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Fig. 1 in Life history traits of three cryptic species Asia I, Asia II-1 and Asia II-7 of Bemisia tabaci (Hemiptera: Aleyrodidae) reconfirm their genetic identities
Fig. 1. Component analysis (PCA) showing the clustering of genetic groups of Bemisia tabaci species complex.
Text-fig. 3. "Glossanodon" musceli A – nearly complete specimen NM Pc 02875a; B – caudal skeleton of specimens NM Pc 02871b and NM Pc 02871a (B-1 and B-2 respectively; part and counterpart) and its tentative reconstruction (B-3); C – specimen NM Pc 02873a, general view (C-1) and detail of the head (C-2); D – specimen NM Pc 02874a (the white arrow shows normally developed neural spine on the anterior abdominal vertebra). Abbreviations: ao – antorbitale; d – dentale; epu – epurale; fr – frontale; hp1-6 – hypurals 1-6; io – infraorbitals; mx – maxillare; npu2 – neural spine of second preural vertebra; ph – parhypurale; pu1 – first preural vertebra; pop – preoperculum; psp – parasphenoideum; stu – stegurale; u1 – urale 1; u2 – urale 2. in An Annotated List Of The Oligocene Fish Fauna From The Osíčko Locality (Menilitic Fm.; Moravia, The Czech Republic)
Text-fig. 3. "Glossanodon" musceli A – nearly complete specimen NM Pc 02875a; B – caudal skeleton of specimens NM Pc 02871b and NM Pc 02871a (B-1 and B-2 respectively; part and counterpart) and its tentative reconstruction (B-3); C – specimen NM Pc 02873a, general view (C-1) and detail of the head (C-2); D – specimen NM Pc 02874a (the white arrow shows normally developed neural spine on the anterior abdominal vertebra). Abbreviations: ao – antorbitale; d – dentale; epu – epurale; fr – frontale; hp1-6 – hypurals 1-6; io – infraorbitals; mx – maxillare; npu2 – neural spine of second preural vertebra; ph – parhypurale; pu1 – first preural vertebra; pop – preoperculum; psp – parasphenoideum; stu – stegurale; u1 – urale 1; u2 – urale 2.
FIGURE 7. Artiodactyla and Perissodactyla from the Drimolen Makondo assemblage. 1 and 2, DNM 143-1 in First description of in situ primate and faunal remains from the Plio-Pleistocene Drimolen Makondo palaeocave infill, Gauteng, South Africa
FIGURE 7. Artiodactyla and Perissodactyla from the Drimolen Makondo assemblage. 1 and 2, DNM 143-1, Hippotragus sp. partial horn core; 1, lateral and 2, anterior views. 3–5, DNM 57, Metridiochoerus sp. right maxillary third premolar; 3, lingual, 4, occlusal, and 5, buccal views. 6 and 7, cf. Eurygnathohippus cornelianus left proximal fourth metatarsal; 6, medial and 7, posterior views. Scale bars equal 1 cm.
FIGURE 4. Vulpes chama craniodental specimens from the Drimolen Makondo. 1 and 2, DNM 471-1 in First description of in situ primate and faunal remains from the Plio-Pleistocene Drimolen Makondo palaeocave infill, Gauteng, South Africa
FIGURE 4. Vulpes chama craniodental specimens from the Drimolen Makondo. 1 and 2, DNM 471-1, partial cranium; 1, dorsal and 2, left lateral views. 3 and 4, DNM 471-2, right maxilla; 3, buccal and 4, occlusal views. 5 and 6, DNM 471-3, right mandible; 5, buccal and 6, lingual views. Scale bars equal 1 cm.
FIGURE 8. Teratodontinae indet. 1 from Chambi CBI-1 in New fossils of Hyaenodonta (Mammalia) from the Eocene localities of Chambi (Tunisia) and Bir el Ater (Algeria), and the evolution of the earliest African hyaenodonts
FIGURE 8. Teratodontinae indet. 1 from Chambi CBI-1 (Tunisia). 1-2, CBI-1-614, right P4 in occlusal (1) and labial (2) views. Scale bar equals 5 mm.
