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5,826 results for “Randomized trial”
Dataset related to article "Sentinel lymph node biopsy versus axillary lymph node dissection in breast cancer patients undergoing mastectomy with one to two metastatic sentinel lymph nodes: sub-analysis of the SINODAR-ONE multicentre randomized clinical trial and reopening of enrolment "
<p>This record contains raw data related to article "Sentinel lymph node biopsy versus axillary lymph node dissection in breast cancer patients undergoing mastectomy with one to two metastatic sentinel lymph nodes: sub-analysis of the SINODAR-ONE multicentre randomized clinical trial and reopening of enrolment"</p><p>Abstract</p><p><strong>Background: </strong>The initial results of the SINODAR-ONE randomized clinical trial reported that patients with T1-2 breast cancer and one to two macrometastatic sentinel lymph nodes treated with breast-conserving surgery, sentinel lymph node biopsy only, and adjuvant therapy did not present worse 3-year survival, regional recurrence, or distant recurrence rates compared with those treated with axillary lymph node dissection. To extend the recommendation of axillary lymph node dissection omission even in patients treated with mastectomy, a sub-analysis of the SINODAR-ONE trial is presented here.</p><p><strong>Methods: </strong>Patients with T1-2 breast cancer and no more than two metastatic sentinel lymph nodes undergoing mastectomy were analysed. After sentinel lymph node biopsy, patients were randomly assigned to receive either axillary lymph node dissection followed by adjuvant treatment (standard arm) or adjuvant treatment alone (experimental arm). The primary endpoint was overall survival. The secondary endpoint was recurrence-free survival.</p><p><strong>Results: </strong>A total of 218 patients were treated with mastectomy; 111 were randomly assigned to the axillary lymph node dissection group and 107 to the sentinel lymph node biopsy-only group. At a median follow-up of 33.0 months, there were three deaths (two deaths in the axillary lymph node dissection group and one death in the sentinel lymph node biopsy-only group). There were five recurrences in each treatment arm. No axillary lymph node recurrence was observed. The 5-year overall survival rates were 97.8 and 98.7 per cent in the axillary lymph node dissection treatment arm and the sentinel lymph node biopsy-only treatment arm, respectively (P = 0.597). The 5-year recurrence-free survival rates were 95.7 and 94.1 per cent in the axillary lymph node dissection treatment arm and the sentinel lymph node biopsy treatment arm, respectively (P = 0.821).</p><p><strong>Conclusion: </strong>In patients with T1-2 breast cancer and one to two macrometastatic sentinel lymph nodes treated with mastectomy, the overall survival and recurrence-free survival rates of patients treated with sentinel lymph node biopsy only were not inferior to those treated with axillary lymph node dissection. To strengthen the conclusion of the trial, the enrolment of patients treated with mastectomy was reopened as a single-arm experimental study.</p><p> </p>
Collection of randomized trials to assess efficacy of treatments against STH
<p>Seven randomized trials conducted in Côte d’Ivoire, Lao PDR, and Tanzania, which assess the efficacy and safety of different treatments against STH infection.</p>
A randomized controlled trial of hand/foot-cooling by hilotherapy to prevent oxaliplatin-related peripheral neuropathy in patients with malignancies of the digestive system
<p>This dataset reports data from a randomized controlled trial of hand/foot-cooling by hilotherapy to prevent oxaliplatin-related peripheral neuropathy in patients with malignancies of the digestive system.</p>
Data from; Concentration-Dependent Impact of Green Tea Catechin Gargling on Acute Upper Respiratory Tract Infections: An Exploratory Randomized Controlled Trial
<p>We conducted an open-label randomized study (UMIN000045060). The target population consisted of 209 students from the University of Shizuoka and Meiji University, who were randomly assigned to high-catechin (70 participants, approximate catechin concentration: 76.4 mg/dL), low-catechin (69 participants, approximate catechin concentration: 30.8 mg/dL), and a control water gargling (70 participants, catechin concentration: 0 mg/dL) groups. All participants gargled water or GT thrice daily for 12 weeks between December 2021 and February 2022. The symptoms experienced by participants who developed URTI during the study period were recorded on a survey form. The primary endpoint of URTI occurred in 6 (9.1%), 7 (10.8%), and 11 (15.7%) participants in the high-catechin, low-catechin, and water groups, respectively (Fisher's exact test for the overall group: <em>p</em>=0.482). Cox proportional hazards analysis, using background factors and prevention status as covariates, revealed a hazard ratio of 0.57 (95% CI: 0.21–1.55, <em>p</em>=0.261) for the high-catechin vs. water group and 0.54 (95% CI: 0.20–1.50, <em>p</em>=0.341) for the low-catechin vs. water group.</p>
Treatment of adults with sleep apnea: a systematic review of randomized non-pharmacological trials with network meta-analysis
<p>Dataset for analyses and additional data</p>
OSTEOPATHIC MANIPULATIVE TREATMENT IMPROVES OUTCOMES AFTER HEART SURGERY: A RANDOMIZED CONTROLLED TRIAL (dataset)
<p>Dataset for reproducing figures 2,3 and 4 </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.