Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
927
datasets available to search
ShareScore release 0.9.0
Dataset results
927 results for “genetic study”
Genetic studies of human-chimpanzee divergence using stem cell fusions
GEO Series GSE184768. Homo sapiens; Pan troglodytes. 69 samples. Type: Expression profiling by high throughput sequencing.
Brisbane Systems Genetics Study – DNA methylation data
GEO Series GSE56105. Homo sapiens. 614 samples. Type: Methylation profiling by genome tiling array.
Somatically Acquired Structural Genetic Differences; a Longitudinal Study of Elderly Danish Twins
GEO Series GSE76390. Homo sapiens. 169 samples. Type: Genome variation profiling by SNP array.
Mammographic density and genetics - A study of breast biopsies in relation to mammoraphic density
GEO Series GSE18672. Homo sapiens. 143 samples. Type: Expression profiling by array.
Deciphering the genetic regulation of peripheral blood transcriptome in pigs through allele-specific expression analysis and expression genome-wide association study
GEO Series GSE97374. Sus scrofa. 243 samples. Type: Expression profiling by array.
A study of genetic variants associated with skin traits in the Vietnamese population
GEO Series GSE248483. Homo sapiens. 96 samples. Type: SNP genotyping by SNP array.
Multi-omics co-localization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus [RNA-Seq]
GEO Series GSE172367. Homo sapiens. 190 samples. Type: Expression profiling by high throughput sequencing.
Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s.
GEO Series GSE74573. Homo sapiens. 8 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
Retinoic Acid Inhibition Alters Intestinal Composition in Zebrafish: a non-genetic model to study Hirschsprung Disease
GEO Series GSE302614. Danio rerio. 1 samples. Type: Expression profiling by high throughput sequencing.
Data from: An indexed, mapped mutant library enables reverse genetics studies of biological processes in Chlamydomonas reinhardtii
The green alga Chlamydomonas reinhardtii is a leading single-celled model for dissecting biological processes in photosynthetic eukaryotes. However, its usefulness has been limited by difficulties in obtaining mutants in genes of interest. To allow generation of large numbers of mapped mutants, we developed high-throughput methods which: (1) Enable easy propagation on agar and cryogenic maintenance of tens of thousands of C. reinhardtii strains; (2) Identify mutant insertion sites and physical coordinates in such collections; (3) Validate the insertion sites in pools of mutants by obtaining >500 bp of flanking genomic sequences. We used these approaches to construct a stably maintained library of 1,935 mapped mutants, representing disruptions in 1,562 genes. We further characterized randomly selected mutants, and found that 33 out of 44 insertion sites (75%) could be confirmed by PCR, and 17 out of 23 mutants (74%) contained a single insertion. To demonstrate the power of this library for elucidating biological processes, we analyzed the lipid content of mutants disrupted in genes encoding proteins of the algal lipid droplet proteome. This study revealed a central role of the long-chain acyl-CoA synthetase LCS2 in the production of triacylglycerol from de novo synthesized fatty acids.
Figure 4 from: Al-Musawi ZJMA, Al-Juhaishi AMR (2024) Association study between D2 receptor A-241G, rs1799978 genetic variation and olanzapine efficacy in Iraqi schizophrenic patients. Pharmacia 71: 1-6. https://doi.org/10.3897/pharmacia.71.e111984
Figure 4 The PANSS score of schizophrenic and healthy volunteers.
Figure 2 from: Al-Musawi ZJMA, Al-Juhaishi AMR (2024) Association study between D2 receptor A-241G, rs1799978 genetic variation and olanzapine efficacy in Iraqi schizophrenic patients. Pharmacia 71: 1-6. https://doi.org/10.3897/pharmacia.71.e111984
Figure 2 The Prevalence of D2 receptor alleles A-241G (rs1799978) among volunteers.
Figure 1 from: Al-Musawi ZJMA, Al-Juhaishi AMR (2024) Association study between D2 receptor A-241G, rs1799978 genetic variation and olanzapine efficacy in Iraqi schizophrenic patients. Pharmacia 71: 1-6. https://doi.org/10.3897/pharmacia.71.e111984
Figure 1 Genotyping of D2 receptor genes A-241G (rs1799978).
