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15,733 results for “article”
Dataset related to article "C3a receptor blockade protects podocytes from injury in diabetic nephropathy"
<p><em>The file contains raw data related to the article "C3a receptor blockade protects podocytes from injury in diabetic nephropathy", available from <a href="https://insight.jci.org/articles/view/131849">https://insight.jci.org/articles/view/131849</a>.</em></p> <ul> <li><strong>Raw data vivo 1</strong>: evaluations of complement protein renal expression in vivo</li> <li><strong>Raw data vivo 2</strong>: evaluations of systemic and laboratory parameters in vivo</li> <li><strong>Raw data vivo 3</strong>: histological evaluation of glomerular damage in vivo</li> <li><strong>Raw data vivo 4</strong>: histological evaluation of podocyte and mitochondrial dysfunction in vivo</li> <li><strong>Raw data vitro 1</strong>: evaluations of mitochondrial functional integrity in cultured podocytes</li> <li><strong>Raw data vitro 2</strong>: western blot analyses of mitochondrial proteins in cultured podocytes</li> <li><strong>Raw data vitro 3</strong>: evaluations of mitochondrial bioenergetic changes in cultured podocytes</li> <li><strong>Raw data vitro 4</strong>: evaluations of the effect of SS-31 in cultured podocytes</li> </ul> <p> </p> <p><strong>Abstract of the manuscript</strong>:</p> <p>Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied whether glomerular C3a, generated by uncontrolled complement activation, promotes podocyte damage, leading to proteinuria and renal injury in mice with type 2 diabetes. BTBR ob/ob mice exhibited podocyte loss, albuminuria, and glomerular injury accompanied by C3 deposits and increased C3a and C3a receptor (C3aR) levels. Decreased glomerular nephrin and α-actinin4 expression, coupled with integrin-linked kinase induction, were also observed. Treatment of DN mice with a C3aR antagonist enhanced podocyte density and preserved their phenotype, limiting proteinuria and glomerular injury. Mechanistically, ultrastructural and functional mitochondrial alterations, accompanied by downregulation of antioxidant superoxide dismutase 2 (SOD2) and increased protein oxidation, occurred in podocytes and were normalized by C3aR blockade. In cultured podocytes, C3a induced cAMP-dependent mitochondrial fragmentation. Alterations of mitochondrial membrane potential, SOD2 expression, and energetic metabolism were also found in response to C3a. Notably, C3a-induced podocyte motility was inhibited by SS-31, a peptide with mitochondrial protective effects. These data indicate that C3a blockade represents a potentially novel therapeutic strategy in DN for preserving podocyte integrity through the maintenance of mitochondrial functions.</p>
dataset related to article "Multiple Genetic Rare Variants in Autism Spectrum Disorders: A Single-Center Targeted NGS Study"
<p>dataset contains: NGS data (.vcf; .bam; .bam.bai) of all 40 ASD patients analysed in the study at title</p>
Dataset related to article "Role of ultrastructural determinants of glomerular permeability in ultrafiltration function loss".
