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1,723 results for “Reactivation”
Stream Chemistry for Reactivated Channel
Data corresponds to the chemistry measurements taken on the reactivated channel, mostly inorganic
Stream Nutrients for Reactivated Channel
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Household Reactive Power Consumption Dataset
<p>This dataset is part of the Monash, UEA & UCR time series regression repository. <a href="http://tseregression.org/">http://tseregression.org/</a></p> <p>The goal of this dataset is to predict total reactive power consumption in a household. This dataset contains 1440 time series obtained from the Individual household electric power consumption dataset from the UCI repository. The time series has 5 dimensions. This includes measurements for voltage, current annd 3 sub-metering energy usage.</p> <p> <br> Please refer to <a href="https://archive.ics.uci.edu/ml/datasets/Individual+household+electric+power+consumption">https://archive.ics.uci.edu/ml/datasets/Individual+household+electric+power+consumption</a> for more details<br> <br> Source<br> Georges Hebrail (georges.hebrail '@' edf.fr), Senior Researcher, EDF R&D, Clamart, France<br> Alice Berard, TELECOM ParisTech Master of Engineering Internship at EDF R&D, Clamart, France</p>
Data-base of dissolved organic matter composition and reactivity in Lake Victoria, the World's largest tropical lake
<p>Data-base of Chlorophyll-a, dissolved organic carbon (DOC) concentration and dissolved organic matter (DOM) composition (stable carbon isotope signatures, absorption and fluorescence properties) obtained from samples collected in Lake Victoria, a large lake in East Africa. Samples were collected in 2018-2019 along a bathymetric gradient (bays to open waters), during three contrasting seasons: long rainy, short rainy and dry, which corresponded to distinctly water column mixing regimes, respectively, stratified, semi-stratified and mixed regimes. Eight DOM components from parallel factor analysis (PARAFAC) were identified based on three-dimensional excitation–emission matrices (EEMs), which were aggregated into three main groups of components (C1, C5 and C7 as microbial humic-like; C2, C3 and C4 as terrestrial humic-like; C6 and C8 as protein-like).</p> <p>Please note that the dataset is attached to the following paper :</p> <p>Deirmendjian, L., Lambert, T., Morana, C. <em>et al.</em> Dissolved organic matter composition and reactivity in Lake Victoria, the world’s largest tropical lake. <em>Biogeochemistry</em> <strong>150, </strong>61–83 (2020). https://doi.org/10.1007/s10533-020-00687-2</p>
Microglia reactive
Drawing uploaded to scidraw.io on: 21 May 2020
Reactive extraction of fructose for efficient separation of sucrose-derived glucosides produced by enzymatic glycosylation
<p>We provide here the underlying data of the scientific publication "Reactive extraction of fructose for efficient separation of sucrose-derived glucosides produced by enzymatic glycosylation". Please find the abstract below:</p> <p>The disaccharide sucrose (α-D-glucopyranosyl-1,2-β-D-fructofuranoside) is a highly efficient donor substrate for enzymatic glucosylation reactions. A large number of commercially relevant glucosides are produced via this general route. Every sucrose-based glucosylation involves co-production of D-fructose in amounts corresponding to the target glucoside. A separation technology for selective removal, and efficient recovery, of the D-fructose co-product would be highly desirable as a generic platform for downstream process development. Here, we demonstrate organoboronate-complex reactive extraction of D-fructose into an 1-octanol/hexane (4/1, v/v) solvent using methyltrioctyl ammonium chloride as phase transfer catalyst and extractant. We show separation of the D-fructose co-product (100 mM) from equimolar mixture with 2-α-D-glucosyl-glycerol, a cosmetic ingredient that is manufactured industrially from sucrose and glycerol using sucrose phosphorylase. With the main parameters of extraction, stripping and organic phase recycling identified and their effect on product/co-product yield and purity characterized, we developed a three-step extraction process with alternating extraction and stripping stages that removed the D-fructose efficiently at 50 ml operating scale. 2-α-D-glucosyl-glycerol and D-fructose were cleanly separated and obtained in excellent purity (≥90%) at a recovery of 90% and 83%, respectively. Reactive extraction appears to be faster and more selective and resource-efficient than applicable alternatives for separation, including chromatography and membrane nanofiltration. Thus, the established extraction process is promising for industrial application. It could be generically useful to separate D-fructose from glucosides</p>
Reactivation of latent infections with migration shapes population-level disease dynamics