The conventional genetic basis for obesity is impacted by adverse childhood experiences: a multi-ethnic study of gene-environment effects
<p>Adverse Childhood Experiences are stressful and traumatic events occurring before the age of eighteen known to cause mental and physical health problems, including increased risk of obesity. Obesity remains an ongoing national challenge with no predicted solution. </p> <p>We examine a subset of the Healthy Nevada Project, focusing on a multi-ethnic cohort of 15,886 sequenced participants with recalled adverse childhood events to study how ACEs and their genotype-environment interactions affect BMI. Specifically, the Healthy Nevada Project participants sequenced by the Helix Exome+ platform were cross-referenced to their electronic medical records and social health determinants questionnaire to identify: (1) the effect of ACEs on BMI in the absence of genetics; (2) the effect of genotype-environment interactions on BMI; (3) how these gene-environment interactions differ from canonical genetic associations of BMI. </p> <p>The study found very strong significant associations between the number of adverse childhood experiences and adult obesity. Additionally, we identified fifty-five common and rare variants that exhibited gene-interaction effects including three variants in the CAMK1D gene and four variants in LHPP; both genes are linked to schizophrenia. Surprisingly, none of the variants identified with interactive effects were in canonical obesity-related genes. Here we show the delicate balance between genes and environment, and how the two strongly influence each other.</p>
Fig. 2 in Preliminary Studies On The Genetic Diversity Of An Endemic And Endangered Species Saussurea Esthonica Baer Ex Rupr. In Latvia
Fig. 2 Band patterns across populations based on AFLP analysis
Health, socioeconomic and genetic predictors of COVID-19 vaccination uptake: a nationwide machine-learning study
<p>Reduced participation in COVID-19 vaccination programs is a key societal concern. Understanding factors associated with vaccination uptake can help in planning effective immunization programs. We considered 2,890 health, socioeconomic, familial, and demographic factors measured on the entire Finnish population aged 30 to 80 (N=3,192,505) and genome-wide information for a subset of 273,765 individuals. Risk factors were further classified into 12 thematic categories and a machine learning model was trained for each category. The main outcome was uptaking the first COVID-19 vaccination dose by 31.10.2021, which has occurred for 90.3% of the individuals.</p> <p>The strongest predictor category was labor income in 2019 (AUC evaluated in a separate test set = 0.710, 95% CI: 0.708-0.712), while drug purchase history, including 376 drug classes, achieved a similar prediction performance (AUC = 0.706, 95% CI: 0.704-0.708). Higher relative risks of being unvaccinated were observed for some mental health diagnoses (e.g. dissocial personality disorder, OR=1.26, 95% CI : 1.24-1.27) and when considering vaccination status of first-degree relatives (OR=1.31, 95% CI:1.31-1.32 for unvaccinated mothers)</p> <p>We derived a prediction model for vaccination uptake by combining all the predictors and achieved good discrimination (AUC = 0.801, 95% CI: 0.799-0.803). The 1% of individuals with the highest risk of not vaccinating according to the model predictions had an average observed vaccination rate of only 18.8%.</p> <p>We identified 8 genetic loci associated with vaccination uptake and derived a polygenic score, which was a weak predictor of vaccination status in an independent subset (AUC=0.612, 95% CI: 0.601-0.623). Genetic effects were replicated in an additional 145,615 individuals from Estonia (genetic correlation=0.80, 95% CI: 0.66-0.95) and, similarly to data from Finland, correlated with mental health and propensity to participate in scientific studies. Individuals at higher genetic risk for severe COVID-19 were less likely to get vaccinated (OR=1.03, 95% CI: 1.02-1.05).</p> <p>Our results, while highlighting the importance of harmonized nationwide information, not limited to health, suggest that individuals at higher risk of suffering the worst consequences of COVID-19 are also those less likely to uptake COVID-19 vaccination. The results can support evidence-informed actions for COVID-19 and other areas of national immunization programs.</p>
Genetic and Epidemiologic Studies of Premature Coronary Artery Disease - SCOR in Arteriosclerosis
ClinicalTrials.gov study NCT00005324. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET
ClinicalTrials.gov study NCT03993873. IPD Sharing: NO. Countries: 5. Publications: 0.
Development of Polygenic Risk Scores in Colon Cancer Patients Through the Study of Ancestry and Diversity in Genetic Maps of the Brazilian Population - ORIGEM Project
ClinicalTrials.gov study NCT06917794. IPD Sharing: NO. Countries: 1. Publications: 0.
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
ClinicalTrials.gov study NCT06991114. IPD Sharing: UNDECIDED. Countries: 8. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.