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6,569 results for “Long-term”
Illustrations for AI for multiple long-term conditions: Research Support Facility
<p>Illustrations created by <a href="http://www.scriberia.co.uk/">Scriberia</a> as part of <a href="https://www.turing.ac.uk/research/research-projects/ai-multiple-long-term-conditions-research-support-facility">AI for multiple long-term conditions: Research Support Facility.</a> The archived website link is available <a href="https://web.archive.org/web/20250212145350/https://www.turing.ac.uk/research/research-projects/ai-for-multiple-long-term-conditions-research-support-facility?__cf_chl_rt_tk=XKaDrLiiU8hmzZk2rKaWDBVpnO8exVqC4EHijqlWTIQ-1739372030-1.0.1.1-hmHFksRkdOQcBH9PsOgRVdNAatQdr3i4hFOqtyPcyZU">here</a>.</p> <p>The AIM RSF is funded by the NIHR Artificial Intelligence for Multiple Long-Term Conditions (AIM) programme (NIHR202647).</p> <p>When using any of the images, please credit them with</p> <p><em>"This image was created by <a href="http://www.scriberia.co.uk/">Scriberia</a> for AI for multiple long-term conditions: Research Support Facility and is used under a CC-BY licence."</em><br><br>We have created Alternative texts (Alt text) for all images stored in PDF and text format.</p>
GCNT-Plume: Long-term observation of global nuclear power plants thermal plumes using Landsat images and deep learning
<p>This repository contains the relevant code and data for the paper <strong>Long-term observation of global nuclear power plants thermal plumes using Landsat images and deep learning</strong><strong> </strong>(Wei et al, 2023, <em>Remote Sensing of Environment</em>).</p> <p>Specifically, the <strong>U-Net.zip</strong> file includes the associated codes for segmenting surface thermal plumes from nuclear power plants along the global coasts and the Great Lakes by using the U-Net model integrated with prior knowledge. The <strong>GCNT-Plume.zip</strong> file includes the occurrence footprints of core area plumes (the <strong>occurrence_all </strong>folder), raw water temperature increment (WST) images (the <strong>delta </strong>folder), mixed area plumes and annotations (the <strong>extractWithLocation </strong>folder), model-predicted core area plumes (the <strong>prediction*_*</strong> folders), the mixed/core area plumes and background areas in shapefile format (the <strong>sampleAnnotation* </strong>folders), and location information (the <strong>location.xlsx </strong>table). Please refer to the <strong>README.md </strong>file in the <strong>U-Net.zip</strong> file for more detailed information.</p>
Primary data for: "Remotely sensed localised primary production anomalies predict the burden and community structure of infection in long-term rodent datasets"
<p>Datasets</p>
Data from: Single-nucleus RNA-seq and ATAC-seq in outbred rats with divergent cocaine addiction behaviors reveal long-term changes in gene regulation and GABAergic inhibition in the amygdala
<p>This dataset accompanies our publication titled: "Single-nucleus RNA-seq and ATAC-seq in outbred rats with divergent cocaine addiction behaviors reveal long-term changes in gene regulation and GABAergic inhibition in the amygdala."</p> <p><strong>Files Included:</strong></p> <p><strong>1. geno.N26.vcf.gz</strong><br> - Description: Contains genotypes for 26 Heterogeneous Stock rats whose gene expression was predicted.</p> <p><strong>2. pred_expr.Brain.N26.tsv</strong><br> - Description: This tab-delimited table contains predicted relative gene expression in the brain for 26 Heterogeneous Stock rats. <br> - Details: Predictions were made for 8,997 genes from linear models based on cis-eQTLs from whole brain hemisphere tissue downloaded from the <a href="https://ratgtex.org/download/">RatGTEx Portal</a>. A gene is included in the table if it had at least one significant cis-eQTL, and if its predicted expression in these 26 animals had nonzero variance. The values in the table give the predicted log2(relative expression), where log2(2) = 1 is the baseline expression from the two haplotypes of the gene if it had only reference alleles at all its regulatory loci.<br> - Additional Info: Predictions were generated using <strong>gene_expr_pred.py</strong> available at https://github.com/PejLab/gene_expr_pred<br> An explanation of the prediction model is given in https://doi.org/10.1101/2022.01.28.478116</p> <p><strong>3. Behavioral data.xlsx</strong><br> - Description: Contains behavioral data for the Heterogeneous Stock (HS) rats.