Find research datasets worth reusing

opencc-by-4.0Oct 2021View details →

Excel sheet to predict Multi-Hydro green roof module's behaviour

To prevent spending long computational times running a lot of simulations using Multi-Hydro it is possible to use this excel sheet to predict the its green roof module's behaviour. It is usefull when some parameters need to be calibrated or estimated before the final simulation.

openother-openOct 2021View details →

To Automatically Map Source Code Entities to Architectural Modules with Naive Bayes: Replication Package

This is the replication package for the JSS article To Automatically Map Source Code Entities to Architectural Modules with Naive Bayes. It provides the source data files and the r-script to produce analysis and images.

opencc-by-4.0Sep 2021View details →

Nanoplastics Modulate the Outcome of Zooplankton- Microparasite Interactions

The updated version of the scripts are in is Github repo: https://github.com/StevetheGreek97/DaMN_Project.git

GCN-TFiLM: Modelling Black-box Audio Effects with Time-varying Feature Modulation

Dataset, checkpoints, evaluation, and supplementary material associated with the following publication: <a href="https://arxiv.org/abs/2211.00497">Modelling Black-box Audio Effects with Time-varying Feature Modulation</a> Citation: <pre><code>@inproceedings{comunita2023modelling, title={Modelling black-box audio effects with time-varying feature modulation}, author={Comunit{\`a}, Marco and Steinmetz, Christian J and Phan, Huy and Reiss, Joshua D}, booktitle={ICASSP 2023-2023 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)}, pages={1--5}, year={2023}, organization={IEEE} }</code></pre>

opencc-by-4.0Nov 2022View details →

Simulation data associated to the manuscript "Controlling the Hydrophilicity of the Electrochemical Interface to Modulate the Oxygen-Atom Transfer in Electrocatalytic Epoxidation Reactions"

Contains input files used to perform the simulations of the article: Controlling the Hydrophilicity of the Electrochemical Interface to Modulate the Oxygen-Atom Transfer in Electrocatalytic Epoxidation Reactions Florian Dorchies, Alessandra Serva, Dorian Crevel, Jérémy de Freitas, Nikolaos Kostopoulos, Marc Robert, Ozlem Sel, Mathieu Salanne and Alexis Grimaud *ChemRxiv*, 2022 https://doi.org/ 10.26434/chemrxiv-2022-wjsbs-v2 Each folder contains 2 input files for MetalWalls, which is available [here](https://gitlab.com/ampere2/metalwalls). The corresponding systems are the following: <ul> <li>Bulk liquids: <ul> <li>Acetonitrile - water - LiClO4</li> <li>Acetonitrile - water - LiClO4 with cyclooctene</li> <li>Acetonitrile - water - TBAClO4</li> <li>Acetonitrile - water - TBAClO4 with cyclooctene</li> </ul> </li> <li>Liquids in contact with gold electrodes: <ul> <li>Acetonitrile - water - LiClO4</li> <li>Acetonitrile - water - LiClO4 with cyclooctene</li> <li>Acetonitrile - water - TBAClO4</li> <li>Acetonitrile - water - TBAClO4 with cyclooctene</li> </ul> </li> </ul>

opencc-zeroNov 2022View details →

How detritivores, plant traits and time modulate coupling of leaf versus woody litter decomposition rates across species

1. Plant functional traits are increasingly used to understand ecological relationships and (changing) ecosystem functions. For understanding ecosystem-level biogeochemistry, we need to understand how (much) traits co-vary between different plant organs across species, and its implications for litter decomposition. However, we do not know how the degree of synchronous variation in decomposition rates between organs across species could be influenced by different keystone invertebrates decomposing different senesced plant organs, especially in warm-climate forests. Here we asked whether interspecific patterns in wood and leaf decomposition rates and in the spectra of resource economics traits underpinning them, co-vary across woody species; and how (much) the keystone invertebrate decomposers of the litter of these organs enhance or lower such co-variation of decomposition rates through time. 2. We addressed these questions through an 18-month "common-garden" decomposition experiment using leaf, twig and branch litter of 41 woody species in two distant subtropical forest sites in east China. We quantified the effects of leaf, twig, and branch functional traits and their respective key invertebrates (moth larvae, termites) on the decomposition rates of those organs. 3. Interspecific variation in wood traits was partly decoupled from that in leaf traits across species, while strong coupling was found between twigs and branches. The co-variation between leaf and woody organ decomposition rates was altered dynamically through the shifting activities of the key decomposers, which created non-linear relationships of invertebrate litter consumption as a function of species rankings along the resource economic trait spectra of leaves and branches. 4. The deviations from coupling of decomposition rates between organs were likely caused by combinations of three mechanisms: (1) (de-)coupling between organs of other traits, not commonly considered in resource economics spectra (e.g., resins) (2) leaf and wood decomposers having specific diet requirements, and (3) temporal patterns of the decomposers' activity. 5. Synthesis. Our study highlights the importance of considering the different ways by which invertebrate detritivores drive decomposition processes through time. Under the ongoing biodiversity decline, future research would benefit from a better understanding of the role of the dynamic interactions between detritivore activities and plant functional traits on the carbon turnover in ecosystems.

