Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,301
datasets available to search
ShareScore release 0.9.0
Dataset results
1,301 results for “retrospective study”
Epigenetic Profiling Linked to Multisystem Inflammatory Syndrome in Children (MIS-C): A Multicenter, Retrospective Study
GEO Series GSE193879. Homo sapiens. 127 samples. Type: Methylation profiling by array.
Data from: Identifying the effects of an upgraded 'fever clinic' on COVID-19 control and the workload of emergency department: a retrospective study in a tertiary hospital in China
<p>Objectives: COVID-19 started spreading widely in China. Outpatient fever clinics (FC),were upgraded to serve for COVID-19 screening and prevention of disease transmission in large tertiary hospitals in China. We aimed to evaluate the effect of upgrading the FC system on rates of nosocomial COVID-19 infection and ED patient attendance at PUMCH Methods: The FC of PUMCH was upgraded on January 20, 2020. We performed a retrospective study of patients presenting to the FC between December 12, 2019 and February 29, 2020. January 20, 2020 was the date when COVID-19 was declared an outbreak in Beijing. Two groups of data were collected and subsequently compared with each other: The first group of data was collected within 40 days before January 20, 2020; The second group of data was collected within 40 days after January 20, 2020. All necessary data, including patient baseline information, diagnosis, follow-up conditions, and the transfer records between the FC and ED were collected and analyzed. Results: 6,365 patients were screened in the FC, among whom 2,912 patients were screened before January 21, 2020, while 3,453 were screened afterward. Screening results showed that upper respiratory infection was the major disease associated with fever. After the outbreak of COVID-19, the number of patients who were transferred from the FC to ED decreased significantly [39.21% vs 15.75%, p<0.001], and patients generally spent more time in the FC [55 vs 203minutes, p, compared with before the outbreak. For critically ill patients waiting for their screening results, the total length of stay in the FC was 22minutes before the outbreak, compared with 442minutes after the outbreak Conclusion: The workload of the FC increased significantly after the COVID-19 outbreak. New protocols regarding the use of FC likely helped prevent the spread of COVID-19 l. The upgraded FC reduce the burden on the ED</p>
Data from: Impact of aspiration pneumonia on the clinical course of progressive supranuclear palsy: a retrospective cohort study
Introduction: Although aspiration pneumonia is the most common complication of progressive supranuclear palsy (PSP), the clinical impact of aspiration pneumonia on disease course and survival has not been fully estimated. Thus, we retrospectively analyzed the prognostic factors and clinical consequences of pneumonia in PSP. Methods: The clinical course of patients with aspiration pneumonia was surveyed. The association between baseline clinical features (2 years from disease onset) and latency to the initial development of pneumonia was investigated using survival time and Cox regression analyses. Results: Ninety patients with a clinical diagnosis of PSP were observed for 5.1±3.8 years (mean±SD), and 22 had aspiration pneumonia. Subsequently, 20 patients (91%) had to discontinue oral feeding entirely and 13 (59%) died, whereas, of 68 patients without pneumonia, only three patients (4%) died. Time to initial development of pneumonia was strongly correlated with survival time (Spearman R = 0.92, P<0.001), with a mean latency of 2.3 years to death. Among baseline clinical features, early fall episodes and cognitive decline were significant predictors of pneumonia (P = 0.001 and P<0.001, respectively, log rank test). Cox regression analysis demonstrated that early fall episodes (adjusted hazard ratio: 3.9, 95% confidence interval: 1.2–12.5, P = 0.03) and cognitive decline (adjusted hazard ratio: 5.2, 95% confidence interval: 1.4–19.3, P = 0.02) independently predicted pneumonia. By contrast, dysphagia was not associated with pneumonia (P = 0.2, log rank test). Conclusion: Initial development of pneumonia indicates an unfavorable clinical course and predicts survival time (mean survival time 2.3 years). Patients with early falls and cognitive decline were at high risk of early development of pneumonia.
