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758 results for “Candidae”
Effects of litter quality on foraging behaviour and demographic parameters in Folsomia candida (Collembola)
<p><span>Litter quality has long been associated with demographic parameters of Collembola populations. However, little is known about the capacity of Collembola to perceive and seek better litter quality. To address this gap, three complementary laboratory experiments were carried out with the Collembola <em>Folsomia candida</em>. First, populations were fed on three different types of leaf litters (<em>Quercus pubescens, Acer opalus </em>and<em> Prunus avium</em>) and a control (agar-agar-brewer's yeast mixture) for six weeks to assess their impacts on demography (reproduction rate and population size). Second, the body length of individuals differentially fed with the same four types of resources was measured to assess a functional trait that can potentially affect movement parameters such as prospected area or foraging speed. Third, <em>F. candida</em> isolated individuals were exposed to the same litter quality gradient and placed at increasing distances from the litter (from 1 to 5 cm). For ten minutes, their foraging behaviours were recorded which included their prospected area, foraging speed, perception distance and success in reaching the litter (foraging success). As expected, low-quality litter (i.e., <em>Q. pubescens</em>) contributed to low population growth compared to the control treatment and the high-quality litters (<em>P. avium </em>and<em> A. opalus</em>). In the third experiment, the probability of finding the resource was negatively correlated to the distance but was unrelated to the litter quality and the Collembola body length. When resource was perceived, F. candida was able to switch from non-directional to directional movements, with a large variability in the perception distance from a few millimeters to several centimeters. Taken together, our results indicate that litter quality plays a relevant role on Collembola demographic parameters once the population settles on litter patch, but not on foraging behaviour to select high-quality resources.<br></span></p>
Effect of Medium Chain Triglyceride Intake on Colonization of Preterm Infants With Candida
ClinicalTrials.gov study NCT03630770. IPD Sharing: NO. Countries: 1. Publications: 2.
Open-Label Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) in Patients With Candidiasis Caused by Candida Auris (CARES)
ClinicalTrials.gov study NCT03363841. IPD Sharing: UNDECIDED. Countries: 4. Publications: 2.
Study With Candida Antigen for Treatment of Warts
ClinicalTrials.gov study NCT00569231. IPD Sharing: Not stated. Countries: 1. Publications: 9.
An Open-label Study of APX001 for Treatment of Patients With Candidemia/Invasive Candidiasis Caused by Candida Auris
ClinicalTrials.gov study NCT04148287. IPD Sharing: NO. Countries: 1. Publications: 1.
An Evaluation Of The Effectiveness And Safety Of Anidulafungin Compared To Caspofungin For The Treatment Of Serious Fungal Infection Due To Candida In Patients With A Dysfunctional Immune System
ClinicalTrials.gov study NCT00806351. IPD Sharing: Not stated. Countries: 6. Publications: 3.
An Evaluation Of The Effectiveness And Safety Of Anidulafungin Compared To Caspofungin For The Treatment Of Deep Tissue Infection Due To Candida
ClinicalTrials.gov study NCT00805740. IPD Sharing: Not stated. Countries: 9. Publications: 4.
Candida in the Respiratory Tract Secretions of Critically Ill Patients and The Efficacy of Antifungal Treatment
ClinicalTrials.gov study NCT00934934. IPD Sharing: Not stated. Countries: 1. Publications: 28.
Isavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infections
ClinicalTrials.gov study NCT00413218. IPD Sharing: YES. Countries: 25. Publications: 2.
A Study Of The Safety, Tolerability And Effective Of Voriconazole For The Treatment Of Serious Candida Infection And Candida Infection Of The Throat In Pediatric Patients
ClinicalTrials.gov study NCT01092832. IPD Sharing: Not stated. Countries: 8. Publications: 1.
Effects of litter quality on foraging behaviour and demographic parameters in Folsomia candida (Collembola)
Open the record for dataset details and reuse information.
The molecular basis of pH sensing by the human fungal pathogen Candida albicans TOK potassium channel
Open the record for dataset details and reuse information.
Cedar Creek Ecosystem Science Reserve site, station Old Field 77 at Cedar Creek, study of plant cover of Dalea candida in units of percent on a yearly timescale
The EcoTrends project was established in 2004 by Dr. Debra Peters (Jornada Basin LTER, USDA-ARS Jornada Experimental Range) and Dr. Ariel Lugo (Luquillo LTER, USDA-FS Luquillo Experimental Forest) to support the collection and analysis of long-term ecological datasets. The project is a large synthesis effort focused on improving the accessibility and use of long-term data. At present, there are ~50 state and federally funded research sites that are participating and contributing to the EcoTrends project, including all 26 Long-Term Ecological Research (LTER) sites and sites funded by the USDA Agriculture Research Service (ARS), USDA Forest Service, US Department of Energy, US Geological Survey (USGS) and numerous universities. Data from the EcoTrends project are available through an exploratory web portal (http://www.ecotrends.info). This web portal enables the continuation of data compilation and accessibility by users through an interactive web application. Ongoing data compilation is updated through both manual and automatic processing as part of the LTER Provenance Aware Synthesis Tracking Architecture (PASTA). The web portal is a collaboration between the Jornada LTER and the LTER Network Office. The following dataset from Cedar Creek Ecosystem Science Reserve (CDR) contains plant cover of Dalea candida measurements in percent units and were aggregated to a yearly timescale.