opencc-by-nc-4.0Nov 2022View details →

datset of "Networks and genes modulated by posterior hypothalamic stimulation in patients with aggressive behaviours: Analysis of probabilistic mapping, normative connectomics, and atlas-derived transcriptomics of the largest international multi-centre dataset"

This dataset accompanies the manuscript: "Networks and genes modulated by posterior hypothalamic stimulation in patients with aggressive behaviours: Analysis of probabilistic mapping, normative connectomics, and atlas-derived transcriptomics of the largest international multi-centre dataset." DOI: (https://doi.org/10.1101/2022.10.29.22281666) by Flavia Venetucci Gouveia1,2,3*&dagger;,Jürgen Germann4,5&dagger;, Gavin JB Elias4,5, Alexandre Boutet4,6, Aaron Loh4,5, Adriana Lucia Lopez Rios7,8, Cristina V Torres Diaz9, William Omar Contreras Lopez10,11, Raquel CR Martinez3,12, Erich T Fonoff13, Juan C Benedetti-Isaac14,  Peter Giacobbe 2,15,16, Pablo M Arango Pava17, Han Yan5,18, George M Ibrahim5, 18,19,20, Nir Lipsman2,5,15, Andres M Lozano4,5, Clement Hamani2,5,15* 1. Neuroscience and Mental Health, Hospital for Sick Children Research Institute; Toronto, Canada  2. Sunnybrook Research Institute; Toronto, Canada 3. Division of Neuroscience, Sírio-Libanês Hospital; São Paulo, Brazil 4. Division of Neurosurgery, Department of Surgery, University Health Network, Toronto, Canada 5. Division of Neurosurgery, Department of Surgery, University of Toronto; Toronto, Canada 6. Joint Department of Medical Imaging, University of Toronto; Toronto, Canada 7. Department of Functional and Stereotactic Neurosurgery, University Hospital San Vicente Fundación,     Medellín, Colombia 8. Department of Functional and Stereotactic Neurosurgery, San Vicente Fundación, Rionegro, Colombia 9. Department of Neurosurgery, University Hospital La Princesa; Madrid, Spain 10. Nemod Research Group, Universidad Autónoma de Bucaramanga; Bucaramanga, Colombia 11. Division of Functional Neurosurgery, Department of Neurosurgery, FOSCAL Clinic; Bucaramanga,       Colombia 12. LIM 23, Institute of Psychiatry, School of Medicine, University of São Paulo; São Paulo, Brazil 13. Department of Neurology, Integrated Clinic of Neuroscience, School of Medicine, University of São Paulo;       São Paulo, Brazil. 14. Stereotactic and Functional Neurosurgery Division of the International Misericordia Clinic; Barranquilla,      Colombia 15. Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre; Toronto, Canada 16. Department of Psychiatry, University of Toronto; Toronto, Canada 17. Servicio de Neuocirugia Funcional y Esterotaxia, Clinica Comuneros Bucaramanga, Clinica Desa y Clinica       Dime Neurocardiovascular de Cali; Clinica Nueva del Lago, Bogota, Colombia. 18. Division of Neurosurgery, The Hospital for Sick Children; Toronto, Canada 19. Institute of Biomedical Engineering, University of Toronto; Toronto, Canada 20. Institute of Medical Science, University of Toronto; Toronto, Canada &dagger; Flavia Venetucci Gouveia and Jürgen Germann contributed equally to this work and share first authorship. * Corresponding Author: Dr. Flavia Venetucci Gouveia. Neuroscience and Mental Health, Hospital for Sick Children Research Institute. 686, Bay Street, Toronto, ON, M5G 0A4, Canada. flavia.venetuccigouveia@sickkids.ca * Corresponding Author: Dr. Clement Hamani. Sunnybrook Research Institute. 2075 Bayview Ave, S126. Toronto, ON, M4N3M5, Canada. clement.hamani@sunnybrook.ca It contains a zip folder ("estimated_binary_Volume_of_Tissue_Activated.zip") with one file (in nii.gz format) per patient estimating the Volume of Activated Tissue for that patient (the estimated 'reach' of the active DBS stimulation) and a demographics file. The case numbers are identical to Table 1 in the manuscript.

