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52 results for “Bicuspid aortic valve”
Dataset related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"
<p>This record contains raw data related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"</p> <p> </p> <p><strong>Abstract</strong></p> <p>Aims</p> <p>Calcific <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve-stenosis">aortic valve stenosis</a> (CAVS) is the most frequent manifestation of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve-disease">aortic valve disease</a> and the third leading cause of cardiovascular disease in the Western countries associated with significant morbidity and mortality. An active biological progression involving inflammation and <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/alpha-oxidation">oxidation</a> leading to valve endothelial damage is considered a hallmark of the early stages of valve degeneration. However, tricuspid (TAV) and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/premolar">bicuspid</a> (BAV) <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve">aortic valve</a> deterioration are considered to differ only by shear stress. We hypothesized that <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/endothelial-cell">endothelial cells</a> (EC) derived from BAV and TAV patients have different <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microrna">miRNA</a> expression patterns and thus distinct pathways could lead to endothelial damage in BAV than TAV patients.</p> <p>Methods and results</p> <p>We isolated ECs from patients with bicuspid or tricuspid aortic valve, which underwent surgery due to CAVS. MiRNA expression profile by PCR revealed eight upregulated <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microrna">miRNAs</a> between BAV and TAV ECs. Functional analysis identified that BAV ECs presented altered cellular response to <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/oxidative-stress">oxidative stress</a> and DNA damage stimulus <em>via</em> <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/protein-p53">p53</a> and alteration in the intrinsic apoptotic <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/signal-transduction">signaling pathway</a>. <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/gpx3">GPX3</a> and SRXN1 <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/messenger-rna">mRNA</a> were express at lower levels in BAV compared to TAV ECs, leading to an increment of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/double-stranded-dna">DNA double-strand</a> breaks. BAV ECs had a sustained <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/programmed-cell-death">apoptosis</a> activation when compared to TAV ECs. This difference was exacerbated by oxidative stress stimulus leading to a reduced survival rate but completely reverted by miR-328-3p inhibition.</p> <p>Conclusion</p> <p>The present data showed molecular differences in oxidative stress susceptibility, DNA damage magnitude, and apoptosis induction between ECs derived from BAV and TAV patients.</p>
Partial dataset related to the article "Sport PRactice and its Effects on aortic size and valve function in bicuspid Aortic valve Disease: a cross-sectional report from the SPREAD study".
<p>This record contains raw data related to the article "<span>Sport PRactice and its Effects on aortic size and valve function in bicuspid Aortic valve Disease: a cross-sectional report from the SPREAD study"</span></p> <p><span>The bicuspid aortic valve (BAV) is the most common congenital heart defect among adults, often leading to severe valve dysfunction and aortic complications. Despite its clinical significance, uncertainties persist regarding the impact of sports participation on the natural course of BAV disease. The SPREAD (Sport PRactice and its Effects on Bicuspid Aortic valve Disease) study is a multicenter and multinational project designed to investigate this relationship. This paper outlines the study's design, and objectives. The study is divided into two phases; phase one involves a cross-sectional analysis comparing aortic dimensions and valve function among competitive athletes with BAV, athletes with tricuspid aortic valves (TAV), and sedentary individuals with BAV. The second phase is a prospective, longitudinal follow-up aiming to evaluate the impact of regular sports training on disease progression. The SPREAD study seeks to provide evidence-based insights into the effects of sports participation on BAV disease progression, guiding clinical decision-making regarding sports eligibility and risk stratification for individuals with BAV.</span></p>
Haemodynamic assessment and the outcomes of aortic valvuloplasty for aortic regurgitation in patients with bicuspid aortic valve
Open the record for dataset details and reuse information.
The Safety and Effectiveness of Transcatheter Aortic Valve Raplacemet in Intermediate Risk Patients With Bicuspid Aortic Stenosis
ClinicalTrials.gov study NCT03163329. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Gene expression in aortic aneurysms associated with tricuspid and bicuspid valves
GEO Series GSE5180. Homo sapiens. 25 samples. Type: Expression profiling by array.
Gene expression profile from the bicuspid aortic valve(BAV), tricuspid aortic valve(TAV) and control samples.
GEO Series GSE284003. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Epigenome analysis of ascending aorta from normal, aortic dissection and bicuspid aortic valve patients
GEO Series GSE84274. Homo sapiens. 24 samples. Type: Methylation profiling by array.
Development of gene expression signatures of ascending aorta of the patients with bicuspid aortic valve compared to tricuspid aortic valve.
GEO Series GSE83675. Homo sapiens. 16 samples. Type: Expression profiling by array.
Effect of XCT790 on Human Aortic Valve (AV) Endothelial Cells (ECs) from Patients with Healthy Tricuspid, Calcified Tricuspid, or Calcified Bicuspid Avs
GEO Series GSE151312. Homo sapiens. 47 samples. Type: Expression profiling by high throughput sequencing.
Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve with Raphe Formation
GEO Series GSE232560. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Data set and 3d model from Emendi M, Sturla F, Ghosh RP, Bianchi M, Piatti F, Pluchinotta FR, Giese D, Lombardi M, Redaelli A, Bluestein D. Patient-Specific Bicuspid Aortic Valve Biomechanics: A Magnetic Resonance Imaging Integrated Fluid-Structure Interaction Approach. Ann Biomed Eng. 2020 Aug 17. doi: 10.1007/s10439-020-02571-4. Epub ahead of print. PMID: 32804291.
<p>Data set and 3d model from Emendi M, Sturla F, Ghosh RP, Bianchi M, Piatti F, Pluchinotta FR, Giese D, Lombardi M, Redaelli A, Bluestein D. Patient-Specific Bicuspid Aortic Valve Biomechanics: A Magnetic Resonance Imaging Integrated Fluid-Structure Interaction Approach. Ann Biomed Eng. 2020 Aug 17. doi: 10.1007/s10439-020-02571-4. Epub ahead of print. PMID: 32804291.</p> <p> </p> <p>This is the abstract:</p> <p>Congenital bicuspid aortic valve (BAV) consists of two fused cusps and represents a major risk factor for calcific valvular stenosis. Herein, a fully coupled fluid-structure interaction (FSI) BAV model was developed from patient-specific magnetic resonance imaging (MRI) and compared against in vivo 4-dimensional flow MRI (4D Flow). FSI simulation compared well with 4D Flow, confirming direction and magnitude of the flow jet impinging onto the aortic wall as well as location and extension of secondary flows and vortices developing at systole: the systolic flow jet originating from an elliptical 1.6 cm<sup>2</sup> orifice reached a peak velocity of 252.2 cm/s, 0.6% lower than 4D Flow, progressively impinging on the ascending aorta convexity. The FSI model predicted a peak flow rate of 22.4 L/min, 6.7% higher than 4D Flow, and provided BAV leaflets mechanical and flow-induced shear stresses, not directly attainable from MRI. At systole, the ventricular side of the non-fused leaflet revealed the highest wall shear stress (WSS) average magnitude, up to 14.6 Pa along the free margin, with WSS progressively decreasing towards the belly. During diastole, the aortic side of the fused leaflet exhibited the highest diastolic maximum principal stress, up to 322 kPa within the attachment region. Systematic comparison with ground-truth non-invasive MRI can improve the computational model ability to reproduce native BAV hemodynamics and biomechanical response more realistically, and shed light on their role in BAV patients' risk for developing complications; this approach may further contribute to the validation of advanced FSI simulations designed to assess BAV biomechanics.</p> <p> </p>
Outcome of transcatheter aortic valve replacement in bicuspid aortic valve stenosis with new-generation devices.
<p>Dataset from Gorla R, Casenghi M, Finotello A, De Marco F, Morganti S, Regazzoli D, Bianchi G, Acerbi E, Popolo Rubbio A, Brambilla N, Testa L, Castriota F, Auricchio F, Reimers B, Bedogni F. Outcome of transcatheter aortic valve replacement in bicuspid aortic valve stenosis with new-generation devices. Interact Cardiovasc Thorac Surg. 2021 Jan 1;32(1):20-28. doi: 10.1093/icvts/ivaa231. PMID: 33201993.</p> <p>Abstract</p> <p><strong>Objectives: </strong>To compare device success and paravalvular leak rates of 3 new-generation transcatheter aortic valve replacement devices in patients with bicuspid aortic valve stenosis and to test their biomechanical performance in a computer-based simulation model of aortic root with increasing ellipticity.</p> <p><strong>Methods: </strong>This retrospective multicentre study included 56 bicuspid aortic valve patients undergoing transcatheter aortic valve replacement with new-generation devices: Lotus/Lotus Edge (N = 15; 27%), Evolut-R (N = 20; 36%) and ACURATE neo (N = 21; 37%). Three virtual simulation models of aortic root with increasing index of eccentricity (0-0.25-0.5) were implemented. Stress distribution, stent-root contact area and paravalvular orifice area were computed.</p> <p><strong>Results: </strong>Device success was achieved in 43/56 patients (77%) with comparable rates among Lotus (87%), Evolut-R (60%) and ACURATE neo (86%; P = 0.085). Moderate paravalvular leak rate was significantly lower in the Lotus group as compared to Evolut-R group (0% vs 30%; P = 0.027) and comparable to the ACURATE neo group (0% vs 10%; P = 0.33). By index of eccentricity = 0.5, Lotus showed a uniform and symmetric pattern of stress distribution with absent paravalvular orifice area, ACURATE neo showed a mild asymmetry with small paravalvular orifice area (1.1 mm2), whereas a severely asymmetric pattern was evident with Evolut-R, resulting in a large paravalvular orifice area (12.0 mm2).</p> <p><strong>Conclusions: </strong>Transcatheter aortic valve replacement in bicuspid aortic valve patients with new-generation devices showed comparable device success rates. Lotus showed moderate paravalvular leak rate comparable to that of ACURATE neo and significantly lower than Evolut-R. On simulation, Lotus and ACURATE neo showed optimal adaptability to elliptic anatomies as compared to Evolut-R.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.