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111,247 results for “cells”
Fig. 2 in Histological, Topographical And Ultrastructural Organization Of Different Cells Lining The Olfactory Epithelium Of Red Piranha, Pygocentrus Nattereri (Characiformes, Serrasalmidae)
Fig. 2. Photomicrographs of the olfactory epithelium of P. nattereri by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and histological features stained with Mallory's triple (MT) stain. A — transitional zone between sensory epithelium (SE) with receptor cells (solid arrows) and non-sensory epithelium (NSE) having a series of mucous cells (MC) (Broken arrows), labyrinth cells (LC) and stratified epithelial cells (arrow heads). Olfactory epithelium separated from central core (CC) by a basement membrane (BM) (MT) ×400. B — surface of non-sensory epithelium showing densely arranged ciliated supporting cells (solid arrows) encircled the non-ciliated supporting cells (SC) with adhering mucin mass (arrow heads). Note the opening of MC (broken arrows) in between SC (SEM) ×4500. C — dendrite of receptor cell (RC) emerging out from basal body (broken arrow). Note microtubules of rod (solid arrow) parallel arranged (TEM) ×5000. D —nuclei of receptor cells (N) showing dispersed heterochromatin (arrow heads). Note the presence of mitochondria (solid arrows) adjacent to nucleus (TEM) ×500. (E) Showing cisterns of rough endoplasmic reticulum (rER) (arrow heads) encircling nucleus (solid arrow). Note Golgi apparatus (broken arrow) adjacent to rER (TEM) ×4000. F — OEP lined with microvillous cells (MV), mucous cell (MC) and supporting cell (broken arrow) (TEM) ×2100. G — microvillous cells exhibiting abundant ribosomes (broken arrows) and extended mitochondria (arrow heads). Solid arrow indicates nucleus (TEM) ×5000. H — axons (broken arrows) of receptor cells run parallel on both sides of basal cells (solid arrow) (TEM) ×5000.
Fig. 3 in Histological, Topographical And Ultrastructural Organization Of Different Cells Lining The Olfactory Epithelium Of Red Piranha, Pygocentrus Nattereri (Characiformes, Serrasalmidae)
Fig. 3. Photomicrographs of the olfactory epithelium of P. nattereri by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). A — olfactory epithelium (OEP showing mucous cell (MC) having granules, microvillous cell (arrow head), labyrinth cell (broken arrow) and vesicular cytoplasm of supporting cell (solid arrow) (TEM) ×2100. B — flat surface ciliated supporting cell (solid arrow) provided with plenty of kinocilia (arrow heads) showing microtubular pattern (broken arrows). Note large number of mitochondria within the cytoplasm of supporting cells (TEM) ×5000. C — non-sensory olfactory epithelium (OEP) comprised of MC filled with large granules and supporting cells (solid arrows) (TEM) ×2100. D — basal cells provided with conspicuous lobular nuclei (N) having dense nucleolus (solid arrow). Note the presence of small vesicles (arrow head) adjacent the nucleus and rough endoplasmic reticulum (rER) (broken arrows) (TEM) ×2500. E — showing nuclear division of basal cells provided with dense nucleus (solid arrows). Broken arrows indicate mature nucleus of basal cells (TEM) ×2500. F — showing labyrinth cells (solid arrow) with conspicuous folding encircled by compactly arranged stratified epithelial cells (SEC). Note the presence of MC (broken arrows) in between SEC and mucin droplets (arrow heads) over SEC (SEM) ×4500. G — surface epithelium of raphe provided with packed SEC having labyrinth pattern microridges. Note the presence of opening of MC (solid arrows) and mucin droplets (arrow heads) over SEC (SEM) ×4500. H — raphe showing oval and elongated nuclei (N) of Stratified epithelial cells. Note the presence of rER (solid arrows) and vesicles (broken arrows) adjacent to nucleus (TEM) × 2500.
