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5,225 results for “moderation”
Incremental prognostic role of left atrial reservoir strain in asymptomatic patients with moderate aortic stenosis
<p>Raw data related to the article</p> <p>Abstract<br> Left atrial (LA) mechanics assessed by two-dimensional speckle tracking echocardiography (2D-STE) have not been extensively<br> studied and clearly characterized in patients with moderate aortic stenosis (AS). Accordingly, we aimed to evaluate<br> the usefulness of LA reservoir strain for risk stratification of asymptomatic patients with moderate AS. This retrospective<br> study included all consecutive asymptomatic patients with moderate AS who underwent transthoracic echocardiography<br> implemented with 2D-STE analysis of LA myocardial strain and strain rate indices at our Institution, between February 2011<br> and September 2019. During the follow-up period, we evaluated the occurrence of any of the following: (1) CV hospitalization;<br> (2) The recourse to AS surgery; (3) Cardiac death or sudden death. A total of 186 patients (mean age 71.9 ± 12.7 years,<br> 61.8% men) were included in the present study. During a mean follow-up of 2.3 ± 1.9 years, no patients died and 63 adverse<br> CV events were recorded: 48 patients were hospitalized because of heart failure (28 patients), acute coronary syndrome (10<br> patients), arrhythmias (10 patients) and 15 patients underwent AS surgery. At the multivariate Cox regression analysis, type 2<br> diabetes mellitus (OR 1.87, 95%CI 1.05–3.34, p = 0.03), NT-proBNP (OR average 1.14, 95%CI 1.02–1.27, p = 0.02), average<br> E/e′ ratio (OR 1.07, 95%CI 1.01–1.15, p = 0.04) and most of all left atrial positive global strain (LA-GSA+) (OR 0.85, 95%CI<br> 0.81–0.90, p < 0.0001) were independently associated with the outcome. LA-GSA+ (optimal cut-off ≤ 19%, AUC = 0.94,<br> 87% sensitivity, 99% specificity, positive predictive value 99%, negative predictive value 88%) showed the highest diagnostic<br> performance. An impaired LA reservoir strain can contribute to identify a subset of asymptomatic patients with moderate<br> AS at higher risk, who may benefit from closer echocardiographic follow-up and/or early surgery.</p>
Association between C‑reactive protein and carotid plaque in mild‑to‑moderate idiopathic pulmonary fibrosis
<p>Raw data related to the article</p> <p> </p> <p>Abstract<br> An association between C-reactive protein (CRP) levels and carotid plaque has never been investigated in idiopathic pulmonary<br> fibrosis (IPF). The aim of this study was to evaluate the extent of carotid atherosclerosis in mild-to-moderate IPF<br> and to assess its relationship to serum CRP. This observational retrospective case–control study included 60 consecutive<br> IPF patients (73.8 ± 6.6 years, 45 males) and 60 matched controls, examined between Sep 2017 and Jan 2019. All patients<br> underwent CRP assessment and a carotid Doppler ultrasonography. CRP levels were significantly higher in IPF patients than<br> controls (0.2 ± 0.09 mg/dl vs 0.09 ± 0.04 mg/dl, p < 0.0001). A total of 46 plaques were detected, with higher prevalence in<br> IPF patients than controls (38 vs 8, p < 0.0001). On univariate logistic regression the main variables independently associated<br> with carotid plaque were: age (HR 1.09, 95% CI 1.03–1.16, p = 0.006), hypertension duration (HR 1.05, 95% CI 1.01–1.09,<br> p = 0.01), diabetes duration (HR 1.09, 95% CI 1.01–1.18, p = 0.03), LDL-cholesterol (HR 1.07, 95% CI 1.04–1.10, p < 0.0001)<br> and finally CRP levels (HR 1.73, 95% CI 0.59–5.00, p < 0.0001). Multivariate logistic regression analysis revealed that<br> LDL-cholesterol (HR 1.05, 95% CI 1.01–1.08, p = 0.009) and CRP levels (HR 1.43, 95% CI 0.39–5.19, p < 0.0001) retained<br> statistical significance. Common carotid artery-intima media thickness was significantly correlated with CRP levels in IPF<br> patients (r = 0.86). SerumCRP might represent both an early marker and a potential therapeutic target for carotid atherosclerosis<br> in mild-to-moderate IPF.</p>
Effects of acute exposure to moderate altitude on blood pressure and sleep breathing patterns - RAW DATA
<p>Raw data of the study "Effects of acute exposure to moderate altitude on blood pressure and sleep breathing patterns" by <strong>Torlasco Camilla</strong>, Bilo Grzegorz Marek, Giuliano Andrea, Soranna Davide, Ravaro Silvia, Oliverio Giorgio, Faini Andrea, Zambon Antonella, Lombardi Carolina, Parati Gianfranco. <em>INTERNATIONAL JOURNAL OF CARDIOLOGY</em> 2020.</p>
Half dose ChAdOx1 nCoV-19 vaccine was equivalent to full doses to reduce moderate and severe COVID-19 cases