Fig. 1 in Use of ITS-1 to identify Bactrocera dorsalis and Bactrocera occipitalis (Diptera: Tephritidae): a case study using flies trapped in California from 2008 to 2018
Fig. 1. ML tree (log likelihood –2782.3671) of C3p790 fragment of COI gene based on the Tamura model with Gamma distributed rates and Invariant sites (T92+G+I). The California fly (16V457) with Bactrocera occipitalis ITS‑1 sequence is marked with an open circle dot. Five flies trapped in California that have ITS‑1 sequences that match Bactrocera dorsalis and reported in Barr et al. (2014a) are marked with black dots. Operational Taxonomic Units and branches are collapsed for species in clades. The collapsed B. dorsalis clade includes both B. dorsalis and B. carambolae records.
Fig. 1 in Crabs (Crustacea, Decapoda) from the Seas of East and Southeast Asia Collected by the RV Hakuhō Maru (KH-72-1 Cruise) 3. Sahul Shelf
Fig. 1.ɹA–C: Cryptodromia amboinensis De Man, ♀ (NSMT-Cr 30697; CB 4.5×CL 4.2 mm) from sta. 29. Dorsal (A), frontal (B) and frontal upper (C) views. D: Urnalana whitei (Bell), ♂ (NSMT-Cr 30704; CB 6.6×CL 7.2 mm) from sta. 29. E: Myra australis Haswell, ♀ (NSMT-Cr 30703; CB 9.7×CL 11.1 mm including posterior tubercle) from sta. 29. F: Drachiella morum (Alcock), ♀ (NSMT-Cr 30701; CB 8.0×CL 7.0 mm) from sta. 29.
SLC35A2 deficiency reduces protein levels of core 1 β-1,3-galactosyltransferase 1 (C1GalT1) and its chaperone Cosmc and affects their subcellular localization - yet unpublished supplementary data
<p>The upload contains raw data files used for the article "SLC35A2 deficiency reduces protein levels of core 1 β-1,3-galactosyltransferase 1 (C1GalT1) and its chaperone Cosmc and affects their subcellular localization".</p> <p><strong>Article abstract</strong></p> <p>Nucleotide sugar transporters (NSTs) are multitransmembrane proteins, localized in the Golgi apparatus and/or endoplasmic reticulum, which provide glycosylation enzymes with their substrates. It has been demonstrated that NSTs may form complexes with functionally related glycosyltransferases, especially in the N-glycosylation pathway. However, potential interactions of NSTs with enzymes mediating the biosynthesis of mucin-type O-glycans have not been addressed to date. Here we report that UDP-galactose transporter (UGT; SLC35A2) associates with core 1 β-1,3-galactosyltransferase 1 (C1GalT1; T-synthase). This provides the first example of an interaction between an enzyme that acts exclusively in the O-glycosylation pathway and an NST. We also found that SLC35A2 associated with the C1GalT1-specific chaperone Cosmc, and that the endogenous Cosmc was localized in both the endoplasmic reticulum and Golgi apparatus of wild-type HEK293T cells. Furthermore, in SLC35A2-deficient cells protein levels of C1GalT1 and Cosmc were decreased and their Golgi localization was less pronounced. Finally, we identified SLC35A2 as a novel molecular target for the antifungal agent itraconazole. Based on our findings we propose that NSTs may contribute to the stabilization of their interaction partners and help them to achieve target localization in the cell, most likely by facilitating their assembly into larger functional units. </p> <p>The Word document (Data description.docx) contains a description of each file.</p>
Text-fig. 2. Soft-tissue imprints and traces of bioerosion on Middle Ordovician cephalopods from Estonia. a: GIT 819-1, Tragoceras falcatum (SCHLOTHEIM, 1820), drag bands; b: GIT 819-1, T. falcatum, pseudosutures; c: GIT 819-2, Estonioceras sp., drag bands; d: GIT 819-3, cf. Anthoceras vaginatum (SCHLOTHEIM, 1820), drag bands; e: GIT 819-4, cf. Orthoceras regulare SCHLOTHEIM, 1820, drag bands; f: Pits on the body chamber of GIT 819-1, T. falcatum. Specimens oriented with aperture downwards. Scale bars 1 mm. in Conch Structures, Soft-Tissue Imprints And Taphonomy Of The Middle Ordovician Cephalopod Tragoceras Falcatum From Estonia
Text-fig. 2. Soft-tissue imprints and traces of bioerosion on Middle Ordovician cephalopods from Estonia. a: GIT 819-1, Tragoceras falcatum (SCHLOTHEIM, 1820), drag bands; b: GIT 819-1, T. falcatum, pseudosutures; c: GIT 819-2, Estonioceras sp., drag bands; d: GIT 819-3, cf. Anthoceras vaginatum (SCHLOTHEIM, 1820), drag bands; e: GIT 819-4, cf. Orthoceras regulare SCHLOTHEIM, 1820, drag bands; f: Pits on the body chamber of GIT 819-1, T. falcatum. Specimens oriented with aperture downwards. Scale bars 1 mm.
