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3,259 results for “type studies”
A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease
ClinicalTrials.gov study NCT03819153. IPD Sharing: YES. Countries: 28. Publications: 11.
Study of Multiple Oral Doses of PF-07081532 in Adult Participants With Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT05158244. IPD Sharing: NO. Countries: 1. Publications: 1.
A Long-term Study on the Side Effects of TRADIANCE in Japanese Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT03761797. IPD Sharing: YES. Countries: 1. Publications: 1.
Retrospective cohort study of a community-based primary care program's effects on pharmacotherapy quality in low-income Peruvians with type 2 diabetes and hypertension
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A gene variation at the ZPR1 locus (rs964184) interacts with the type of diet to modulate postprandial triglycerides in patients with coronary artery disease: From the Cordioprev Study
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CMT1A-BioStampNPoint2023: Charcot-Marie-Tooth disease type 1A accelerometry dataset from three wearable sensor study
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Data from: Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study
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Data and Code to support COVID-19 - exploring the implications of long-term condition type and extent of multimorbidity on years of life lost: a modelling study
<p>Data and code to support paper published in Wellcome Open research on years of life lost among people who died with COVID-19.</p>
Data offspring performance following two-donor crosses at different floral stages and with different competitor types in greenhouse studies of Collinsia heterophylla
<p>Data on two offspring performance traits (seeds per capsule and flower number) in greenhouse studies of Collinsia heterophylla to investigate indirect benefits of mate choice. We performed two-donor pollinations during successive floral stages and with different competitor types (outcross and self) to assess how stigma receptivity and two pollen traits known to affect siring success influence offspring performance. We also investigated the link between seed production in mothers and offspring as an indication of heritability of this trait, and differential resource allocation by studying the influence of sibling performance in the same capsule.</p>
Study Material for the paper: Does People's Keyboard Typing Reflect their Stress Level – An Explorative Study
<p>This release bundles the study materials for the research paper "Does People's Keyboard Typing Reflect their Stress Level – An Explorative Study" by Freihaut & Göritz</p> <p> </p> <p>The release includes the data, data analysis and processing code as well as the results for both the labratory study and the online study and also the source code of the experiment live demo app.</p>
Data from: Relationship type affects the reliability of dispersal distance estimated using pedigree inferences in partially sampled populations: a case study involving invasive American mink in Scotland
Estimating dispersal—a key parameter for population ecology and management—is notoriously difficult. The use of pedigree assignments, aided by likelihood-based software, has become popular to estimate dispersal rate and distance. However, the partial sampling of populations may produce false assignments. Further, it is unknown how the accuracy of assignment is affected by the genealogical relationships of individuals and is reflected by software-derived assignment probabilities. Inspired by a project managing invasive American mink (Neovison vison), we estimated individual dispersal distances using inferred pairwise relationships of culled individuals. Additionally, we simulated scenarios to investigate the accuracy of pairwise inferences. Estimates of dispersal distance varied greatly when derived from different inferred pairwise relationships, with mother–offspring relationship being the shortest (average = 21 km) and the most accurate. Pairs assigned as maternal half-siblings were inaccurate, with 64%–97% falsely assigned, implying that estimates for these relationships in the wild population were unreliable. The false assignment rate was unrelated to the software-derived assignment probabilities at high dispersal rates. Assignments were more accurate when the inferred parents were older and immigrants and when dispersal rates between subpopulations were low (1% and 2%). Using 30 instead of 15 loci increased pairwise reliability, but half-sibling assignments were still inaccurate (>59% falsely assigned). The most reliable approach when using inferred pairwise relationships in polygamous species would be not to use half-sibling relationship types. Our simulation approach provides guidance for the application of pedigree inferences under partial sampling and is applicable to other systems where pedigree assignments are used for ecological inference.
