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434 results for “Activity level”
Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels
ClinicalTrials.gov study NCT01588561. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Study to Explore the Antiviral Activity, Clinical Outcomes, Safety, Tolerability, and Pharmacokinetics of JNJ-53718678 at Two Dose Levels in Non-Hospitalized Adult Participants Infected With Respira
ClinicalTrials.gov study NCT03379675. IPD Sharing: Not stated. Countries: 19. Publications: 1.
Expression levels and activities of energy-yielding ATPases in the oligohaline neritid snail Theodoxus fluviatilis under changing environmental salinities
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Data from: Dynamic shifts in predator diel activity patterns across landscapes and threat levels
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Integrating light-level geolocation with activity tracking reveals unexpected nocturnal migration patterns of the tawny pipit
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Datasets for: Colony-nesting gulls restrict activity levels of native top carnivore during the breeding season
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Data from: Polybrominated diphenyl ether (DE-71) exposure skews phenotypic sex ratio, and alters steroid hormone levels and steroidogenic enzyme activities in juvenile Silurana tropicalis
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Blood lead levels in an endangered vulture decline following changes in hunting activity
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Habitat complexity dampens selection on prey activity level
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Database for Study: Shear-wave elastography for assessment of trapezius muscle stiffness: reliability and association with low-level muscle activity
<p>This is the database for the study entitled <strong>Shear-wave elastography for assessment of trapezius muscle stiffness: reliability and association with low-level muscle activity. </strong>In this study, we explored the reliability of shear-wave elastography for assessment of the trapezius muscle stiffness and its relationship with low-level muscle activity.Twenty participants were included in a two-session experiment. Measurements of shear modulus and muscle activity were performed at rest and during low-level activity, induced by shoulder abduction without additional external resistance. Good to excellent intra-session repeatability (ICC > 0.80) and moderate inter-rater and inter-session reproducibility (ICC = 0.66-0.74) were observed. Typical errors were acceptable only for intra-session measurements in resting conditions. Inverse relationships between shear modulus and muscle activity at 40° and 60° of shoulder abduction (r = -0.53 and -0.57) were observed on a group level. We also found lower shear modulus in females, for perpendicular probe position and for the non-dominant side of the body. Previous studies have demonstrated positive within-individual relationships between muscle activity and shear modulus. Our results suggested that, at least when the activity levels are low, an inverse relationship exists between muscle activity and shear modulus on a group level, suggesting inherent passive stiffness could account for a larger portion of the variance (compared to muscle activity) in shear modulus when the muscle activity is low. Our results imply that shear-wave elastography can be used in research exploring muscle stiffness, however, caution is needed since only intra-session examination in resting conditions showed acceptable within-participant typical errors.</p>
Data from: Social context affects thermoregulation but not activity level during avian immune response
Determining how an animal's social context alters its immune responses will help us understand how pathogens impact individual health and spread within groups. Several studies have shown that group-housed animals can suppress components of the acute phase immune response, specifically sickness behaviors like lethargy. However, we do not know whether individuals alter sickness behaviors or other components of the acute phase response, including thermoregulation, in response to the infection status of other group members. We used automated radio telemetry on captive house sparrows (Passer domesticus) to test whether sickness behaviors and thermoregulation differed during immune challenge under 2 social contexts: 1) all of the flock inoculated with lipopolysaccharide (LPS), a non-replicating component of gram-negative bacterial cell walls, or 2) half of the flock inoculated. We predicted that with half of the flock inoculated, LPS-treated birds would be under more pressure to maintain competitive behaviors, so would suppress components of the acute phase response. As we predicted, LPS-inoculated birds showed less pronounced heterothermia (fever) when housed with a mixture of inoculated and healthy flockmates. In contrast, LPS-inoculated birds exhibited similar degrees of lethargy regardless of the infection status of their flockmates. Our results show that the infection status of an individual's social group did exert an effect on the acute phase response but surprisingly did not impact the expression of lethargy, a canonical sickness behavior. Determining the mechanisms underlying these responses will require testing additional social contexts with different ratios of infected to uninfected birds.
