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1,052 results for “Cell growth”
A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lun
ClinicalTrials.gov study NCT05388669. IPD Sharing: YES. Countries: 20. Publications: 1.
A Study of Nivolumab + Chemotherapy or Nivolumab + Ipilimumab Versus Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Who Failed 1L
ClinicalTrials.gov study NCT02864251. IPD Sharing: Not stated. Countries: 10. Publications: 1.
Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE)
ClinicalTrials.gov study NCT05253781. IPD Sharing: YES. Countries: 1. Publications: 29.
A Study of Tarceva (Erlotinib) as First Line Therapy in Participants With Non-Small Cell Lung Cancer Harbouring Epidermal Growth Factor Receptor (EGFR) Mutations
ClinicalTrials.gov study NCT01310036. IPD Sharing: Not stated. Countries: 4. Publications: 1.
A Study of Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)
ClinicalTrials.gov study NCT04035486. IPD Sharing: YES. Countries: 21. Publications: 7.
Study to Evaluate Safety, Pharmacokinetics, and Efficacy of Rociletinib (CO-1686) in Previously Treated Mutant Epidermal Growth Factor Receptor (EGFR) in Non-Small Cell Lung Cancer (NSCLC) Patients
ClinicalTrials.gov study NCT01526928. IPD Sharing: Not stated. Countries: 4. Publications: 2.
A Study of E7080 Alone, and in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Renal Cell Carcinoma Following One Prior Vascular Endothelial Growth Factor (VEGF)-Targe
ClinicalTrials.gov study NCT01136733. IPD Sharing: Not stated. Countries: 5. Publications: 2.
The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer
ClinicalTrials.gov study NCT03454529. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila
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Intestinal transit amplifying cells require METTL3 for growth factor signaling and cell survival
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The role of cell-envelope synthesis for envelope growth and cytoplasmic density in Bacillus subtilis
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Data from: Intrinsic growth heterogeneity of mouse leukemia cells underlies differential susceptibility to a growth-inhibiting anticancer drug
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Data from: Downregulation of sST2, a decoy receptor for interleukin-33, enhances subcutaneous tumor growth in murine pancreatic cancer cells
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Hormone receptors AR, ER, PR and growth factor receptor Her-2 expression in oral squamous cell carcinoma: Correlation with overall survival, disease-free survival and 10-year survival in a high-risk population
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Tumor growth kinetics of subcutaneously implanted Lewis Lung carcinoma cells
<p><strong>Please cite</strong><br> Benzekry, S., Lamont, C., Beheshti, A., Tracz, A., Ebos, J. M. L., Hlatky, L., & Hahnfeldt, P. (2014). Classical mathematical models for description and prediction of experimental tumor growth. <em>PLoS Computational Biology</em>, <em>10</em>(8), e1003800. http://doi.org/10.1371/journal.pcbi.1003800</p> <p><strong>Cell culture</strong><br> Murine Lewis lung carcinoma (LLC) cells, originally derived from a spontaneous tumor in a C57BL/6 mouse [1], were obtained from American Type Culture Collection (Manassas, VA). </p> <p><strong>Tumor injections</strong><br> For the subcutaneous mouse syngeneic lung tumor model, C57BL/6 male mice with an average lifespan of 878 days were used [2]. At time of injection mice were 6 to 8 weeks old (Jackson Laboratory, Bar Harbor, Maine). Subcutaneous injections of 10<sup>6</sup> LLC cells in 0.2 ml phosphate-buffered saline (PBS) were performed on the caudal half of the back in anesthetized mice.</p> <p><strong>Tumor measurements</strong><br> Tumor size was measured regularly with calipers to a maximum of 1.5 cm<sup>3</sup> for the lung data set. Largest (L) and smallest (w) diameters were measured subcutaneously using calipers and the formula V = <span class="math-tex">\(\frac{\pi}{6}w^2 L\)</span> was then used to compute the volume (ellipsoid). Volumes ranged 14–1492 mm<sup>3</sup> over time spans from 4 to 22 days for the lung tumor model (two experiments of 10 animals each).</p> <p>[1] Bertram JS, Janik P (1980) Establishment of a cloned line of Lewis Lung Carcinoma cells adapted to cell culture. Cancer Lett 11: 63–73. Available: http://www.ncbi.nlm.nih.gov/pubmed/7226139. Accessed 9 July 2013.</p> <p>[2] Kunstyr I, Leuenberger HG (1975) Gerontological data of C57BL/6J mice. I. Sex differences in survival curves. J Gerontol 30: 157–162. Available: http:// www.ncbi.nlm.nih.gov/pubmed/1123533. Accessed 9 July 2013.</p>
