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Dataset results
94 results for “Activation loop”
SFPQ protects DNA repeat stability by recruiting histone H3.3 chaperon activity to R-loop structures [ChIP-seq]
GEO Series GSE281893. Homo sapiens. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The vascular endothelial thromboxane A2/prostaglandin H2 receptor controls its own activation and impairs angiogenesis via an autocrine cyclooxygenase-2-dependent positive feedback loop.
GEO Series GSE146888. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide in vivo dynamics of cohesin-mediated loop extrusion and its role in transcription activation [SLAM-seq]
GEO Series GSE277898. Homo sapiens. 84 samples. Type: Other.
ARID1A suppresses R-loop mediated STING-Type I Interferon pathway activation of anti-tumor immunity
GEO Series GSE217807. Mus musculus. 62 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
ADAR1 Links R-Loop Homeostasis to ATR Activation in Replication Stress Response
<p>Unscheduled R-loops are a major source of replication stress and DNA damage. R-loop-induced replication defects are sensed and suppressed by ATR kinase, whereas it is not known whether R-loop itself is actively involved in ATR activation and, if so, how this is achieved. Here, we report that the nuclear form of RNA-editing enzyme ADAR1 promotes ATR activation and resolves genome-wide R-loops, a process that requires its double-stranded RNA-binding domains. Mechanistically, ADAR1 interacts with TOPBP1 and facilitates its loading on perturbed replication forks by enhancing the association of TOPBP1 with RAD9 of the 9-1-1 complex. When replication is inhibited, DNA-RNA hybrid competes with TOPBP1 for ADAR1 binding to promote the translocation of ADAR1 from damaged fork to R-loop region. There, ADAR1 recruits RNA helicases DHX9 and DDX21 to unwind R-loops, simultaneously allowing TOPBP1 to stimulate ATR more efficiently. Collectively, we propose that the tempo-spatially regulated assembly of ADAR1-nucleated protein complexes link R-loop clearance and ATR activation, while R-loops crosstalk with blocked replication forks by transposing ADAR1 to finetune ATR activity and safeguard the genome.</p>
T1D Closed-loop and Physical Activity
ClinicalTrials.gov study NCT06460558. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Atrial Fibrillation After Catheter Versus Thoracoscopic Ablation Using Patient Activated Implantable Loop Recorders: The ACTUAL Study
ClinicalTrials.gov study NCT01503268. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Neuronal Activation Accuracy in Closed-loop Spinal Cord Stimulation
ClinicalTrials.gov study NCT06775535. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of SmartGuard vs Temp Target in Patients With Type 1 Diabetes Users of Advanced Hybrid Closed Loop System (AHCL) in Anaerobic Physical Activity.
ClinicalTrials.gov study NCT06728423. IPD Sharing: YES. Countries: 1. Publications: 0.
AATF/Che-1 localizes to paraspeckles and suppresses R-loops accumulation and interferon activation in Multiple Myeloma
GEO Series GSE178868. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Role of LDB1 in the transition from chromatin looping to transcription activation
GEO Series GSE54549. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
ARID1A suppresses R-loop mediated STING-Type I Interferon pathway activation of anti-tumor immunity (scRNA/TCR-seq)
GEO Series GSE217806. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
TDP-43 stable deficiency leads to transcriptional dysregulation and transposable elements activation via global R-loops and 5hmC landscape alteration [DRIP-Seq II]
GEO Series GSE245331. Homo sapiens. 6 samples. Type: Other.
ELF3 activated by a super-enhancer and an autoregulatory feedback loop is required for high level HLA-C expression on extravillous trophoblasts
GEO Series GSE165511. Homo sapiens. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis
GEO Series GSE106869. Homo sapiens. 9 samples. Type: Expression profiling by array.
An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
GEO Series GSE121321. Homo sapiens. 46 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide in vivo dynamics of cohesin-mediated loop extrusion and its role in transcription activation [Hi-C]
GEO Series GSE277719. Homo sapiens. 62 samples. Type: Other.
Identification of active microRNA/transcription factor feed-forward loops during human adipogenesis (miRNA)
GEO Series GSE29185. Homo sapiens. 14 samples. Type: Non-coding RNA profiling by array.
The Drosophila Dosage Compensation Complex activates target genes via chromosome looping within the active compartment
GEO Series GSE94115. Drosophila melanogaster. 116 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
SCOPE-C Reveals the Key Role of Long-Range Loop Extrusion in Dynamic Enhancer Networks for Robust Gene Activation in Human Fetal Cortical Neurogenesis
GEO Series GSE267089. Homo sapiens; Macaca mulatta; Mus musculus. 150 samples. Type: Other.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.