Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
46,151
datasets available to search
ShareScore release 0.9.0
Dataset results
46,151 results for “Safety”
Raw Data for the article: Impact of the Organizational Model Adopted during the COVID-19 Pandemic on the Perceived Safety of Intensive Care Unit Staff
<p><strong>Background: </strong>The SARS-CoV-2 pandemic had a devastating health, social, and economic effect on the population. Organizational, technical and structural operations aimed at protecting staff, outpatients and inpatients were implemented in an Italian hospital with a COVID-19 dedicated intensive care unit. The impact of the organizational model adopted on the perceived safety among staff was evaluated.</p> <p><strong>Methods: </strong>Descriptive, structured and voluntary, anonymous, non-funded, self-administered cross-sectional surveys on the impact of the organizational model adopted during COVID-19 on the perceived safety among staff.</p> <p><strong>Results: </strong>Response rate to the survey was 67.4% (153 completed surveys). A total of 91 (59%) of respondents had more than three years of ICU experience, while 16 (10%) were employed for less than one year. Group stratification according to profession: 74 nurses (48%); 12 medical-doctors (7%); 11 physiotherapists (7%); 35 nurses-aides (22%); 5 radiology-technicians (3%); 3 housekeeping (1%); 13 other (8%). The organizational model implemented at ISMETT made them feel safe during their workday. A total of 113 (84%) agreed or strongly agreed with the sense of security resulting from the implemented measures. A vast majority of respondents perceived COVID-19 as a dangerous and deadly disease (94%) not only for themselves but even more as vectors towards their families (79%). A total of 55% of staff took isolation measures and moved away from their home by changing personal habits. The organizational model was perceived overall as appropriate (91%) to guarantee their health.</p> <p><strong>Conclusion: </strong>The vast majority of respondents perceived the overall model applied during an unexpected, emergency situation as appropriate.</p>
Raw Data for the article: COVID-19 safety measures at the Radiology Unit of a Transplant Institute: the non-COVID-19 patient's confidence with safety procedures
<p><strong>Purpose: </strong>To support the wellbeing of both patients and their families, our aim was to investigate the satisfaction of non-COVID in- and out-patients regarding safety measures implemented at our radiology unit of a transplant institute against COVID infection.</p> <p><strong>Materials and methods: </strong>Over a five-month period, adult patients' feedback was obtained by a questionnaire on the fear of contracting COVID-19 during a radiology examination, the perceived delay in treatment, and the following safety measures implemented: modified schedules to limit the number of patients in the waiting area and to maximize social distancing; assistance by staff when visitors were not admitted; cleaning and disinfection of machines; mask wearing and hand hygiene of staff; and staff advice on hand hygiene and infection control precautions.</p> <p><strong>Results: </strong>Over a five-month period, our preliminary results (387 patients) showed general patient satisfaction (99.1%) with safety measures applied at our radiology unit. Patients were satisfied with distancing and assistance by staff (100%), cleaning and disinfection (91%), mask wearing and hand hygiene of the staff (97%), and staff advice (94%). There was some criticism of the perceived delay in treatment (7.3%) and in the scheduling of the waiting list (5.4%), with 5.4% fearing contracting the virus. Patients' awareness of safety measures and confidence in the hospital preparedness policy was perceived by all interviewers, and 100% appreciated being questioned.</p> <p><strong>Conclusion: </strong>The feedback given by the non-COVID patient helps to measure the quality in health care, to improve the quality service, and to protect and satisfy more vulnerable patients, also during the COVID-19 pandemic.</p>
The effectiveness and safety of intensive lipid-lowering with different Rosuvastatin-based regimens in patients at high risk: A nonblind, randomized, controlled trial