<p><em>The files contain the raw data related to the manuscript: "Role of ultrastructural determinants of glomerular permeability in ultrafiltration function loss" available at <a href="https://insight.jci.org/articles/view/137249">https://insight.jci.org/articles/view/13724</a>9.</em></p> <p><strong>Datasets:</strong></p> <p><strong>Scripts for CFD simulation of water passage through the glomerular filtration barrier (GFB) of Wistar, MWF and MWF-treated rats:</strong></p> <p><strong>STL_models</strong> - contains STL models of the unit cell of GFB reconstructed for the three groups of rats (i.e., WIST, MWF and MWFL). The dimensions assumed are presented in tables 2 and 4 in the main text and well explained in the Supplemental Material.</p> <p><strong>CFD_cases</strong> – contains cases in .rar archives for each group of rats; each case includes scripts which needed to run a CFD simulation of steady for incompressible, turbulent flow with porosity treatment, using the <strong><em>porousSimpleFoam</em></strong> solver in OpenFOAM. OpenFOAM version 6 (openfoam.org) was used for generating all data presented in this paper, but scripts should run well with updated versions.</p> <p><strong>Figure 1_Pores morphometrical analysis.xlsx </strong>- dataset for the calculation of distribution of slit pore size. These data are presented in Figure 1. </p> <p><strong>Figure 2_subpodocyte space morphometry.xlsx </strong>- dataset for the quantification of subpodocyte area. These data are presented in Figure 2. </p> <p><strong>Figure 5_CD151 and a3 integrin expression.xlsx </strong>- dataset related to the quantification of CD151, a3 integrin and their colocalization. These data are presented in Figure 5. </p> <p><strong>k_SupplTable2.xlsx</strong> – dataset for the calculation and total and relative permeability of each structural layer of GFB. These data are presented in Supplemental Table 2.</p> <p><strong>Neal-model_graphs_Figure4_SupplFigure3.xlsx</strong> - dataset for the calculation and of hydraulic resistances of GFB using the models of Neal et al. (2007). These data are presented in Figure 4 and Supplemental Figure 3.</p> <p><strong>Table 1_Systemic parameters.xlsx </strong>- dataset related to the systemic parameters. These data are presented in Table 1.</p> <p><strong>Table 2_Morphometric characterization.xlsx </strong>- dataset related to the morphometric characterization of epithelial slit pores and GBM. These data are presented in Table 2. </p> <p> </p> <p><strong>Abstract of the manuscript</strong></p> <p>The epithelial filtration slit is a crucial component of the glomerular capillary membrane, which is essential for maintaining glomerular filtration function. Though chronic kidney diseases are an immense clinical problem, the mechanisms through which structural alterations reduce glomerular water filtration have not yet been understood completely. To investigate the mechanisms underlying filtration function loss, we studied rats with spontaneously occurring progressive kidney disease, either treated with angiotensin II antagonist or untreated, combining high-resolution electron microscopy of the glomerular capillary wall with theoretical water filtration modeling. Under pathological conditions, epithelial filtration pores and the extension of the subpodocyte space were larger than in normal controls. Numerical analyses indicated that these ultrastructural changes increased hydraulic resistance of the glomerular capillary wall by extending coverage of the filtration barrier by the subpodocyte space, with the changes in hydrodynamic forces acting on podocytes likely being responsible for their detachment. Angiotensin II inhibition normalized the subpodocyte space's hydraulic resistance, restored mechanical podocyte load, and preserved CD151-α3 integrin complex assembly, improving podocyte adherence and survival. Our results show that ultrastructural changes in podocytes are major determinants of the hydraulic resistance of the glomerular capillary wall and highlight the mechanism of podocyte loss in kidney disease progression, as well as the mechanisms underlying angiotensin II inhibition.</p>
Dataset related to article "Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin"
