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12,683 results for “tolerability”
Data from: The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner
Type 2 diabetes is typified by insulin-resistance in adipose tissue, skeletal muscle, and liver, leading to chronic hyperglycemia. Additionally, obesity and type 2 diabetes are characterized by chronic low-grade inflammation. Membrane-associated RING-CH-1 (MARCH1) is an E3 ubiquitin ligase best known for suppression of antigen presentation by dendritic and B cells. MARCH1 was recently found to negatively regulate the cell surface levels of the insulin receptor via ubiquitination. This, in turn, impaired insulin sensitivity in mouse models. Here, we report that MARCH1-deficient (knockout; KO) female mice exhibit excessive weight gain and excessive visceral adiposity when reared on standard chow diet, without increased inflammatory cell infiltration of adipose tissue. By contrast, male MARCH1 KO mice had similar weight gain and visceral adiposity to wildtype (WT) male mice. MARCH1 KO mice of both sexes were more glucose tolerant than WT mice. The levels of insulin receptor were generally higher in insulin-responsive tissues (especially the liver) from female MARCH1 KO mice compared to males, with the potential to account in part for the differences between male and female MARCH1 KO mice. We also explored a potential role for MARCH1 in human type 2 diabetes risk through genetic association testing in publicly-available datasets, and found evidence suggestive of association. Collectively, our data indicate an additional link between immune function and diabetes, specifically implicating MARCH1 as a regulator of lipid metabolism and glucose tolerance, whose function is modified by sex-specific factors.
Data from: Improving accuracies of genomic predictions for drought tolerance in maize by joint modeling of additive and dominance effects in multi-environment trials
Breeding for drought tolerance is a challenging task that requires costly, extensive and precise phenotyping. Genomic selection (GS) can be used to maximize selection efficiency and the genetic gains in maize (Zea mays L.) breeding programs for drought tolerance. Here we evaluated the accuracy of genomic selection of additive (A) against additive+dominance (AD) models to predict the performance of untested maize single-cross hybrids for drought tolerance in multi-environment trials. Phenotypic data of five drought-tolerance traits were measured in 308 hybrids in eight trials under water-stressed (WS) and well-watered (WW) conditions over two years and two locations in Brazil. Hybrids' genotypes were inferred based on their parents' genotypes (inbred lines) using single nucleotide polymorphism data obtained via genotyping-by-sequencing. GS analyses were performed using genomic best linear unbiased prediction by fitting a factor analytic (FA) multiplicative mixed model. Results showed differences in the predictive accuracy between A and AD models for the five traits under consideration in both water conditions. For grain yield (GY), the AD model doubled the predictive accuracy in comparison to the A model. FA framework allowed for investigating the stability of additive and dominance effects across environments, as well as the additive- and dominance-by-environment interactions, with interesting applications for parental and hybrid selection. Prediction performance of untested hybrids using GS that benefit from borrowing information from correlated trials increased 40% and 9% for A and AD models, respectively. These results highlighted the importance of multi-environment trial analysis with GS that incorporate dominance effects into genomic predictions of GY in maize single-cross hybrids.
Data from: Potential application of the Oryza sativa monodehydroascorbate reductase gene (OsMDHAR) to improve the stress tolerance and fermentative capacity of Saccharomyces cerevisiae
Monodehydroascorbate reductase (MDHAR; EC 1.6.5.4) is an important enzyme for ascorbate recycling. To examine whether heterologous expression of MDHAR from Oryza sativa (OsMDHAR) can prevent the deleterious effects of unfavorable growth conditions, we constructed a transgenic yeast strain harboring a recombinant plasmid carrying OsMDHAR (p426GPD::OsMDHAR). OsMDHAR-expressing yeast cells displayed enhanced tolerance to hydrogen peroxide by maintaining redox homoeostasis, proteostasis, and the ascorbate (AsA)-like pool following the accumulation of antioxidant enzymes and molecules, metabolic enzymes, and molecular chaperones and their cofactors, compared to wild-type (WT) cells carrying vector alone. The addition of exogenous AsA or its analogue isoascorbic acid increased the viability of WT and ara2Δ cells under oxidative stress. Furthermore, the survival of OsMDHAR-expressing cells was greater than that of WT cells when cells at mid-log growth phase were exposed to high concentrations of ethanol. High OsMDHAR expression also improved the fermentative capacity of the yeast during glucose-based batch fermentation at a standard cultivation temperature (30°C). The alcohol yield of OsMDHAR-expressing transgenic yeast during fermentation was approximately 25% (0.18 g·g-1) higher than that of WT yeast. Accordingly, OsMDHAR-expressing transgenic yeast showed prolonged survival during the environmental stresses produced during fermentation. These results suggest that heterologous OsMDHAR expression increases tolerance to reactive oxygen species-induced oxidative stress by improving cellular redox homeostasis and improves survival during fermentation, which enhances fermentative capacity.