<p><span><strong>Background</strong>:</span> <span>Statin alone or nonstatins as add-ons have been introduced to intensive low-density lipoprotein cholesterol (LDL-C) </span><span>lowering</span><span> therapy in patients at high cardiovascular disease (CVD) risk. The purpose of this study was to evaluate the effectiveness and safety of different statin-based regimens for patients at high risk</span><span>.</span></p> <p><span><strong>Methods</strong>:</span> <span>Three hundred patients at high CVD risk were randomly assigned to the statin group</span><span> (Rosuvastatin 20mg/d</span><span>), statin_EZ group</span> <span>(Rosuvastatin 10mg/d + ezetimibe </span><span>10mg/d</span><span>), statin_pcsk group (Rosuvastatin </span><span>10mg/d</span><span> + alirocumab </span><span>75mg/2</span><span>weeks) or combine3 group (Rosuvastatin 10mg/d + ezetimibe 10mg/d + alirocumab 75mg/2weeks)</span><span>.</span> <span>The primary outcome measure was cholesterol levels </span><span>(LDL-C, total cholesterol (TC) triglycerides (TGs), and high-density lipoprotein cholesterol (HDL-C))</span><span> after 24</span><span> weeks of</span><span> follow-up. The secondary outcome measures were safety markers and the proportion of patients who achieved the < 70 mg/dL (1.8 mmol/L) LDL-C target. </span><span>A logistic</span><span> regression model was performed to explore the factors affecting lipid target achievement.</span></p> <p><span><strong>Results</strong>:</span> <span>The TC and LDL-C levels after treatment were significantly different among the four groups</span> <span>(p < 0.05). The levels in both the combine3 group and </span><span>the </span><span>statin_pcsk9 group were significantly lower than </span><span>those in </span><span>the statin group and the statin_EZ group (</span><span>p < 0.05</span><span>), but there was no significant difference between</span><span> the</span><span> combine3 group and </span><span>the </span><span>statin_pcsk9 group. The incidence of adverse events in the four groups was low.</span><span> Body mass index (BMI) and hypertensive status were related to target achievement.</span></p> <p><span><strong>Conclusion</strong>:</span><span> The combination of a statin</span><span> and a PCSK9 inhibitor was safe and more effective for the treatment of high-risk CVD patients, while the addition of </span><span>ezetimibe was</span><span> unable to significantly lower lipid levels any further. The rate of achieving </span><span>the </span><span>target was higher in patients </span><span>with</span><span> hypertension and a low BMI.</span></p>
Large leaf hydraulic safety margins limit the risk of drought-induced leaf hydraulic dysfunction in Neotropical rainforest canopy tree species
<p>The sequence of key water potential thresholds from the onset of water stress to mortality, and the timing of stomatal closure with regard to leaf xylem embolism formation are essential to characterizing plant adaptive strategies to drought. This constitutes a critical knowledge gap for tropical rainforest species, which may be less vulnerable to drought than previously thought.</p> <p>We recorded key leaf and stem water potential thresholds, leaf hydraulic safety margins (HSMleaf), leaf stomatal safety margins (SSMleaf) and estimated native embolism levels during a normal-intensity dry season across 18 Neotropical rainforest tree species. We also solved a sequence of key water potential thresholds. Additionally, we provide a cross-biome analysis of SSMleaf encompassing 97 species from four major biomes based on a literature survey.</p> <p>In the studied rainforest species, leaf turgor loss point, used as a surrogate for stomatal closure, typically occurred before the onset of leaf xylem embolism. Most species exhibited positive HSMleaf and SSMleaf, with contrasting values across species and nearly absent embolism levels during the dry season irrespective of the experienced midday leaf water potentials. Our results point out that leaf xylem embolism is not routine for Neotropical rainforest tree species.</p> <p>Based on our proposal of the water potential sequence for tropical rainforest trees, we argue that leaf xylem embolism is a rare event for these species. This was supported by the literature survey, indicating that across biomes, most woody species have rather large SSM<sub>leaf</sub> and that leaves of tropical rainforest trees are not necessarily more vulnerable than in other biomes. However, we found evidence that some tropical rainforest species may be more vulnerable than others to ongoing climate change. Our data provide an opportunity to parametrize tree-based or land-surface models for tropical rainforests.</p>