Drosophila carboxypeptidase D (SILVER) is a key enzyme in neuropeptide processing required to maintain locomotor activity levels and survival rate
<p>Neuropeptides are processed from larger preproproteins by a dedicated set of enzymes. The molecular and biochemical mechanisms underlying preproprotein processing and the functional importance of processing enzymes are well‐characterised in mammals, but little studied outside this group. In contrast to mammals, Drosophila melanogaster lacks a gene for carboxypeptidase E (CPE), a key enzyme for mammalian peptide processing. By combining peptidomics and neurogenetics, we addressed the role of carboxypeptidase D (dCPD) in global neuropeptide processing and selected peptide‐regulated behaviours in Drosophila. We found that a deficiency in dCPD results in C‐terminally extended peptides across the peptidome, suggesting that dCPD took over CPE function in the fruit fly. dCPD is widely expressed throughout the nervous system, including peptidergic neurons in the mushroom body and neuroendocrine cells expressing adipokinetic hormone. Conditional hypomorphic mutation in the dCPD‐encoding gene silver in the larva causes lethality, and leads to deficits in starvation‐induced hyperactivity and appetitive gustatory preference, as well as to reduced viability and activity levels in adults. A phylogenomic analysis suggests that loss of CPE is not common to insects, but only occurred in Hymenoptera and Diptera. Our results show that dCPD is a key enzyme for neuropeptide processing and peptide‐regulated behaviour in Drosophila. dCPD thus appears as a suitable target to genetically shut down total neuropeptide production in peptidergic neurons. The persistent occurrence of CPD in insect genomes may point to important further CPD functions beyond neuropeptide processing which cannot be fulfilled by CPE.</p>
Data from: How are different levels of knowledge about physical activity associated with physical activity behaviour in Australian adults?
People with knowledge of the benefits of physical activity tend to be more active; however, such knowledge is typically operationalized as a basic understanding that physical activity is 'good' for health. Therefore, the aim of this study was to investigate whether there are differences in how detailed a person's knowledge is about the benefits of physical activity. Participants (N=615) completed an online survey to measure their current physical activity behaviour, as well as their level of knowledge of the benefits and risks of physical (in)activity. The majority of participants (99.6%) strongly agreed that physical activity is good for health, however on average, participants only identified 13.8 out of 22 diseases associated with physical inactivity and over half of participants (55.6%) could not identify how much physical activity is recommended for health benefits. Furthermore, 45% of the participants overestimated, 9% underestimated and 27% did not know the increased risk of disease resulting from inactivity as indicated by the Australian Department of Health. Participants were significantly more active when they correctly identified more diseases associated with physical inactivity and when they overestimated the risks associated with inactivity. Therefore, health promotion initiatives should increase knowledge of the types of diseases associated with inactivity. Low knowledge of physical activity guidelines suggest they should be promoted more, as this knowledge provides guidance on frequency, types and duration of physical activity needed for health.
The guide sRNA sequence determines the activity level of Box C/D RNPs
<p class="western">2'-O-rRNA methylation, which is essential in eukaryotes and archaea, is catalysed by the Box C/D RNP complex in an RNA-guided manner. Despite the conservation of the methylation sites, the abundance of site-specific modifications shows variability across species and tissues, suggesting that rRNA methylation may provide a means of controlling gene expression. As all Box C/D RNPs are thought to adopt a similar structure, it remains unclear how the methylation efficiency is regulated. Here, we provide the first structural evidence that, in the context of the Box C/D RNP, the affinity of the catalytic module fibrillarin for the substrate–guide helix is dependent on the RNA sequence outside the methylation site, thus providing a mechanism by which both the substrate and guide RNA sequences determine the degree of methylation. To reach this result, we develop an iterative structure calculation protocol that exploits the power of integrative structural biology to characterize conformational ensembles. </p> <p class="western"> </p>
Physical Activity Levels on Functional Outcomes and Quality of Life in Musculoskeletal Rehabilitation.
<p><span>Physical Activity Levels on Functional Outcomes and Quality of Life in Musculoskeletal Rehabilitation.</span></p>
Rest-activity daily rhythm and physical activity levels after hip and knee joint replacement: the role of actigraphy in orthopedic clinical practice.