<p><em>The file contains raw data related to the article "Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin", available from </em><a href="https://doi.org/10.1016/j.neuropharm.2020.108221">https://doi.org/10.1016/j.neuropharm.2020.108221</a><em>.</em></p> <p> </p> <p><strong>Abstract of the manuscript</strong></p> <p> Motor skill is a specific area of disability of Rett syndrome (RTT), a rare disorder occurring almost exclusively in girls, caused by loss-of-function mutations of the X-linked methyl-CpG-binding protein2 (MECP2) gene, encoding the MECP2 protein, a member of the methyl-CpG-binding domain nuclear proteins family. Brain 5-HT, which is defective in RTT patients and Mecp2 mutant mice, regulates motor circuits and SSRIs enhance motor skill learning and plasticity. In the present study, we used heterozygous (Het) Mecp2 female and Mecp2-null male mice to investigate whether fluoxetine, a SSRI with pleiotropic effects on neuronal circuits, rescues motor coordination deficits. Repeated administration of 10 mg/kg fluoxetine fully rescued rotarod deficit in Mecp2 Het mice regardless of age, route of administration or pre-training to rotarod. The motor improvement was confirmed in the beam walking test while no effect was observed in the hanging-wire test, suggesting a preferential action of fluoxetine on motor coordination. Citalopram mimicked the effects of fluoxetine, while the inhibition of 5-HT synthesis abolished the fluoxetine-induced improvement of motor coordination. Mecp2 null mice, which responded poorly to fluoxetine in the rotarod, showed reduced 5-HT synthesis in the prefrontal cortex, hippocampus and striatum, and reduced efficacy of fluoxetine in raising extracellular 5-HT as compared to female mutants. No sex differences were observed in the ability of fluoxetine to desensitize 5-HT<sub>1A</sub> autoreceptors upon repeated administration. These findings indicate that fluoxetine rescues motor coordination in Mecp2 Het mice through its ability to enhance brain 5-HT and suggest that drugs enhancing 5-HT neurotransmission may have beneficial effects on motor symptoms of RTT.</p>
data sets for the article Short‑term impact of crop diversifcation on soil carbon fuxes and balance in rainfed and irrigated woody cropping systems under semiarid Mediterranean conditions
<p>Diversifcation practices such as intercropping in woody cropping systems have recently been proposed as a promising management strategy for addressing problems related to soil degradation, climate change mitigation and food security. In this study, we assess the impact of several diversifcation practices in diferent management regimes on the main carbon fuxes regulating the soil carbon balance under semiarid Mediterranean conditions.</p>
Global Flash Drought Data for the article "Global Distribution, Trends, and Drivers of Flash Drought Occurrence"
<p>Data is provided (in netcdf format) to reproduce Figures 1-4 in the article entitled "Global Distribution, Trends, and Drivers of Flash Drought Occurrence."</p>
Graph Laplacians used in the article "Numerically Efficient $H_{\infty}$ Analysis of Cooperative Multi-Agent Systems"
<p>The repository contains four graph Laplacians written in the Matlab format. These matrices are used in the section "Numerical Examples" in the article "Numerically Efficient $H_{\infty}$ Analysis of Cooperative Multi-Agent Systems".</p>
Data related to research article: Towards mouse genetic-specific RNA-sequencing read mapping
<p>This dataset contains data related to the research article: "Towards mouse genetic-specific RNA-sequencing read mapping".</p>
Dataset related to article "Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis"
<p>The mass spectrometry proteomics data have been deposited at the ProteomeXchange Consortium (<a href="http://proteomecentral.proteomexchange.org/cgi/GetDataset">http://proteomecentral.proteomexchange.org/cgi/GetDataset</a>) via the PRIDE partner repository with the data set identifier PXD020629.</p>
Datasets and OpenLCA foreground data processes for the article: Understanding environmental trade-offs and resource demand of direct air capture technologies through comparative life-cycle assessment