2015/16 El Niño increased water demand and pushed plants from a Mesic tropical montane grassland beyond their hydraulic safety limits
<p>In 2015/16, a strong El Niño event caused anomalously high temperatures and reduced precipitation resulting in Pantropical drought‐induced diebacks and wildfires. Although many studies have documented the El Niño impacts on tropical forests, little we know about its effects on tropical grasslands. Here, we investigated plant drought responses during and after the 2015/16 El Niño event (Jun 2016 to Aug 2017) in 12 species with contrasting drought strategies (tolerance, avoidance and escape) in a Brazilian tropical montane grassland. We tested if (1) the El Niño event induced meteorological drought anomalies, (2) the atmospheric and/or soil drought led to plant water stress and (3) plants showed signs of drought recovery. In contrast to other tropical areas, we found that the 2015/16 El Niño event did not strongly affect precipitation in our study site. However, it increased air temperature and vapour pressure deficit, thus pushing all grassland species, even the most drought‐tolerant ones, beyond their hydraulic safety margins during the dry season. Most species showed signs of drought recovery, returning to positive hydraulic margins in the wet season after the El Niño. However, the finding that all evaluated species, regardless of their drought‐response strategy, are already operating close to their hydraulic safe thresholds for stomatal closure and turgor loss suggests that this cool–humid tropical montane grassland is especially vulnerable to meteorological extremes exacerbated by the additive effects of El Niño and climate change.</p>
The efficacy and safety of meal replacement in patients with type 2 diabetes: a systematic review and meta-analysis
<p>There are supplemental materials for a systematic review and meta-analysis, which studied the efficacy and safety of meal replacement in patients with type 2 diabetes, with a focus on subgroup analysis of variable participant characteristics and MR prescription.</p>
Replication Package: A Systematic Mapping Study on Security in Configurable Safety-critical Systems Based on Product-Line Concepts
<p><strong>Welcome to the public repository for the additional content of the paper "A Systematic Mapping Study on Security in Configurable Safety-critical Systems Based on Product-Line Concepts", accepted at the ICSOFT 2023.</strong></p> <p>This repository provides additional information to the conducted mapping study, including the following files:</p> <ul> <li>fetched_results_ICSOFT2023.csv: sheet containing all papers fetched from IEEEXplore, Scopus, and the ACM Guide to Computing Literature.</li> <li>excluded_paper.csv: sheet containing all excluded papers related to safety-critical systems but not referring to security.</li> <li>analysis_sheet_ICSOFT2023.csv: sheet containing information regarding the analysis results of 44 included papers based on the extraction criteria.</li> </ul>
COVID-19 and Traffic Safety: Exploring Exposure, Crash Frequency and Severity, and Roadway and Network Design
<p>Early COVID-19 lockdowns in the first half of 2020 largely kept people at home, thereby reducing motor vehicle traffic levels. Theoretically, reduced traffic exposure should have resulted in reduced motor vehicle crashes. However, a variety of factors may have complicated this relationship. In order to better understand the impact of COVID-19 lockdowns on traffic safety outcomes, we explore fatalities, injuries, and total crashes before and during the lockdowns on both the national and state levels. We provide descriptive statistics and create negative binomial regressions exploring the role of vehicle, user, and built environment factors on traffic safety outcomes. Findings suggest that crash counts in Region 6 were 35%-50% lower in 2020 during the COVID-19 lockdowns. Crashes that occurred during the COVID-19 lockdowns were more likely to be more severe. Fatal pedestrian crashes across the U.S. decreased during COVID-19 (although not as much as overall fatal crashes) and fatal bicyclist crash counts increased. Drunk drivers were less prevalent in nationwide fatalities but more prevalent in overall Region 6 crashes. Overall, crashes were more likely single-vehicle fixed-object or rollover crashes involving unsafe speeds. In Texas, suburban areas saw the most crashes before and during COVID-19, although they also saw the greatest decrease. Rural Texas crashes were most likely to result in a fatality or serious injury, and that likelihood got worse during the COVID-19 lockdowns. While Texas freeways and arterials saw the largest decreases in crash counts, these functional classifications still had the most crashes. Urban interstates and rural local roads in Texas were notable because these two functional classifications actually saw increases in the number of fatal and serious injury crashes during COVID-19 lockdowns.</p>