Data from: Evolution and plasticity of thermal performance: An analysis of variation in thermal tolerance and fitness in 22 Drosophila species
The thermal biology of ectotherms is often used to infer species' responses to changes in temperature. It is often proposed that temperate species are more cold-tolerant, less heat-tolerant, more plastic, have broader thermal performance curves (TPCs), and lower optimal temperatures, when compared to tropical species; however, relatively little empirical work has investigated these expectations. Here we measure thermal tolerance limits and thermal performance of the fitness components viability, developmental speed, and fecundity at seven temperatures in 22 species of Drosophila reared at a common temperature. For 10 of these species, we also measured thermal tolerance and thermal performance following developmental acclimation to three additional temperatures. Using these data, we test several fundamental hypotheses about the evolution and plasticity of heat and cold resistance and thermal performance. We find that cold (and to a lesser degree heat) tolerance varied between the species in a predictable pattern. This confirms the marked effect of evolutionary adaptation and acclimation on thermal tolerance. However, contrary to expectation, find that the breadth of thermal performance in fitness traits were similar in temperate, widespread and tropical species and we also find that the plasticity of TPCs is constrained. These data support the idea that thermal tolerance limits have evolved in response to extreme environmental conditions that limits species persistence whereas the temperature range for optimal thermal performance is likely under selection by the temperatures that prevail during the more benign seasons. Further, it calls to question the utility of TPCs in inferring ecological adaptation. We conclude that the thermal performance of fitness traits in Drosophila species are temporally and spatially stable and that thermal tolerance varies considerably across latitudes.
Data from: Evolutionary changes in plant tolerance against herbivory through a resurrection experiment
Both theoretical and empirical works have highlighted the difference in the evolutionary implications of host resistance and tolerance against their enemies. However, it has been difficult to show evolutionary changes in host defences in natural populations; thus, evaluating theoretical predictions of simultaneous evolution of defences remains a challenge. We studied the evolutionary changes in traits related to resistance and tolerance against herbivory in a natural plant population using seeds from two collections made in a period of 20 years. In a common garden experiment, we compared defensive traits of ancestral (1987) and descendant (2007) subpopulations of the annual plant Datura stramonium that shows genetic variation for tolerance and to which the specialist herbivore Lema daturaphila is locally adapted. We also examined the effects of different plant genotypes on the herbivore for testing the plant genetic variation in resistance. Based on the response to the contemporary herbivore populations, results revealed a nonsignificant response in plant resistance traits (herbivore consumption, foliar trichomes and tropane alkaloids), but a significant one in tolerance. The survival of herbivores in laboratory experiments depended on the plant genotype, which suggests genetic variation in plant resistance. Although we cannot identify the selective agent for the change nor exclude genetic drift, the results are consistent with the expectation that when resistance fails to control herbivory, tolerance should play a more important role in the evolution of the interaction.