<p>This data set contains the supplementary data sets (1-3) and exported foreground data processes from OpenLCA for the manuscript “Understanding environmental trade-offs and resource demand of direct air capture technologies through comparative life-cycle assessment”, submitted to Nature Energy.</p> <p>This repository contains:</p> <ul> <li>Supplementary data set 1: Ancillary calculations and numerical values for HT-Aq DAC</li> <li>Supplementary data set 2: Ancillary calculations and numerical values for TSA DAC</li> <li>Supplementary data set 3: Ancillary calculations and numerical values shown in plots and table 3</li> <li>Foreground data from OpenLCA. OpenLCA process model for different cases of HT-Aq DAC and TSA DAC. To re-run the LCA calculations, OpenLCA (freeware) and the Ecoinvent 3.5 database (license required) need to be installed on a standard desktop computer or laptop with at least 8 GB RAM.</li> </ul>
Data for the article "Evidence for spin current driven Bose-Einstein condensation of magnons"
<p>Data for the article "Evidence for spin current driven Bose-Einstein condensation of magnons"</p>
Sample audio data for JSEALS article "Tonal variation in Pyen"
<p>Audio data samples corresponding to sections 1.1, 5.1 and 6 in the JSEALS article "Tonal variation in Pyen." </p>
A Guide To Review Article Adopted From Multiple Sources
<p>This document's goal is to construct knowledge for reviewing scientific publications; it is not allowed for commercial use because a primary goal is to disseminate knowledge regarding reviewing articles. In addition, based on my experience, the learning of reviewing scientific papers does not originate through formal education, e.g., universities, but rather by engaging in scientific activities like writing. Examining scientific papers, on the other hand, which are currently hardly surface processed throughout all academic fields, will assist various individuals and groups who are interested in and concerned about being actively involved in scientific writing in quantitatively mastering scientific article review knowledge.<a href="https://archive.org/details/a-guide-to-review-article-adopted-from-multiple-sources">A Guide To Review Article Adopted From Multiple Sources</a></p>
Supplementary material for "Phase Retrieval from overexposed PSF" article
<p>Supplementary material for "Phase Retrieval from overexposed PSF" article, submitted to Optics Communications (http://dx.doi.org/10.2139/ssrn.4267855).</p> <p>The pdf files present the results of the phase retrieval task as described in Sections 5 and 6 of the article and provide an easy-to-navigate tool for browsing through the parameter space of the simulation and of the algorithm. Click on the parameter values in the right-hand side of the browser page to navigate to the corresponding result.</p>
Data for article "Assembling diuranium complexes in different states of charge with a bridging redox-active ligand"
<p>This upload contains raw data (NMR, X-Ray, Elemental Analysis, AC & DC SQUID, EPR) files for the article.</p>
Systematic Literature Mapping - Selected Articles Data Extraction
<p>- CSV with the raw data extracted from abstract + full-text review from the selected articles.</p> <p>- CSV with normalized data.</p> <p>- CSV with the normalized data after being a feature engineering step in which some columns have been deleted.</p> <p>- CSV with formal context to extract the concepts lattice.</p>
Data for the article "Strain-induced shape anisotropy in antiferromagnetic structures"
<p>Data for the article "Strain-induced shape anisotropy in antiferromagnetic structures" </p> <p>URL: https://link.aps.org/doi/10.1103/PhysRevB.106.094430<br> DOI: 10.1103/PhysRevB.106.094430</p>
PID table for the articles of the "Dialektikê. Cahiers de typologie analytique" journal
<p>This table contains the different persistent identifier (PID) related to the digital version of the articles of the <em>Dialektikê. Cahiers de typologie analytique</em> journal of archaeology (ISSN 1147-114X and 1169-0046). These articles are referenced by multiple services:</p> <ul> <li><em>HAL</em> <em>– Hyper Articles en Ligne </em>(<a href="https://hal.archives-ouvertes.fr/search/index/?qa[journalTitle_t][]=%22Cahiers+de+typologie%22">https://hal.archives-ouvertes.fr</a>).</li> <li>The <em>Lithic Types</em> blog (<a href="https://lithictypes.hypotheses.org/">https://lithictypes.hypotheses.org</a>).</li> <li><em>Isidore</em> (<a href="https://isidore.science">https://isidore.science</a>).</li> <li><em>Worldcat</em> (<a href="https://www.worldcat.org)">https://www.worldcat.org)</a>.