Data from: Analysis of early postoperative pain in the first and second knee in staged bilateral total knee arthroplasty: a retrospective controlled study
Objective: A retrospective analysis of early postoperative pain in the first and second knee in staged bilateral total knee arthroplasty (TKA) to provide a clinical evidence for the change of analgesic strategy. Methods: From January 2009 to January 2013, 87 cases which meet the inclusion criterion were retrospectively reviewed. In stage TKA, the postoperative pain in the first and second knee at 24h, 48h, 72h after operation were compared using the visual analogue scale (VAS) score in the rest and maximum knee flexion position. The difference in pain scores (ΔVAS) was also compared between the second and first knee at different time intervals (less than 6 months, 6-12 months, more than 12 months). Results: The VAS scores in the second knee were significantly higher than those in the first knee at 24h, 48h after surgery, but with no difference at 72h. The ΔVAS in the group of less than 6 months was significantly higher than of those more than 6 months, and there was no difference in ΔVAS between group of 6-12 months and group of more than 12 months. Conclusions: Patient receiving staged bilateral TKA experiences greater postoperative pain within 48h after operation in the second knee than in the first knee, which can provide a clinical evidence to enhance the analgesic strategy in the second operation of the staged bilateral TKA. And for the management of postoperative pain in staged bilateral TKA, it's better to recommend that the interval between two operations should be more than 6 months, which may reduce the postoperative pain in the second knee, improve patient satisfaction, and speed up patient's rehabilitation process.
Data from: Outcomes in patients with infections and augmented renal clearance: a multicenter retrospective study
Recently, augmented renal clearance (ARC), which accelerates glomerular filtration of renally eliminated drugs thereby reducing the systemic exposure to these drugs, has started to receive attention. However, the clinical features associated with ARC are still not well understood, especially in the Japanese population. This study aimed to evaluate the clinical characteristics and outcomes of ARC patients with infections in Japanese intensive care unit (ICU) settings. We conducted a retrospective observational study from April 2013 to May 2017 at two tertiary level ICUs in Japan, which included 280 patients with infections (median age 74 years; interquartile range, 64–83 years). We evaluated the estimated glomerular filtration rate (eGFR) at ICU admission using the Japanese equation, and ARC was defined as eGFR >130 mL/min/1.73 m2. Multivariable logistic regression analysis was performed to identify the independent risk factors for ARC and to determine if it was a predictor of ICU mortality. In addition, a receiver operating curve (ROC) analysis was performed, and the area under the ROC (AUROC) was determined to examine the significant variables that predict ARC. In total, 19 patients (6.8%) manifested ARC. Multivariable logistic regression analysis identified younger age as an independent risk factor for ARC (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.91–0.96). However, ARC was not found to be a predictor of ICU mortality (OR, 0.57; 95% CI, 0.11–2.92). In addition, the AUROC of age was 0.79 (95% CI, 0.68–0.91), and the optimal cut off age for ARC was ≤63 years (sensitivity, 68.4%; specificity, 78.9%). The incidence of ARC was, therefore, low among patients with infections in the Japanese ICUs. Although younger age was associated with the incidence of ARC, it was not an independent predictor of ICU mortality.
