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Figure 3 in Conservation Note on the Status of the Rare Endemic Marquesan Snout Butterfly, Libythea collenettei
Figure 3. Images of the Marquesas Islands, close to localities where L. collenettei has been previously found. A. Nuku Hiva, partially preserved ecosystem near Mount Tekao. B–D. Nuku Hiva, Toovii Plateau with extensive Caribbean pine forests, feral horses, and intensive grazing damages the native ecosystem. E. Nuku Hiva, view of Ho'oumi Bay (type locality) now covered by coconut tree plantations. F. Hiva Oa, Mount Temetiu cloud forest where endangered endemic invertebrates can still be found. G. Ua Pou, site where L. collenettei was found in 2001 in front of Mount Pouhekaei. H. Ua Pou, west side of Hakahetau Valley along "La Traversière" trail with some remaining endemic vegetation. Photograph credit: Emmanuel F.A. Toussaint.
Conserved angio-immune subtypes of the cancer microenvironment predict response to immune checkpoint blockade therapy
<p>Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment. However, only a fraction of the patients respond to ICB therapy. Accurate prediction of patients to likely respond to ICB would maximize the efficacy of ICB therapy. The tumor microenvironment (TME) dictates tumor progression and therapy outcome. Here, we classify the TME by analyzing the transcriptome from 11,069 cancer patients based on angiogenesis and T-cell activity. We find three distinct angio-immune TME subtypes conserved across 30 non-hematological cancers. There is a clear inverse relationship between angiogenesis and anti-tumor immunity in TME. Remarkably, patients displaying TME with low angiogenesis with strong anti-tumor immunity show the most significant responses to ICB therapy in four cancers. Re-evaluation of the renal cell carcinoma clinical trials provides compelling evidence that the baseline angio-immune state is robustly predictive of ICB responses. This study offers a rationale for incorporating baseline angio-immune scores for future ICB treatment strategies.</p>
Figure 7. 2007-2008 in Conservation considerations revealed by the movements of post-nesting green turtles from the Republic of the Marshall Islands
Figure 7. 2007-2008 post-nesting movement of a 101 cm CCL green turtle ID 40702, "Loj5", from Erikub Atoll, Republic of the Marshall Islands to pelagic waters east of Erikub. Loj5 traveled a total distance of 4,212 km, in the 278 days the satellite tag transmitted.
Figure 6. 2007 in Conservation considerations revealed by the movements of post-nesting green turtles from the Republic of the Marshall Islands
Figure 6. 2007 post-nesting movement of a 100 cm CCL green turtle ID 40605, "Loj4", from Erikub Atoll, Republic of the Marshall Islands to Pohnpei, Federated States of Micronesia. Loj4 traveled a total distance of 4,039 km, in the 162 days the satellite tag transmitted.
Figure 5. 2007-2008 in Conservation considerations revealed by the movements of post-nesting green turtles from the Republic of the Marshall Islands
Figure 5. 2007-2008 post-nesting movement of a 96 cm CCL green turtle ID 40703, "Loj3", from Erikub Atoll, Republic of the Marshall Islands to the southern islands of Bikini Atoll. Loj3 traveled a total distance of 6,739 km, in the 215 days the satellite tag transmitted.
Figure 3. 2007-2008 in Conservation considerations revealed by the movements of post-nesting green turtles from the Republic of the Marshall Islands
Figure 3. 2007-2008 post-nesting movement of a 105 cm CCL green turtle ID 40719, "Loj2", from Erikub Atoll, Republic of the Marshall Islands to Palawan Island, Philippines. Loj2 traveled a total distance of 6,935 km, in the 345 days the satellite tag transmitted.
Figure 4. 2007-2008 in Conservation considerations revealed by the movements of post-nesting green turtles from the Republic of the Marshall Islands
Figure 4. 2007-2008 post-nesting movement of a 100 cm CCL green turtle ID 40728, "Loj1", from Erikub Atoll, Republic of the Marshall Islands to Tarawa, Kiribati. Loj1 traveled a total distance of 2,795 km, in the 234 days the satellite tag transmitted.
Figure 2. 2007-2008 in Conservation considerations revealed by the movements of post-nesting green turtles from the Republic of the Marshall Islands
Figure 2. 2007-2008 post-nesting movement of five green turtles from Erikub Atoll, Republic of the Marshall Islands.
Figure 1 in Conservation considerations revealed by the movements of post-nesting green turtles from the Republic of the Marshall Islands
Figure 1. Map of Republic of the Marshall Islands – major atolls labeled. Inset map of Erikub Atoll, Republic of the Marshall Islands. Loj island, the nesting site where turtles were satellitetagged, is indicated by red arrow.
FIG. 4 in A complete description and conservation assessment of Riella affinis Howe & Underwood (Riellaceae, Sphaerocarpales) new to continental Europe
FIG. 4. — Riella affinis Howe & Underwood: A, habit; B-D, vegetative scales; E, cells from margin of thallus wing; F, female involucre; G, cross-section of female involucre showing seven wings; H, spore in distal view; I, spore in proximal view; J, spore spines from distal face; K, spore spines from proximal face. (all from VAL-Briof. 11.797). Scale bars: A, 5 mm; B, C, D, 100 μm; E, 200 μm; F, G, 500 μm; H, I, 30 μm; J, K, 8 μm.