Data from: Host-induced genome instability rapidly generates phenotypic variation across Candida albicans strains and ploidy states
<p>Candida albicans is an opportunistic fungal pathogen of humans that is typically diploid yet has a highly labile genome tolerant of large-scale perturbations including chromosomal aneuploidy and loss-of-heterozygosity events. The ability to rapidly generate genetic variation is crucial for C. albicans to adapt to changing or stressful environments, like those encountered in the host. Genetic variation occurs via stress-induced mutagenesis or can be generated through its parasexual cycle, in which tetraploids arise via diploid mating or stress-induced mitotic defects and undergo nonmeiotic ploidy reduction. However, it remains largely unknown how genetic background contributes to C. albicans genome instability in vitro or in the host environment. Here, we tested how genetic background, ploidy, and the host environment impacts C. albicans genome stability. We found that host association induced both loss-of-heterozygosity events and genome size changes, regardless of genetic background or ploidy. However, the magnitude and types of genome changes varied across C. albicans strain background and ploidy state. We then assessed if host-induced genomic changes resulted in fitness consequences on growth rate and nonlethal virulence phenotypes and found that many host-derived isolates significantly changed relative to their parental strain. Interestingly, diploid host-associated C. albicans predominantly decreased host reproductive fitness, whereas tetraploid host-associated C. albicans increased host reproductive fitness. Together, these results are important for understanding how host-induced genomic changes in C. albicans alter its relationship with the host.</p> <p>IMPORTANCE Candida albicans is an opportunistic fungal pathogen of humans. The ability to generate genetic variation is essential for adaptation and is a strategy that C. albicans and other fungal pathogens use to change their genome size. Stressful environments, including the host, induce C. albicans genome instability. Here, we investigated how C. albicans genetic background and ploidy state impact genome instability, both in vitro and in a host environment. We show that the host environment induces genome instability, but the magnitude depends on C. albicans genetic background. Furthermore, we show that tetraploid C. albicans is highly unstable in host environments and rapidly reduces in genome size. These reductions in genome size often resulted in reduced virulence. In contrast, diploid C. albicans displayed modest host-induced genome size changes, yet these frequently resulted in increased virulence. Such studies are essential for understanding how opportunistic pathogens respond and potentially adapt to the host environment.</p> <p> </p>
Data from: Multilocus microsatellite markers for molecular typing of Candida tropicalis isolates
Background: Candida tropicalis is considered to be the leading pathogen causing nosocomial fungemia and hepatosplenic fungal infections in patients with cancer, particularly those with leukemia. Microsatellite-based typing methods using sets of genetic markers have been developed and reported for population structure analysis of C. albicans, C. glabrata, and C. parapsilosis, but no studies have been published for genetic analysis of C. tropicalis. The objective of this study was to develop new microsatellite loci that have the ability to distinguish among C. tropicalis isolates. Results: DNA sequences containing over 10 bi- or tri-nucleotide repeats were selected from the C. tropicalis genome database. Thirty PCR primers sets specific for the microsatellite loci were designed and tested using eight clinically independent isolates. According to the amplification efficiency, specificity, and observed polymorphisms, eight markers were selected for further population structure analysis and molecular typing. Sixty-five independent C. tropicalis isolates were genotyped using these 8 markers. Based on these analyses, six microsatellite loci were confirmed, although two loci were found to be with unstable flanking areas. The six polymorphic loci displayed 4–22 alleles and 7–27 genotypes. The discriminatory power of the six loci ranged from 0.70 to 0.95. Genotyping results obtained by microsatellite analysis were compared to PCR-fingerprinting and multi-locus sequence typing (MLST). The comparisons showed that microsatellite analysis and MLST had the similar discriminatory power for C. tropicalis, which were more powerful than PCR-fingerprinting. Conclusions: This is the first attempt to develop new microsatellite loci for C. tropicalis. These newly developed markers will be a valuable resource for the differentiation of C. tropicalis isolates. More C. tropicalis isolates will need to be sequenced and analyzed in order to fully show the potential of these newly developed microsatellite markers.
