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5,412 results for “Cell differentiation”
Substained DNA demethylation and discordant chromatin accessibility dynamics define enhancer regulation during neural progenitor cell differentiation [RNAseq]
GEO Series GSE271129. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Substained DNA demethylation and discordant chromatin accessibility dynamics define enhancer regulation during neural progenitor cell differentiation [6base]
GEO Series GSE271401. Homo sapiens. 6 samples. Type: Other.
Analysis of differential genes in the intestinal epithelial cell from M. tuberculosis-treated mice
GEO Series GSE184292. Mus musculus. 8 samples. Type: Expression profiling by array.
Differential expressed genes in WT and SCRN1 KO HepG2 cells.
GEO Series GSE250086. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Differential Lysotracker Uptake Defines Two Populations of Distal Epithelial Cells in Idiopathic Pulmonary Fibrosis
GEO Series GSE185691. Homo sapiens. 14 samples. Type: Expression profiling by array.
Immunohistochemical and transcriptional analysis uncover RasGRF2-mediated regulation of nestin-positive stem cell density and early neuronal differentiation in the dentate gyrus of the hippocampus of
GEO Series GSE98213. Mus musculus. 12 samples. Type: Expression profiling by array.
Hypoxia differentially accelerates cognitive impairment related features in cerebral cortex revealed by single cell sequencing in APP/PS1 mice
GEO Series GSE197151. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Wnt/planar cell polarity primed intestinal stem cells directly differentiate into enteroendocrine or Paneth cells
GEO Series GSE72112. Mus musculus. 18 samples. Type: Expression profiling by array.
FAM83B is involved in thyroid cancer cell differentiation and migration
<p>FAM83B has been recently identified as an oncogene, but its role in thyroid cancers (TC) is still unclear. We examined the expression of FAM83B and its possible involvement in cell migration and differentiation, in neoplastic/normal thyroid tissues and in TC human cell lines. FAM83B expression in TC varies according to the tumor histotype, being significantly downregulated in more aggressive and metastatic tissues. FAM83B levels in cell lines recapitulate patients' samples variations, and its total and cytoplasmic levels decrease upon the induction of migration, together with an increase in its nuclear localization. Similar variations were detected in the primary tumor and in the metastatic tissues from a follicular TC. FAM83B knock down experiments confirmed its role in thyroid differentiation and cell migration, as demonstrated by the reduction of markers of thyroid differentiation and the increase of the mesenchymal marker vimentin. Moreover, the silencing of FAM83B significantly increased cells migration abilities, while not affecting the oncogenic RAS/MAPK/PI3K pathways. Our data indicate for the first time a role for FAM83B in TC cell differentiation and migration. Its expression is reduced in dedifferentiated tumors and its nuclear re-localization could favour distant migration, suggesting that FAM83B should be considered a possible diagnostic and prognostic biomarker.</p>
The analysis of differentially expressed genes relevant to glycolysis in hypoxia-treated gastric cancer cells
<p> RNA sequencing was conducted to identify hypoxia-altered genes in GC cells. A total of 13,469 genes were included, with 430 genes upregulated and 476 genes downregulated. Gene Ontology (GO) analysis indicated that hypoxia-regulated genes mainly focused in glycolysis and canonical glycolysis pathways. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that hypoxia-regulated genes were significantly correlated with glycolysis pathway.</p>
EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma
<p><strong>Chimeric proteins resulting from chromosomal translocations play a major role as driver oncogenes in cancer. Among them, fusions between EWSR1 and transcription factors (TFs) generate oncogenes with powerful chromatin regulatory activities, capable of establishing complex gene expression programs.</strong><strong> Specific fusion partners are implicated in distinct tumor types, suggesting that the oncogenic activity of EWSR1 fusions is determined by their DNA binding properties and the chromatin environment of precursor cells</strong><strong>. Here we combined functional epigenomics with nuclear topology mapping to define the epigenetic and 3D connectivity landscape of Clear Cell Sarcoma (CCS), one of the most aggressive forms of human cancer, which is driven by the </strong><em><strong>EWSR1-ATF1</strong></em><strong> fusion gene. We find that </strong><strong>EWSR1-ATF1 displays a distinctive DNA binding pattern that depends on the EWSR1 prion-like domain and is divergent from wild type ATF1. </strong><strong>EWSR1-ATF1 promotes ATF1 retargeting to new distal sites, leading to chromatin activation and the establishment of a 3D network that controls oncogenic and differentiation signatures shared with primary CCS tumors. Conversely, EWSR1-ATF1 depletion results in a marked </strong><strong>reconfiguration of 3D connectivity</strong><strong>, including the emergence of a new set of connections controlling neural crest-related developmental programs. Accordingly, interrogation of more than 160’000 single cell expression profiles from the human skin atlas reveals that loss of EWSR1-ATF1 expression induces a differentiated cell state that resembles cells in the Schwann cell-melanocytic axis. Taken together, our study uncovers the cooperativity network of EWSR1-ATF1, delineates the molecular underpinnings of its epigenetic function in CCS, and points to precursor cells in the neural crest lineage as candidate cells of origin for these tumors. </strong></p>
Differential gene expression analysis at different stages of neuronal development in mutant and wild type ATRX cells
GEO Series GSE212922. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.