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542 results for “PCOS”
Economic Burden of Mental Health Disorders in PCOS-Supplemental Data
<p>This data set includes supplemental data denoting the search terms used for the systematic review, the characteristics of the studies included, the quality scores of the studies analyzed, the results of the sensitivity analysis excklduing self-reported PCOS and the results of the Eggers' test for publication bias. It also includes the Trim and Fill Funnel Plots for the meta-analyses.</p> <p> </p> <p>Use MS Word to read.</p>
Comparing Effects of Ultra Low Dose (Ethinyl Estradiol 20µg or 15µg) with Low Dose (Ethinyl Estradiol 30µg) Hormonal Pills on Lipid Discordance in Non-Obese PCOS Women: A Randomized Control Trial
<p>Ultra-low dose hormonal pills have become the favoured treatment option over low dose pills in PCOS. Existing literature shows marked heterogeneity in metabolic effects of pills with different compositions. This might have been due to improper choice of outcome variable for comparison. Total cholesterol - high density lipoprotein ratio (TC/HDL) discordance with Low Density Lipoprotein cholesterol (LDL-C) was a better marker of future risk of atherosclerotic cardio-vascular disease and stable to variations. Present study was a randomised controlled trial conducted to compare prevalence of TC/HDL and LDL discordance among non-obese PCOS women treated with hormonal pills of different compositions. Role of baseline participant features and pill composition on discordance after treatment was determined. Women were randomised into three arms, two arms receiving ultra-low dose pills (either Ethinyl Estradiol 20µg with drosperinone 3mg or Ethinyl Estradiol 15µg with gestodene 60µg) and one arm receiving low dose pill (Ethinyl Estradiol 30µg with desogestrel 150 µg). Discordance was observed in more than 1/4<sup>th</sup> participants prior to intervention. After one year of treatment less than 1/5<sup>th</sup> of participants were discordant. Ultra-low dose pill users had lower discordance, LDL and TC compared to low dose pill users after one year of treatment. Random Forest a non-linear classifier showed the highest accuracy in predicting discordance. Baseline Parameters having maximal impact on occurrence of discordance were triglyceride (TG), HOMA-IR, BMI and HDL.Ultra-low dose hormonal pills have become the favoured treatment option over low dose pills in PCOS. Existing literature shows marked heterogeneity in metabolic effects of pills with different compositions. This might have been due to improper choice of outcome variable for comparison. Total cholesterol - high density lipoprotein ratio (TC/HDL) discordance with Low Density Lipoprotein cholesterol (LDL-C) was a better marker of future risk of atherosclerotic cardio-vascular disease and stable to variations. Present study was a randomised controlled trial conducted to compare prevalence of TC/HDL and LDL discordance among non-obese PCOS women treated with hormonal pills of different compositions. Role of baseline participant features and pill composition on discordance after treatment was determined. Women were randomised into three arms, two arms receiving ultra-low dose pills (either Ethinyl Estradiol 20µg with drosperinone 3mg or Ethinyl Estradiol 15µg with gestodene 60µg) and one arm receiving low dose pill (Ethinyl Estradiol 30µg with desogestrel 150 µg). Discordance was observed in more than 1/4<sup>th</sup> participants prior to intervention. After one year of treatment less than 1/5<sup>th</sup> of participants were discordant. Ultra-low dose pill users had lower discordance, LDL and TC compared to low dose pill users after one year of treatment. Random Forest a non-linear classifier showed the highest accuracy in predicting discordance. Baseline Parameters having maximal impact on occurrence of discordance were triglyceride (TG), HOMA-IR, BMI and HDL.</p>
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