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5,931 results for “laterality”
Patients' stem cells differentiation in a 3D environment as a promising experimental tool for the study of Amyotrophic Lateral Sclerosis
<p>The database includes the raw data of the article “Patients’ stem cells differentiation in a 3D environment as a promising experimental tool for the study of Amyotrophic Lateral Sclerosis”. Aim of this work was to demonstrate the validity of 3D cultures for the differentiation of stem cells for the study of Amyotrophic Lateral Sclerosis in a more realistic model.</p> <p>The database contains the data obtained by the following evaluations: a) immunofluorescence analysis for the study of cells’ proliferation during differentiation b) confocal microscopy for the evaluation of differentiation markers c) RT-qPCR for the confirmation of stem cells’ differentiation d) immunofluorescence analysis for the evaluation of the electrophysiological characteristics of differentiated NSC34 cells.</p> <p>We first reprogrammed healthy and sALS PBMCs in iPSCs and differentiated them in NSCs in 2D. NSCs were then included in Cellink Bioink and printed. We differentiated NSCs first in MNPs and finally in MNs and evaluated every step of 3D differentiation in comparison with 2D. We found that NSCs maintain a good viability and proliferation rate during the differentiation in 3D. Moreover, we confirmed the good differentiation by confocal microscopy and RT-qPCR by the use of specific markers for every specific differentiation step. We concluded that cell’s inclusion in the hydrogel does not interfere with the correct differentiation process. Moreover, Bioprinting allows the study of cells in a 3D environment which better mimics tissue organization. Furthermore, RT-qPCR results suggest that the 3D environment increases the differentiation of CTRL MNPs in mature MNs when compared to 2D.</p> <p>Finally, we evidenced that the electrophysiological characteristics of cells are maintained after the inclusion and the printing.</p> <p>Such evidence confirmed that 3D Bioprinting can be considered a good model for the study of ALS pathogenesis.</p>
Assessment of Sticky Bone in one- stage Lateral Sinus Lift Procedures: A 4 year retrospective study
Open the record for dataset details and reuse information.
In defence of the guidance theory? A systematic review and meta-analysis of studies on the association between maxillary lateral incisor agenesis and displacement or impaction of the permanent canine
<p>Dataset for all analyses</p>
Figure 3. Oscheius siddiqii Tabassum and Shahina, 2016 (light microscopy). A: Male posterior end at ventral view showing pattern of the genital papillae; B-F: Male posterior end at lateral view showing variations in spicules.
<p>Morphological, morphometrical and molecular characterization of <em>Oscheius siddiqii</em> Tabassum and Shahina 2010 (Rhabditida, Rhabditidae) from India with its taxonomic consequences for the subgenus <em>Oscheius</em> Andrássy, 1976.</p>
Transcriptome profiling of Arabidopsis roots upon lateral root induction in WT and TOR knock down [dataset1]
GEO Series GSE199202. Arabidopsis thaliana. 24 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Profile Analysis of the Lateral Geniculate Nucleus in Monocular Deprived Macaque Monkeys
GEO Series GSE2165. Macaca mulatta; Homo sapiens. 12 samples. Type: Expression profiling by array.
TOR acts as metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana
GEO Series GSE199211. Arabidopsis thaliana. 42 samples. Type: Expression profiling by high throughput sequencing.
Data set from the article Cairo B, De Maria B, Bari V, Vaini E, Heusser K, Tank J, Jordan J, Barbic F, Furlan R, Marinou K, Dalla Vecchia L, Porta A. Information-domain method for the quantification of the complexity of the sympathetic baroreflex regulation in healthy subjects and amyotrophic lateral sclerosis patients. Physiol Meas. 2019 Apr 4;40(3):034004. doi: 10.1088/1361-6579/ab0d4b. PMID: 30840931.