<p><strong>Data Dictionary</strong></p> <table> <tbody> <tr> <td>Column</td> <td>Description</td> <td>Type</td> </tr> <tr> <td>Main ID</td> <td>A unique and primary identification assigned to each individual.</td> <td>Integer</td> </tr> <tr> <td>Study ID</td> <td>A specific research identification assigned to each patient.</td> <td>String</td> </tr> <tr> <td>Gender</td> <td>The biological sex of the patient, which can be male or female (M or F).</td> <td>String</td> </tr> <tr> <td>Severity</td> <td>A measure of the severity of the illness. 1- not infected 2- hospitalized 3- hospitalized ICU</td> <td>Integer</td> </tr> <tr> <td>Age</td> <td>The age of the patient, usually in completed years.</td> <td>Integer</td> </tr> <tr> <td>Age_group</td> <td>A category in which the patient's age is grouped, age ranges like 25-34 years or 45-54 years, etc.</td> <td>String</td> </tr> <tr> <td>Length_of_hospital_stay</td> <td>The amount of time the participant spent hospitalized in days.</td> <td>Integer</td> </tr> <tr> <td>Hospitalization_and_outcome</td> <td>Information about the participant's hospitalization and the outcome of the hospitalization.</td> <td>Integer</td> </tr> <tr> <td>Outcome</td> <td>The outcome of the patient, whether there was death or not.</td> <td>String</td> </tr> <tr> <td>Before_d1</td> <td>Information about the patient's condition before the first dose of the vaccine.</td> <td>Float</td> </tr> <tr> <td>Severity_before</td> <td>The measure of the severity of the participant's condition before the first dose of the vaccine.</td> <td>Float</td> </tr> <tr> <td>t_hospitalized_before</td> <td>The amount of time the participant spent hospitalized before the first dose of the vaccine.</td> <td>Float</td> </tr> <tr> <td>time_hospitalization_before</td> <td>The total amount of time the participant spent hospitalized in intensive care unit (ICU) before the first dose of the vaccine.</td> <td>Float</td> </tr> <tr> <td>Between_d1_d2</td> <td>Information about the patient's condition between dose 1 and dose 2 of the vaccine.</td> <td>Float</td> </tr> <tr> <td>Severity_between</td> <td>The measure of the severity of the patient's condition between dose 1 and dose 2 of the vaccine.</td> <td>Float</td> </tr> <tr> <td>t_hospitalized_between</td> <td>The amount of time the patient spent hospitalized between dose 1 and dose 2 of the vaccine.</td> <td>Float</td> </tr> <tr> <td>time_hospitalization_between</td> <td>The total amount of time the patient spent hospitalized in intensive care unit (ICU) between dose 1 and dose 2 of the vaccine.</td> <td>Float</td> </tr> <tr> <td>After_d2</td> <td>Information about the patient's condition after dose 2 of the vaccine.</td> <td>Float</td> </tr> <tr> <td>Severity_after</td> <td>The measure of the severity of the patient's condition after dose 2 of the vaccine.</td> <td>Float</td> </tr> <tr> <td>t_hospitalized_after</td> <td>The amount of time the patient spent hospitalized after dose 2 of the vaccine.</td> <td>Float</td> </tr> <tr> <td>time_hospitalization_after</td> <td>The total amount of time the patient spent hospitalized in intensive care unit (ICU) after dose 2 of the vaccine.</td> <td>Float</td> </tr> <tr> <td>Date_of_death</td> <td>The date on which the patient died, if applicable.</td> <td>Date</td> </tr> <tr> <td>Immunization</td> <td>Information about the patient's immunization for example HD - Half Dose and FD - Full Dose</td> <td>String</td> </tr> <tr> <td>Comorbidity</td> <td>Whether the patient has any pre-existing medical conditions or not.</td> <td>String</td> </tr> </tbody> </table> <p> </p> <p>This database contains information about the administration of the ChAdOx1 nCoV-19 vaccine in half doses and its equivalence in reducing moderate and severe cases of COVID-19 compared to full doses.</p> <p>The ChAdOx1 nCoV-19 vaccine is developed to prevent infection by the SARS-CoV-2 virus, which causes COVID-19. The study analyzed the efficacy of administering the vaccine in half doses compared to full doses. The objective was to evaluate if the half dose would be as effective as the full dose in reducing moderate and severe cases of the disease.</p> <p>Through this database, it is possible to analyze and assess the effectiveness of administering the ChAdOx1 nCoV-19 vaccine in half doses, as well as comparing it to the use of full doses. This information can be used by researchers, healthcare professionals, and authorities responsible for vaccination policies to support decisions and recommendations related to COVID-19 immunization.</p>
VIIRS/JPSS2 Moderate Resolution Terrain Corrected Geolocation 6-Min L1 Swath 750 m
The VIIRS/JPSS2 Moderate Resolution Terrain Corrected Geolocation 6-Min L1 Swath 750 m, short-name VJ203MOD is the Joint Polar-orbiting Satellite System-2 (JPSS-2/NOAA-21) platform-based NASA Visible-Infrared Imaging-Radiometer Suite (VIIRS) L1 terrain-corrected geolocation product, and contains the derived line-of-sight (LOS) vectors for each of the 750-m moderate-resolution, or M-bands. The geolocation algorithm uses a number of inputs that include an Earth ellipsoid, geoid, and a digital terrain model along with the SNPP platform’s ephemeris and attitude data, and knowledge of the VIIRS sensor and satellite geometry. It produces geodetic coordinates (latitude and longitude), and related parameters for each VIIRS L1 pixel. The VJ203MOD product includes geodetic latitude, longitude, surface height above the geoid, solar zenith and azimuth angles, sensor zenith and azimuth angles, land/water mask, and quality flag for every pixel location. VJ203MOD provides a fundamental input to derive a number of VIIRS M-band higher-level products.The J2 VIIRS geolocation underwent an on-orbit validation. Geolocation errors of about 350 m in the along-scan direction and about 165 m in the along-track direction were corrected for the image-resolution bands and moderate-resolution bands. The Day-Night band (DNB) geolocation error of about 2000 m was corrected. For more information and documents, visit LAADS product page at:https://ladsweb.modaps.eosdis.nasa.gov/missions-and-measurements/products/VJ203MOD
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.