<p>Annual migration is common across animal taxa and can dramatically shape the spatial and temporal patterns of infectious disease. Although migration can decrease infection prevalence in some contexts, these energetically costly long-distance movements can also have immunosuppressive effects that may interact with transmission processes in complex ways. Here we develop a mechanistic model for the reactivation of latent infections driven by physiological changes or energetic costs associated with migration (i.e., "migratory relapse") and its effects on disease dynamics. We determine conditions under which migratory relapse can amplify or reduce infection prevalence across pathogen and host traits (e.g., infectious periods, virulence, overwinter survival, timing of relapse) and transmission phenologies. We show that relapse at either the start or end of migration can dramatically increase prevalence across the annual cycle and may be crucial for maintaining pathogens with low transmissibility and short infectious periods in migratory populations. Conversely, relapse at the start of migration can reduce the prevalence of highly virulent pathogens by amplifying culling of infected hosts during costly migration, especially for highly transmissible pathogens and those transmitted during migration or the breeding season. Our study provides a mechanistic foundation for understanding the spatiotemporal patterns of relapsing infections in migratory hosts, with implications for zoonotic surveillance and understanding how infection patterns will respond to shifts in migratory propensity associated with environmental change. Further, our work suggests incorporating within-host processes into population-level models of pathogen transmission may be crucial for reconciling the range of migration–infection relationships observed across migratory species.</p>
Systematic evaluation of ReaxFF reactive force fields for biochemical applications
<p>The tar archive contains supporting information to accompany the publication. The data includes the ReaxFF force field files, XYZ and BGF geometry files for amino acid conformers and dipeptides, pathways of initial DNEB interpolations and full connected pathways of condensation reactions.</p>
Data for "Resonant collisional shielding of reactive molecules using electric fields"
<p>Raw data for Figs. 2-4, https://arxiv.org/abs/2009.07461</p>
On the Importance and Shortcomings of Code Readability Metrics: A Case Study on Reactive Programming - replication package
<p>This is the replication package for the conference paper submission "On the Importance and Shortcomings of Code Readability Metrics: A Case Study on Reactive Programming"</p> <p><strong>Contents:</strong></p> <ul> <li>measurements.zip <ul> <li>DATASET_ORIGINAL.csv</li> <li>DATASET_REACTIVE.csv</li> </ul> </li> <li>source_code.zip <ul> <li> source_code_orig <ul> <li>Client.java</li> <li>Connection.java</li> <li>Server.java</li> <li>TcpConnection.java</li> <li>UdpConnection.java</li> </ul> </li> <li> source_code_rx <ul> <li>Client.java</li> <li>Connection.java</li> <li>Server.java</li> <li>TcpConnection.java</li> <li>UdpConnection.java</li> </ul> </li> </ul> </li> </ul> <p> </p>
Mitochondrial oxygen consumption and reactive oxygen species production in hepatopancreas mitochondria of Mya arenaria acclimated under different oxygen regimes
<p>These are the metadata for a publication "Effects of variable oxygen regimes on mitochondrial bioenergetics and reactive oxygen species production in a marine bivalve <em>Mya arenaria</em>" under consideration for publication in the Journal Of Experimental Biology. To study the impacts of different oxygen regimes, we exposed a common sediment-dwelling bivalve, the soft-shell clam <em>Mya arenaria</em>, for 21 days to chronic hypoxia (P<sub>O2</sub>~4.1 kPa), cyclic hypoxia (P<sub>O2</sub>~12.7-1.9 kPa, mean = 5.7 kPa), or normoxia (P<sub>O2</sub>~21.1 kPa). pH was manipulated to mimic the covariation in CO<sub>2</sub>/pH and oxygen levels in coastal hypoxic zones. Mitochondrial respiration, including the proton leak, the capacity for oxidative phosphorylation (OXPHOS), the maximum activity of the electron transport system (ETS), reactive oxygen species (ROS) production, and activity and oxygen affinity of cytochrome c oxidase (CCO) were assessed. Acclimation to constant hypoxia did not affect the studied mitochondrial traits except for a modest decrease in the OXPHOS coupling efficiency. Cyclic hypoxia had no effect on the OXPHOS or ETS capacity, but increased the proton leak and lowered the mitochondrial OXPHOS coupling efficiency. Furthermore, mitochondria of clams acclimated to cyclic hypoxia had higher rates of ROS generation compared with the clams acclimated to normoxia or chronic hypoxia. CCO activity was upregulated under the cyclic hypoxia, but oxygen affinity of CCO did not change. These findings indicate that long-term cyclic hypoxia has a stronger impact on the mitochondria of <em>M. arenaria</em> than chronic hypoxia and might lead to impaired ATP synthesis, higher costs of the mitochondrial maintenance and oxidative stress. These changes might negatively affect populations of <em>M. arenaria</em> in the coastal Baltic Sea under increasing hypoxia pressure.</p>
Data from: Pseudomonas syringae enhances herbivory by suppressing the reactive oxygen burst in Arabidopsis
Plant-herbivore interactions have evolved in the presence of plant-colonizing microbes. These microbes can have important third-party effects on herbivore ecology, as exemplified by drosophilid flies that evolved from ancestors feeding on plant-associated microbes. Leaf-mining flies in the genus Scaptomyza, which is nested within the paraphyletic genus Drosophila, show strong associations with bacteria in the genus Pseudomonas, including Pseudomonas syringae. Adult females are capable of vectoring these bacteria between plants and larvae show a preference for feeding on P. syringae-infected leaves. Here we show that Scaptomyza flava larvae can also vector P. syringae to and from feeding sites, and that they not only feed more, but also develop faster on plants previously infected with P. syringae. Our genetic and physiological data show that P. syringae enhances S. flava feeding on infected plants at least in part by suppressing anti-herbivore defenses mediated by reactive oxygen species.