<br> - Organization: Each sheet in the file corresponds to data for a specific figure.</p> <p><strong>Additional Dataset Locations:</strong></p> <p>The primary datasets generated during this study can be found on the Gene Expression Omnibus under accession number <a href="https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE212417">GSE212417</a></p> <p><strong>Publicly Available Datasets Utilized:</strong></p> <p>- Rattus norvegicus Ensembl v98 reference genome and genome assembly: <a href="http://useast.ensembl.org/Rattus_norvegicus/Info/Index">Rnor_6.0 </a><br> - JASPAR2022 transcription factor binding profiles for vertebrates: <a href="https://jaspar.genereg.net/">JASPAR</a><br> - ENCODE Honeybadger 2 ChIP-seq: <a href="https://personal.broadinstitute.org/meuleman/reg2map/">Broad Institute</a><br> - Liu et al. 2019106 GWAS for tobacco and nicotine addiction summary statistics: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358542/">PubMed</a><br> - RatGTEx Portal tissue-specific cis-eQTLs: <a href="https://ratgtex.org/download/">RatGTEx Portal </a><br> - 1000 Genomes European reference panel: <a href="https://alkesgroup.broadinstitute.org/LDSCORE/">Alkes Group</a><br> - KEGG pathways: <a href="https://www.kegg.jp/kegg/rest/keggapi.html">KEGG API</a></p>
Data from: Long-term changes in soil carbon and nitrogen fractions in switchgrass, native grasses, and no-till corn bioenergy production systems
<p>Cellulosic bioenergy is a primary land-based climate mitigation strategy, with soil carbon (C) storage and nitrogen (N) conservation as important mitigation elements. Here, we present 13 years of soil C and N change under three cellulosic cropping systems: monoculture switchgrass (<em>Panicum virgatum</em> L.), a five native grasses polyculture, and no-till corn (<em>Zea mays</em> L.). Soil C and N fractions were measured four times over 12 years. Bulk soil C in the 0–25 cm depth at the end of the study period ranged from 28.4 (± 1.4 se) Mg C ha<sup>−1</sup> in no-till corn, to 30.8 (± 1.4) Mg C ha<sup>−1</sup> in switchgrass, and to 34.8 (± 1.4) Mg C ha<sup>−1</sup> in native grasses. Mineral-associated organic matter (MAOM) ranged from 60% to 90% and particulate organic matter (POM) from 10% to 40% of total soil C. Over 12 years, total C as well as both C fractions persisted under no-till corn and switchgrass and increased under native grasses. In contrast, POM N stocks decreased 33% to 45% across systems, whereas MAOM N decreased by less than 13% and only in no-till corn. Declining POM N stocks likely reflect pre-establishment land use, which included alfalfa and manure in earlier rotations. Root production and large soil aggregate formation explained 69% (p < 0.001) and 36% (p = 0.024) of total soil C change, respectively, and 60% (p = 0.020) and 41% (p = 0.023) of soil N change, demonstrating the importance of belowground productivity and soil aggregates for producing and protecting soil C and conserving soil N. Differences between switchgrass and native grasses also indicate a dependence on plant diversity. Soil C and N benefits of bioenergy crops depend strongly on root productivity and pre-establishment land use.</p>
Alien plant fitness is limited by functional trade-offs rather than a long-term increase in competitive effects of native communities
<p><span>Alien plants experience novel abiotic conditions and interactions with native communities in the introduced area. Intra- and interspecific selection on functional traits in the new environment may lead to increased population growth with time since introduction (residence time). However, selection regimes might differ depending on the invaded habitat. Additionally, in high-competition habitats, a build-up of biotic resistance of native species due to accumulation of eco-evolutionary experience to aliens over time may limit invasion success. We tested if the effect of functional traits and the population dynamics of aliens depends on interspecific competition with native plant communities. We conducted a multi-species experiment with 40 annual Asteraceae that differ in residence time in Germany. We followed their population growth in monocultures and in interspecific competition with an experienced native community (varying co-existence times between focals and community). To more robustly test our findings, we used a naïve community that never co-existed with the focals. We found that