Text-fig. 1. Megastriae and post mortem epicoles on Tragoceras falcatum (SCHLOTHEIM, 1820). Arrows and M1–M3 indicate megastriae, bryozoan colonies are indicated by B1 and B2. a: GIT 819-1, left lateral view; b: body chamber of GIT 819-1, dorsal view; c: body chamber of GIT 819-1, left lateral view; d: GIT 819-1, right lateral view; e: PIMUZ 37299, right lateral view; f: detail of the body chamber of GIT 819-1, right lateral view, encrusted by bryozoans; g: bryozoan colony with Trypanites borings growing on an older bryozoan crust GIT 819-1. Specimens oriented with aperture downwards. Scale bars 10 mm. in Conch Structures, Soft-Tissue Imprints And Taphonomy Of The Middle Ordovician Cephalopod Tragoceras Falcatum From Estonia
Text-fig. 1. Megastriae and post mortem epicoles on Tragoceras falcatum (SCHLOTHEIM, 1820). Arrows and M1–M3 indicate megastriae, bryozoan colonies are indicated by B1 and B2. a: GIT 819-1, left lateral view; b: body chamber of GIT 819-1, dorsal view; c: body chamber of GIT 819-1, left lateral view; d: GIT 819-1, right lateral view; e: PIMUZ 37299, right lateral view; f: detail of the body chamber of GIT 819-1, right lateral view, encrusted by bryozoans; g: bryozoan colony with Trypanites borings growing on an older bryozoan crust GIT 819-1. Specimens oriented with aperture downwards. Scale bars 10 mm.
Text-fig. 1. Spermophilinus bredai (VON MEYER, 1848): 3D models of a right upper jaw with (abnormal) P3, P4 and all molars (mirrored; NMA-2019-1/2352). a – the specimen in occlusal view showing the relative position of the three roots in place of P3 (yellow) compared to P4 (green); b – same view, with focus on P3–P4; c – lingual view; d – mesial view. Scale bars 2 mm. in Dental Anomaly In A Middle Miocene Fossil Of The Genus Spermophilinus (Rodentia, Sciuridae) From Southern Germany
Text-fig. 1. Spermophilinus bredai (VON MEYER, 1848): 3D models of a right upper jaw with (abnormal) P3, P4 and all molars (mirrored; NMA-2019-1/2352). a – the specimen in occlusal view showing the relative position of the three roots in place of P3 (yellow) compared to P4 (green); b – same view, with focus on P3–P4; c – lingual view; d – mesial view. Scale bars 2 mm.
Fig. 1. NASDA JERS-1 in Ecology and life history of an Amazon floodplain cichlid: the discus fish Symphysodon (Perciformes: Cichlidae)
Fig. 1. NASDA JERS-1 radar image of the Tefé region, Brazil: (a) high water (May 1995); (b) low water (September 1995). Flooded forests appear white, illustrating the maximum extent of the seasonal flooding. The area between the dotted lines is whitewater floodplain. R. Solimões is the local name for the Amazon River. Discus occur in the following habitats: 1, blackwater flooded forest (igapó), 2, blackwater lakes, 3, whitewater flooded forest, 4, whitewater floodplain lakes. Study are marked A (Uxi Bay) and B (lago Urini). Inset (c) shows Uxi Bay from Landsat TM-5 image, 1998. Here, the white dot represents the locality of a large discus colony and the line X-Y refer to the cross-sectional schematic (d). In (d) the dotted horizontal line represents the water level at the beginning of 1998 samples. The 4 m water-level (see also Fig. 2) marks the lower levels of shore scrub growing on beaches and sand bars. Shore scrub is dominated by Coccoloba ovata Benth. and Symmeria paniculata Benth. (Polygonaceae).