Data from: Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies
Based on an extensive simulation study, McGregor and colleagues recently recommended the use of surrogate variable analysis (SVA) to control for the confounding effects of cell-type heterogeneity in DNA methylation association studies in scenarios where no cell-type proportions are available. As their recommendation was mainly based on simulated data, we sought to replicate findings in two large-scale empirical studies. In our empirical data, SVA did not fully correct for cell-type effects, its performance was somewhat unstable, and it carried a risk of missing true signals caused by removing variation that might be linked to actual disease processes. By contrast, a reference-based correction method performed well and did not show these limitations. A disadvantage of this approach is that if reference methylomes are not (publicly) available, they will need to be generated once for a small set of samples. However, given the notable risk we observed for cell-type confounding, we argue that, to avoid introducing false-positive findings into the literature, it could be well worth making this investment.
Data from: The effect of meal frequency in a reduced-energy regimen on the gastrointestinal and appetite hormones in patients with type 2 diabetes: a randomised crossover study
Background: Appetite and gastrointestinal hormones (GIHs) participate in energy homeostasis, feeding behavior and regulation of body weight. We demonstrated previously the superior effect of a hypocaloric diet regimen with lower meal frequency (B2) on body weight, hepatic fat content, insulin sensitivity and feelings of hunger compared to the same diet divided into six smaller meals a day (A6).Studies with isoenergetic diet regimens indicate that lower meal frequency should also have an effect on fasting and postprandial responses of GIHs.The aim of this secondary analysis was to explore the effect of two hypocaloric diet regimens on fasting levels of appetite and GIHs and on their postprandial responses after a standard meal. It was hypothesized that lower meal frequency in a reduced-energy regimen leading to greater body weight reduction and reduced hunger would be associated with decreased plasma concentrations of GIHs: gastric inhibitory peptide (GIP), glucagon-like peptide-1(GLP-1), peptide YY(PYY), pancreatic polypeptide (PP) and leptin and increased plasma concentration of ghrelin. The postprandial response of satiety hormones (GLP-1, PYY and PP) and postprandial suppression of ghrelin will be improved. Methods: In a randomized crossover study, 54 patients suffering from type 2 diabetes (T2D) underwent both regimens.The concentrations of GLP-1, GIP, PP, PYY, amylin, leptin and ghrelin were determined using multiplex immunoanalyses. Results: Fasting leptin and GIP decreased in response to both regimens with no difference between the treatments (p=0.37 and p=0.83, respectively). Fasting ghrelin decreased in A6 and increased in B2 (with difference between regimens p=0.023). Fasting PP increased in B2with no significant difference between regimens (p=0.17). Neither GLP-1 nor PYY did change in either regimen. The decrease in body weight correlated negatively with changes in fasting ghrelin (r=-0.4, p<0.043) and the postprandial reduction of ghrelin correlated positively with its fasting level (r=0.9, p<0.001). The postprandial responses of GIHs and appetite hormones were similar after both diet regimens. Conclusions: Both hypocaloric diet regimens reduced fasting leptin and GIP and postprandial response of GIP comparably. The postprandial responses of GIHs and appetite hormones were similar after both diet regimens. Eating only breakfast and lunch increased fasting plasma ghrelin more than the same caloric restriction split into six meals. The changes in fasting ghrelin correlated negatively with the decrease in body weight. These results suggest that for type 2 diabetic patients on a hypocaloric diet, eating larger breakfast and lunch may be more efficient than six smaller meals during the day.