Data from: Clinical factors associated with long-term complete remission versus poor response to chemotherapy in HIV-infected children and adolescents with Kaposi sarcoma receiving bleomycin and vincristine: a retrospective observational study
Kaposi sarcoma (KS) is the most common HIV-associated malignancy in children and adolescents in Africa. Pediatric KS is distinct from adult disease. We evaluated the clinical characteristics associated with long-term outcomes. We performed a retrospective observational analysis of 70 HIV-infected children and adolescents with KS less than 18 years of age diagnosed between 8/2010 and 6/2013 in Lilongwe, Malawi. Local first-line treatment included bleomycin and vincristine plus nevirapine-based highly active anti-retroviral therapy (HAART). Median age was 8.6 years (range 1.7–17.9); there were 35 females (50%). Most common sites of presentation were: lymph node (74%), skin (59%), subcutaneous nodules (33%), oral (27%), woody edema (24%), and visceral (16%). Eighteen (26%) presented with lymphadenopathy only. Severe CD4 suppression occurred in 28%. At time of KS diagnosis, 49% were already on HAART. Overall, 28% presented with a platelet count < 100 x 109/L and 37% with hemoglobin < 8 g/dL. The 2-year event-free (EFS) and overall survival (OS) were 46% and 58% respectively (median follow-up 29 months, range 15–50). Multivariable analysis of risk of death and failure to achieve EFS demonstrated that visceral disease (odds ratios [OR] 19.08 and 11.61, 95% CI 2.22–163.90 and 1.60–83.95 respectively) and presenting with more than 20 skin/oral lesions (OR 9.57 and 22.90, 95% CI 1.01–90.99 and 1.00–524.13 respectively) were independent risk factors for both. Woody edema was associated with failure to achieve EFS (OR 7.80, 95% CI 1.84–33.08) but not death. Univariable analysis revealed that lymph node involvement was favorable for EFS (OR 0.28, 95% CI 0.08–0.99), while T1 TIS staging criteria, presence of cytopenias, and severe immune suppression were not associated with increased mortality. Long-term complete remission is achievable in pediatric KS, however outcomes vary according to clinical presentation. Based on clinical heterogeneity, treatment according to risk-stratification is necessary to improve overall outcomes.
Figure 1 from: Abu-Zaid A, Abu-Zaid S, Barakat M, Al-Huniti R, Khair H (2024) Effectiveness of combination therapy of magnesium, vitamin B2 and Co-enzyme 10 supplementation on vestibular migraine: a retrospective cohort study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e112909
Figure 1 Decrease in vestibular migraine symptom duration following supplementation (n = 57).
Figure 3 from: Abu-Zaid A, Abu-Zaid S, Barakat M, Al-Huniti R, Khair H (2024) Effectiveness of combination therapy of magnesium, vitamin B2 and Co-enzyme 10 supplementation on vestibular migraine: a retrospective cohort study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e112909
Figure 3 Decrease in frequency of vestibular migraines following supplementation (n = 57).
Figure 2 from: Abu-Zaid A, Abu-Zaid S, Barakat M, Al-Huniti R, Khair H (2024) Effectiveness of combination therapy of magnesium, vitamin B2 and Co-enzyme 10 supplementation on vestibular migraine: a retrospective cohort study. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e112909
Figure 2 Decrease in severity of vestibular migraine following supplementation (n = 57).
Can Cranioplasty Be Considered a Tool to Improve Cognitive Recovery Following Traumatic Brain Injury? A 5-Years Retrospective Study
<p>Cranioplasty (CP) is a neurosurgical intervention of skull repairing following a decompressive craniectomy. Unfortunately, the impact of cranioplasty on cognitive and motor function is still controversial. Fifteen TBI subjects aged 26-54 years with CP after decompressive craniectomy were selected in this observational retrospective study. As per routine clinical practice, a neuropsychological evaluation carried out immediately before the cranioplasty (Pre CP) and one month after the cranioplasty (T0) was used to measure changes due to CP surgery. This assessment was performed each year for 5 years after discharge in order to investigate long-term cognitive changes (T1-T5). Before cranioplasty, about 53.3% of subjects presented a mild to severe cognitive impairment and about 40.0% a normal cognition. After CP, we found a significant improvement in all neuropsychological test scores. The more significant differences in cognitive recovery were detected after four years from CP. Notably, we found significant differences between T4 and T0-T1, as well as between T5 and T0-T1-T2 in all battery tests. This retrospective study further suggests the importance of CP in the complex management of patients with TBI showing how these patients might improve their cognitive function over a long period after the surgical procedure.e</p>