Figure 1 in Phylogenetic structure of the Sphaeriinae, a global clade of freshwater bivalve molluscs, inferred from nuclear (ITS-1) and mitochondrial (16S) ribosomal gene sequences
Figure 1. Strict consensus of the four equally most parsimonious trees (L = 526; CI = 0.447; RI = 0.743) obtained from the phylogenetic analysis of sphaeriid mitochondrial 16S rDNA sequences. Two Eupera species, E. cubensis and E. platensis, were designated as outgroups and inferred sequence gaps were considered as missing data. Numbers above the branches represent bootstrap values and numbers below indicate decay index values.
Therapeutic activation of endothelial sphingosine 1-phosphate receptor-1 by chaperone-bound S1P suppresses proliferative retinal neovascularization
<p>Sphingosine-1-phosphate (S1P), the circulating HDL-bound lipid mediator that acts via S1P receptors (S1PR), is required for normal vascular development. The role of this signaling axis in vascular retinopathies is unclear. Here we show in a mouse model of oxygen-induced retinopathy (OIR) that endothelial overexpression of <em>S1pr1</em> suppresses while endothelial knockout of <em>S1pr1</em> worsens neovascular tuft formation. Furthermore, neovascular tufts are increased in <em>Apom<sup>-/-</sup> </em>mice which lack HDL-bound S1P while they are suppressed in <em>Apom<sup>TG</sup> </em>mice which has more circulating HDL-S1P. These results suggest that circulating HDL-S1P activation of endothelial S1PR1 suppresses neovascular pathology in OIR. Additionally, systemic administration of ApoM-Fc-bound S1P or a small molecule Gi-biased S1PR1 agonist suppressed neovascular tuft formation. Circulating HDL-S1P activation of endothelial S1PR1 may be a key protective mechanism to guard against neovascular retinopathies that occur not only in premature infants but also in diabetes and aging.</p>
SinoLC-1: the first 1-meter resolution national-scale land-cover map of China created with the deep learning framework and open-access data (User guide V2.4)
<p>The<strong> User Guide V2.4 </strong>of the SinoLC-1 land-cover product. The SinoLC-1 was created by the Low-to-High Network (L2HNet), which can be found at: <strong><a href="https://doi.org/10.1016/j.isprsjprs.2022.08.008">L2HNet</a></strong>. A more detailed description of the data can be found in the<strong> <a href="https://doi.org/10.5194/essd-15-4749-2023">paper</a>.</strong> More related work can be found at my <strong><a href="https://lizhuohong.github.io/lzh/">homepage</a>.</strong></p> <p><a href="https://zenodo.org/search?q=parent.id%3A7707461&f=allversions%3Atrue&l=list&p=1&s=10&sort=version"><strong>Click to check all the data versions and download the data (点击查看/下载所有数据版本)</strong></a></p> <p><strong>NOTE: If you have any data needs, questions, or technical issues, contact us at </strong><a href="http://ashelee@whu.edu.cn"><strong>ashelee@whu.edu.cn</strong></a><strong> (Zhuohong Li, 李卓鸿).</strong></p> <p>The land-cover mapping method with Python code is open-access at <a href="https://github.com/LiZhuoHong/Paraformer/"><strong>Code link</strong></a>. You can now update the high-resolution land-cover map by yourself with the code! The updated method is accepted by CVPR 2024 (<strong><a href="https://arxiv.org/abs/2403.02746">Paper link</a></strong>).</p> <p><strong>我们的最新制图算法被计算机视觉顶会CVPR2024接收(<a href="https://arxiv.org/abs/2403.02746">Paper link</a>),代码开源在:<a href="https://github.com/LiZhuoHong/Paraformer/">Code link</a>,您可以利用该代码高效地更新自己数据集的高分土地覆盖图。</strong></p> <p><strong>Citation format of the paper:</strong><br>Li, Z., He, W., Cheng, M., Hu, J., Yang, G., and Zhang, H.: SinoLC-1: the first 1 m resolution national-scale land-cover map of China created with a deep learning framework and open-access data, Earth Syst. Sci. Data, 15, 4749–4780, 2023. </p> <p>Li, Z., Zhang, H., Lu, F., Xue, R., Yang, G. and Zhang, L.: Breaking the resolution barrier: A low-to-high network for large-scale high-resolution land-cover mapping using low-resolution labels, <em>ISPRS Journal of Photogrammetry and Remote Sensing</em>. <em>192</em>, pp.244-267, 2022.