high seed mass decreased population growth in monocultures but tended to increase population growth under high interspecific competition. We found no evidence for a build-up of competition-mediated biotic resistance by the experienced community over time. Instead, population growth of the focal species was similarly inhibited by the experienced and naïve community. By</span><span> comparing the effect of experienced and naïve communities on population dynamics over two years across a large set of species with a high variation in functional traits and residence time, </span><span>this study advances the understanding of the long-term dynamics of plant invasions. I</span><span>n our study system, population growth of alien species was not limited by</span> <span>an increase of competitive effects by native communities (one aspect of biotic resistance) over time. </span><span>Instead, invasion success of alien plants may be limited because initial spread in low-competition habitats requires different traits than establishment in high-competition habitats. </span></p>
Stage-mediated priority effects and season lengths shape long-term competition dynamics
<p>The relative arrival time of species can affect their interactions and thus determine which species persist in a community. Although this phenomenon, called priority effect, is widespread in natural communities, it is unclear how it depends on the length of growing season. Using a seasonal stage-structured model, we show that differences in stages of interacting species could generate priority effects by altering the strength of stabilizing and equalizing coexistence mechanisms, changing outcomes between exclusion, coexistence, and positive frequency dependence. However, these priority effects are strongest in systems with just one or a few generations per season and diminish in systems where many overlapping generations per season dilute the importance of stage-specific interactions. Our model reveals a novel link between the number of generations in a season and the consequences of priority effects, suggesting that consequences of phenological shifts driven by climate change should depend on specific life histories of organisms.</p>
Data from: evaluating the use of lake sedimentary DNA in palaeolimnology: a comparison with long-term microscopy-based monitoring of the phytoplankton community
<p>Palaeolimnological records provide valuable information about how phytoplankton respond to long-term drivers of environmental change. Traditional palaeolimnological tools such as microfossils and pigments are restricted to taxa that leave sub-fossil remains, and a method that can be applied to the wider community is required. Sedimentary DNA (sedDNA), extracted from lake sediment cores, shows promise in palaeolimnology, but validation against data from long-term monitoring of lake water is necessary to enable its development as a reliable record of past phytoplankton communities. To address this need, 18S rRNA gene amplicon sequencing was carried out on lake sediments from a core collected from Esthwaite Water (English Lake District) spanning ~105 years. This sedDNA record was compared with concurrent long-term microscopy-based monitoring of phytoplankton in the surface water. Broadly comparable trends were observed between the datasets, with respect to the diversity and relative abundance and occurrence of chlorophytes, dinoflagellates, ochrophytes and bacillariophytes. Up to 20% of genera were successfully captured using both methods, and sedDNA revealed a previously undetected community of phytoplankton. These results suggest that sedDNA can be used as an effective record of past phytoplankton communities, at least over timescales of less than 100 years. However, a substantial proportion of genera identified by microscopy were not detected using sedDNA, highlighting the current limitations of the technique that require further development such as reference database coverage. The taphonomic processes which may affect its reliability, such as the extent and rate of deposition and DNA degradation, also require further research.</p>
Predation risk drives long-term shifts in migratory behavior and demography in a large herbivore population