Pharmacokinetic dataset of a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19
<p>Abstract</p> <p>Background</p> <p>The coronavirus disease 2019 (COVID-19) pandemic has led to a disruptive increase in the number of intensive care unit (ICU) admissions with acute respiratory distress syndrome (ARDS). ARDS is a severe, life-threatening medical condition characterized by widespread inflammation and vascular leak in the lungs. Although there is no proven therapy to reduce pulmonary vascular leak in ARDS, recent studies demonstrated that the tyrosine kinase inhibitor imatinib reinforces the endothelial barrier and prevents vascular leak in inflammatory conditions, while leaving the immune response intact.</p> <p>Methods</p> <p>This is a randomized, double-blind, parallel-group, placebo-controlled, multicenter clinical trial of intravenous (IV) imatinib mesylate in 90 mechanically ventilated subjects with COVID-19-induced ARDS. Subjects are 18 years or older, admitted to the ICU for mechanical ventilation, meeting the Berlin criteria for moderate-severe ARDS with a positive polymerase chain reaction test for SARS-CoV2. Participants will be randomized in a 1:1 ratio to either imatinib (as mesylate) 200 mg bis in die (b.i.d.) or placebo IV infusion for 7 days, or until ICU discharge or death. The primary study outcome is the change in Extravascular Lung Water Index (EVLWi) between day 1 and day 4. Secondary outcome parameters include changes in oxygenation and ventilation parameters, duration of invasive mechanical ventilation, number of ventilator-free days during the 28-day study period, length of ICU stay, and mortality during 28 days after randomization. Additional secondary parameters include safety, tolerability, and pharmacokinetics.</p> <p>Discussion</p> <p>The current study aims to investigate the efficacy and safety of IV imatinib in mechanically ventilated subjects with COVID-19-related ARDS. We hypothesize that imatinib decreases pulmonary edema, as measured by extravascular lung water using a PiCCO catheter. The reduction in pulmonary edema may reverse hypoxemic respiratory failure and hasten recovery. As pulmonary edema is an important contributor to ARDS, we further hypothesize that imatinib reduces disease severity, reflected by a reduction in 28-day mortality, duration of mechanical ventilation, and ICU length of stay.</p>
Digitalizing Europe: The promising impact of AI on Car Safety Development
<p>Video through which the ESR09 Giada Colella applied to the MSCA Science-Policy Pitch Competition and Awards.</p>
SUPPLIMANTRY [Vacuum Ohmic Heating: A Promising Technology for the Improvement of Tomato Paste Processing, Safety, Quality and Storage Stability]
<p><strong>Abstract</strong>: Ohmic heating (OH) is an electrothermal technology used to inactivate enzyme and microbial activities. This work aimed to study the impact of Ohmic Heating Under Vacuum (OHUV) which compared to conventional heating (CH) as well as storage stability at 5°C and 25 °C on microbial safety, and nutritional quality. The evaluation parameters were pH, titratable acidity, TSS, lycopene, ascorbic acid, PME, HMF, and microbiological activity. The obtained results showed that tomato paste samples that were treated by OHUV are significantly superior to CH in terms of all physicochemical and microbiological characteristics, as well as being the least harmful during storage in both transparent and dark packages. The results showed the changes in ascorbic acid, lycopene, and HMF values that were treated by OHUV at 25 °C and filled in transparent package are most affected compared to other treated samples. On the other hand, tomato paste samples stored in dark packages at 5 °C performed significantly better than those subjected to CH under the same conditions and activated PME the most had higher ascorbic acid and lycopene and fewer changes in HMF during storage time for 90 days. OHUV found to be a good alternative treatment in the production of tomato paste.</p>