opencc-zeroNov 2022View details →

Blood glucose modulation and safety of efferent vagus nerve stimulation in a type 2 diabetic rat model

Vagus nerve stimulation is emerging as a promising treatment for type 2 diabetes. Here, we evaluated the ability of stimulation of the vagus nerve to reduce glycaemia in awake, freely moving metabolically compromised rats. A model of type 2 diabetes (n=10) was induced using a high-fat diet and low doses of streptozotocin. Stimulation of the abdominal vagus nerve was achieved by pairing 15 Hz pulses on a distal pair of electrodes with high-frequency blocking stimulation (26 kHz, 4 mA) on a proximal pair of electrodes to preferentially produce efferent conducting activity (eVNS). Stimulation was well tolerated in awake, freely moving rats. During 1 hour of eVNS, glycaemia decreased in 90% of subjects (-1.25±1.25 mM·h, P=0.017), and 2 dB above neural threshold was established as the most effective 'dose' of eVNS (P=0.009). Following 5 weeks of implantation, eVNS was still effective, resulting in significantly decreased glycaemia (-1.7±0.6 mM·h, P=0.003) during 1 hour of eVNS. There were no overt changes in fascicle area or signs of histopathological damage observed in implanted vagal nerve tissue following chronic implantation and stimulation. Demonstration of the biocompatability and safety of eVNS in awake, metabolically compromised animals is a critical first step to establishing this therapy for clinical use. With further development, eVNS could be a promising novel therapy for treating type 2 diabetes.

SALTECH Module video | Detailed version

In August 2022, a detailed version of the SALTECH Module video was developed. It included more technical details on each of the technologies and the partners involved in their development and implementation. After multiple revisions to refine the technical information and infographics, the video was published in November 2022. The production of this video included pre-production (script-writing, creating storyboards), production (designing and animating infographics, motion graphics and recording voice-over), and post-production (compiling, video and audio editing, subtitling, visual effects and rendering). -- Project Ô has developed SALTECH module to remove nitrates from land-based mariculture systems. It will treat mariculture water to create the opportunity for an almost 100% closed loop of water use by removing nitrates. Some of the used water can also be treated to remove some of the salt. This allows the nutrient-rich water to be used for salt-tolerant crops. These crops can be used as food for the fish.

MOBILE3TECH Module video | Detailed version

In August 2022, a detailed version of the MOBILE3TECH module video was developed. It included more technical details on each of the technologies and the partners involved in their development and implementation. After multiple revisions to refine the technical information and infographics, the video was published in November 2022. The production of this video included pre-production (script-writing, storyboards), production (designing and animating infographics, creating motion graphics, recording voice-over), and post-production (compiling, video and audio editing, subtitling, visual effects and rendering). -- Project Ô has developed MOBILE3TECH module to treat the toxic used water produced by industry MOBILE3TECH module is a cost-effective and mobile solution. It contains an advanced control unit, which can assess the toxicity of used water before it is sent to a water treatment plant. This will determine if pre-treatment is needed with MOBILE3TECH module and therefore ensure that only required treatments are carried out.

opencc-by-4.0Jun 2022View details →

MOBILE3TECH Module video | Short version (Spanish)

Using Project Ô deliverables as a reference as well as a series of meetings held with the partners who developed each of the technologies, the MOBILE3TECH module video was published in July 2022. The production of these videos included pre-production (script-writing, creating storyboards), production (designing and animating infographics, motion graphics, translating the script to Spanish and recording voice-overs), and post-production (compiling, video and audio editing, subtitling, visual effects and rendering). -- Project Ô has developed MOBILE3TECH module to treat the toxic used water produced by industry MOBILE3TECH module is a cost-effective and mobile solution. It contains an advanced control unit, which can assess the toxicity of used water before it is sent to a water treatment plant. This will determine if pre-treatment is needed with MOBILE3TECH module and therefore ensure that only required treatments are carried out.

