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Dataset results
571 results for “Sex differences”
Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells
GEO Series GSE198631. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
The effect of Repeated Cross Fostering (RCF) on transcriptomic profiles of mouse Ventral Tegmental Areas across different sexes and strains
GEO Series GSE165922. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Sex differences in brain transcriptomes of juvenile Cynomolgus macaques
GEO Series GSE247236. Macaca mulatta. 18 samples. Type: Expression profiling by high throughput sequencing.
Effects of Fmr1 gene mutations on sex differences in autism-like behavior and dendritic spine development in mice and transcriptomic studies
GEO Series GSE224521. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
DIAPASON Project: EXPLORING SEX DIFFERENCES IN PHYSICAL ACTIVITY PATTERNS AMONG INDIVIDUALS WITH SCHIZOPHRENIA SPECTRUM DISORDER: INSIGHTS FROM THE DIAPASON PROJECT
<p>Dataset of the paper entitled <i>EXPLORING SEX DIFFERENCES IN PHYSICAL ACTIVITY PATTERNS AMONG INDIVIDUALS WITH SCHIZOPHRENIA SPECTRUM DISORDER: INSIGHTS FROM THE DIAPASON PROJECT from the DIAPASON project</i> of the project "DAILY TIME USE, PHYSICAL ACTIVITY, QUALITY OF CARE AND INTERPERSONAL RELATIONSHIPS IN PSYCHIATRIC RESIDENTIAL FACILITIES: AN ITALIAN MULTICENTRE STUDY" Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2018-12365514) (https://www.diapason-study.eu/)</p><p> </p>
Sex-related changes in LDH-A expression differently impact on immune response in melanoma
<p><span>Marta Iozzo1, Giuseppina Comito1, Luigi Ippolito1, Giada Sandrini2, Elisa Pardella1, Erica Pranzini1,<strong> </strong>Mariaelena Capone3, Gabriele Madonna3, Paolo Antonio Ascierto3, Paola Chiarugi1, Elisa Giannoni1.</span></p> <p><span>1 Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy</span></p> <p><span>2 Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), Bellinzona, Switzerland</span></p> <p><span>3 Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, 80131, Naples, Italy </span></p> <p> </p> <p>Abstract<br>Melanoma incidence and mortality are higher in male patients than female ones, likely associated to the sex dimorphism in immune responses. Pro- and anti-tumor immune immunity are altered by the metabolic changes occurring in the tumor microenvironment.<br>Here, we identified the lactate dehydrogenase A (LDH-A), the key enzyme deputed to the lactate production, as a crucial metabolic player discriminating sex-related melanoma immune responses both in in vitro and in patient-derived specimens. Specifically, LDH-A-associated higher lactate secretion in male melanoma cells leads to a significant enrichment in pro-tumoral regulatory T cells (Treg) with a decrease in the number and activity of anti-tumor CD8+ T cells. Remarkably, pharmacological and genetic impairment of LDH-A in male melanoma cells are able to phenocopy female ones in terms of Treg and CD8+ infiltration. In keeping, in vivo pharmacological targeting of LDH-A in melanoma-bearing male mice significantly impairs tumor growth and lung colonization, and this correlates with a concomitant modulation of Treg and CD8+ T cells infiltration. Taken together, our findings underline sex-related differences in the melanoma LDH-A-promoting immune reshaping and suggest LDH-A targeting as an effective strategy to abolish the sex-gap in melanoma progression.</p> <p> </p>
Sex differences and effect of testosterone on the transcriptome in brain regions underlying quail sexual behavior
GEO Series GSE167203. Coturnix japonica. 36 samples. Type: Expression profiling by high throughput sequencing.
Sex Differences in the Late First Trimester Human Placenta Transcriptome
GEO Series GSE109120. Homo sapiens. 39 samples. Type: Expression profiling by high throughput sequencing.
The effect of Bcl6 on liver sex difference
GEO Series GSE107435. Mus musculus. 8 samples. Type: Expression profiling by array.
Spatial Transcriptomics of C. elegans Males and Hermaphrodites Identifies Sex-Specific Differences in Gene Expression Patterns
GEO Series GSE114723. Caenorhabditis elegans. 10 samples. Type: Expression profiling by high throughput sequencing.
Sex differences in transcriptome profiles in hypothalamic and extrahypothalamic nuclei of rats impacted by adolescent stress
GEO Series GSE169296. Rattus norvegicus. 108 samples. Type: Expression profiling by high throughput sequencing.
Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX
GEO Series GSE217794. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenome-Wide Methylation Profile in Normal Human Kidney: Sex, Age, and Ethnic Differences
GEO Series GSE79100. Homo sapiens. 31 samples. Type: Methylation profiling by genome tiling array.
Sex differences in the expression and function of hepatic very low-density lipoprotein receptor during protein deficiency in mice
GEO Series GSE259313. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
The sex difference under non-stressed and chronic-stressed conditions in C57BL/6 mice
GEO Series GSE211276. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Cross-Species Single-Cell Analysis Reveals Sex Differences in Mitochondrial Dysfunction as a Conserved Feature of Tau Pathology
GEO Series GSE310345. Danio rerio. 8 samples. Type: Expression profiling by high throughput sequencing.
Sex-linked differences in glyco-gene expression in thymocytes
GEO Series GSE27054. Homo sapiens; Mus musculus. 6 samples. Type: Expression profiling by array.
Sex Differences in the Skeletal Muscle Response to a High Fat, High Sucrose Diet in Rats
GEO Series GSE228215. Rattus norvegicus. 23 samples. Type: Expression profiling by high throughput sequencing.
Geographical and host plant influences on transcriptional variation in Drosophila mojavensis: mapping gene expression differences in both sexes
GEO Series GSE78852. Drosophila mojavensis. 127 samples. Type: Expression profiling by array.
Sex Differences in the Relationship between Chronotype and Eating Behaviour: A Focus on Binge Eating and Food Addiction
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.