Data on heat tolerance of aquatic insects
<p>data on heat tolerance of various aquatic insects, measured under normoxia (20 kPa; 100% oxygen saturation).</p><p> </p>
Habitual and Daily Emotion Regulation Goals and Strategies among Individuals with Low Distress Tolerance
<p><strong><span>Background:</span></strong><span> Goals determine the selected strategy in the emotion regulation process. In addition, the habitual use of some strategies is predicted by distress tolerance (DT). Here, the relationship between DT with emotion regulation goals and strategies `is assessed in two separate studies.</span></p> <p><strong><span>Design: </span></strong><span>Cross-sectional correlational (first study) and experience sampling (second study)</span></p> <p><strong><span>Method:</span></strong><span> In order to conduct the study, the students in University of Tehran (n=251) voluntarily responded to a set of global self-reports related to DT and emotion regulation goals and strategies. During the second study, the students with low DT (n=61) recorded their daily emotion regulation including goals and strategies for two weeks.</span></p> <p><strong><span>Results: </span></strong><span>A negative correlation was observed between DT with impression management (IM) and pro-social (PS) goals, as well as experiential avoidance (EA), expressive suppression (ES), and rumination (RU) strategies in global measurement. However, a significant relationship was reported between goals and strategies in the first and second studies. IM goals were related to greater use of EA, ES, and RU. In addition, pro-hedonic (PH) goals were related to greater cognitive reappraisal (CR) and less ES.</span></p> <p><span><strong><span>Conclusion:</span></strong></span><span><span> The DT capacity plays a critical role in people's emotion regulation goals and strategies. In addition, different strategies are predicted by different goals at the habitual and daily levels</span></span><span><span>.</span></span></p>
supplemental data for QTL MAPPING TO IDENTIFY LOCI AND CANDIDATE GENES ASSOCIATED WITH FREEZING TOLERANCE TRAIT IN CAMELINA SATIVA
Open the record for dataset details and reuse information.
Environmental fluctuations accelerate molecular evolution of thermal tolerance in a marine diatom
<p>Data (other than molecular data, which are in the Sequence Read Archive as Bioproject PRJNA397360) for "Environmental fluctuations accelerate molecular evolution of thermal tolerance in a marine diatom" https://doi.org/10.1038/s41467-018-03906-5. </p> <p>1. "Data Figure01 natcomms Schaum et al.xlsx" contains data to analyse (and produce Figure 1A and B) for the fitness trajectories and thermal tolerance curves of growth.</p> <p>2. The raw growth rate data for the thermal tolerance curves of growth are provided in separate files: Data_thermal_tolerance_growth_t000.csv,Data_thermal_tolerance_growth_t100.csv,Data_thermal_tolerance_growth_t300.csv contain the growth rates across a temperature gradient for the ancestor (t000), the evolved samples after 100 generations (t100) and after 300 generations (t300). In these files, assayT is the assay temperature in degrees C, selected is the selection regime, and bore is the biological replicate. r is the growth rate, K is carrying capacity. quasi r2 (or 2) is a measure of the goodness of the fit that the growth rate was calculated from. pa is an identification column that gives a unique name to individual bioreplicate/ assay temperature/selection regime combinations. </p> <p>3. Photosynthesis and respiration data for Figure 2 a-e is contained in the files</p> <p>"tdep_metab_t300_32" for 32 degree C data after 300 generations</p> <p>"tdep_metab_t000" for the ancestor</p> <p>"tdep_metab_all_else" for all other metabolism data, i.e. photosynthesis and respiration data after 100 and 300 generations of evolution in all selection environments. </p> <p>As this is a large amount of data, they are saved in RDS format. they can be opened in any version of R using the command readRDS(name of file here). </p> <p>4. File "Data_cell_volume_CNratio_etc" contains pg C per cell, CN ratios, NP ratios, and CN ratios, as well as cell volume and chlorophyll to carbon ratios for all selection regimes in the ancestor and the evolved lineages. </p> <p>5. File "Data_cell_size_RNAProtein_etc.csv" contains data on size in µm, RNA and protein per cell, as well as silicate per cell. </p> <p> </p>
Testing the Fault-Tolerance of Multi-Sensor Fusion Perception in Autonomous Driving Systems
<p>Here we provide some example videos of safety violations of Apollo caused by sensor faults</p>
Raw data supporting: Solvent-controlled O2 diffusion enables air-tolerant solar hydrogen generation
<p>Raw experimental data supporting the article "Solvent-controlled O2 diffusion enables air-tolerant solar hydrogen generation", Energy Environ Sci 2021, DOI: 10.1039/D1EE01822A</p>