</p> <p><strong>BibTex format of the paper:</strong></p> <blockquote> <pre>@article{li2023sinolc, title={SinoLC-1: the first 1 m resolution national-scale land-cover map of China created with a deep learning framework and open-access data}, author={Li, Zhuohong and He, Wei and Cheng, Mofan and Hu, Jingxin and Yang, Guangyi and Zhang, Hongyan}, journal={Earth System Science Data}, volume={15}, number={11}, pages={4749--4780}, year={2023}, publisher={Copernicus Publications G{\"o}ttingen, Germany} }</pre> <pre>@article{li2022breaking, title={Breaking the resolution barrier: A low-to-high network for large-scale high-resolution land-cover mapping using low-resolution labels}, author={Li, Zhuohong and Zhang, Hongyan and Lu, Fangxiao and Xue, Ruoyao and Yang, Guangyi and Zhang, Liangpei}, journal={ISPRS Journal of Photogrammetry and Remote Sensing}, volume={192}, pages={244--267}, year={2022}, publisher={Elsevier} }</pre> </blockquote>
Fig. 1 in Antifreeze Water-Rich Dormant Cysts of the Terrestrial Ciliate Colpoda cucullus Nag-1 at -65 ℃: Possible Involvement of Ultra-Antifreeze Polysaccharides
Fig. 1. Tolerance and antifreeze activity of wet resting cysts of C. cucullus Nag-1 in response to cooling (−65℃) and their osmolality. (A-1) Tolerance of encysting cells at various encystment stages. The abscissa indicates the cyst age of encysting cells. The ordinate indicates the excystment rates (%) of resting cysts (aged 1 day or more) or viability (%) of vegetative cells. Closed and open circles show the excystment rate or viability of the cells cooled at −65℃ for 24 h or more and those without cooling, respectively. The viability (%) of frozen vegetative cells is expressed as a percentage of the total number of tested cells (> 50 cells). The rate of excystment was expressed as a percentage of the total number of observed cells (50 cells). Points and attached bars correspond to the means of 6 measurements and the standard errors (SE), respectively. In each set of experiments (i.e., the cooling group and control group experiments), the same lot samples were used. (A-1, inset photograph) 1-week-old cysts cooled at −65℃ for 24 h, and thawed at room temperature. 'a': a living cyst, 'b': a cyst whose cell body shrank and detached from the cyst wall (killed cysts). (A-2) Inhibition of ice crystal growth in cell fluid obtained from C. cucullus Nag-1 resting cysts (2 or more weeks old). Upper and lower photomicrographs are pure water and cell fluid obtained from Colpoda cysts cooled at −65℃ for 30 min. (B-1) Changes in cell size of 2-week-old cysts after transfer from encystment-inducing medium without sucrose to medium containing 1 M sucrose. One run of measurement was done in the same cells. Points and attached bars correspond to the mean diameter obtained from 5 cells and the SE, respectively. (B-1, inset photograph) A 1-week-old resting cyst kept in encystment-inducing medium (left), and the same cyst transferred and kept for 5 min in the encystment-inducing medium containing 1 M sucrose (right). (B-2) Cell size of 2-week-old resting cysts immersed for 10 min in encystment-inducing medium containing various concentrations of sucrose. One run of measurement (0, 0.05, 0.1, 0.3, 1 M sucrose) was done in the same cell. Points and attached bars correspond to the mean diameter obtained from 10 cells and the SE, respectively.
Fig. 1. 2-D in Analysis of Water-Soluble Proteins by Two-Dimensional Electrophoresis in the Encystment Process of Colpoda cucullus Nag-1 and Cytoskeletal Dynamics
Fig. 1. 2-D PAGE showing an alteration of the water-soluble protein composition at 0 h–4 weeks after the onset of encystment induction of C. cucullus Nag-1. Arrowheads indicate the proteins (p56, p37, p19) whose amount uniquely and markedly changed during resting cyst formation. These proteins were identified as β-tubulin and its fragments by MS analysis (see Table 1).
