Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
818
datasets available to search
ShareScore release 0.9.0
Dataset results
818 results for “neutralization”
HERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
GEO Series GSE238169. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of gene expression changes in mouse subcutaneous adipose tissue in cold compared to thermal neutrality
GEO Series GSE84860. Mus musculus. 2 samples. Type: Expression profiling by array.
Stability of Aire-upregulated and Aire-neutral transcripts in medullary thymic epithelial cells
GEO Series GSE140815. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
CAR T Cells Secreting NGF-Neutralizing scFv Enhance Efficacy in Clear Cell Renal Cell Carcinoma by Relieving Immunosuppression through Immunosympathectomy [bulk RNA-seq]
GEO Series GSE279393. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing anti
GEO Series GSE234425. Mus musculus. 46 samples. Type: Expression profiling by high throughput sequencing.
Bacteriophage antidefense genes that neutralize TIR and STING immune responses
GEO Series GSE222071. Bacteriophage sp.. 6 samples. Type: Other.
Development, Cryo-EM structure and function of potent monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and variant B.1.351
GEO Series GSE174635. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Neutral competition explains the clonal composition of neural organoids
GEO Series GSE255232. Homo sapiens. 10 samples. Type: Other.
Identification and characterization of a non-biological small molecular mimic of a Zika virus conformational neutralizing epitope
GEO Series GSE254062. synthetic construct. 81 samples. Type: Other.
Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors
GEO Series GSE214884. Homo sapiens; Mus musculus. 54 samples. Type: Other.
Transcriptional effects of IL-10 neutralization on LPS-activated M-CSF-derived macrophages
GEO Series GSE181250. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
An RNA-based platform to neutralize DNMT1 function AptaDiR is an innovative RNA-based platform to neutralize DNMT1 function
GEO Series GSE154471. Homo sapiens. 6 samples. Type: Methylation profiling by array.
Loss of ER and nuclear envelope-associated neutral sphingomyelinase SMPD4 causes a severe neurodevelopmental disorder with microcephaly and congenital arthrogryposis
GEO Series GSE133264. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Neutral sphingomyelinase 2 inhibition alters inflammatory gene expression signatures in the brain of mice infected with West Nile virus
GEO Series GSE256333. Mus musculus. 27 samples. Type: Expression profiling by high throughput sequencing.
MD simulations of bilayers containing POPC and Cholesterol: 120POPC_8CHL_31Nwat_neutral (lipid14)
<p>NMRLipids III CholXray project (nmrlipids.blogspot.fi)</p> <p>Gromacs 5.0.4, lipid14 FF (Madej et al. JPCB 2015, 119, 12424), 1 atm, 303K, 200ns</p> <p>128 lipids (120 POPC, 8 CHL), N_wat/lipid = 31, 28576 Atoms</p>
Data for the paper "Impacts of soft electron precipitations on the neutral density and satellite drag during the 28-29 May 2010 geomagnetic storm"
<p>Data for the paper "Impacts of soft electron precipitations on the neutral density and satellite drag during the 28-29 May 2010 geomagnetic storm" by Qingyu Zhu, Yue Deng, Cheng Sheng, Phil Andersen and Aaron Bukowski</p> <p>GITM_3D.zip: GITM outputs at 12 UT, 05/29/2010 (Figure 3)</p> <p>HPs.zip: NOAA and Z2019 HP (Figure 1)</p> <p>rhos.zip: Neutral density along the GOCE orbit from observation, run1, run2, run3 and JB2008 model (Figures 2 and 4)</p>
Elastic Scattering of Electron in Neutral Plasma: Interaction Model and Plasma Environment Effects
<p>please see Elastic Scattering of Electron in Neutral Plasma: Interaction Model and Plasma Environment Effects</p>
Data from: Mapping polyclonal HIV-1 antibody responses via next-generation neutralization fingerprinting
Computational neutralization fingerprinting, NFP, is an efficient and accurate method for predicting the epitope specificities of polyclonal antibody responses to HIV-1 infection. Here, we present next-generation NFP algorithms that substantially improve prediction accuracy for individual donors and enable serologic analysis for entire cohorts. Specifically, we developed algorithms for: (a) selection of optimized virus neutralization panels for NFP analysis, (b) estimation of NFP prediction confidence for each serum sample, and (c) identification of sera with potentially novel epitope specificities. At the individual donor level, the next-generation NFP algorithms particularly improved the ability to detect multiple epitope specificities in a sample, as confirmed both for computationally simulated polyclonal