Tumor growth kinetics of human MDA-MB-231 cells transfected with dTomato lentivirus
<p>Tumor growth data involve human MDA-MB-231 cells stably transfected with dTomato lentivirus.</p> <p>Animals were orthotopically implanted (80,000 cells at injection) into the mammary fat pads of 6-week-old female nude mice.</p> <p>Tumor size was monitored regularly with fluorescence imaging. The data comprised a total of 64 observations.</p> <p> </p> <p>In the file, the columns correspond to:</p> <ul> <li>ID: identifier of the animal</li> <li>Time: day of the tumor measurement after implantation</li> <li>Observation: tumor measurement (in phot./s)</li> </ul> <p> </p> <p><strong>Please cite: </strong>Vaghi C, Rodallec A, Fanciullino R, Ciccolini J, Mochel JP, et al. (2020) Population modeling of tumor growth curves and the reduced Gompertz model improve prediction of the age of experimental tumors, PLoS Comput Biol, 16, p. e1007178. <a href="https://doi.org/10.1371/journal.pcbi.1007178">https://doi.org/10.1371/journal.pcbi.1007178</a></p>
Data from: Immediate and carry-over effects of insect outbreaks on vegetation growth in West Greenland assessed from cells to satellite
Aim: Tundra ecosystems are highly vulnerable to climate change and climate-growth responses of Arctic shrubs are variable and altered by microsite environmental conditions and biotic factors. With warming and drought during the growing season, insect-driven defoliation is expected to increase in frequency and severity with potential broad-scale impacts on tundra ecosystem functioning. Here we provide the first broad-scale reconstruction of spatiotemporal dynamics of past insect outbreaks by assessing their effects on shrub growth along a typical Greenlandic fjord climate gradient from the inland ice to the sea. Location: Nuuk Fjord (64°30′N/51°23′W) and adjacent areas, West Greenland. Taxa: Great brocade (Eurois occulta L.) and grey willow (Salix glauca L.). Methods: We combined dendro-anatomical and remote sensing analyses. Time series of ring width and wood-anatomical traits were obtained from chronologies of > 40 years established from 153 individuals of S. glauca collected at nine sites. We detected anomalies in satellite-based Normalized Difference Vegetation Index (NDVI) related to defoliation and reconstructed past changes in photosynthetic activity across the region. Results: We identified outbreaks as distinctive years with reduced ring width, cell-wall thickness and vessel size, without being directly related to climate but matching with years of parallel reduction in NDVI. The two subsequent years after the defoliation showed a significant increase in ring width. The reconstructed spatiotemporal dynamics of these events indicate substantial regional variation in outbreak intensity linked to the climate variability across the fjord system. Main conclusions: Our results highlight the ability of S. glauca to cope with severe insect defoliation by changing carbon investment and xylem conductivity leading to high resilience and rapid recovery after the disturbance. Our multi-proxy approach allows us to pin-point biotic drivers of narrow ring formation and to provide new broad-scale insight on the C-budget and vegetation productivity of shrub communities in a widespread arctic ecosystem
Data from: Phytoplankton growth and stoichiometric responses to warming, nutrient addition and grazing depend on lake productivity and cell size
<p>Global change involves shifts in multiple environmental factors that act in concert to shape ecological systems in ways that depend on local biotic and abiotic conditions. Little is known about the effects of combined global change stressors on phytoplankton communities, and particularly how these are mediated by distinct community properties such as productivity, grazing pressure and size distribution. Here, we tested for the effects of warming and eutrophication on phytoplankton net growth rate and C:N:P stoichiometry in two phytoplankton cell size fractions (<30 μm and >30 μm) in the presence and absence of grazing in microcosm experiments. Because effects may also depend on lake productivity, we used phytoplankton communities from three Dutch lakes spanning a trophic gradient. We measured the response of each community to