Safety and Immunotherapeutic Activity of an Anti-PD-1 Antibody (Cemiplimab) in Participants With HIV-1 on Suppressive cART
ClinicalTrials.gov study NCT03787095. IPD Sharing: YES. Countries: 1. Publications: 2.
plan4res - public dataset for case study 1 part MIM-1: time series used for multi-modal investment pathway modelling
<p>Public data set which is used within the plan4res project for performing case study 1 "Multi-modal European energy concept for achiving COP21" - Multi-modal Investment modelling (MIM) Part 1: Time series for the reference year 2015</p> <p>The related documentation is included in plan4res' deliverable D4.5 chapter 3.2 (see 10.5281/zenodo.3785010) </p> <p>The data set includes the following data:</p> <p>a) characteristic annual load profiles for large industrial heat demand for chemical, iron & steel, food & beverage and pulp & paper industries for the reference year 2015</p> <p>HOTMAPS__TD_OUT_D_CHEM__20200608T160653__20200422T120000Z__v01.csv <br> HOTMAPS__TD_OUT_D_FOOD__20200608T160724__20200422T120000Z__v01.csv <br> HOTMAPS__TD_OUT_D_IRON__20200608T160705__20200422T120000Z__v01.csv HOTMAPS__TD_OUT_D_PAPER__20200608T160715__20200422T120000Z__v01.csv </p> <p>b) characteristic demand profiles for road-side car passenger transport and availability of cars for charging while (home) parking for the reference year 2015 </p> <p>SIEMENS__TD_OUT_D_RoadCar__20200608T160627__20200401T120000Z__v01.csv SIEMENS__TD_CAP_CarPark__20200608T160637__20200401T120000Z__v01.csv </p> <p>c) load profiles for exogeneous demand of electricity for the reference year 2015. The exogenous demand includes all electricity consumptions not explicitly modeled within MIM modeling.</p> <p>HRE4__TD_OUT_ElectricityExo__20200608T160732__20200401T120000Z__v01.csv </p> <p>c) regionally resolved demand profiles for (individual) space heating and space cooling for the reference year 2015</p> <p>HRE4__TRD_CAP_Cool_2015__20200608T160051__20200401T120000Z__v01.csv <br> HRE4__TRD_CAP_HeatInd_2015__20200608T155849__20200401T120000Z__v01.csv</p> <p>d) regionally resolved generation profiles of electricity from photovoltaic, wind onshore, wind offshore, hydro run-of-river, and for heat generation from solar thermal for the reference year 2015</p> <p>NINJA__TRD_CAP_PV_2015__20200608T160440__20191104T120000Z__v01.csv <br> NINJA__TRD_CAP_WindOFF_2015__20200608T155422__20191104T120000Z__v01.csv <br> NINJA__TRD_CAP_WindON_2015__20200608T155251__20191104T120000Z__v01.csv HRE4__TRD_CAP_HydroRoR_2015__20200608T155550__20200401T120000Z__v01.csv <br> HRE4__TRD_CAP_SolarThermal_2015__20200608T155718__20200401T120000Z__v01.csv </p> <p>e) regionally resolved generation profile of electricity from wind offshore transformed in a way to represent potential capacity factors in future as stated by doi:10.2760/041705. Data based on reference year 2015</p> <p>SIEMENS__TRD_CAP_WindOFF_2040__20200608T155127__20200401T120000Z__v01.csv </p> <p>x) A list of geographical description of the zone hierarchy data used in MIM for the EU33 region set.:</p> <p>SIEMENS__ZoneHierarchy_MIM_EU33__20181231T120000Z___20200131T1200000Z__v001.csv </p> <p>Further info:</p> <p>Time series are based on historical data for the reference year 2015. </p> <p>Values are normalized over one reference year in a way that either the maximum = 1 (CAP) or the integral = 1 (OUT).</p> <p>All values are listed in arbitrary units. </p> <p>All country names are according to ISO 3166-1 alpha-2.</p>
Human Galatose-1-phosphate Uridylyltransferase (GALT), Galactokinase 1 (GALK1); A Target Enabling Package
<p>This project describes a drug discovery plan for Classic Galactosemia, a rare disorder of galactose metabolism where there is currently no disease-transforming therapy. This TEP provides the protein reagents, biophysical assays, and structural information to facilitate two aspects of galactosemia research: (i) to understand the molecular basis of the disease due to defective GALT enzyme, and (ii) to provide chemical starting points to explore metabolic intervention of the upstream enzyme GALK1 aimed at mitigating the GALT defect (substrate reduction).</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.