Risk for excessive anticoagulation during hemodialysis is associated with type of vascular access and bedside coagulation testing: Results of a cross-sectional study
<p>Anonymized dataset of the cross-sectional study assessing (i) heparin dosing within a prevalent hemodialysis cohort, (ii) the anticoagulant effects of the heparinization strategy and (iii) identifying predictive factors of the heparin dosing regimen.</p>
Data from: Clinical characteristics and lipid lowering treatment of patients initiated on Proprotein convertase subtilisin/kexin type 9 inhibitors – a nationwide cohort study
Objectives: Given the novelty of proprotein convertase subtilisin–kexin type 9 inhibitors (PCSK9i), little is known regarding overall implementation or clinical characteristics among patients who initiate treatment. We aimed to assess the total number of patients initiated on PCSK9i along with a description of the clinical characteristics and lipid lowering treatment (LLT) of such patients. Setting: A register based descriptive cohort study of patients receiving a PCSK9i in the time period from 01-01-2016 to 31-03-2017 using a cross-linkage between three nationwide Danish registers. Information regarding PCSK9i prescriptions, patient demographics, concurrent pharmacotherapy, comorbidities, and previous coronary procedures was identified. Results: Overall, 137 patients initiated treatment with PCSK9i in the study period from 11 in the first quarter of 2016 to 40 in the first quarter of 2017. The majority had a history of ischemic heart disease (67.9%) with ischemic stroke and diabetes mellitus being present in 7.3% and 16.8% of patients, respectively. All patients initiated on PCSK9i had been previous prescribed statin treatment with Atorvastatin and Simvastatin being most frequently prescribed in 53% and 36% of patients, respectively. The majority of patients had received both statins and Ezetimibe (94.9%) and approximately half of these patients had also received bile acid sequestrant (45.3%). Clinical characteristics mainly differed in patients receiving triple LLT compared to patients not receiving triple LLT in the regards of heart failure. Conclusion: Patients treated with PCSK9i were rare, characterized by having ischemic heart disease and had received various and intensive conventional LLT prior to PCSK9i initiation in agreement with current international guidelines.
FIGURES 15–27. Types and determined material. Figs 15–19, A. alcocki, neotype puparium. 15 in Studies on the Indian species of Aleuroplatus (Hemiptera: Aleyrodidae), with designation of a neotype puparium for Aleurodes alcocki Peal
FIGURES 15–27. Types and determined material. Figs 15–19, A. alcocki, neotype puparium. 15, same, puparium. 16, cephalic median fold. 17, thoracic tracheal comb. 18, vasiform orifice and posterior marginal area. 19, neotype slide. Figs 20–23, A. incisus. 20, same, puparium. 21, thoracic tracheal comb. 22, vasiform orifice and posterior marginal area. 23, enlarged view of vasiform orifice. Figs 24–27, A. cinnamomi, holotype puparium. 24, same, abdominal area, 25, median abdominal area showing three pores and associated porettes. 26, vasiform orifice and caudal tracheal comb. 27, margin and submarginal tubercles.
FIGURE 1 in Systematic studies of the genus Aegialomys Weksler, Percequillo and Voss, 2006 (Rodentia: Cricetidae: Sigmodontinae): Annotated catalogue of the types of the species-group taxa
FIGURE 1. Dorsal, ventral and lateral views of the skull, and details of the maxillary molar row and incisive foramina of an adult Euryoryzomys russatus, illustrating the limits of the 15 craniodental measurements taken on the specimens of genus Aegialomys. Abbreviations are defined in text.
FIGURE 8 in Systematic studies of the genus Aegialomys Weksler, Percequillo and Voss, 2006 (Rodentia: Cricetidae: Sigmodontinae): Annotated catalogue of the types of the species-group taxa
FIGURE 8. Size comparisons between selected skull measurements of the type specimens of the five nominal taxa of the species-group of the genus Aegialomys. White square represents M. galapagoensis; cross represents O. baroni; black triangle represents O. bauri; white triangle represents O. xanthaeolus; and black square represents O. xanthaeolus ica. The acronyms of measurements are provided in the Material and Methods section.
FIGURE 5 in Systematic studies of the genus Aegialomys Weksler, Percequillo and Voss, 2006 (Rodentia: Cricetidae: Sigmodontinae): Annotated catalogue of the types of the species-group taxa
FIGURE 5. Dorsal, ventral and lateral views of the skull, and lateral view of the mandible of the specimen BMNH 85.4.1.47, holotype of Oryzomys xanthaeolus Thomas, 1894 (ONL not available; Thomas, 1894 recorded the length of the "front of interparietal to nasal tip": 28.3 mm).
FIGURE 7 in Systematic studies of the genus Aegialomys Weksler, Percequillo and Voss, 2006 (Rodentia: Cricetidae: Sigmodontinae): Annotated catalogue of the types of the species-group taxa
FIGURE 7. Dorsal, ventral and lateral views of the skull, and lateral view of the mandible of the specimen FMNH 53157, holotype of Oryzomys xanthaeolus ica Osgood, 1944 (ONL: 32.88 mm).
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.