Data from: Pre- and post-natal effects of experimentally manipulated maternal corticosterone on growth, stress reactivity, and survival of nestling house wrens
1. Corticosterone plays a central role in maintaining homeostasis, promoting energy acquisition, and regulating the stress response in birds. Exposure to elevated levels of corticosterone during development can profoundly alter offspring behaviour and physiology, but the effects of elevated maternal corticosterone on offspring development remain poorly understood. 2. We tested two competing hypotheses concerning the effect of maternally derived corticosterone on growth and development of free-living house wrens: i) elevated maternal corticosterone causes damaging effects on nestling phenotype and fitness (collateral damage hypothesis) and (ii) increased maternal corticosterone enhances offspring fitness by preparing nestlings for the environment experienced by their mother (environmental/maternal-matching hypothesis). 3. We used a non-invasive means to increase maternal corticosterone by providing females with corticosterone-injected mealworms prior to and during egg production in the absence of any overt pre-natal maternal stress. To disentangle pre- and post-natal effects of this elevation in maternal corticosterone, we cross-fostered young in two experiments: i) nestlings of control and experimental females were reared by unmanipulated, natural females in a uniform maternal environment; ii) a split-brood design that enabled us to assess the interaction between the mother's corticosterone treatment and that of the nestlings. 4. There were significant pre-natal effects of increased maternal corticosterone on nestling growth and survival. Offspring of females experiencing experimentally increased corticosterone were heavier and larger than offspring of control females. There also was a significant interaction between maternal corticosterone treatment and the corticosterone treatment to which young were exposed within the egg in their effect on nestling survival while in the nest; experimental young exhibited greater survival than control young, but only when reared by control mothers. There was also a significant effect of maternal corticosterone treatment on nestling stress reactivity and, in both experiments, on the eventual recruitment of offspring as breeding adults in the local population. 5. These patterns are broadly consistent with the environmental/maternal-matching hypothesis, and highlight the importance of disentangling pre- and post-natal effects of manipulations of maternal hormone levels on offspring phenotype.
Data from: Hybridization increases mitochondrial production of reactive oxygen species in sunfish
Mitochondrial dysfunction and oxidative stress have been suggested to be possible mechanisms underlying hybrid breakdown, as a result of mito-nuclear incompatibilities in respiratory complexes of the electron transport system. However, it remains unclear whether hybridization increases the production of reactive oxygen species (ROS) by mitochondria. We used high-resolution respirometry and fluorometry on isolated liver mitochondria to examine mitochondrial physiology and ROS emission in naturally occurring hybrids of pumpkinseed (Lepomis gibbosus) and bluegill (L. macrochirus). ROS emission was greater in hybrids than in both parent species when respiration was supported by complex I (but not complex II) substrates, and was associated with increases in lipid peroxidation. However, respiratory capacities for oxidative phosphorylation, phosphorylation efficiency, and O2 kinetics in hybrids were intermediate between those in parental species. Flux control ratios of capacities for electron transport (measured in uncoupled mitochondria) relative to oxidative phosphorylation suggested that the limiting influence of the phosphorylation system is reduced in hybrids. This likely helped offset impairments in electron transport capacity and complex III activity, but contributed to augmenting ROS production. Therefore, hybridization can increase mitochondrial ROS production, in support of previous suggestions that mitochondrial dysfunction can induce oxidative stress and thus contribute to hybrid breakdown.