The protein organization of a red blood cell
<p>Elution profiles, feature matrix, train and test ppis, and metadata for the paper "The protein organization of a red blood cell". Sae-Lee et al., </p>
MD simulation of the crystal unit cell of the second PDZ domain of LNX2 protein
<p>This molecular dynamics simulation data is provided as part of the manuscript "<strong>LAWS: Local Alignment for Water Sites - a method to analyze crystallographic water in simulations</strong>". The code for the algorithm is provided: <a href="https://github.com/rauscher-lab/LAWS">on github</a><br> <br> The system contains one unit cell of the crystal (PDB ID: 5E11) with 4 symmetrically related protein chains. The total simulation length is 1 microsecond. </p> <p><strong>Force field + water model</strong>: CHARMM36m + CHARMM-modified TIP3P<br> <strong>Number of atoms</strong>: 9650<br> <strong>Number of time frames:</strong> 100,000 with 10-ps stride<br> <em>The details of the simulations are provided in the manuscript.</em></p>
Oneat division model for Hela cells
<p>Trained models for hela cells for the bright field channel for locating mitosis events. Provided is an example dataset for bright field image and its corresponding model that can be used using the notebook here: https://github.com/Kapoorlabs-CAPED/CAPED-AI-oneat</p> <p> </p> <p>Made by oneat software, pip install oneat for training of such datasets.</p> <p> </p> <p>Original data published by Romain Guiet at https://zenodo.org/record/6139958#.YmAh1NpBxhG</p>
Long read proteogenomics to characterize protein isoform diversity in human umbilical vein endothelial cells (HUVECs)
<p>Endothelial cells (ECs) comprise the lumenal lining of all blood vessels and are critical for the functioning of the cardiovascular system and their phenotypes can be modulated by protein isoforms. To characterize the isoform landscape within EC, we applied a long read proteogenomics approach to analyze human umbilical vein endothelial cells (HUVECs). Transcripts delineated from PacBio sequencing serve as the basis for a sample-specific protein database used for downstream MS analysis to infer protein isoform expression. We detected 53,836 transcript isoforms from 10,426 genes, with 22,195 of those transcripts being novel. Furthermore, the predominant isoform in HUVECs does not correspond with the accepted “reference isoform” 25% of the time, with vascular pathway-related genes among this group. We found 2,597 protein isoforms supported through unique peptides, with an additional 2,280 isoforms nominated upon incorporation of long-read transcript evidence. We characterized a novel alternative acceptor for endothelial-related gene <em>CDH5</em>, suggesting potential changes in its associated signaling pathways. Finally, we identified novel protein isoforms arising from a diversity of splicing mechanisms supported by uniquely mapped novel peptides. Our results represent a high resolution atlas of known and novel isoforms of potential relevance to endothelial phenotypes and function.</p>
SCADIE: simultaneous estimation of cell type proportions and cell type-specific gene expressions using SCAD-based iterative estimating procedure
<p>This repository contains the source code and data used in the paper: SCADIE: simultaneous estimation of cell type proportions and cell type-specific gene expressions using SCAD-based iterative estimating procedure.1.</p>
IGM Population of HFF structures using Hi-C, laminB1 DamID, 3D HIPMAp FISH and single cell SPRITE data
<p>This repository accompanies the manuscript "<strong>Integrative Genome Modeling Platform reveals essentiality of rare contact events in 3D genome organizations</strong>", to appear in Nat. Methods (2022), see also https://www.biorxiv.org/content/10.1101/2021.08.22.457288v1.</p> <p>It contains the preprocessed input data files (Hi-C, laminB1 DamID, 3D HIPMAp FISH and single cell SPRITE) for the HFF fibroblast cell line to be used in the Integrative Genome Modeling platform (IGM) developed in the Alber lab at UCLA (https://github.com/alberlab/igm).</p> <p>Also, we provide the configuration file to run IGM with those datasets, as we did in generating the HDSF population discussed in the accompanying manuscript. Such population is also provided as an "hss" file. Documentation and a simple demo/tutorial on how IGM can be run is given on the Alber lab Github @ https://github.com/alberlab/igm.</p> <p>All files can be read in using the <em>h5py</em> and <em>alabtools</em> (available @https://github.com/alberlab/alabtools) Python packages. More detailed information is provided in the manuscript and associated Supplementary Information file. </p> <p>For any inquiry/suggestions/doubts please reach out to Lorenzo Boninsegna (bonimba@g.ucla.edu) or Dr. Frank Alber (falber@g.ucla.edu).</p> <p> </p>
β-cell-specific deletion of Zfp148 improves nutrient-stimulated β-cell Ca2+ responses
<p>Insulin secretion from pancreatic β-cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We previously showed that β-cell-specific deletion of <em>Zfp148</em> (β-<em>Zfp148</em><sup>KO</sup>) improves glucose tolerance and insulin secretion in mice. Here, we performed Ca<sup>2+</sup> imaging of islets from β‑<em>Zfp148</em><sup>KO</sup> and control mice on both a chow and a Western-style diet. β-<em>Zfp148</em><sup>KO</sup> islets demonstrate improved sensitivity and sustained Ca<sup>2+</sup> oscillations in response to elevated glucose. β-<em>Zfp148</em><sup>KO</sup> islets also exhibit elevated sensitivity to amino acid-induced Ca<sup>2+</sup> influx under low glucose conditions, suggesting enhanced mitochondrial phosphoenolpyruvate (PEP)-dependent KATP channel closure, independent of glycolysis. RNA sequencing and proteomics of β-<em>Zfp148</em><sup>KO</sup> islets revealed altered levels of enzymes involved in amino acid metabolism (SLC3A2, SLC7A8, GLS, GLS2, PSPH, PHGDH, PSAT1) and intermediary metabolism (GOT1, PCK2), consistent with altered PEP cycling. In agreement with this, β-<em>Zfp148</em><sup>KO</sup> islets displayed enhanced insulin secretion in response to L-glutamine and activation of glutamate dehydrogenase. Understanding pathways controlled by ZFP148 may provide promising strategies for improving β-cell function that are robust to the metabolic challenge imposed by a Western diet.</p>
