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1,048
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Dataset results
1,048 results for “aging effects”
The Effects of Aging on the Molecular and Cellular Composition of the Prostate Microenvironment
GEO Series GSE21542. Mus musculus. 40 samples. Type: Expression profiling by array.
Exploring the effect of aging, TNFα, and RBM25 on the gene expresssion of inner ear
GEO Series GSE273939. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Effects of losmapimod on antigen-specific response in aged skin
GEO Series GSE130633. Homo sapiens. 126 samples. Type: Expression profiling by high throughput sequencing.
Effect of aging on gene expression in round spermatids from Brown Norway rats
GEO Series GSE219040. Rattus norvegicus. 10 samples. Type: Expression profiling by high throughput sequencing.
Effect of donor age on the proportion of mesenchymal stem cells derived from anterior cruciate ligaments
GEO Series GSE59662. Homo sapiens. 6 samples. Type: Expression profiling by array.
Dataset from 'Billino, J. & Drewing, K. (2017). Age effects on visuo-haptic length discrimination: Evidence for optimal integration of senses in senior adults. Mulitsensory Research
<p>Dataset associated with the following publication:</p> <p>Billino, J. & Drewing, K. (2017). Age effects on visuo-haptic length discrimination: Evidence for optimal integration of senses in senior adults. Multisensory Research.</p> <p>The folder contains a data file and a description file providing column labels.</p> <p>For further questions, please contact:<br> jutta.billino[at]psychol.uni-giessen.de</p>
3D reconstruction of skin and spatial mapping of immune cell density, vascular distance and effects of sun exposure and aging
<p>Mapping the human body at single cell resolution in three dimensions (3D) is an important step toward a “digital twin” model that digitizes organ structure and the dynamics of cell-cell interactions. Current approaches for 3D reconstruction of multiplexed serial sections are relatively cumbersome and not automated. We present a novel 3D reconstruction workflow for multiplexed sequential tissue sections: MATRICS-A (Multiplexed Image Three-D Reconstruction and Integrated Cell Spatial - Analysis). This combines a reproducible and streamlined method for two-dimensional (2D) cell segmentation and cell type classification, followed by 3D volume reconstruction. We also provide novel tools for 3D visualization of immune cell cluster density, cell-to-vasculature distance, and distance maps for cellular markers of UV damage/repair and proliferation to the skin surface. We used MATRICS-A to reconstruct 26 serial sections of fixed skin from 12 donors aged between 32-72 years. Samples were collected from six distinct anatomical regions with mild to marked sun exposure effects. Each tissue section was multiplexed with 18 fluorescently labeled antibodies covering 14 cell types in the epidermis and dermis. We demonstrate several new findings that are only possible in 3D, We present novel visualization of immune cell clusters and show that there are 10-70% more T cells (total) within 30 µm of a T helper cell in 3D vs 2D. Distances of cell markers of DNA damage (p53), DNA repair (DDB2) and proliferation (Ki67) to the skin surface were consistent across all ages/sun exposure. MATRICS-A provides a new powerful integrated open access approach to quantify 3D spatial cell relationships in healthy and aging organs and could be further extended to diseased organs. </p>
Effects of Aging on Primary and Secondary Vaccine Responses
ClinicalTrials.gov study NCT03312699. IPD Sharing: YES. Countries: 1. Publications: 0.
Effects of Exercise Interventions in Frail Middle-aged and Older Adults
ClinicalTrials.gov study NCT05279625. IPD Sharing: NO. Countries: 1. Publications: 0.
Assessment of the Intervention Effectiveness of Branched-chain Amino Acids(BCAA) Combined With Medium-chain Fatty Acid(MCFA) Products in Sarcopenia Among Middle-aged and Elderly Individuals
ClinicalTrials.gov study NCT06376266. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Age, Physical Fitness and a Single Bout of Aerobic Exercise on Motor and Cognitive Functions
ClinicalTrials.gov study NCT03750812. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Isoflavone Combined With Astaxanthin on Skin Aging
ClinicalTrials.gov study NCT02373111. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Age and Gender on the PK and Tolerability of Finafloxacin
ClinicalTrials.gov study NCT01904162. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Dietary Nitrate on Age-related Vascular Function
ClinicalTrials.gov study NCT01729234. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Assess Effects of Age, Weight, and Body Composition on the Pharmacokinetics of IV Diclofenac Sodium
ClinicalTrials.gov study NCT00509743. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Hybrid Effectiveness-implementation Evaluation on Programs Promoting Healthy Aging With Sport Exercise (PHASE Program)
ClinicalTrials.gov study NCT06090253. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Evaluation of the Effect of Pure Canterbury Stage 1 Infant Formula Milk Powder on the Growth of Infant 0-6 Months of Age
ClinicalTrials.gov study NCT02239588. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of the Effects of Food and Age on Danicopan
ClinicalTrials.gov study NCT04551599. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Open-Label Study to Evaluate the Effect of Age Upon the Pharmacokinetics of Androxal
ClinicalTrials.gov study NCT02169804. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Sweet Orange and Pomegranate Extract Supplementation on Exercise Capacity in Middle-aged Adults
ClinicalTrials.gov study NCT05133778. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.