<p>Data set from the article Cairo B, De Maria B, Bari V, Vaini E, Heusser K, Tank J, Jordan J, Barbic F, Furlan R, Marinou K, Dalla Vecchia L, Porta A. Information-domain method for the quantification of the complexity of the sympathetic baroreflex regulation in healthy subjects and amyotrophic lateral sclerosis patients. Physiol Meas. 2019 Apr 4;40(3):034004. doi: 10.1088/1361-6579/ab0d4b. PMID: 30840931.</p> <p>this is the abstract:</p> <p><strong>Background: </strong>The sympathetic baroreflex (sBR) adjusts muscle sympathetic nerve activity (MSNA) in response to arterial pressure changes but the relevance of assessing sBR control complexity is unclear.</p> <p><strong>Objective: </strong>We propose a method for the evaluation of sBR control complexity.</p> <p><strong>Approach: </strong>The approach comprises the quantification of complexity of the sBR latency regulation and the assessment of complexity of the relationship linking MSNA burst to R-wave peak regardless of the variability of the sBR latency. The Shannon entropy (SE) of the sBR latency distribution is taken as an estimate of complexity of the sBR latency regulation. The conditional entropy (CE) of the beat-to-beat binary series obtained by coding the presence/absence of the MSNA burst after an R-wave peak is taken as an estimate of complexity of the sBR control regardless of the sBR latency variability. Surrogate analysis was utilized to set the level of inactive or impaired sBR. The approach was applied to 10 young healthy subjects undergoing head-up tilt (HUT) followed by lower body negative pressure to evoke presyncope (preSYNC) before and after 21 d head-down bed rest (HDBR), and to five amyotrophic lateral sclerosis (ALS) patients undergoing HUT.</p> <p><strong>Main results: </strong>In healthy subjects the surrogate analysis suggested that HUT and preSYNC significantly activated the sBR control but its response was weakened after 21 d HDBR. During preSYNC sBR latency increased significantly only after 21 d HDBR. In ALS patients the complexity of the sBR latency regulation was close to the level set by surrogate analysis and HUT did not trigger any sBR control response.</p> <p><strong>Significance: </strong>The proposed method for sBR control complexity quantification was useful in detecting the impairment of the sBR control after 21 d HDBR in healthy subjects and the dysfunction of the sBR regulation in ALS patients.</p>
Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis
<p><strong>Objective </strong>To determine the diagnostic and prognostic performance of serum neurofilament light chain (NFL) in amyotrophic lateral sclerosis (ALS).</p> <p><strong>Methods </strong>This single-centre, prospective, longitudinal study included the following patients: 124 patients with ALS; 50 patients without neurodegenerative diseases; 44 patients with conditions included in the differential diagnosis of ALS (disease controls); 65 patients with other neurodegenerative diseases (20 with frontotemporal dementia, 20 with Alzheimer’s disease, 19 with Parkinson’s disease, 6 with CreutzfeldtJakob disease (CJD)). Serum NFL levels were measured using the ultrasensitive single molecule array (Simoa) technology.</p> <p><strong>Results</strong> Serum NFL levels were higher in ALS in comparison to all other categories except for CJD. A cut-off level of 62 pg/mL discriminated between ALS and all other conditions with 85.5% sensitivity (95% CI 78% to 91.2%) and 81.8% specificity (95% CI 74.9% to 87.4%). Among patients with ALS, serum NFL correlated positively with disease progression rate (rs =0.336, 95% CI 0.14 to 0.506, p=0.0008), and higher levels were associated with shorter survival (p=0.0054). Serum NFL did not differ among patients in different ALS pathological stages as evaluated by diffusion-tensor imaging, and in single patients NFL levels were stable over time.</p> <p><strong>Conclusions </strong>Serum NFL is increased in ALS in comparison to other conditions and can serve as diagnostic and prognostic biomarker. We established a cut-off level for the diagnosis of ALS.</p>
Drawing lines and circles in Parkinson's Disease: The lateralized symptoms interfere with the movements of the unaffected hand