ADV.ERT Module video | Detailed version

In August 2022, a detailed version of the ADV.ERT module video was developed. It included more technical details on each of the technologies and the partners involved in their development and implementation. After multiple revisions to refine the technical information and infographics, the video was published in November 2022. The production of this video included pre-production (script-writing, storyboards), production (designing and animating infographics, creating motion graphics, recording voice-over), and post-production (compiling, video and audio editing, subtitling, visual effects and rendering). -- Project Ô has developed ADV.ERT module to treat contaminated freshwater, including that from groundwater sources. It can be operated as a remote unit, independently of a water treatment plant to aid the sustainable recovery of an untapped water resource. This module has low investment and operational costs, and a low environmental impact. It can be used as part of a circular water economy by ensuring high-quality water is returned to its source after use.

opencc-by-4.0Jul 2022View details →

SALTECH Module video | Short version

Using Project Ô deliverables as a reference as well as a series of meetings held with the partners who developed each of the technologies, the SALTECH Module video was published in August 2022. The production of this video included pre-production (script-writing, creating storyboards), production (designing and animating infographics, motion graphics, translating the script to Hebrew and Arabic, recording voice-over), and post-production (compiling, video and audio editing, subtitling, visual effects and rendering). -- Project Ô has developed SALTECH module to remove nitrates from land-based mariculture systems. It will treat mariculture water to create the opportunity for an almost 100% closed loop of water use by removing nitrates. Some of the used water can also be treated to remove some of the salt. This allows the nutrient-rich water to be used for salt-tolerant crops. These crops can be used as food for the fish.

opencc-by-4.0Jun 2022View details →

MOBILE3TECH Module video | Short version

Using Project Ô deliverables as a reference as well as a series of meetings held with the partners who developed each of the technologies, the MOBILE3TECH module video was published in July 2022. The production of these videos included pre-production (script-writing, creating storyboards), production (designing and animating infographics, motion graphics, translating the script to Spanish and recording voice-overs), and post-production (compiling, video and audio editing, subtitling, visual effects and rendering). -- Project Ô has developed MOBILE3TECH module to treat the toxic used water produced by industry MOBILE3TECH module is a cost-effective and mobile solution. It contains an advanced control unit, which can assess the toxicity of used water before it is sent to a water treatment plant. This will determine if pre-treatment is needed with MOBILE3TECH module and therefore ensure that only required treatments are carried out.

Data from: Wallace 2: A shiny app for modeling species niches and distributions redesigned to facilitate expansion via module contributions

These are the occurrence locality datasets used in the example provided in "wallace 2: a shiny app for modeling species niches and distributions redesigned to facilitate expansion via module contributions" published in Ecography (DOI: 10.1111/ecog.06547). The analysis workflow is displayed in the Supporting information of the paper (Fig. S1), and these data are also used in the wallace 2 vignette (<a href="https://wallaceecomod.github.io/wallace/articles/tutorial-v2.html">https://wallaceecomod.github.io/wallace/articles/tutorial-v2.html</a>).

Source data for - Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo: Implications for theragnostics

Neurovascular coupling (NVC) is a mechanism that, amongst other known and latent critical functions, ensures activated brain regions are adequately supplied with oxygen and glucose. This biological phenomenon underpins non-invasive perfusion-related neuroimaging techniques, and recent reports have implicated NVC impairment in several neurodegenerative disorders. Yet, much remains unknown regarding NVC in health and disease, and only recently has there been burgeoning recognition of a close interplay with brain thermodynamics. Accordingly, we developed a novel multi-modal approach to systematically modulate cortical temperature and interrogate the spatiotemporal dynamics of sensory-evoked NVC. We show that changes in cortical temperature profoundly and intricately modulate NVC, with low temperatures associated with diminished oxygen delivery, and high temperatures inducing a distinct vascular oscillation. These observations provide novel insights into the relationship between NVC and brain thermodynamics, with important implications for brain-temperature-related therapies, functional biomarkers of elevated brain temperature, and in-vivo methods to study neurovascular coupling.

