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548
datasets available to search
ShareScore release 0.7.1
Dataset results
548 results for “cardiac function”
Functional analysis of human cardiac enhancers by tiling mutagenesis
GEO Series GSE208284. Homo sapiens. 8 samples. Type: Other.
Effects of silencing miR-142-3p on the pathological and physiological functions of cardiac fibroblasts
GEO Series GSE262000. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis
GEO Series GSE270517. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
DCA-TGR5 signaling activation alleviates inflammatory response and improves cardiac function in myocardial infarction
GEO Series GSE158415. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Neddylation inhibition extends lifespan and preserves cardiac function during aging via mitophagy
GEO Series GSE317599. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
β3 agonist administration before reperfusion reduces infarct size and improves long term cardiac function in small and large animal models of myocardial infarction
GEO Series GSE42999. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity (RNA-seq: WT vs PKI)
GEO Series GSE136770. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Functional Optimization of Designer Cardiac Organoids Enabled by Machine Learning Techniques
GEO Series GSE267438. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Partial dataset related to the article: "Fibrosis Rescue Improves Cardiac Function in Dystrophin-Deficient Mice and Duchenne Patient-Specific Cardiomyocytes by Immunoproteasome Modulation".
<p>This record contains raw data related to the article: "Fibrosis Rescue Improves Cardiac Function in Dystrophin-Deficient Mice and Duchenne Patient-Specific Cardiomyocytes by Immunoproteasome Modulation".</p> <p>Abstract</p> <p>Patients affected by Duchenne muscular dystrophy (DMD) develop a progressive dilated cardiomyopathy<br> characterized by inflammatory cell infiltration, necrosis, and cardiac fibrosis. Standard<br> treatments consider the use of b-blockers and angiotensin-converting enzyme inhibitors that are<br> symptomatic and unspecific toward DMD disease. Medications that target DMD cardiac fibrosis are<br> in the early stages of development. We found immunoproteasome dysregulation in affected hearts<br> of mdx mice (murine animal model of DMD) and cardiomyocytes derived from induced pluripotent<br> stem cells of patients with DMD. Interestingly, immunoproteasome inhibition ameliorated cardiomyopathy<br> in mdx mice and reduced the development of cardiac fibrosis. Establishing the<br> immunoproteasome inhibitionedependent cardioprotective role suggests the possibility of modulating<br> the immunoproteasome as new and clinically relevant treatment to rescue dilated cardiomyopathy<br> in patients with DMD.</p>
MCUb upregulation in the type 2 diabetic heart impacts cardiac function by altering mitochondrial metabolic fuel flux and the cardiac myocyte phosphoproteome
GEO Series GSE145294. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The function of TEAD1 in cardiac fibroblast activation [ChIP-Seq]
GEO Series GSE253118. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of Latrophilin-2, a Specific Cell-surface Marker for Cardiac Progenitor Cells, and its Functional Significance in Heart Development [RNA-Seq]
GEO Series GSE102973. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Histone deacetylase inhibition replicates aspects of the adaptive response to exercise and improves muscle metabolism and cardiac function in obesity.
GEO Series GSE54642. Mus musculus. 20 samples. Type: Expression profiling by array.
Estrogen-independent Epigenetic Mechanisms Regulate Gender Dimorphisms in Cardiac Reparative Functions of Bone Marrow Progenitor Cells [RNA-Seq]
GEO Series GSE252946. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Cannabidiol (CBD) exposure during gestation leads impaired cardiac function exclusively in male rat offspring
GEO Series GSE242079. Rattus norvegicus. 18 samples. Type: Expression profiling by high throughput sequencing.
Unique Transcription Factor Functions Regulate Epigenetic and Transcriptional Dynamics During Cardiac Reprogramming
GEO Series GSE138061. Mus musculus. 9 samples. Type: Methylation profiling by high throughput sequencing.
The functional benefits of cardiac progenitor cells can be equaled by their secreted extracellular vesicles
GEO Series GSE69401. Mus musculus. 9 samples. Type: Expression profiling by array.
CxVB3 infection and cardiac function
GEO Series GSE1457. Mus musculus. 7 samples. Type: Expression profiling by array.
Titered FOXO overexpression maintains cardiac proteostasis and ameliorates age-associated functional decline
GEO Series GSE73205. Drosophila melanogaster. 8 samples. Type: Expression profiling by array.
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity
GEO Series GSE136787. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.