[DATABASE] Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial
<p><strong>Background: </strong>People who smoke and who face challenges trying to quit or wish to continue to smoke may benefit by switching from traditional cigarettes to noncombustible nicotine delivery alternatives, such as heated tobacco products (HTPs) and electronic cigarettes (ECs). HTPs and ECs are being increasingly used to quit smoking, but there are limited data about their effectiveness.</p> <p><strong>Objective: </strong>We conducted the first randomized controlled trial comparing quit rates between HTPs and ECs among people who smoke and do not intend to quit.</p> <p><strong>Methods: </strong>We conducted a 12-week randomized noninferiority switching trial to compare effectiveness, tolerability, and product satisfaction between HTPs (IQOS 2.4 Plus) and refillable ECs (JustFog Q16) among people who do not intend to quit. The cessation intervention included motivational counseling. The primary endpoint of the study was the carbon monoxide-confirmed continuous abstinence rate from week 4 to week 12 (CAR weeks 4-12). The secondary endpoints included the continuous self-reported ≥50% reduction in cigarette consumption rate (continuous reduction rate) from week 4 to week 12 (CRR weeks 4-12) and 7-day point prevalence of smoking abstinence.</p> <p><strong>Results: </strong>A total of 211 participants completed the study. High quit rates (CAR weeks 4-12) of 39.1% (43/110) and 30.8% (33/107) were observed for IQOS-HTP and JustFog-EC, respectively. The between-group difference for the CAR weeks 4-12 was not significant (P=.20). The CRR weeks 4-12 values for IQOS-HTP and JustFog-EC were 46.4% (51/110) and 39.3% (42/107), respectively, and the between-group difference was not significant (P=.24). At week 12, the 7-day point prevalence of smoking abstinence values for IQOS-HTP and JustFog-EC were 54.5% (60/110) and 41.1% (44/107), respectively. The most frequent adverse events were cough and reduced physical fitness. Both study products elicited a moderately pleasant user experience, and the between-group difference was not significant. A clinically relevant improvement in exercise tolerance was observed after switching to the combustion-free products under investigation. Risk perception for conventional cigarettes was consistently higher than that for the combustion-free study products under investigation.</p> <p><strong>Conclusions: </strong>Switching to HTPs elicited a marked reduction in cigarette consumption among people who smoke and do not intend to quit, which was comparable to refillable ECs. User experience and risk perception were similar between the HTPs and ECs under investigation. HTPs may be a useful addition to the arsenal of reduced-risk alternatives for tobacco cigarettes and may contribute to smoking cessation. However, longer follow-up studies are required to confirm significant and prolonged abstinence from smoking and to determine whether our results can be generalized outside smoking cessation services offering high levels of support.</p>
Tolerance Statue
The Statues of Trade and Tolerance in 1892 were originally part of the sculpture of Emperor Joseph II. In the Moravian square. In 1918 the sculpture was dismantled, the statues of Trade and Tolerance wandered first into Denis' slashes and in 2005 they were moved to park Lužánky in Brno. Source: Objaverse 1.0 / Sketchfab
A Study in Healthy Men to Test How Different Doses of BI 3032950 Are Tolerated
ClinicalTrials.gov study NCT05518708. IPD Sharing: NO. Countries: 1. Publications: 0.
Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of a Long Acting GLP-1 Analogue (NNC0113-0987) in Healthy Male Subjects
ClinicalTrials.gov study NCT01967589. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study o Evaluate the Safety, Tolerability, and Immunogenicity of MVC-COV1901, CT-COV-21 Sub-study
ClinicalTrials.gov study NCT05038618. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of Tolerability and Safety of Adding Ustekinumab to INGAP Peptide for 12 Weeks in Adult Patients With TD1 Melitis
ClinicalTrials.gov study NCT02204397. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Study Assessing the Safety, Tolerability, and Pharmacokinetics of SEP-363856 in Male and Female Subjects With Schizophrenia
ClinicalTrials.gov study NCT01940159. IPD Sharing: YES. Countries: 1. Publications: 0.
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BIA 5-1058
ClinicalTrials.gov study NCT03708146. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Study to Evaluate the Efficacy, Safety and Tolerability of PDNO Infusion in Patients With Pulmonary Hypertension After Cardiopulmonary Bypass Surgery
ClinicalTrials.gov study NCT05699486. IPD Sharing: NO. Countries: 1. Publications: 0.
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