Expert consensus on core topics of sustainable development online learning module for family physicians: A Delphi study

Objectives Medical institutions must provide learning experiences that enhance the knowledge and perspectives of Sustainable Development (SD) to prepare trainees of family medicine to become competent global citizens. The aim of this study was to develop an SD online learning module for trainees of family medicine. Design This mixed-methods study was conducted from January 2020 to May 2021, beginning with a literature review concerning Sustainable Development Goals (SDG) and Education for Sustainable Development (ESD) in medicine. In-depth interviews were held to assess the relevant needs of family medicine training, followed by a two-round Delphi survey with experienced educators (n = 21) in family medicine to refine and achieve consensus on the appropriate SDG topics for family physicians. Setting All residency training programmes in Thailand. Participants Members of the Residency Training Committee, Royal College of Family Physicians of Thailand. Results The literature review and in-depth interviews identified 12 topics of SD that were required for family physicians. The first round of the Delphi survey was concluded by identifying 7 core topics with additional suggestions. In the second round, a consensus was obtained among the experienced educators regarding 7 core topics: 1) A definition of SD, 2) Principles of SD, 3) SDG, 4) A new concept of SD, 5) SD in the context of Thailand, 6) SD and principles of family medicine and 7) SD and family practice. These core topics were grouped within three main objectives and three sub-modules. Conclusions An online learning module of SD for family physicians was developed using a modified Delphi method. This included three sub-modules: 1) Concept and principles of SD, 2) SDG and 3) SD and its integration with family practice. This online learning module will provide additional resources for trainees of family medicine and Thai family physicians to expand their knowledge and perspectives of sustainable development.

Data from: Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice

Lipopolysaccharide (LPS)-accelerated autoimmune glomerulonephritis (GN) in lupus-prone NZBWF1 mice is a preclinical model that is potentially applicable for investigating lipidome-modulating interventions. LPS can be expressed as one of two chemotypes: smooth LPS (S-LPS) and rough LPS (R-LPS) which is devoid of O-antigen polysaccharide sidechain. Since these chemotypes differentially affect TLR4-mediated immune cell responses, these differences may influence GN induction. Therefore, we initially compared the effects of subchronic i.p. injection for 5 wk with 1) Salmonella S-LPS, 2) Salmonella R-LPS, or 3) saline vehicle (VEH) (Study 1) in female NZBWF1 mice. R-LPS induced robust elevations in blood urea nitrogen, proteinuria, and hematuria that were not evident in VEH- or S-LPS-treated mice. Histopathologic examination of R-LPS-treated mice one week after final injection further revealed more robust hypertrophy, hyperplasia, thickened membranes, lymphocytic accumulation containing B and T cells, and glomerular IgG deposition consistent with GN but not in VEH- or S-LPS-treated groups. R-LPS but not S-LPS induced spleen enlargement with lymphoid hyperplasia as well as modest inflammatory cell recruitment in the liver. We next employed our optimized R-LPS model to discern the impact of two lipidome-modulating interventions, omega-3 polyunsaturated fatty acid (PUFA) supplementation and soluble epoxide hydrolase (sEH) inhibition, on GN (Study 2). Specifically, the effects of consuming the omega-3 PUFA docosahexaenoic acid (DHA) (10 g/kg diet) and/or the sEH inhibitor TPPU (22.5 mg/kg diet) on R-LPS triggering were compared. Resultant blood fatty acid profiles and epoxy fatty acid concentrations reflected the anticipated DHA- and TPPU-mediated lipidome changes. The relative rank order of R-LPS-induced GN severity among groups fed experimental diets based on proteinuria, hematuria, histopathologic scoring, and glomerular IgG deposition was: VEH/CON < R-LPS/DHA ≈ R-LPS/TPPU <<< R-LPS/ TPPU+DHA ≈ R-LPS/CON. These interventions had modest to negligible effects on R-LPS-induced splenomegaly, plasma antibody responses, liver inflammation, and inflammation-associated kidney gene expression. Collectively, our results show for the first time that absence of O-antigenic polysaccharide in R-LPS is critical to accelerated GN in lupus-prone mice. Furthermore, intervention by lipidome modulation through DHA feeding or sEH inhibition suppressed R-LPS-induced GN; however, these ameliorative effects were greatly diminished upon combining the treatments.

