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873
datasets available to search
ShareScore release 0.9.0
Dataset results
873 results for “ligands”
Chemokine Ligand 2 Expressing Fibroblast Recruitment of Macrophages Enhanced in Loeys-Dietz Syndrome Aortic Root Aneurysm Formation [human]
GEO Series GSE235678. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Mineralocorticoid receptor co-expression effect on ligand-induced glucocorticoid receptor interaction with the genome in human cell line
GEO Series GSE274344. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Ligand-binding pockets in RNA, and where to find them [II]
GEO Series GSE276279. Bacillus subtilis. 16 samples. Type: Other.
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis.
GEO Series GSE260669. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cel
GEO Series GSE22208. Homo sapiens. 48 samples. Type: Genome variation profiling by SNP array.
Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand doses
GEO Series GSE146438. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
[cJun ChIP-seq]: Characterization of transcriptional and chromatin accessibility landscape of human bronchial epithelial cells treated with synergistic immunostimulatory ligands.
GEO Series GSE299552. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Nurr1 and Retinoid X Receptor ligands stimulate Ret signaling in dopamine neurons and can alleviate α-synuclein disrupted gene expression
GEO Series GSE70368. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
A pan-family screen of Nuclear Receptors in immunocytes reveals ligand-dependent inflammasome control [scRNA-seq]
GEO Series GSE254572. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide mapping of ligand-dependent progesterone receptor chromatin interactions in human breast cell lines using PR ChIP-seq
GEO Series GSE31129. Homo sapiens. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Spatial heterogeneity of integrins and their ligands in primary breast tumors
GEO Series GSE242311. Homo sapiens. 16 samples. Type: Other.
Deletion of Ligand Dependent Corepressor-Like (LCoRL) Protects Against Diet-induced Obesity Deletion of Ligand Dependent Corepressor-Like (LCoRL) Protects Against Diet-induced Obesity
GEO Series GSE250603. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Chemo- versus immuno-precipitation of G-quadruplex-DNA (G4- DNA): a direct comparison of the efficiency of the antibody BG4 versus the small-molecule ligands TASQs for G4 affinity capture
GEO Series GSE200171. Oryza sativa. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcriptional and functional characterization of dendritic cell differentiation induced by CD137 ligand reverse signaling in human monocytes
GEO Series GSE60199. Homo sapiens. 30 samples. Type: Expression profiling by array.
The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration
GEO Series GSE266157. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Dynamic Ligand Impacts on Dissolved Iron Distributions in a Global Ocean Biogeochemical Model
<p>Annual mean CESM ocean output files on the coarse resolution gx3v7 grid.<br> Archived here in support of the paper submitted to JAMES by<br> Sherman et al. "Dynamic Ligand Impacts on Dissolved Iron Distributions in a<br> Global Ocean Biogeochemical Model".</p> <p> </p> <p>gdev.450 = dynamic ligand<br> gdev.457 = constant ligand = 1 nM<br> gdev.460 = implicit ligand</p> <p>gdev.458 = dynamic ligand + Sol Fe Depo X3<br> gdev.459 = constant ligand = 1 nM + Sol Fe Depo X3<br> gdev.461 = implicit ligand + Sol Fe Depo X3</p>
Photo-induced receptor confinement drives ligand-independent GPCR signaling
<p>Cell-cell communication relies on the assembly of receptor-ligand complexes at the plasma membrane. The spatiotemporal receptor organization has a pivotal role in evoking cellular responses. We studied the clustering of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) and established a photo-instructive matrix with ultra-small lock-and-key interaction pairs to control lateral membrane organization of hormone neuropeptide Y<sub>2</sub> receptors in living cells by light. Within seconds, receptor clustering was modulated in size, location, and density. After <em>in-situ</em> confinement, changes in cellular morphology, motility, and calcium signaling revealed ligand-independent receptor activation. This approach may enhance exploration of mechanisms in cell signaling and mechanotransduction.</p>
Data from: High-throughput screening for ligands of the HEPN domain of sacsin
Sacsin is a large protein implicated in the neurodevelopmental and neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), which features the loss of Purkinje neurons in the cerebellum. Although the domain architecture of sacsin suggests that it is a neuronal chaperone assisting in protein quality control, the precise function of sacsin remains elusive. Using fluorescence polarization (FP) assays, we confirmed that the HEPN domain of sacsin binds to nucleotides with low micromolar affinities. FP competition assays with a variety of nucleotides and nucleotide analogs revealed that the binding is primarily mediated by the phosphate groups of nucleotides. A high-throughput screen subsequently identified novel small molecule ligands of HEPN, providing new chemical probes for cell culture studies and drug development. Together, the results are consistent with the HEPN domain contributing to the functional activity of sacsin by binding to nucleotides or other multiply charged anionic compounds in neurons.
Structure prediction of protein-ligand complexes from sequence information with Umol
<p>posebusters_benchmark_set.tar.zst - files for the prediction (features to Umol) and scoring of the pose busters benchmark </p><p>posebusters_pred_native.tar.zst - pdb and sdf files of proteins and ligands. Includes native structures, predicted structures and relaxed predicted structures with plDDT in the B factor column.</p><p>posebusters_scores.csv - contains ligand RMSD and other metrics for the unrelaxed structures predicted with Umol.</p><p>PDBBind_processed.tar.zst - files for the training (features to Umol) using PDBbind version 2020</p><p> </p><p> </p>
Dataset for "Identification of Potential inhibitors of the SARS-CoV2 NSP13 Helicase via Structure-Based Ligand Design, Molecular Docking and Nonequilibrium Alchemical Simulations"
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International Brain Laboratory public data
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OpenNeuro
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