Data from: Interactive effects of soil moisture, air temperature and litter nutrient diversity on soil microbial communities and Folsomia candida population
<p>Soil organisms play a key role in carbon and nutrient cycling in forest ecosystems. While soil organisms are strongly influenced by litter chemistry and are highly sensitive to abiotic conditions, little is known about how the interactive effects of these two factors. To address this gap in knowledge, we conducted a 10-week microcosm experiment in which we simulated the effects of climate change on soil ecology. More specifically, we studied relationships among litter nutrient concentration, microbial biomass, Collembola demographic parameters, and litter decomposition, exploring the potential impacts of increasing air temperature and decreasing soil moisture. To develop a gradient of nutrient concentrations, we created six tree litter mixtures with materials gathered from <em>Quercus pubescens</em> and its companion species. In contrast to microbes, we observed that Collembola abundance and litter decomposition were interactively affected by soil moisture and air temperature: the negative effect of increasing air temperature on Collembola abundance was amplified by reduced soil moisture, whereas the positive effect of increasing air temperature on litter decomposition disappeared under reduced soil moisture conditions. In contrast to fungi, the response of bacterial biomass and Collembola abundance to litter nutrient concentration was dependent on abiotic conditions. More specifically, the relationships between nutrients, especially calcium and magnesium, and bacterial biomass and Collembola abundance were less robust or disappeared under drier or warmer conditions. In conclusion, our findings underscore that ongoing climate change could affect soil organisms directly as well as indirectly, by altering their responses to litter nutrient concentrations. In addition, we found that nutrient-rich habitats might be more affected than nutrient-poor habitats by altered climatic conditions.</p>
FIGURE 30 in <p class="HeadingRunIn" align="left"><strong><em>Cradoscrupocellaria</em>, a new bryozoan genus for <em>Scrupocellaria bertholletii</em> (Audouin) and related species (Cheilostomata, Candidae): taxonomy, biodiversity and distribution</strong></p>
FIGURE 30. Distribution of Cradoscrupocellaria species. Colours: green, Eastern Pacific species; black, Atlantic species; blue, North Sea specimens; red, Mediterranean species; pink, Red Sea and Indian species; orange, Indo-Pacific species; blue, southern Australian species.
FIGURE 28 in <p class="HeadingRunIn" align="left"><strong><em>Cradoscrupocellaria</em>, a new bryozoan genus for <em>Scrupocellaria bertholletii</em> (Audouin) and related species (Cheilostomata, Candidae): taxonomy, biodiversity and distribution</strong></p>
FIGURE 28. Cradoscrupocellaria hirsuta (Jullien & Calvet, 1903) n. comb. A–B, MOM 420323, lectotype, Azores. C–F, NHMUK 2012.7.1.1, Azores. A, Frontal surface of branch; note the presence of a dimorphic frontal avicularium and absence of scutum. B, Abfrontal surface of branch. C, Frontal surface of branch bifurcation; note the dimorphic frontal avicularia and three ovicelled zooids proximally in the colony. D, Frontal surface of branch; note the presence of seven long oral spines in each zooid and the absence of a scutum. E, Close-up of four ovicelled zooids and dimorphic frontal avicularia. F, Abfrontal surface of branch.
FIGURE 27. Cradoscrupocellaria odonoghuei n in <p class="HeadingRunIn" align="left"><strong><em>Cradoscrupocellaria</em>, a new bryozoan genus for <em>Scrupocellaria bertholletii</em> (Audouin) and related species (Cheilostomata, Candidae): taxonomy, biodiversity and distribution</strong></p>
FIGURE 27. Cradoscrupocellaria odonoghuei n. sp. A–F, NHMUK 2010.12.6.21, holotype, Scotland. A, Frontal surface of colony. B, Frontal surface of branch bifurcation; note the joints passing across gymnocyst of outer zooids at the bifurcation. C, Close-up of a branch bifurcation. D, Close-up of gigantic frontal avicularium. E, Abfrontal surface of colony; note the smooth rhizoids arising from proximal end of some vibracular chambers. F, Abfrontal surface of branch bifurcation.
FIGURE 26. Cradoscrupocellaria macrorhynchoides n in <p class="HeadingRunIn" align="left"><strong><em>Cradoscrupocellaria</em>, a new bryozoan genus for <em>Scrupocellaria bertholletii</em> (Audouin) and related species (Cheilostomata, Candidae): taxonomy, biodiversity and distribution</strong></p>
FIGURE 26. Cradoscrupocellaria macrorhynchoides n. sp. A–F, NHMUK 2010.12.6.19, holotype, Queensland, Australia. A, Frontal surface of colony. B, Frontal surface of branch bifurcation; note the gigantic frontal avicularium on axial zooid. C, Close-up of a branch bifurcation; note the ovicelled zooids and the gigantic frontal avicularium. D, Close-up of gigantic frontal avicularium. E, Abfrontal surface of colony. F, Abfrontal surface of branch bifurcation.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.