opencc-by-4.0Aug 2022View details →

Modulation of glia activation by TRPA1 antagonism in a pre-clinical model of migraine

This dataset comprises the findings obtained in the study aimed at investigating the relationship between TRPA1 channels and glia activation in the modulation of trigeminal hyperalgesia in preclinical models of migraine. In vivo assessments performed in male Sprague-Dawley rats four hours after treatment with nitroglycerin (10mg/kg, i.p.) or its vehicle in the acute model, and 24h after the last treatment with nitroglycerin (5mg/kg, i.p.) or its vehicle in the chronic model (injections every other day over a 9-day period for a total of five injections): - evaluation of trigeminal hyperalgesia in the orofacial formalin test: the face rubbing was measured counting the seconds the animal spent grooming the injected area (upper lip, lateral to the nose) with the ipsilateral forepaw or hindpaw 0–3 min (Phase I) or 12–45 min (Phase II) after formalin injection (50 µl, s.c.). The observation time was divided into 15 blocks of 3 min each. Ex vivo assessments performed on samples collected at the end of the behavioral test: - Microglia and astroglia activation was evaluated the trigeminal nucleus caudalis by means of immunofluorescence staining. Specifically, the medullary segment containing the trigeminal nucleus caudalis (between +1 and -5 mm from the obex) was removed and cut transversely at 30 µm thickness on a freezing sliding microtome. The anti-cluster of differentiation molecule 11b (anti-CD11b, 1:300) primary antibody (to detect microglia) or rabbit anti-glial fibrillary acidic protein (anti-GFAP, 1:500) primary antibody (to label astrocytes) were used. Cell count for microglia and astroglia was assessed by counting CD11b- or GFAP-positive cells, respectively, from a stack of 16 pictures (1μm-thick, 20x magnification) taken from four representative sections alongside the trigeminal nucleus caudalis. The total number of CD11b- and GFAP-positive cells of the four sections were summed and expressed per mm2. Glial activation state was rated on a scale ranging from score 0 to 3. The final activation state was calculated as the average of the scores assessed for each of the four representative sections of the trigeminal nucleus caudalis. - Satellite glial cells activation (anti-GFAP, 1:600), calcitonin gene-related peptide (CGRP) immunoreactivity (anti-CGRP, 1:500) and macrophage infiltration (anti-Iba1, 1:500) were evaluated in trigeminal ganglia using immunofluorescence staining. Specifically, trigeminal ganglia were removed and sectioned longitudinally at 20 µm thickness using a cryostat.  In the trigeminal ganglia, the number of Iba1+ cells/area and the % of GFAP-encircled neurons and of CGRP+ neurons were assessed in whole TG sections acquired at 20X magnification. - Gene expression analysis: mRNA expression levels of (TNF-alpha), interleukin (IL) -1beta, IL-6, IL-10, inducible nitric oxide synthase (iNOS), GFAP, CD11b and CGRP in medulla oblongata and trigeminal ganglia. mRNA levels were measured by rt-PCR. All samples were assayed in triplicate and gene expression levels were calculated according to 2−∆∆Ct = 2− (∆Ct gene − ∆Ct housekeeping gene) formula by using Ct (cycle threshold) values. Results - In nitroglycerin-treated rats, ADM_12 showed an anti-hyperalgesic effect in both the acute and chronic models. ADM_12 was able to counteract the acute and chronic nitroglycerin-induced changes in cytokines’ gene expression in both the areas of interest. In the acute nitroglycerin model, we reported a significant increase in microglial and astroglial activation in the trigeminalis nucleus caudalis area, which was abolished by ADM_12 treatment. In the chronic model, we detected an activation of satellite glial cells in the trigeminal ganglia in nitroglycerin-treated rats; this was inhibited by ADM_12. This latter also prevented the increase in CGRP gene expression levels in the trigeminal ganglia of nitroglycerin-treated animals.