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507
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ShareScore release 0.9.0
Dataset results
507 results for “pneumococcal”
HtrA-Mediated Selective Degradation of DNA Uptake Apparatus Accelerates Termination of Pneumococcal Transformation
GEO Series GSE112169. Streptococcus pneumoniae. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcription in peripheral and alveolar neutrophils during pneumococcal pneumonia
GEO Series GSE168929. Mus musculus. 9 samples. Type: Expression profiling by array.
Cell-specific Interleukin-15 and Interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia
GEO Series GSE3631. Mus musculus. 3 samples. Type: Expression profiling by array.
Influenza A virus infection sustainably rewires pneumocyte gene regulatory network responses to different pneumococcal serotypes in secondary Streptococcus pneumoniae infection [ATAC-seq]
GEO Series GSE225498. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Activation by CcpA-FDP of two key determinants of pneumococcal virulence, capsule production and choline utilization.
GEO Series GSE9670. Streptococcus pneumoniae. 6 samples. Type: Expression profiling by array.
Influenza A virus infection sustainably rewires pneumocyte gene regulatory network responses to different pneumococcal serotypes in secondary Streptococcus pneumoniae infection
GEO Series GSE225343. Mus musculus. 42 samples. Type: Expression profiling by array.
Dataset related to article "Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3"
<p>This record contains raw data related to article "Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3". </p><p><strong>Abstract</strong></p><p><i>Streptococcus pneumoniae</i> is a major pathogen in children, elderly subjects, and immunodeficient patients. Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule (PRM) involved in resistance to selected microbial agents and in regulation of inflammation. The present study was designed to assess the role of PTX3 in invasive pneumococcal infection. In a murine model of invasive pneumococcal infection, PTX3 was strongly induced in non-hematopoietic (particularly, endothelial) cells. The IL-1β/MyD88 axis played a major role in regulation of the <i>Ptx3</i> gene expression. <i>Ptx3</i>-/- mice presented more severe invasive pneumococcal infection. Although high concentrations of PTX3 had opsonic activity in vitro, no evidence of PTX3-enhanced phagocytosis was obtained in vivo. In contrast, <i>Ptx3</i>-deficient mice showed enhanced recruitment of neutrophils and inflammation. Using <i>P-selectin-</i>deficient mice, we found that protection against pneumococcus was dependent upon PTX3-mediated regulation of neutrophil inflammation. In humans, <i>PTX3</i> gene polymorphisms were associated with invasive pneumococcal infections. Thus, this fluid-phase PRM plays an important role in tuning inflammation and resistance against invasive pneumococcal infection.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.