Data from: Development of the Combined Assessment of Risk Encountered in Surgery (CARES) surgical risk calculator for prediction of post-surgical mortality and need for intensive care unit admission risk – a single-centre retrospective study
[No abstract entered]
Large-Population based Deep Learning Models in Classifying Primary Bone Tumors and Bone Infections based on Radiographs: a Retrospective and Multi-reader Multi-center Study
<p>This retrospective multicenter study collected patients via consecutive sampling between 2013 and 2022 from two cohorts: training cohort (from the Second Xiangya Hospital of Central South University) and testing cohort (from Xiangya Hospital of Central South University and Hunan Children's Hospital of Central South University). These lesions were identified to have bone involvement through pre-operative radiographs and were histologically diagnosed following biopsy or surgery. <br>(i) For the inclusion criteria, lesions were confirmed and diagnosed as PBTs according to the 2020 World Health Organization (WHO) system for the classification for tumors of bone 1 while bone infections were confirmed and proven by histology and (or) bacterial culture. The other vital inclusion criteria are evident as well as available clinical information and pre-operative radiographs. <br>(ii) The screening criteria: (a) radiographs were from patients diagnosed between 2013 and 2022 (b) in selected three hospitals; (c) radiographs with robust quality for reliable assessments of the bone lesions and (d) all of these radiographs were pre-operative. <br>Clinical characteristics like age, gender, and the location of the lesion of interest and so on were obtained from the patients' electronic medical records after data desensitization and standardization.<br>Radiographs were kept and downloaded as Digital Imaging and Communications in Medicine (DICOM) files from the picture archiving and communication system (PACS) at their original sizes and resolutions. All of these radiograph images have undergone desensitization processing of disengaging patient protected health information from DICOM data to meet the relevant legal criteria and requirements of US (HIPAA) as well as European (GDPR). Delineating the region of interest (ROI) was performed by two proficient radiologists. ROIs were meticulously outlined via Click 2 Crop (version 5.2.2) (https://click-2-crop.en.softonic.com/) to closely segment pertinent entities present in each PBT or bone infection. The smallest rectangular box that can completely cover the ROI was manually annotated as the boundary box by senior seniority radiologist to ensure accuracy. Afterwards, the annotated ROIs were used as ground truth for the model development process.</p>
Single-step transepithelial photorefractive keratectomy (T-PRK) or ASLA (SCHWIND) without addition of mitomycin-C in high myopia: a retrospective study of 69 eyes
<p>This table contains the dataset used to generate the paper entitled "Single-step transepithelial photorefractive keratectomy (T-PRK) or ASLA (SCHWIND) without addition of mitomycin-C in high myopia: a retrospective study of 69 eyes" by Giral et al.</p>
Dataset from "Night-time bracing could reduce pain in adults with scoliosis: Six months results of a pilot retrospective controlled study"
<p>Dataset from a still non-published study titled "Night-time bracing could reduce pain in adults with scoliosis: Six months results of a pilot retrospective controlled study"</p>
Retrospective Observational Comparison Study Between Ustekinumab and Tofacitinib as Third Line Therapy in a Multicenter Cohort of Patients With Refractory Ulcerative Colitis.
ClinicalTrials.gov study NCT05728008. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Retrospective EGFR Mutation Status Study in Chinese NSCLC Patients Using Paired Plasma and Tissue Samples
ClinicalTrials.gov study NCT01382992. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Correlation Between Body Composition and Pathologic Grade/Prognosis in GEP-NENs: A Retrospective Study
ClinicalTrials.gov study NCT06983106. IPD Sharing: NO. Countries: 1. Publications: 0.
Retrospective Non-interventional Study of Stiripentol Use in Dravet Patients in the USA
ClinicalTrials.gov study NCT05544058. IPD Sharing: NO. Countries: 1. Publications: 0.
Colorectal Cancers :A Retrospective Study
ClinicalTrials.gov study NCT07024225. IPD Sharing: NO. Countries: 1. Publications: 0.
Multicenter Retrospective Study on Optimizing Combination Immunotherapy Strategies in MSS/MSI-L/pMMR Advanced Colorectal Cancer
ClinicalTrials.gov study NCT06849362. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.