<p>Migration is an adaptive life-history strategy that helps individuals across taxa maximize fitness by obtaining forage and avoiding predation risk. The mechanisms driving migratory changes are poorly understood, and links between migratory behavior, space use, and demographic consequences are rare. Here, we use a nearly 20-year record of individual-based monitoring of elk (<em>Cervus canadensis</em>) to test hypotheses for changing patterns of migration in a large herbivore, elk (<em>Cervus canadensis</em>), in and adjacent to a large protected area in Banff National Park (BNP), Canada. We test whether bottom-up (forage quality) or top-down (predation risk) factors explained trends in i) the proportion of individuals using 5 different migratory tactics, ii) differences in survival rates of migratory tactics during migration and whilst on summer ranges, iii) cause-specific mortality by wolves and grizzly bears, and iv) population abundance. We found dramatic shifts in migration consistent with behavioral plasticity in individual choice of annual migratory routes. Shifts were inconsistent with exposure to the bottom-up benefits of migration. Instead, exposure to landscape gradients in predation risk caused by exploitation outside the protected area drove migratory shifts. Carnivore exploitation outside the protected area led to higher survival rates for female elk remaining resident or migrating outside the protected area. Cause-specific mortality aligned with exposure to predation risk along migratory routes and summer ranges. Wolf predation risk was higher on migratory routes than summer ranges of montane-migrant tactics, but wolf predation risk traded-off with heightened risk from grizzly bears on summer ranges. A novel eastern migrant tactic emerged following a large forest fire that enhanced forage in an area with lower predation risk outside of the protected area. The changes in migratory behavior translated to population abundance, where abundance of the montane-migratory tactics declined over time. The presence of diverse migratory life histories maintained a higher total population abundance than would have been the case with one migratory tactic in the population. Our study demonstrates the complex ways in which migratory populations change over time through behavioral plasticity and associated demographic consequences because of individuals balancing predation risk and forage trade-offs.</p>
Long-term Safety and Efficacy Study of Teduglutide in Pediatric Participants With Short Bowel Syndrome (SBS)
ClinicalTrials.gov study NCT02954458. IPD Sharing: NO. Countries: 6. Publications: 0.
A Phase 3, Long-term, Extension Study of TVP-1012 (1 mg) in Early Parkinson's Disease Participants
ClinicalTrials.gov study NCT02337751. IPD Sharing: YES. Countries: 1. Publications: 1.
A Randomized, Double-Blind, Placebo-Controlled Study With an Open-Label, Long-Term Safety Phase to Evaluate the Efficacy and Safety of TV-44749 in Adults With Schizophrenia
ClinicalTrials.gov study NCT05693935. IPD Sharing: YES. Countries: 5. Publications: 2.
Long-term Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome Who Completed the TED-C13-003 Study
ClinicalTrials.gov study NCT02949362. IPD Sharing: NO. Countries: 2. Publications: 0.
A Study of Long-Term Safety and Efficacy of Lanadelumab for Prevention of Acute Attacks of Non-histaminergic Angioedema With Normal C1-Inhibitor
ClinicalTrials.gov study NCT04444895. IPD Sharing: YES. Countries: 10. Publications: 1.
Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks
ClinicalTrials.gov study NCT04739059. IPD Sharing: YES. Countries: 14. Publications: 0.
Phase IIIB-IV Long-Term Follow-up Study for Patients Who Participated in CAMMS03409
ClinicalTrials.gov study NCT02255656. IPD Sharing: YES. Countries: 19. Publications: 9.
Long-Term Study of Hospitalized Dengue & Safety in Thai Children Included in a Tetravalent Dengue Vaccine Efficacy Study
ClinicalTrials.gov study NCT01983553. IPD Sharing: YES. Countries: 1. Publications: 3.
A Study of Long-term Effects of Vedolizumab Subcutaneous in Adults With Ulcerative Colitis and Crohn's Disease
ClinicalTrials.gov study NCT02620046. IPD Sharing: YES. Countries: 33. Publications: 1.
A Long-Term Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency
ClinicalTrials.gov study NCT02004704. IPD Sharing: YES. Countries: 7. Publications: 3.
An Extension Study of HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Idursulfase-IT in Conjunction With Elaprase in Pediatric Participants With Hunter Syndrome and Cognitive Impairme
ClinicalTrials.gov study NCT01506141. IPD Sharing: YES. Countries: 3. Publications: 3.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.