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579
datasets available to search
ShareScore release 0.9.0
Dataset results
579 results for “Microvascular”
Comparative profile of microtubule destabilizers, a microtubule stabilizer, and TNF-α in human pulmonary microvascular endothelial cells
GEO Series GSE286439. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Mechanisms and treatment of cold-storage-induced microvascular obstructions in normothermic machine perfusion of human kidney
GEO Series GSE139017. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Effect of ADAM10 depletion in human retinal microvascular endothelial cells (HRMVECs)
GEO Series GSE245783. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of human brain microvascular endothelial cells with Nox4 overexpression
GEO Series GSE205176. Homo sapiens. 2 samples. Type: Expression profiling by array.
Reduced Retinal Microvascular Density, Improvement in Forepaw Reach, Comparative Microarray and Gene Set Enrichment Analysis using DNA Enzyme Targeting c-jun mRNA
GEO Series GSE37898. Mus musculus. 4 samples. Type: Expression profiling by array.
Effect of high or low chronic shear stress on microvascular endothelial cells cultured on native- versus AGE-fibronectin
GEO Series GSE2424. Homo sapiens. 3 samples. Type: Expression profiling by SAGE.
Gene expression profiling in endothelial precursor cells of patients protected from microvascular complications
GEO Series GSE43950. Homo sapiens. 14 samples. Type: Expression profiling by array.
Gene expression profiling of human brain microvascular pericytes with hypoxia and acidosis stimulation
GEO Series GSE109187. Homo sapiens. 4 samples. Type: Expression profiling by array.
Paired-end RNA Sequencing on human dermal microvascular endothelial cells (HMEC-1) infected or not with Borrelia burgdorferi (MOI= 200 bacteria/cell) examined at different times post-infection (namely
GEO Series GSE174545. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Single-cell dissection of ex vivo human heart tissue reveals pro-inflammatory microvascular changes in the right atrium in ischemic heart disease and heart failure
GEO Series GSE214731. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Efficient method for the differentiation of human pluripotent stem cells (hPSCs) into functional brain microvascular endothelial (BME)-like cells
GEO Series GSE148534. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
The transcriptomic profile of human microvascular endothelial cells after exposure to preeclamptic or normotensive third trimester trophoblast debris
GEO Series GSE86032. Homo sapiens. 10 samples. Type: Expression profiling by array.
Molecular Evidence of Chronic Cellular Rejection in C4d and Microvascular Inflammation Negative Transplant Glomerulopathy
GEO Series GSE93659. Homo sapiens. 44 samples. Type: Expression profiling by array.
Microarray analysis of mRNA expression in human microvascular endothelial cells exposed to colorectal cancer cell derived stimuli
GEO Series GSE67914. Homo sapiens. 4 samples. Type: Expression profiling by array.
Effects of of Nogo-B receptor deficiency on transcriptomic profilig in human brain microvascular endothelial cells
GEO Series GSE198351. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression data from Human Microvascular Endothelial Cells exposed or not to low-dose ionizing radiation
GEO Series GSE73341. Homo sapiens. 8 samples. Type: Expression profiling by array.
C5a and C5aR1 are key drivers of microvascular platelet aggregation in clinical entities spanning from aHUS to COVID-19
<p>Unrestrained activation of the complement system till the terminal products, C5a and C5b-9, plays a pathogenetic role in acute and chronic inflammatory diseases. In endothelial cells, complement hyperactivation may translate into cell dysfunction, favoring thrombus formation. The aim of this study was to investigate the role of the C5a/C5aR1 axis as opposed to C5b-9 in inducing endothelial dysfunction and loss of antithrombogenic properties. In vitro and ex vivo assays with serum from patients with atypical hemolytic uremic syndrome (aHUS), a prototype rare disease of complement-mediated microvascular thrombosis due to genetically determined alternative pathway dysregulation, and cultured microvascular endothelial cells, demonstrated that the C5a/C5aR1 axis is a key player in endothelial thromboresistance loss. C5a added to normal human serum fully recapitulated the prothrombotic effects of aHUS serum. Mechanistic studies showed that C5a caused RalA-mediated exocytosis of von Willebrand factor (vWF) and P-selectin from Weibel-Palade bodies, which favored further vWF binding on the endothelium and platelet adhesion and aggregation. In patients with severe COVID-19 who suffered from acute activation of complement triggered by severe acute respiratory syndrome coronavirus 2 infection, we found the same C5a-dependent pathogenic mechanisms. These results highlight C5a/C5aR1 as a common prothrombogenic effector spanning from genetic rare diseases to viral infections, and it may have clinical implications. Selective C5a/C5aR1 blockade could have advantages over C5 inhibition because the former preserves the formation of C5b-9, which is critical for controlling bacterial infections that often develop as comorbidities in severely ill patients. </p>
Lipopolysaccharide-induced Changes in Gene Expression in Human Lung Microvascular Endothelial Cells over Time
GEO Series GSE5883. Homo sapiens. 24 samples. Type: Expression profiling by array.
Differential microvascular endothelial cell responses in the retina in diabetes compared to the heart and kidneys, a spatial transcriptomic analysis.
GEO Series GSE263128. Mus musculus. 24 samples. Type: Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.