FIG. 3 in A complete description and conservation assessment of Riella affinis Howe & Underwood (Riellaceae, Sphaerocarpales) new to continental Europe
FIG. 3. — LM and SEM images of spores of Riella affinis Howe & Underwood: A, distal view; B, spines and reticulum from distal pole; C, spines from distal side; D, equatorial row of spines; E, proximal view; F, spines from proximal side; G, distal view; H, spines and reticulum of basal membranes at distal pole; I, spines from distal side; J, proximal view; K, transition between distal and proximal side, showing the equatorial row of distal spines; L, proximal spines and rugose spore surface. (all from VAL-Briof. 11.797). Scale bars: A, E, 50 μm; B, C, D, F, 10 μm; G, J, 30 μm; H, 9 μm; I, 5 μm; K, L, 8 μm.
FIG. 1 in A complete description and conservation assessment of Riella affinis Howe & Underwood (Riellaceae, Sphaerocarpales) new to continental Europe
FIG. 1. — World distribution of Riella affinis Howe & Underwood. Each symbol represents a population. Known records of R. affinis are designated by black dots, new records by a star (populations from Caja and Viso lagoons, Las Lomas, Malaga province, Spain).
FIG. 2 in A complete description and conservation assessment of Riella affinis Howe & Underwood (Riellaceae, Sphaerocarpales) new to continental Europe
FIG. 2. — Habitat, LM and SEM images of Riella affinis Howe & Underwood: A, habitat at the Caja lagoon; B, one individual showing the lobulate wing; C, thallus apex showing a developing winged female involucre with a sporophyte enclosed and antheridia solitary or in small groups in sinuses of the thallus wing (arrowed); D, E, two female involucres showing the variation in involucre wing morphologies; F, SEM image of female involucre showing an interrupted wing (all from VALBriof. 11.797). Scale bars: B, 5 mm; C, 500 μm; D, F, 200 μm; E, 300 μm.
Developments in taxonomy could see safari hunters killing 25 types of antelope, instead of the previous 9, to achieve the 'spiral horned grand slam'. in Taxonomy anarchy hampers conservation
Developments in taxonomy could see safari hunters killing 25 types of antelope, instead of the previous 9, to achieve the 'spiral horned grand slam'.
MIX 'N' MATCH Di egent ogganizations gecognize di egent numbegs of bigd species, mostcy because they use di egent de nitions fog what constitutes a species. in Taxonomy anarchy hampers conservation
MIX 'N' MATCH Di egent ogganizations gecognize di egent numbegs of bigd species, mostcy because they use di egent de nitions fog what constitutes a species.
Figure 6 in Molecular characterization and protective efficacy of a new conserved hypothetical protein of Eimeria tenella
Figure 6. Localization of EtCHP18905 in infected DF-1 cells by indirect immunofluorescence. Parasites incubated with anti-rEtCHP18905, stained with FITC (green)-conjugated secondary antibodies, and counterstained with DAPI (blue). Infected DF-1 cells were collected at indicated time points post-infection. (A) Sporozoites (Spz) in PBS, pRB, posterior refractile body; (B) Spz in complete medium. Infected DF-1 cells were collected at the indicated time points post-infection (pi); (C) 2 hours pi (hpi); (D) immature schizonts (iSC) 48 hpi; (E) mature schizonts (mSC) 72 hpi; (F) merozoites (Mrz) in PBS.
Figure 3 in Molecular characterization and protective efficacy of a new conserved hypothetical protein of Eimeria tenella
Figure 3. Expression and purification of rEtCHP18905. (A) SDS-PAGE analysis of the 5rEtCHP18905. Lanes 1, protein marker; 2, negative control (not induced with IPTG); 3, the rEtCHP18905 protein with the GST-tag protein of the vector (induced with IPTG for 6 h). (B) Western blot analysis of purified rEtCHP18905 protein. Lane 2, protein recognized by an anti GST-Tag monoclonal antibody. (C) Western blot analysis of purified rEtCHP18905 protein. Lane 2, protein recognized by rabbit sera against sporozoite, lane 4 incubated with naïve rabbit serum.
Figure 2 in Molecular characterization and protective efficacy of a new conserved hypothetical protein of Eimeria tenella
Figure 2. Bioinformatic analysis of EtCHP18905. The stop codon is indicated with an asterisk. N-myristoylation sites are double underlined. The transmembrane domain is shaded yellow with black lettering. N-glycosylation sites are surrounded by a black box. cAMP- and cGMP-dependent protein kinase phosphorylation sites are shaded black with white lettering. Tyrosine kinase phosphorylation site is shaded grey with black lettering. Casein kinase II phosphorylation sites are indicated with red lettering. Protein kinase C phosphorylation sites are underlined by a wavy line.
Figure 1 in Molecular characterization and protective efficacy of a new conserved hypothetical protein of Eimeria tenella
Figure 1. Multiple alignment analysis of EtCHP18905 with other Eimeria proteins. DNAMAN was used to analyze the deduced protein sequences. The identical amino acids are listed at the bottom. NCBI reference sequence accession numbers: Eimeria tenella, XP_013231819, Eimeria necatrix, XP_013438465, Eimeria mitis, XP_013355934, Eimeria maxima, XP_013336337, Eimeria acervulina, XP_013251133; GenBank accession numbers: Eimeria praecox, CDI76926, Eimeria brunetti, CDJ52365.
Figure 7 in Molecular characterization and protective efficacy of a new conserved hypothetical protein of Eimeria tenella
Figure 7. Inhibition of sporozoite invasion in vitro by antirEtCHP18905. Anti-rEtCHP18905, rabbit anti-rEtCHP18905 IgG; NA, naïve rabbit sera IgG; GST control, rabbit anti-GST IgG. The symbol "*" represents p <0.05, "**" represents p <0.01, and "***" represents p <0.001 for comparison of treatment with antirEtCHP18905 and naïve rabbit sera IgG and anti-GST IgG at the same concentration. The error bars indicate the standard deviation. All assays were performed in triplicate.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.