Discrete Flow Cytometry of Underway Samples from Gradients 4 (2021) Using a BD Influx Cell Sorter
<p>The dataset consists of BD Influx-based analysis of phytoplankton populations from discrete flow cytometry data collected underway during the Gradients 2021 (Gradients 4/TN397) oceanographic research cruise in the equatorial Pacific Ocean. The analysis includes cell abundance, forward light scatter, and pigment fluorescence of individual cells, including picoeukaryotes and the cyanobacteria Prochlorococcus and Synechococcus. The analysis also includes estimates of cell size, carbon content, and biomass using forward light scatter values and Mie Theory. Time is in UTC format, latitude and longitude are in decimal degrees, and depth is in meters. Further information can be found here: https://github.com/fribalet/FCSplankton</p>
Dataset for the development of a "Flow cell for operando X-ray photon-in-photon-out studies on photo-electrochemical thin film devices"
<p>All raw experimental data concerning this published ChemRxiv manuscript: https://doi.org/10.26434/chemrxiv.12382529.v1 which is now published slightly revised here: https://doi.org/10.12688/openreseurope.14433.1<br> <br> The dataset comprises raw data, analysis and short description:<br> - the CAD-files of the operando cell<br> - the grazing-incidence X-ray diffraction (GIXRD) files of the as-synthesized thin film samples<br> - the high-energy resolution fluoresence-detected (HERFD) X-ray absorption (XAS) files of thin films during photoelectrochemical experimentation<br> - the photoelectrochemical data gathered during HERFD-XAS experiments<br> - the non-operando photoelectrochemical data on the thin film samples<br> - scanning electron microscopy (SEM) image of a representative thin film cross-section<br> - the extended data contains additional information arranged in a word document that are directly linked to the main manuscript</p>
Human single-cell TCR data from irradiated sporozoite trial
<p>This is the MiAIRR-compliant single-cell AIRR-seq data of the study "Clonal evolution and TCR specificity of the human<br> TFH cell response to Plasmodium falciparum CSP" by Wahl <em>et al.,</em> <em>Sci Immunol</em> 7:eabm9644 (2022). The study defines the clonal evolution and epitope specificity of the human cTFH cell response to Plasmodium falciparum CSP.</p>
Hippocampal CA1 pyramidal cell membrane voltage recorded in response to noise stimuli at two temperatures.
<p>Electrophysiological recording of the membrane voltage (whole-cell patch-clamp) of three hippocampal CA1 pyramidal cells. Cells are stimulated with a current step chosen to ensure a firing rate around 5-10Hz (amplitude of the current step is given in the filenames) and a noise stimulus with zero mean (Ornstein-Uhlenbeck process with 4ms timescale). Each CSV file contains three columns, the timepoints (saved at 10000Hz), the noise stimulus, and the voltage trace recorded in response to the given noise stimulus. Voltages are recorded at low temperatures (around 32 degrees Celsius) and at high temperatures (around 37 degrees Celsius for cell 1, around 40 degrees Celsius for cells 2 and 3), exact temperatures are given in the filenames. The file metadata.csv contains additional information.</p>
Data: Computed tomography lacks sensitivity to image gold labelled mesenchymal stromal cells in vivo as evidenced by multispectral optoacoustic tomography.
<p>This data set includes all the raw data collected for the following article: "Computed tomography lacks sensitivity to image gold labelled mesenchymal stromal cells in vivo as evidenced by multispectral optoacoustic tomography."</p>
Virtual screening on Nsp16: screening of 1084 compounds in VeroE6-eGFP cells
<p>This report describes the most relevant results of virtually screening the Janssen Pharmaceutica compound collection for potential activity against SARS-CoV-2 Nsp16 and confirmation of potential hits in a VeroE6 cell-based anti-SARS-CoV-2 assay.</p>
Single-Cell Autism data stored as sce object
<p>The raw autism dataset is from UCSC Cell Browser Dataset, Autism section (<a href="https://cells.ucsc.edu/">https://cells.ucsc.edu</a>). It is stored as SingleCellExperiment object for further usage. </p>
Data of FigS2, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS2, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS2.PNG). The corresponding raw data and subsequent data analysis obtained from proteomics analysis are provided as nine files in CSV format (31003A-179400_10.3390-cancers14133074_SS_SA_DHRS7_5_1-3_M1-3.csv). All further experiment related information provided as one meta-data-file (31003A-179400_10.3390-cancers14133074_SS_SA_DHRS7_5_1_M .txt) in txt format.</p>
Data of FigS4, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS4, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS4.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_6_M1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_6_M.txt) and three files in CSV-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_6_1-3.csv).</p>
Data of Fig7, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig7, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig7.PNG). The Corresponding raw data and subsequent data analysis obtained for TCGA analysis contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M.txt), and all further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M1.pdf)</p> <p> </p>
Data of Fig8, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig8, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig8.PNG). The Corresponding raw data and subsequent data analysis obtained for immunohistochemistry contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1_M .txt) and one file in csv-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1.csv), and all further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1_M1 .pdf)</p> <p> </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.