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2,032
datasets available to search
ShareScore release 0.9.0
Dataset results
2,032 results for “metastases”
Intralesional Treatment With Interleukin-2 (Proleukin) in Soft Tissue Melanoma Metastases
ClinicalTrials.gov study NCT00204581. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Role of Positron Emission Tomography/ Computed Tomography (PET/CT) and in Bone Metastases.
ClinicalTrials.gov study NCT04080271. IPD Sharing: Not stated. Countries: 1. Publications: 5.
miRNA Machinery in Melanoma, Melanoma Metastases and Benign Melanocytic Naevi
ClinicalTrials.gov study NCT01444560. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Abraxane in Patients With Visceral Metastases Dominant Metastatic Breast Cancer
ClinicalTrials.gov study NCT02687490. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Role of Surgery of the Primary Tumour in Patients With Synchronous Unresectable Metastases of Colorectal Cancer
ClinicalTrials.gov study NCT01606098. IPD Sharing: UNDECIDED. Countries: 2. Publications: 3.
To Evaluate the Efficacy and Safety of QL1206 and Xgeva in Patients With Bone Metastases From Solid Tumors
ClinicalTrials.gov study NCT04550949. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Neurocognitive Outcome of Conformal WBRT w/wo Hippocampal Avoidance for Brain Metastases
ClinicalTrials.gov study NCT02393131. IPD Sharing: NO. Countries: 1. Publications: 1.
DOTA-TOC in Metastasized Neuroendocrine Tumors
ClinicalTrials.gov study NCT00978211. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Radiation Therapy With or Without RSR13 in Treating Patients With Brain Metastases
ClinicalTrials.gov study NCT00005887. IPD Sharing: Not stated. Countries: 9. Publications: 1.
Icotinib Combined With Whole Brain Radiotherapy in Treating Multiple Brain Metastases From Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT01514877. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Genomic and transcriptomic characterization of papillary microcarcinomas with lateral neck lymph node metastases
Open the record for dataset details and reuse information.
Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases
<div class="WordSection1"> <p>Genetic diversity among metastases is poorly understood but contains important information about disease evolution at secondary sites. Here we investigate inter- and intra-lesion heterogeneity for two types of metastases that associate with different clinical outcomes: lymph node and distant organ metastases in human colorectal cancer. We develop a rigorous mathematical framework for quantifying metastatic phylogenetic diversity. Distant metastases are typically monophyletic and genetically similar to each other. Lymph node metastases, in contrast, display high levels of inter-lesion diversity. We validate these findings by analyzing 317 multi-region biopsies from an independent cohort of 20 patients. We further demonstrate higher levels of intra-lesion heterogeneity in lymph node than in distant metastases. Our results show that fewer primary tumor lineages seed distant metastases than lymph node metastases, indicating that the two sites are subject to different levels of selection. Thus, lymph node and distant metastases develop through fundamentally different evolutionary mechanisms.</p> </div>
Data from: Origins of lymphatic and distant metastases in human colorectal cancer
The spread of cancer cells from primary tumors to regional lymph nodes is often associated with reduced survival. One prevailing model to explain this association posits that fatal, distant metastases are seeded by lymph node metastases. This view provides a mechanistic basis for the TNM staging system and is the rationale for surgical resection of tumor-draining lymph nodes. Here we examine the evolutionary relationship between primary tumor, lymph node, and distant metastases in human colorectal cancer. Studying 213 archival biopsy samples from 17 patients, we used somatic variants in hypermutable DNA regions to reconstruct high-confidence phylogenetic trees. We found that in 65% of cases, lymphatic and distant metastases arose from independent subclones in the primary tumor, whereas in 35% of cases they shared common subclonal origin. Therefore, two different lineage relationships between lymphatic and distant metastases exist in colorectal cancer.
ESMO-GROW checklist for the publication PD-1/PD-L1 blockade plus abnobaViscum® therapy is associated with improved survival in advanced or metastasized NSCLC patients, a real-world data registry study according to the ESMO-GROW criteria
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Glyburide vs Placebo as Prophylaxis Against Cerebral Edema in Patients Receiving Radiosurgery for Brain Metastases (RAD 1502/UAB 1593)
ClinicalTrials.gov study NCT02460874. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Research on the Optimization of Treatment for Spinal Metastases With Radioactive Particle Implantation Using TPS and Mechanical Dual Simulation
ClinicalTrials.gov study NCT07171996. IPD Sharing: YES. Countries: 1. Publications: 0.
Cryotherapy in Treating Patients With Primary Lung Cancer or Lung Metastases That Cannot Be Removed By Surgery
ClinicalTrials.gov study NCT00303901. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ZK219477 (Sagopilone) in Patients With Breast Cancer and Brain Metastases
ClinicalTrials.gov study NCT00496379. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy of Cryoablation Combined With Radiation Therapy for the Palliation of Painful Bone Metastases
ClinicalTrials.gov study NCT01461252. IPD Sharing: Not stated. Countries: 0. Publications: 13.
Stereotactic Radiosurgery (SRS) for Spine Metastases
ClinicalTrials.gov study NCT00593320. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.