<p>Elective hip and knee joint replacement for osteoarthritis are cost-effective surgical procedures requiring specific rehabilitation programs. Actigraphy is widely used in both research and clinical practice to study activity patterns with great accuracy and validity but it has never been utilized in orthopedic patients. Therefore, the aim of this study was to objectively assess, through actigraphy, physical activity (PA) levels and rest-activity daily rhythm (RAR) in patients undergoing hip or knee joint replacement and hospitalized for ten days after surgery. Twenty subjects (11 males and 9 females; age: 62.68 ± 10.39 years old; BMI: 29.03 ± 3.92 kg/m2) wore the Actiwatch 2 actigraph (Philips Respironics, Portland, OR) to record both PA levels and RAR for 11 consecutive days and data on subjective scores of pain, by a visual analog scale (VAS), and functional and clinical scores were collected. The following time-points were considered for the statistical analysis: pre-surgery (PRE), the first (POST1), the fourth (POST4) and the tenth (POST10) day after surgery. RAR were processed with the population mean cosinor to describe the rhythm's characteristics (acrophase, amplitude and MESOR) while data on actigraphy-based PA, VAS, and functional clinical scores were compared among PRE, POST1, POST4 and POST 10 with the RM-ANOVA or the non-parametric Friedman test. The day after surgery the subjects had a flattened RAR compared to the other conditions: lower values were detected in POST1 compared to both PRE, POST4 and POST10 for MESOR (<em>p</em> < .0001; η2p = .71, large) and amplitude (<em>p</em> < .0001; η2p = .63, large) while RAR's acrophase (<em>p</em> < .0001; η2p = .61, large) was delayed in PRE (16:45) compared to POST1 (12:42), POST4 (14:38), and POST10 (14:38). PA levels were significantly lower at POST 1 (76.7 ± 33.4) compared to PRE (192.3 ± 91.5; <em>p</em> < .0001 and ES: 1.68, large), POST4 (137.9 ± 45.9; <em>p</em> < .0001 and ES: 1.54, large), and POST10 (131.2 ± 54.3; <em>p</em> < .0001 and ES: 1.21, large) whereas VAS and functional clinical values significantly improved at POST10. Hip and knee joint replacement negatively influenced RAR and PA the first day after surgery but a progressive improvement in the circadian pattern of rest-activity cycle, PA levels, VAS and functional ability was recorded from POST4 to POST10. Actigraphy has the ability to collect real-life data without interfering with clinical practice and give clinicians a new measure of performance that is currently not available. This tool could allow to identify patients with disrupted circadian rhythm and reduced PA in the peri-operative period in orthopedic surgery, and timely intervene on these subjects with personalized rehabilitative intervention.</p>
Experimental evolution reveals differential evolutionary trajectories in male and female activity levels in response to sexual selection and metapopulation structure
<p>Behavior is central to interactions with the environment and thus has significant consequences for individual fitness. Sexual selection and demographic processes have been shown to independently shape behavioral evolution. However, while some studies have tested the simultaneous effects of these forces, no studies have investigated their interplay in behavioral evolution. We applied experimental evolution in the seed beetle <i>Callosobruchus maculatus</i> to investigate, for the first time, the interactive effects of sexual selection intensity (high (polygamy) vs. minimal (enforced monogamy)) and metapopulation structure (yes/no) on the evolution of movement activity, a crucial behavior involved in multiples functions (e.g., dispersal, predator avoidance or resource acquisition) and thus, closely related to <a>fitne</a>ss. We found that the interactive effects of the selection regimes did not affect individual activity, which was assayed under two different environments (absence vs. presence of conspecific cues from both sexes). However, contrasting selection regimes led to sex- and context-dependent divergence in activity. The relaxation of sexual selection favored an increase in female, but not male, movement activity that was consistent between environmental contexts. In contrast, selection associated with the presence/absence of metapopulation structure led to context-dependent responses only in male activity. In environments containing cues from conspecifics, males from selection lines under population subdivision showed increased levels of activity compared to those assayed in an environment devoid of conspecifics cues, while the opposite was true for males from panmictic lines. These results underscore that both the effects of sexual selection and population spatial structure may be crucial in shaping sex-specific behavioral evolution.</p>