<p>Dataset associated with the article:</p> <p>Scarpina F, Bruno V, Rabuffetti M, Priano L, Tagini S, Gindri P, Mauro A, Garbarini F. Drawing lines and circles in Parkinson's Disease: The lateralized symptoms interfere with the movements of the unaffected hand. <em>Neuropsychologia.</em> 2020 Dec 10;151:107718. doi: 10.1016/j.neuropsychologia.2020.107718.</p> <p> </p>
Quantification of serum TDP-43 and neurofilament-light chain in patients with amyotrophic lateral sclerosis stratified by UNC13A genotype
<p>Raw data for "Quantification of serum TDP-43 and neurofilament-light chain in patients with amyotrophic lateral sclerosis stratified by UNC13A genotype"</p>
Upper motor neuron dysfunction is associated with the presence of behavioural impairment in patients with amyotrophic lateral sclerosis
<p>Dataset of the paper "Upper motor neuron dysfunction is associated with the presence of behavioural impairment in patients with amyotrophic lateral sclerosis". The upload includes the anonymized dataset of the patients' cohort. The study was supported by the Italian Ministry of Health (Ricerca Corrente to Istituto Auxologico Italiano IRCCS).</p>
lateral_signaling_data_test
<p>Test upload of data</p>
Ecological validity of performance-based cognitive screeners in amyotrophic lateral sclerosis: preliminary evidence
<p>Dataset associated with the paper "Ecological validity of performance-based cognitive screeners in amyotrophic lateral sclerosis:<br>preliminary evidence". Data cannot be made publicly available on ethical-legal grounds but can be made available upon reasonable request of interested researchers to the corresponding author (Dr. Barbara Poletti; e-mail: b.poletti@auxologico.it), who will forward a request for a data transfer agreement to the relevant Ethical Committee.</p>
Public perception of gingival margin contour in absent maxillary lateral incisor-canine substitution cases
<p>Dataset for all analyses of the study; initially made available to editor and referees during peer review procedure. After acceptance, dataset will be made openly available to anyone.</p>
Clinical usefulness of the Verbal Fluency Index (VFI) in amyotrophic lateral sclerosis
<p>Dataset associated with the paper "Clinical usefulness of the Verbal Fluency Index (VFI) in amyotrophic lateral sclerosis". These datasets cannot be made publicly available on ethical legal grounds but can be made available upon reasonable request of interested researchers to the Corresponding Author(s), who will forward a request for a data transfer agreement to the relevant Ethical Committee(s). Please, write to Dr. Barbara Poletti (b.poletti@auxologico.it)</p>
Figure 4. Oscheius siddiqii Tabassum and Shahina, 2016 (scanning electron microscopy). A, B, D: Lip region in lateral (A, B) and frontal (D) views (arrows pointing the amphids); C: Female posterior end (arrow pointing the phasmid); E: Excretory pore (arrow); F, G, H: Vulva; I: Lateral field (arrows pointing the longitudinal incisures); J, K: Male posterior end in right lateral, subventral and ventral views, respectively (black arrows pointing the phasmids, ph, white arrow pointing the filiform part of tail); M: Spicules' tips.
<p>Morphological, morphometrical and molecular characterization of <em>Oscheius siddiqii</em> Tabassum and Shahina 2010 (Rhabditida, Rhabditidae) from India with its taxonomic consequences for the subgenus <em>Oscheius</em> Andrássy, 1976.</p>
Prevalence and determinants of language impairment in non-demented amyotrophic lateral sclerosis patients
<p>Dataset associated with the paper "Prevalence and determinants of language impairment in non-demented amyotrophic lateral sclerosis patients".</p>
Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients
<p>Dataset associate with the paper: "Validity and diagnostics of the Reading the Mind in the Eyes Test (RMET) in non-demented amyotrophic lateral sclerosis (ALS) patients".</p>
Diagnostics and clinical usability of the Montreal Cognitive Assessment (MoCA) in amyotrophic lateral sclerosis
<p>Dataset associated with the paper: "Diagnostics and clinical usability<br> of the Montreal Cognitive Assessment (MoCA) in amyotrophic lateral sclerosis".</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.