDisease-GlobalRisk-Predictions" target="_blank" rel="noopener">GitHub</a> repo.</p>

openother-openMar 2022View details →
zenodo40/100

Custom language model checkpoints used in "Testing the limits of natural language models for predicting human language judgments"

<p>Checkpoint files for an RNN, LSTM, BILSTM and n-gram models used the paper &quot;Testing the limits of natural language models for predicting human language judgments&quot;</p>

opencc-by-4.0Mar 2022View details →
dryad40/100

Data from: Cortico-Fugal regulation of predictive coding

<p>Sensory systems must account for both contextual factors and prior experience to adaptively engage with the dynamic external environment. In the central auditory system, neurons modulate their responses to sounds based on statistical context. These response modulations can be understood through a hierarchical predictive coding lens: responses to repeated stimuli are progressively decreased, in a process known as repetition suppression, whereas unexpected stimuli produce a prediction error signal. Prediction error incrementally increases along the auditory hierarchy from the inferior colliculus (IC) to the auditory cortex (AC), suggesting that these regions may engage in hierarchical predictive coding. A potential substrate for top-down predictive cues is the massive set of descending projections from the auditory cortex to subcortical structures. To assess the role of these projections in predictive coding, we optogenetically suppressed the auditory cortico-collicular feedback in awake mice while recording responses from IC neurons to stimuli designed to test prediction error and repetition suppression. Suppression of the cortico-collicular pathway led to a decrease in prediction error in IC. Repetition suppression was unaffected by cortico-collicular inactivation, suggesting that this metric may reflect fatigue of bottom-up sensory inputs rather than predictive processing. We also discovered populations of IC neurons that exhibit repetition enhancement, an increase in firing with stimulus repetition, and error suppression, a stronger response to a tone in a predictable rather than unpredictable context. Cortico-collicular suppression led to a decrease in repetition enhancement in the central nucleus and a reduction in error suppression in shell regions of IC. These changes in predictive coding metrics arose from bidirectional modulations in the response to the standard and deviant contexts, such that neurons in IC responded more similarly to each context in the absence of cortical input. Our results demonstrate that the auditory cortex provides cues about the statistical context of sound to subcortical brain regions via direct feedback, regulating processing of both prediction and repetition.</p>

opencc-zeroApr 2022View details →
zenodo40/100

FastNLO interpolation tables for NLO pQCD predictions of Inclusive Jet Production in $pp$ collisions at $\sqrt{s}=200$ and $510$~GeV

<p>This is generated using the NLOJet++ interface using&nbsp;jet pT for&nbsp;renormalization and factorization scale.</p> <p><strong>run12pp200_R050.tab:</strong></p> <p>\sqrt{s} = 200 GeV<br> anti-kT R=0.5<br> |eta| bins: 0.0 0.5 0.9<br> pT&nbsp;bins (GeV): 6.9 8.2 9.7 11.5 13.6 16.1 19.0 22.5 26.6 31.4 37.2 44.0 52.0</p> <p><strong>run12pp510.tab:</strong></p> <p>\sqrt{s} = 510 GeV<br> anti-kT R=0.5<br> |eta| bins: 0.0 0.5 0.9<br> pT&nbsp;bins (GeV): 8.0 10.0 13.0 17.0 21.0 26.0 32.0 39.0 47.0 57.0 68.0 80.0</p> <p><em>This research was supported in part by Lilly Endowment, Inc., through its support for the Indiana University Pervasive Technology Institute.</em></p> <p>If you use this, please cite:&nbsp;D. Britzger, T. Kluge, K. Rabbertz, F. Stober, M. Wobisch, arXiv:1109.1310</p>

opencc-by-4.0Mar 2022View details →

ScienceDex guides

Understand access before you commit

These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.

Compare curated datasets

Allen Brain Atlas

Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.

allen-brain-atlas
neuroscienceopenDocumentation, web resources, and API references are available online.
Last verified 2026-04-30Open record

Annotated Behaviour and Observability Dataset (ABODe)

ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.

abode-home-cage
behavioral-neuroscienceopenThe DataShare record exposes download links for annotations, documentation, license text, and the zipped per-snippet data directory.
Last verified 2026-04-30Open record

DANDI Archive for NWB datasets

DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.

dandi-nwb
electrophysiologyopenPublished Dandiset metadata and archive endpoints are available through the production DANDI API.
Last verified 2026-04-30Open record

International Brain Laboratory public data

The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.

ibl
behavioral-neuroscienceopenPublic sessions can be searched and loaded from the IBL public data server through ONE.
Last verified 2026-04-29Open record

OpenNeuro

OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.

openneuro
neuroscienceopenPublished datasets are available on demand over the internet.
Last verified 2026-04-29Open record

ScienceDex for faculty

Your academic CV and NIH biosketch

Make your CV in your school's format and your NIH biosketch from it, then download both as Word files.