Nesokia is sister to Bandicota and are nested in Rattus phylogenetically, making Rat- tus paraphyletic. Tarsomys, Limnomys, and Diplothrix are also phylogenetically in Rat- tus, and the clade is in need of focused re- vision at the generic level. Nesokia bunnui was originally described as a separate ge-nus, Erythronesokia, because it is morphologically very distinctive from N. indica. Type specimen was destroyed during the Iraq War, and a neotype was recently designated to replace it. Monotypic. Distribution. Tigris and Euphrates river valleys, SE Iraq. Descriptive notes. Head—body 230-260 mm, tail 205-270 mm, ear 18-21 mm, hindfoot 49-58 mm; weight 519 g. The Long-tailed Bandicoot Rat is larger than the Short-tailed Bandicoot Rat (N. indica). Pelage is soft and woolly, interspersed with harsher coarse hair and long black hairs near mid-back. Dorsum is fawn to ocherous red, washed with purple or chestnuton darker individuals. Hairs are basally slate-gray and distally rufous, occasionally with whitish or black tips. Muzzle is drab. Sides arefawn, with gray edge toward venter. Venteris whitish, extending onto cheeks where the same pattern from gray to fawn to dorsal pelage occurs. Feet are large and robust, being light brown and well-furred dorsally. Claws are amber on forefeet and dull brown on hindfeet; pollux is extremely small. Ears are moderately long and brownish, with no hair internally. Tail is ¢.82-104% of head-body length and deep brownish drab, interspersed with visible white hair. Skull is large and robust, similarly to the Short-tailed Bandicoot Rat. Habitat. Marsh and swamp land. Food and Feeding. No information. Breeding. No information. Activity patterns. The Long-tailed Bandicoot Rat is terrestrial, although it isfound in swampy and marshy areas and is probably amphibious. Movements, Home range and Social organization. No information. Status and Conservation. Classified as Endangered on The IUCN Red List. The Longtailed Bandicoot Rat is apparently rare and is known from very few specimens. Marsh and swamp habitats in which it is found were completely destroyed during the Iraq War by draining, war damage, and agricultural expansion. In recent years, flooding from Tigris and Euphrates rivers and high snow fall and melt haveresulted in partial restoration ofits native habitat, although restoration is not a complete. Populations are now probably highly fragmented. Bibliography. Al-Ansari et al. (2012), Al-Robaae & Felten (1990), Khajuria (1981), Krystufek et al. (2017), Musser & Carleton (2005), Richardson & Hussain (2006), Stuart (2008). in Muridae
Nesokia is sister to Bandicota and are nested in Rattus phylogenetically, making Rat- tus paraphyletic. Tarsomys, Limnomys, and Diplothrix are also phylogenetically in Rat- tus, and the clade is in need of focused re- vision at the generic level. Nesokia bunnui was originally described as a separate ge-nus, Erythronesokia, because it is morphologically very distinctive from N. indica. Type specimen was destroyed during the Iraq War, and a neotype was recently designated to replace it. Monotypic. Distribution. Tigris and Euphrates river valleys, SE Iraq. Descriptive notes. Head—body 230-260 mm, tail 205-270 mm, ear 18-21 mm, hindfoot 49-58 mm; weight 519 g. The Long-tailed Bandicoot Rat is larger than the Short-tailed Bandicoot Rat (N. indica). Pelage is soft and woolly, interspersed with harsher coarse hair and long black hairs near mid-back. Dorsum is fawn to ocherous red, washed with purple or chestnuton darker individuals. Hairs are basally slate-gray and distally rufous, occasionally with whitish or black tips. Muzzle is drab. Sides arefawn, with gray edge toward venter. Venteris whitish, extending onto cheeks where the same pattern from gray to fawn to dorsal pelage occurs. Feet are large and robust, being light brown and well-furred dorsally. Claws are amber on forefeet and dull brown on hindfeet; pollux is extremely small. Ears are moderately long and brownish, with no hair internally. Tail is ¢.82-104% of head-body length and deep brownish drab, interspersed with visible white hair. Skull is large and robust, similarly to the Short-tailed Bandicoot Rat. Habitat. Marsh and swamp land. Food and Feeding. No information. Breeding. No information. Activity patterns. The Long-tailed Bandicoot Rat is terrestrial, although it isfound in swampy and marshy areas and is probably amphibious. Movements, Home range and Social organization. No information. Status and Conservation. Classified as Endangered on The IUCN Red List. The Longtailed Bandicoot Rat is apparently rare and is known from very few specimens. Marsh and swamp habitats in which it is found were completely destroyed during the Iraq War by draining, war damage, and agricultural expansion. In recent years, flooding from Tigris and Euphrates rivers and high snow fall and melt haveresulted in partial restoration ofits native habitat, although restoration is not a complete. Populations are now probably highly fragmented. Bibliography. Al-Ansari et al. (2012), Al-Robaae & Felten (1990), Khajuria (1981), Krystufek et al. (2017), Musser & Carleton (2005), Richardson & Hussain (2006), Stuart (2008).
Healthcare Professionals Interpersonal variability and determinants of medical decision thresholds for active management of extremely preterm infants in a level 3 perinatal center in France
<p>Raw data and R script</p>
Risk Level Analysis of Land Contaminated with B3 Waste from Traditional Oil Mining Activities in Wonocolo Village, Kedewan District, Bojonegoro Regency, East Java Province
<p>This material has presented on 2nd International Conference on Advanced Research in Engineering and Technology in October 25, 2023.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.