multifactorial combinations of temperature, nutrient, and grazing treatments and found that nutrients elevated net growth rates and reduced carbon:nutrient ratios of all three phytoplankton communities. Warming effects on growth and stoichiometry depended on nutrient supply and lake productivity, with enhanced growth in the most productive community dominated by cyanobacteria, and strongest stoichiometric responses in the most oligotrophic community at ambient nutrient levels. Grazing effects were also most evident in the most oligotrophic community, with reduced net growth rates and phytoplankton C:P stoichiometry that suggests consumer‐driven nutrient recycling. Our experiments indicate that stoichiometric responses to warming and interactions with nutrient addition and grazing are not universal but depend on lake productivity and cell size distribution.</p>
Data from: Oscillatory signatures underlie growth regimes in Arabidopsis pollen tubes: computational methods to estimate tip location, periodicity and synchronization in growing cells
Oscillations in pollen tubes have been reported for many cellular processes, including growth, extracellular ion fluxes, and cytosolic ion concentrations. However, there is a shortage of quantitative methods to measure and characterize the different dynamic regimes observed. Herein, a suite of open-source computational methods and original algorithms were integrated into an automated analysis pipeline that we employed to characterize specific oscillatory signatures in pollen tubes of Arabidopsis thaliana (Col-0). Importantly, it enabled us to detect and quantify a Ca2+ spiking behaviour upon growth arrest and synchronized oscillations involving growth, extracellular H+ fluxes, and cytosolic Ca2+, providing the basis for novel hypotheses. Our computational approach includes a new tip detection method with subpixel resolution using linear regression, showing improved ability to detect oscillations when compared to currently available methods. We named this data analysis pipeline 'Computational Heuristics for Understanding Kymographs and aNalysis of Oscillations Relying on Regression and Improved Statistics', or CHUKNORRIS. It can integrate diverse data types (imaging, electrophysiology), extract quantitative and time-explicit estimates of oscillatory characteristics from isolated time series (period and amplitude) or pairs (phase relationships and delays), and evaluate their synchronization state. Here, its performance is tested with ratiometric and single channel kymographs, ion flux data, and growth rate analysis.
Data from: Medial pith cells per meter in twigs as a proxy for mitotic growth rate (Phi/m) in the apical meristem
The Φ model for plant mating system evolution proposes a causal link between Φ, the number of mitoses that occur within a plant's lifetime from zygote to gamete production, and constraints on the evolution of inbreeding depression and thereby on the evolution of plant mating systems. Through its use of plant stature, the Φ model emphasizes the important role of morphology in creating developmental and genetic constraints on plant evolution. However, the estimation of Φ itself is likely to be extraordinarily complex. Here I describe a protocol for estimating Φ per meter linear growth by an apical meristem (Φ/m) using medial pith cells from mature internodes of twigs. While such cells are produced by the apical meristem, during internode elongation these pith cells also undergo further mitoses and thus their measurement can only approximate a 'true' Φ/m via the application of a multiplier (the adjustment ratio) that partially corrects for the occurrence of cell divisions and cell growth beyond the apical meristem. I apply this method to Delonix regia (Caesalpiniaceae) and derive several adjustment ratios from the literature. As variation in Φ/m can have profound evolutionary implications, I also examine interspecific and intraspecific variation as well as within-individual variation in Φ/m. Conifers apparently have lower Φ/m than angiosperms, while 20% of the total variance in Φ/m for D. regia was found among individual trees, with the remainder found within trees. Given the large differences in stature between 'high-Φ' plants such as trees and 'low-Φ' plants such as herbs, these results support the idea that the total per-generation mutation rate for high-Φ plants is likely to be many times higher than that for low-Φ plants.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.