Data from: Liquid chromatography-tandem mass spectrometry metabolic profiling of nazartinib reveals the formation of unexpected reactive metabolites
Nazartinib (EGF816, NZB) is a promising third-generation human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. This novel irreversible mutant-selective EGFR inhibitor targets EGFR containing both the resistance mutation (T790M) and the activating mutations (L858R and Del19), while it does not affect wild-type EGFR. However, the metabolic pathway and bioactivation mechanisms of NZB are still unexplored. Thus, using liquid chromatography-tandem mass spectrometry, we screened for products of NZB metabolism formed in vitro by human liver microsomal preparations and investigated the formation of reactive intermediates using potassium cyanide as a nucleophile trap. Unexpectedly, the azepane ring was not bioactivated. Instead, the carbon atom between the aliphatic linear tertiary amine and electron-withdrawing system (butenoyl amide group) was bioactivated, generating iminium intermediates as reactive species. Six NZB phase I metabolites, formed by hydroxylation, oxidation, and N-demethylation, were characterized. Moreover, two reactive iminium ions were characterized and their corresponding bioactivation mechanisms were proposed. Based on our results, we speculate that bioactivation of NZB can be blocked by small sterically hindering groups, isosteric replacement, or a spacer. This approach might reduce the toxicity of NZB by avoiding the generation of reactive species.
Data from: Emotion reactivity is increased 4-6 weeks postpartum in healthy women: a longitudinal fMRI study
Marked endocrine alterations occur after delivery. Most women cope well with these changes, but the postpartum period is associated with an increased risk of depressive episodes. Previous studies of emotion processing have focused on maternal–infant bonding or postpartum depression (PPD), and longitudinal studies of the neural correlates of emotion processing throughout the postpartum period in healthy women are lacking. In this study, 13 women, without signs of post partum depression, underwent fMRI with an emotional face matching task and completed the MADRS-S, STAI-S, and EPDS within 48 h (early postpartum) and 4–6 weeks after delivery (late postpartum). Also, data from a previous study including 15 naturally cycling controls assessed in the luteal and follicular phase of the menstrual cycle was used. Women had lower reactivity in insula, middle frontal gyrus (MFG), and inferior frontal gyrus (IFG) in the early as compared to the late postpartum assessment. Insular reactivity was positively correlated with anxiety in the early postpartum period and with depressive symptoms late postpartum. Reactivity in insula and IFG were greater in postpartum women than in non-pregnant control subjects. Brain reactivity was not correlated with serum estradiol or progesterone levels. Increased reactivity in the insula, IFG, and MFG may reflect normal postpartum adaptation, but correlation with self-rated symptoms of depression and anxiety in these otherwise healthy postpartum women, may also suggest that these changes place susceptible women at increased risk of PPD. These findings contribute to our understanding of the neurobiological aspects of the postpartum period, which might shed light on the mechanisms underlying affective puerperal disorders, such as PPD.
Data from: Identification of reactive intermediate formation and bioactivation pathways in Abemaciclib metabolism by LC–MS/MS: in vitro metabolic investigation
Abemaciclib (Verzenio®) is approved as tyrosine kinase inhibitor (TKI) for breast cancer treatment. In this study, in vitro phase I metabolic profiling of Abemaciclib (ABC) was done using rat liver microsomes (RLMs). We checked the formation of reactive intermediates in ABC metabolism using (RLMs) in the presence of potassium cyanide (KCN) that was used as capturing agent for iminium reactive intermediates forming a stable complex that can be characterized by LC-MS/MS. Nine in vitro phase I metabolites and three cyano adducts were identified. The metabolic reactions involved in formation of these metabolites and adducts are reduction, oxidation, hydroxylation and cyanide addition. The bioactivation pathway was also proposed. Knowing the electrodeficient bioactive centre in ABC structure helped in making targeted modifications to improve its safty and retain its efficacy. Blocking or isosteric replacement of α carbon to the tertiary nitrogen atoms of piperazine ring can aid in reducing toxic side effects of ABC. No previous articles were found about in vitro metabolic profiling for ABC or structural identification of the formed reactive metabolites for ABC.
Reactivity of a model SCILL: Influence of co-adsorbed [C2C1Im][OTf] on the dehydrogenation of dimethylamine on Pt(111)
<p>Raw and evaluated data of the IRAS measurements and DFT calculations</p>
Dynamic Charge Distribution as a Key Driver of Catalytic Reactivity in an Artificial Metalloenzyme
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Measurement report: Impact of emission control measures on environmental persistent free radicals and reactive oxygen species – A short-term case study in Beijing
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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