sera and for samples from HIV-infected donors. Specifically, the next-generation NFP algorithms detected multiple specificities in twice as many samples of simulated sera. Further, unlike the first-generation NFP, the new algorithms were able to detect both of the previously confirmed antibody specificities, VRC01-like and PG9-like, in donor CHAVI 0219. At the cohort level, analysis of ~150 broadly neutralizing HIV-infected donor samples suggested a potential connection between clade of infection and types of elicited epitope specificities. Most notably, while 10E8-like antibodies were observed in infections from different clades, an enrichment of such antibodies was predicted for clade B samples. Ultimately, such large-scale analyses of antibody responses to HIV-1 infection can help guide the design of epitope-specific vaccines that are tailored to take into account the prevalence of infecting clades within a specific geographic region. Overall, the next-generation NFP technology will be an important tool for the analysis of broadly neutralizing polyclonal antibody responses against HIV-1.
Data from: Community assembly in Lake Tanganyika cichlid fish: quantifying the contributions of both niche-based and neutral processes
The cichlid family features some of the most spectacular examples of adaptive radiation. Evolutionary studies have highlighted the importance of both trophic adaptation and sexual selection in cichlid speciation. However, it is poorly understood what processes drive the composition and diversity of local cichlid species assemblages on relatively short, ecological timescales. Here, we investigate the relative importance of niche-based and neutral processes in determining the composition and diversity of cichlid communities inhabiting various environmental conditions in the littoral zone of Lake Tanganyika, Zambia. We collected data on cichlid abundance, morphometrics, and local environments. We analyzed relationships between mean trait values, community composition, and environmental variation, and used a recently developed modeling technique (STEPCAM) to estimate the contributions of niche-based and neutral processes to community assembly. Contrary to our expectations, our results show that stochastic processes, and not niche-based processes, were responsible for the majority of cichlid community assembly. We also found that the relative importance of niche-based and neutral processes was constant across environments. However, we found significant relationships between environmental variation, community trait means, and community composition. These relationships were caused by niche-based processes, as they disappeared in simulated, purely neutrally assembled communities. Importantly, these results can potentially reconcile seemingly contrasting findings in the literature about the importance of either niche-based or neutral-based processes in community assembly, as we show that significant trait relationships can already be found in nearly (but not completely) neutrally assembled communities; that is, even a small deviation from neutrality can have major effects on community patterns.
Data from: Phanerozoic diversity and neutral theory
Although Phanerozoic increases in the global richness, local richness, and evenness of marine invertebrates are well documented, a common explanation for these patterns has been difficult to identify. Evidence is presented here from marine invertebrate communities that there is a Phanerozoic increase in the fundamental biodiversity number (θ), which describes diversity and relative abundance distributions in neutral ecological theory. If marine ecosystems behave according to the rules of Hubbell's Neutral Theory of Biodiversity and Biogeography, the Phanerozoic increase in θ suggests three possible mechanisms for the parallel increases in global richness, local richness, and evenness: (1) an increase in the per-individual probability of speciation, (2) an increase in the area occupied by marine metacommunities, and (3) an increase in the density (per-area abundance) of marine organisms. Because speciation rates have declined over time and because there is no clear evidence for an increase in metacommunity area through the Phanerozoic, the most likely of these is an increase in the spatial density of marine invertebrates over the Phanerozoic, an interpretation supported by previous studies of fossil abundance. This, coupled with a Phanerozoic rise in body size, suggests that an increase in primary productivity through time is the primary cause of Phanerozoic increases in θ, global richness, local richness, local evenness, abundance, and body size.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.