</li> <li><em>FRANTIQ</em> (<a href="https://catalogue.frantiq.fr">https://catalogue.frantiq.fr</a>)</li> </ul> <p>Each row of the table corresponds to an article and present the following data:</p> <ul> <li><strong>authors</strong>: authors of the article.</li> <li><strong>year</strong>: publication year of the article.</li> <li><strong>doi</strong>: doi of the digital version of the article stored in <em>Zenodo</em>.</li> <li><strong>hdl-hypotheses</strong>: <em>Isidore </em>handle of the reference to the article on the <em>Lithic types</em> blog.</li> <li><strong>oclc-hypotheses</strong>: OCLC unique identifier of the reference to the article on the <em>Lithic types</em> blog.</li> <li><strong>hal</strong>: HAL unique identifier to the reference to the article.</li> <li><strong>hdl-hal</strong>: <em>Isidore</em> handle of the reference to the article in <em>HAL</em>.</li> <li><strong>ark-frantiq</strong>: ark of the reference to the article in <em>FRANTIQ</em>.</li> </ul>
Dataset related to the article "LITHOTRIPSY OF CALCIFIED AORTIC VALVE LEAFLETS BY A NOVEL ULTRASOUND TRANSCATHETER-BASED DEVICE"
<p>This record contains raw data related to the article “LITHOTRIPSY OF CALCIFIED AORTIC VALVE LEAFLETS BY A NOVEL ULTRASOUND TRANSCATHETER-BASED DEVICE”</p> <p>The increasing incidence of calcific aortic valve disease necessitates the elaboration of new strategies to retard the progression of the pathology with an innovative solution. While the increasing diffusion of the transcatheter aortic valve replacements (TAVRs) allows a mini-invasive approach to aortic valve substitution as an alternative to conventional surgical replacement (SAVR) in an always larger patient population, TAVR implantation still has contraindications for young patients. In addition, it is liable to undergo calcification with the consequent necessity of re-intervention with conventional valve surgery or repeated implantation in the so-called TAVR-in-TAVR procedure. Inspired by applications for non-cardiac pathologies or for vascular decalcification before stenting (i.e., coronary lithotripsy), in the present study, we show the feasibility of human valve treatment with a mini-invasive device tailored to deliver shockwaves to the calcific leaflets. We provide evidence of efficient calcium deposit ruptures in human calcified leaflets treated <em>ex vivo</em> and the safety of the treatment in pigs. The use of this device could be helpful to perform shockwaves valvuloplasty as an option to retard TAVR/SAVR, or as a pretreatment to facilitate prosthesis implantation and minimize the occurrence of paravalvular leak.</p>
CommonCrawl News Articles by Political Orientation
<p><strong>Dataset description & reproduction steps</strong></p> <p>The dataset includes news articles gathered from CommonCrawl for media outlets that were selected based on their political orientation. The news articles span publication dates from 2010 to 2021. For more details, please check out our <a href="https://aclanthology.org/2022.findings-emnlp.152/">Paper</a> and <a href="https://github.com/webis-de/emnlp22-social-bias-representation-accuracy">GitHub repository</a>.</p> <p>The database file containing the news articles has two main tables, <em>article_urls</em> and <em>article_contents</em>. The tables have the following columns:</p> <p><em>article_urls</em>:</p> <ul> <li><code>uuid</code>: An ID that uniquely identifies this URL entry. This column is used as primary key for the table.</li> <li><code>url</code>: The plain text URL for the news article, as found in CommonCrawl.</li> <li><code>outlet_name</code>: The name of the news outlet that published the article.</li> </ul> <p><em>article_contents</em>:</p> <ul> <li><code>uuid</code>: An ID that uniquely identifies this content entry. This column is used as primary key for the table. The key is the same key used in the <em>article_urls</em> table to allow for cross-referencing.</li> <li><code>date</code>: The automatically extracted publishing date of the article. If it was not possible to automatically extract the date, this field remains empty.</li> <li><code>content</code>: The plain text content of the article automatically extracted from the crawled HTML document.</li> <li><code>content_preprocessed</code>: The articles content split by sentences.</li> <li><code>langauge</code>: The langauge of the article, as identified by the langdetect module (as ISO 639-1 code).</li> </ul>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.