Angiosperms follow a convex trade-off to optimize hydraulic safety and efficiency
<p><span>Intervessel pits are considered to function as valves that avoid embolism spreading and optimize efficient transport of xylem sap across neighbouring vessels. Hydraulic transport between vessels would therefore follow a safety-efficiency trade-off, which is directly related to the total intervessel pit area (A<sub>p</sub>), inversely related to the pit membrane thickness (T<sub>PM</sub>), and driven by a pressure difference.</span></p> <p><span>To test this hypothesis, we modelled the relative transport rate of gas (k<sub>a</sub>) and water (Q) at the intervessel pit level for 23 angiosperm species, and correlated these parameters with the water potential at which 50% of embolism occurs (</span><span>Ψ</span><sub><span>50</span></sub><span>). We also measured k<sub>a</sub> for 10 species using pneumatic measurements.</span></p> <p><span>The pressure difference across adjacent vessels, and estimated values of k<sub>a </sub>and Q were related to </span><span>Ψ</span><sub><span>50</span></sub><span>, following a convex safety-efficiency trade-off based on modelled and experimental data. Minor changes in T<sub>PM</sub> and A<sub>p </sub>exponentially affected the pressure difference and flow, respectively. </span></p> <p><span>Our results provide clear evidence that a xylem safety-efficiency trade-off is not linear, but convex due to flow across intervessel pit membranes, which represent mesoporous media within microporous conduits. Moreover, the convex nature of long-distance xylem transport may contribute to an adjustable fluid balance of plants, depending on environmental conditions. </span></p>
Safety, effectiveness, and skin immune response in a controlled human infection model of sand fly transmitted cutaneous leishmaniasis.
<p>Safety, effectiveness, and skin immune response in a controlled human infection model of sand fly transmitted cutaneous leishmaniasis.</p><p>Vivak Parkash1, Helen Ashwin1, Shoumit Dey1, Jovana Sadlova2, Barbora Vojtkova2, Katrien Van Bocxlaer1,3, Rebecca Wiggins1, David Thompson4 Nidhi Sharma Dey1, Charles L. Jaffe5, Eli Schwartz6, Petr Volf2, Charles J. N. Lacey1, Alison M. Layton1,3 * and Paul M. Kaye1,3 *.</p><p> </p><p>1 York Biomedical Research Institute, Hull York Medical School, University of York, York, UK</p><p>2 Department of Parasitology, Faculty of Science, Charles University, Viničná 7, Prague, Czech Republic</p><p>3 Skin Research Centre, Hull York Medical School, York, UK</p><p>4 York and Scarborough Teaching Hospitals NHS Foundation Trust, York, UK </p><p>5 Department of Microbiology and Molecular Genetics, Kuvin Center for the Study of Infectious and Tropical Diseases, IMRIC, The Hebrew University – Hadassah Medical School, Jerusalem, Israel</p><p>6 The Center for Geographic Medicine and Tropical Diseases, Chaim Sheba Medical Center, and The School of Medicine, Tel Aviv University, Israel.</p><p> </p><p>*Corresponding authors: paul.kaye@york.ac.uk and alison.layton@hyms.ac.uk</p><p> </p>
Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis
ClinicalTrials.gov study NCT01714817. IPD Sharing: Not stated. Countries: 23. Publications: 1.
The Safety and Efficacy of vBloc Therapy Delivered by the Maestro Rechargeable System for the Treatment of Obesity
ClinicalTrials.gov study NCT01327976. IPD Sharing: NO. Countries: 2. Publications: 2.
Evaluating QTc, PK, Safety of Gemtuzumab Ozogamicin (GO) in Patients With CD33+ R/R AML
ClinicalTrials.gov study NCT03727750. IPD Sharing: YES. Countries: 6. Publications: 1.
Efficacy and Safety of Aliskiren 300 mg Compared to Telmisartan 80 mg After 1 Week of Treatment Withdrawal
ClinicalTrials.gov study NCT00865020. IPD Sharing: Not stated. Countries: 16. Publications: 3.
A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT00553280. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety of Remifentanil Infusion
ClinicalTrials.gov study NCT01303627. IPD Sharing: Not stated. Countries: 1. Publications: 1.
GRACE: A Study to Compare the Effectiveness, Safety and Tolerability of PREZISTA (Darunavir)/Ritonavir by Gender and Race When Administered With Other Antiretroviral Medications in Human Immunodeficie
ClinicalTrials.gov study NCT00381303. IPD Sharing: Not stated. Countries: 3. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.